Category: chlorides-buliding-blocks

Li, Ziyong published the artcileBlue-/NIR light-excited fluorescence switch based on a carbazole-dithienylethene-BF₂bdk triad, Synthetic Route of 219537-97-0, the publication is Journal of Organic Chemistry (2019), 84(21), 13364-13373, database is CAplus and MEDLINE.

The development of novel solid-state fluorescence switches, particularly triggered by visible light, is of increasing interest for the potential application in optical data storage and super-resolution fluorescence microscopies. In this study, two carbazole-dithienylethene-BF₂bdk triads CDB1 and CDB2, suspending carbazole and BF₂bdk moieties on both sides of dithienylethene unit, have been developed. They exhibit blue-/NIR light-controlled photochromism with solvent-dependent characteristics. Moreover, CDB1 (o) reveals blue-/NIR light-induced reversible fluorescent switching behaviors in toluene, chloroform, poly(Me methacrylate) (PMMA) film, and powder state, while its analog CDB2 (o) in the powder state exhibits no fluorescence due to a strong intermol. π-π stacking interaction, and the fluorescent switching performance is observed only in toluene and PMMA film. The d. functional theory calculations further validate the differences in their optical properties in the solution and powder states.

Journal of Organic Chemistry published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Synthetic Route of 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Ziyong published the artcileDithienylethene-bridged difluoroboron β-diketonate dyes: Optical switching behaviors and triple sensing for volatile amine vapors, Computed Properties of 219537-97-0, the publication is Dyes and Pigments (2020), 108419, database is CAplus.

Developing new visible light-triggered NIR photochromic sensors for the accurate detection of volatile amine vapors in the solid state is highly desirable. Herein, three novel dithienylethene-bridged difluoroboron β-diketonate dyes Di-BF₂bdk-DTE1-Di-BF₂bdk-DTE3, in which BF₂bdk group not only functions as electron acceptor but also responds to amine vapors, have been developed. Upon alternating irradiation with blue light (460-470 nm) and near-IR light (760-770 nm), they displayed excellent NIR photochromism and fluorescent switching behaviors in toluene and in the PMMA film. Moreover, they showed an unprecedented triple sensing performance for volatile n-propylamine vapor in the PMMA film state (fluorescent-colorimetric-colorimetric). Therefore, they would be utilized as triple sensing membranes for selective detection towards volatile primary or secondary amine vapors in environmental and biol. systems.

Dyes and Pigments published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Computed Properties of 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cheng, Huicheng published the artcileHighly efficient synthesis of aryl and heteroaryl trifluoromethyl ketones via o-iodoxybenzoic acid (IBX), Product Details of C8H4ClF3O, the publication is Tetrahedron Letters (2013), 54(33), 4483-4486, database is CAplus.

A 2-step process for the synthesis of aryl and heteroaryl trifluoromethyl ketones from the corresponding aldehydes is described. Trifluoromethyl alcs. were prepared from aryl and heteroaryl aldehydes in excellent yields using catalytic amounts of K₂CO₃. The trifluoromethyl alcs. were then oxidized conveniently and efficiently by 2-iodoxybenzoic acid (IBX) under mild conditions to give the desired functionalized aryl and heteroaryl trifluoromethyl ketones.

Tetrahedron Letters published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, Product Details of C8H4ClF3O.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ye, Xiaohan published the artcileGold-Catalyzed Oxidative Coupling of Alkynes toward the Synthesis of Cyclic Conjugated Diynes, SDS of cas: 21286-54-4, the publication is Chem (2018), 4(8), 1983-1993, database is CAplus and MEDLINE.

Gold-catalyzed oxidative coupling of alkynes was developed as an efficient approach for the synthesis of challenging cyclic conjugated diynes (CCD), e.g., I. Compared with the classic copper-promoted oxidative coupling reaction of alkynes, this gold-catalyzed process exhibited a faster reaction rate due to rapid reductive elimination from the Au(III) intermediate. This unique reactivity thus allowed a challenging diyne macrocyclization to take place with high efficiency. Condition screening revealed an [(n-Bu)₄N]⁺[Cl-Au-Cl]^– salt as the optimal pre-catalyst. Macrocycles with ring size between 13 and 28 atoms were prepared in moderate to good yields, which highlighted the broad substrate scope of this new strategy. Furthermore, the synthetic utilities of the CCDs for copper-free click chem. have been demonstrated, showcasing the potential application of this strategy in biol. systems.

Chem published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C9H16BNO2, SDS of cas: 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Yang published the artcileDiscovery of novel Ponatinib analogues for reducing KDR activity as potent FGFRs inhibitors, COA of Formula: C6H4ClNO2, the publication is European Journal of Medicinal Chemistry (2017), 122-132, database is CAplus and MEDLINE.

FGF receptors (FGFRs) are tyrosine kinases that are overexpressed in diverse tumors by genetic alterations such as gene amplifications, somatic mutations and translocations. Owing to this characteristic, FGFRs are attractive targets for cancer treatment. It has been demonstrated that most multi-targeted, ATP competitive tyrosine kinase inhibitors are active against FGFRs as well as other kinases. The design of new and more selective inhibitors of FGFRs, which might be reduced off-target and side effects, is a difficult yet significant challenge. The results of the current investigation, show that novel Ponatinib analogs are highly active as FGFR inhibitors and that they possess reduced kinase insert domain receptor (KDR) activities. Observations made in a structure and activity relationship (SAR) investigation led to the development of a promising, orally available lead compound 4-chloro-N-(4-((4-methylpiperazin-1-yl) methyl)-3-(trifluoromethyl) phenyl)-3-((5-morpholinopyridin-3-yl) ethynyl) benzamide (compound 4, I), which displays a 50-100-fold in vitro selectivity for inhibition of FGFR1-3 over KDR. In addition, biol. evaluation of I showed that it displays significant antitumor activities in FGFR1-amplificated H1581 and FGFR2-amplificated SNU-16 xenograft models.

European Journal of Medicinal Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, COA of Formula: C6H4ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chen, Jun published the artcileDiscovery of 1-(4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one, an orally active multi-target agent for the treatment of diabetic nephropathy, Safety of 3-Chloro-4-fluoronitrobenzene, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(2), 222-229, database is CAplus and MEDLINE.

Oxidative stress, inflammation and fibrosis can cause irreversible damage on cell structure and function of kidney and are key pathol. factors in Diabetic Nephropathy (DN). Therefore, multi-target agents are urgently need for the clin. treatment of DN. Using Pirfenidone as a lead compound and based on the previous research, two novel series (5-trifluoromethyl)-2(1H)-pyridone analogs were designed and synthesized. SAR of (5-trifluoromethyl)-2(1H)-pyridone derivatives containing nitrogen heterocyclic ring have been established for in vitro potency. In addition, compound I, a novel agent that act on multiple targets of anti-DN with IC₅₀ of 90 μM in NIH3T3 cell lines, t_1/2 of 4.89 ± 1.33 h in male rats and LD₅₀ > 2000 mg/kg in mice, has been advanced to preclin. studies as an oral treatment for DN.

Bioorganic & Medicinal Chemistry Letters published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Safety of 3-Chloro-4-fluoronitrobenzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hwang, Soo-Yeon published the artcileField-based rational design of p300 histone acetyltransferase inhibitor and systematic evaluation as an anti-fibrotic agent, Recommanded Product: 3-Chlorobenzylchloride, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(68), 9795-9798, database is CAplus and MEDLINE.

(E)-3-(3-(4-((3-Carbamoylbenzyl)oxy)-3-iodo-5-methoxyphenyl) acryloyl)benzamide (A6) was found to be a potent p300 inhibitor (IC₅₀ = 870 nM) showing a similar binding mode to that of acetyl-CoA, a p300 substrate, and effective anti-fibrotic activity in both TGF-β1-stimulated lung fibroblast cells and bleomycin-induced in vivo lung fibrosis mice.

Chemical Communications (Cambridge, United Kingdom) published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Recommanded Product: 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jung, Eun Ae published the artcileSynthesis and photoelectronic properties of thermally stable poly[oxy(2,7-fluoren-9-onenylene)oxy(diorganosilylene)]s, HPLC of Formula: 14799-93-0, the publication is Bulletin of the Korean Chemical Society (2012), 33(6), 2031-2036, database is CAplus.

Melt copolymerization reactions of several bis(diethylamino)silane derivatives, bis(diethylamino)methylphenylsilane, bis(diethylamino)methyloctylsilane, 1,2-bis(diethylamino)tetramethyldisilane, and 1,3-bis(diethylamino)tetramethyldisiloxane, with 2,7-dihydroxyfluoren-9-one were carried out to yield poly[oxy(2,7-fluoren-9-onenylene)oxy(diorganosilylene)]s bearing the fluoren-9-one fluorescent aromatic group in the polymer main chain: poly[oxy(2,7-fluoren-9-onenylene)oxy(methylphenylsilylene)], poly[oxy(2,7-fluoren-9-onenylene)oxy(methyloctylsilylene)], poly[oxy(2,7-fluoren-9-onenylene)oxy(tetramethyldisilylene)], and poly[oxy(2,7-fluoren-9-onenylene)oxy(tetramethyldisiloxanylene)]. These polymeric materials are soluble in common organic solvents such as CHCl₃ and THF. FTIR spectra of all the materials reveal characteristic Si-O-C stretching frequencies at 1012-1018 cm^-1. In the THF solution, the prepared materials show strong maximum absorption peaks at 258-270 nm, strong maximum excitation peaks at 260-280 nm, and strong maximum fluorescence emission bands at 310-420 nm. TGA thermograms suggest that most of the polymers are essentially stable to 200° without any weight loss and up to 300° with only a weight loss of less than 5% in nitrogen.

Bulletin of the Korean Chemical Society published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, HPLC of Formula: 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kim, Ji Ho published the artcileOxidative coupling polymerization of diethynylsilane derivatives and 1,2-diethynyl-1,1,2,2-tetramethyldisilane, Category: chlorides-buliding-blocks, the publication is Bulletin of the Korean Chemical Society (2006), 27(6), 869-874, database is CAplus.

The Glaser oxidative coupling polymerizations was performed on diethynyldiphenylsilane, diethynylmethylphenylsilane, diethynylmethyloctylsilane, and 1,2-diethynyl-1,1,2,2-tetramethyldisilane to afford polycarbosilanes containing diethynyl and organosilane groups in the main chain, such as poly(diethynyldiphenylsilane), poly(diethynylmethylphenylsilane), poly(diethynylmethyloctylsilane), and poly(1,2-diethynyl-1,1,2,2-tetramethyldisilane), resp. These obtained materials are almost insoluble in common organic solvents such as CHCl₃ and THF probably due to the presence of a rigid rod diacetylene group along the polymer main chain. Therefore, the polymers were characterized using several spectroscopic methods in solid state. FTIR spectra of all the polymeric materials show that the characteristic CC stretching frequencies appear at 2147-2154 cm^-1, in particular. The polymers in the solid state exhibit that the strong maximum excitation peaks appear at 260-283 nm and the strong maximum fluorescence emission bands at 367-412 nm, especially Thermogravimetric anal. of the materials shows that about 55-68% of the initial polymer weights remain at 400°C in nitrogen.

Bulletin of the Korean Chemical Society published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yun, Seung Beom published the artcileSynthesis and properties of poly(carbomethyloctylsiloxane)s by melt copolymerization of bis(diethylamino)methyloctylsilane and aryldiol derivatives, HPLC of Formula: 14799-93-0, the publication is Bulletin of the Korean Chemical Society (2008), 29(12), 2373-2378, database is CAplus.

We carried out the melt copolymerizations of bis(diethylamino)methyloctylsilane with several aryldiols to afford poly(carbomethyloctylsiloxane)s containing fluorescent aromatic chromophore groups in the polymer main chain: poly(oxybiphenyloxymethyloctyl silane), poly(oxy(4,4′-isopropylidene)diphenyleneoxymethyloctylsilane), poly(oxy(4,4′-hexafluoroisopropylidene)diphenyleneoxymethyloctylsilane),poly(oxy-2,6-naphthalenediyloxymethyloctylsilane),and poly(oxyphenyleneoxymethyloctylsilane). These materials are soluble in common organic solvents such as CHCl₃ and THF. FTIR spectra of all the polymeric materials show the characteristic Si-O-C stretching frequencies at 1051-1082 cm^-1. The polymers in THF solution exhibit strong maximum absorption peaks at 263-341 nm with the strong maximum excitation peaks at 253-325 nm, and strong maximum fluorescence emission bands at 300-420 nm. According to TGA all the polymers are stable up to 200 °C with weight loss of less than 9% in nitrogen.

Bulletin of the Korean Chemical Society published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C7H8BBrO3, HPLC of Formula: 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics