Category: chlorides-buliding-blocks

Nevalainen, Vesa published the artcileStudies on the preparation of dihydro-1,4-oxathiines. Computer-assisted evaluation of the results of retrosynthetic analysis verified by synthetic experiments and by-product analyses. Synthetic pathways involving α-sulfenylated ketones and 1,3-oxathiolanes of α-halo and α-hydroxy ketones, COA of Formula: C4H8Cl2S2, the publication is Acta Chemica Scandinavica (1990), 44(6), 591-602, database is CAplus.

The preparation of 2- and 2,3-substituted 5,6-dihydro-1,4-oxathiines (I, R = Me or Ph, R¹ = H, Me, CO₂H, CO₂Me, CO₂Et, or CONHPh) was studied by computer simulation and by experiment Three major synthetic pathways, involving 2-(1-hydroxyalkyl)-1,3-oxathiolanes, 2-(1-haloalkyl)-1,3-oxathiolanes, 2-hydroxyethylthiomethyl ketones, methanesulfonates of 2-hydroxyethylthiomethyl ketones and 2-chloroethylthiomethyl ketones as intermediates, were evaluated, by running the program CAMEO, and by experiment The results of the two approaches were compared and the major byproducts of the reactions were identified by GLC/MS.

Acta Chemica Scandinavica published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, COA of Formula: C4H8Cl2S2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nevalainen, Vesa published the artcileStudies on the formation of dihydro-1,4-oxathiines by halogenation of 1,3-oxathiolanes, Computed Properties of 1002-41-1, the publication is Journal of Chemical Research, Synopses (1988), 182-3, database is CAplus.

Dihydro-1,4-oxathiins I (R, R¹ = Me, H; Et, H; Ph, H; Me, Ph; CO₂Me, H; Me, CO₂Me; Me, CONHPh) were prepared in 6-45% yields by the halogenation of the resp. 1,3-oxathiolanes II (R, R¹ = Me, H; Me, Me; Ph, H; Me, Ph; CO₂Me, H; Me, CO₂Me; Me, CONHPh) with SOCl₂. Several byproducts were formed.

Journal of Chemical Research, Synopses published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Computed Properties of 1002-41-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Proevska, L. I. published the artcile¹H NMR spectra and structure of safranines. Hindered rotation of the 3-dialkylamino group in 7-azo derivatives, HPLC of Formula: 4569-86-2, the publication is Dyes and Pigments (1998), 36(2), 177-190, database is CAplus.

The ¹H NMR spectra of safranine derivatives are reported. Semiempirical calculations indicate that the high shielding of the 4- and 6-proton adjacent to an amino or hydroxyl group (resonating between 5.5 and 6.0 ppm) is due to accumulation of neg. charge on the 4-and 6-C atoms, augmented by the magnetic anisotropy effect of the orthogonal 5-Ph ring. The ortho protons of the latter resonate up field to the meta and para protons. Hindered rotation of dialkylamino groups, altogether unexpected in view of the rather low barriers in similar anilines, is observed only in the azo derivatives AM1 suggests that this is due to destabilization of the transition state when an amino group is substituted for an azo group.

Dyes and Pigments published new progress about 4569-86-2. 4569-86-2 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, and the molecular formula is C22H23ClN4, HPLC of Formula: 4569-86-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gosset, Antoine published the artcileEcotoxicological risk assessment of micropollutants from treated urban wastewater effluents for watercourses at a territorial scale: Application and comparison of two approaches, Recommanded Product: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, the publication is International Journal of Hygiene and Environmental Health (2020), 113437, database is CAplus and MEDLINE.

In most cases, urban Wastewater Treatment Plants (WWTP) only partially abate pollutants occurring in the influent. Treated effluents can thus contain a complex mixture of ecotoxic pollutants, such as heavy metals, detergents, disinfectants, plasticizers, pharmaceuticals residues or pesticides. In this context, Ecotoxicol. Risk Assessment (ERA) provide essential decision-making tools to public authorities for establishing environmental policies and conducting territorial planning. The present work aims to develop a territorial-scale ERA methodol. using two complementary approaches based on a Risk Quotient (RQ) calculation: (1) the first, based on the risk linked to each individual pollutant (single substances ERA); (2) the second, considering all pollutants present, and the “cocktail effect” (mixture ERA). This research was performed at 33 urban WWTPs of in a highly urbanized part of France (Lyon area). Initial min., median and maximum pollutant concentrations in treated effluents were obtained from a literature review of physico-chem. anal. studies, to reconstitute “typical” effluents. The classical approach (single substances ERA) identified the riskiest substances (e.g. endocrine disruptors, as the Estrone with RQ up to 593.75), and showed the risks for each WWTP. The mixture ERA approach revealed new risks, which were not highlighted in the classical ERA approach, thus increasing the number of WWTPs identified as at risk. This study shows the importance of accounting for the cocktail effect, which is not considered in current regulatory decisions. Finally, this methodol. allowed us to identify the riskiest situations (often medium sized WWTPs, releasing into small streams), that could worsen in the context of climate change.

International Journal of Hygiene and Environmental Health published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Recommanded Product: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Eremeev, A. V. published the artcileAsymmetric unbridged nitrogen. 37. Absolute configuration of diastereomeric derivatives of N-substituted aziridine-2-carboxylic acids, Computed Properties of 18791-02-1, the publication is Khimiya Geterotsiklicheskikh Soedinenii (1984), 1343-8, database is CAplus.

Both (R,S)- and (S,S)-aziridinecarboxanilides (I; R, R¹ = Me, H; Me, Br; CHMe₂, Br) were prepared and the diastereoisomers distinguished by their ¹H and ¹⁵N NMR and CD spectra.

Khimiya Geterotsiklicheskikh Soedinenii published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Computed Properties of 18791-02-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Brzozowski, Zdzislaw published the artcileDerivatives of 2-mercaptobenzenesulfonamide. XIII. Syntheses and some pharmacological properties of 1-[4-chloro-2-(dialkylaminoalkylthio)-5-methylbenzenesulfonyl]-2-imidazolidinone hydrochlorides, COA of Formula: C5H13Cl2N, the publication is Acta Poloniae Pharmaceutica (1993), 50(4-5), 359-64, database is CAplus and MEDLINE.

In the search for new antiarrhythmic agents, 3-[(4-chloro-2-mercapto-5-methylphenyl)sulfonyl]imidazolidinone I (R = H) was treated with dialkylaminoalkyl chloride hydrochlorides in Me₂CHONa-Me₂CHOH to yield I (R = Me₂NCH₂CHMe, Me₂NCMe₂CH₂, and R¹CH₂CH₂; R¹ = Pr₂N, Bu₂N, (C₆H₁₁)₂N, piperidinyl, 2,6-dimethylpiperidinyl, morpholinyl, and piperazinyl). Data for LD₅₀ and activity against acinitine- and BaCl₂-induced arrhythmia in rats are presented for I hydrochlorides.

Acta Poloniae Pharmaceutica published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, COA of Formula: C5H13Cl2N.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Belyakova, Z. V. published the artcileEffect of catalysts on the reaction of allyl esters with hydrosilanes, Name: Dichloro(methyl)(octyl)silane, the publication is Russian Journal of General Chemistry (2010), 80(4), 728-733, database is CAplus.

Hydrosilylation of allyl esters XOCH₂CH:CH₂ (X = MeCO, CF₃CO, C₃F₇CO, CH₂:C(Me)CO), PhOCH₂CH:CH₂ and ClCH₂CH:CH₂ with hydrosilanes HSiCl₃, HSi(OEt)₃ and HSiMeCl₂ in the presence of Speier’s catalyst, Speier’s catalyst with additives, and of various Ni compounds was studied. The catalytic hydrosilylation reaction in the presence of the Speier catalyst is accompanied by reductions Additives to the Speier catalyst (vinyltriethoxysilane, allyl acetate and trifluoroacetate) suppress the reduction reaction considerably. E.g., hydrosilylation of allyl methacrylate with HSiCl₃ in the presence of Speier’s catalyst gave CH₂:C(Me)CO₂CH₂CH₂CH₂SiCl₃ in 67% yield and a ratio of 5.55 of the addition product to the reduction product. The same reaction in the presence of Speier’s catalyst and vinyltriethoxysilane afforded CH₂:C(Me)CO₂CH₂CH₂CH₂SiCl₃ in 87% yield and a ratio of 114.1 of the addition product to the reduction product. In the presence of the studied Ni compounds mainly reduction and isomerization reactions of allyl Ph ether occurred. The best Ni catalysts for hydrosilylation were mixtures of NiCl₂ or Ni(acac)₂ with phosphine oxides. In contrast to allyl Ph ether, the hydrosilylation of simple olefins proceeds easier. E.g., hydrosilylation of 1-heptene with HSiCl₃ in the presence of NiCl₂ and (octyl)₃P:O gives the hydrosilylation product trichloroheptylsilane in 94% yield in the reaction mixture

Russian Journal of General Chemistry published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Name: Dichloro(methyl)(octyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nongmaithem, Sapana published the artcileEnhanced Polar Auxin Transport in Tomato Polycotyledon Mutant Seems to be Related to Glutathione Levels, Safety of 3-Chloro-4-hydroxyphenylacetic acid, the publication is Journal of Plant Growth Regulation (2021), 40(2), 761-773, database is CAplus.

Glutathione-dependent root growth in Arabidopsis is linked to polar auxin transport (PAT). Arabidopsis mutants with reduced glutathione (GSH) levels also show reduced PAT. To gain an insight into the relationship between PAT and GSH level, we analyzed tomato polycotyledon mutant, pct1-2, which has enhanced PAT. Microarray anal. of gene expression in pct1-2 mutant revealed underexpression of several genes related to glutamate and glutathione metabolism In consonance with microarray anal., enzymic as well as in vivo assay revealed higher glutathione levels in the early phase of pct1-2 seedling growth than WT. The inhibition of auxin transport by 2,3,5-triiodobenzoic acid (TIBA) reduced both GSH level and PIN1 expression in pct1-2 root tips. The reduction of in vivo GSH accumulation in pct1-2 root tips by buthionine sulfoximine (BSO) stimulated elongation of the short root of pct1-2 mutant akin to TIBA. The rescue of the short root phenotype of the pct1-2 mutant was restricted to TIBA and BSO. The other auxin transport inhibitors 1-N-naphthylphthalamic acid (NPA), 2-[4-(diethylamino)-2-hydroxybenzoyl] benzoic acid (BUM), 3-chloro-4-hydroxyphenylacetic acid (CHPAA), brefeldin and gravacin inhibited root elongation in both WT and pct1-2 mutant. Our results indicate a relationship between PAT and GSH levels in tomato akin to Arabidopsis. Our work also highlights that TIBA rescues the short root phenotype of the pct1-2 mutant by acting on a PAT component distinct from the site of action of other PAT inhibitors.

Journal of Plant Growth Regulation published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Safety of 3-Chloro-4-hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Doobary, Sayad published the artcileIntramolecular Alkene Fluoroarylation of Phenolic Ethers enabled by Electrochemically Generated Iodane, COA of Formula: C8H7ClO3, the publication is Journal of Organic Chemistry (2021), 86(22), 16095-16103, database is CAplus and MEDLINE.

Herein, synthesis of 3-fluorinated chromanes from allylic phenol ethers was described. Oxidant-free approach takes advantage of an electrochem. generation of a hypervalent iodine species, difluoro-λ³-tolyl iodane, which mediates the alkene fluoroarylation. High yields and selectivity for this transformation are achieved for electron poor substrates. The redox chem. has been characterized for the electrochem. generation of the iodane in the presence of fluoride, and insights into the mechanism are given. The transformation has been demonstrated on larger gram scales, which represents the potential broader utility of the process.

Journal of Organic Chemistry published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, COA of Formula: C8H7ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Davies, W. published the artcilePolymerization of thiophene derivatives. V. The self-condensation of 4,5- and 6,7-benzothianaphthene 1,1-dioxides. A new route to 1-(1-naphthyl)- and 4-(2-naphthyl)phenanthrene, Related Products of chlorides-buliding-blocks, the publication is Journal of the Chemical Society (1956), 2609-14, database is CAplus.

cf. C.A. 50, 1752d. 2-(1-Naphthyl)ethanol, b_0.2 130-2°, with PBr₃ gave 2-(1-naphthylethyl) bromide (I). I (98 g.) was refluxed and stirred 15 hrs. with 170 g. of Na₂SO₃.7H₂O to give 81 g. of Na 2-(1-naphthyl)ethanesulfonate (II). II stirred 30 min. with 66 g. PCl₅ at room temperature, the mixture warmed 30 min. on a steam bath and extracted with Et₂O, and the extract cooled precipitated gave 48 g. 2-(1-naphthyl)ethanesulfonyl chloride (III), m. 48-8.5°; anilide, m. 133.5-34°; amide, m. 172.5-73°. III (40 g.) in 75 ml. PhNO₂ was added to 24 g. powd. AlCl₃ in 200 ml. PhNO₂, the mixture kept 1 hr. at room temperature and 2 hrs. at 70°, the complex decomposed with dilute HCl, the solvent steam distilled, and the residue extracted with C₆H₆ gave 14.8 g. 2,3-dihydro-4,5-benzothianaphthene 1,1-dioxide (IV), m. 178-8.5°. IV (6.0 g.) refluxed 8 hrs. with 4.8 g. N-bromosuccinimide and 0.1 g. Bz₂O₂ in 150 ml. CCl₄, the solvent removed, and the residue dissolved in hot C₆H₆, filtered, and chromatographed on Al₂O₃ gave 2.7 g. 4,5-benzothianaphthene 1,1-dioxide (V), m. 136-7° or 141-2° with evolution of SO₂. V was reduced with LiAlH₄ to give 2,3-dihydrothianaphthene (VI), m. 86.5-87°. VI refluxed with chloranil in xylene 6 hrs. and the mixture cooled, filtered, diluted with C₆H₆, and chromatographed gave 4,5-benzothianaphthene. V (2.5 g.) in 50 ml. xylene was refluxed until evolution of SO₂ ceased. Evaporation gave 1.6 g. 10,11-dihydro-9-thia-5,6-benzonaphtho(1′,2′,3,4)fluorene 9,9-dioxide (VII), m. 226°. VII refluxed 10 min. in 50% aqueous KOH in (HOCH₂CH₂)₂O and the mixture diluted with H₂O and extracted with Et₂O gave 1-(1-naphthyl)phenanthrene, m. and mixed m.p. 115-16°. By the same sequence of reactions, the following compounds were prepared from 2-(2-naphthyl)ethanol, m. 66°: Na 2-(2-naphthyl)ethanesulfonate; 2,2′-naphthylethanesulfonyl chloride, m. 66-6.5° (amide, m. 200-200.5°); 2,3-dihydro-6,7-benzothianaphthene 1,1-dioxide, m. 187.5-88°; 6,7-benzothianaphthene 1,1-dioxide, m. 181-2°or 194-5° (decomposition); 10,11-dihydro-9-thia-7,8-benzonaphtho(2′,1′-3,4)fluorene 9,9-dioxide, m. 166-7°; and 4-(2-naphthyl)phenanthrene, m. 105-6°. 6-Tetralinsulfonyl chloride, m. 57-8°, was reduced with Zn and H₂SO₄ to 6-mercaptotetralin (VIII), b₃₅ 161-2°. VIII added to still-reacting Na in EtOH, followed by chloroacetal and NaBr, the mixture refluxed 6 hrs., the solution extracted with 2% aqueous NaOH, then Et₂O, the Et₂O extract distilled gave (6-tetralylthio)acetaldehyde di-Et acetal (IX), b_0.5 160-1°. Slow addition of IX to mixed P₂O₅ and H₃PO₄ gave a yellow oil which was distilled to give a mixture of tetrahydrobenzothianaphthenes, b_0.3 119-21°. Tetralin (50 g.) stirred 1 hr. into ClSO₃H at -5° warmed to room temperature, the mixture precipitated with ice and extraction with CCl₄, and the extract evaporated gave a mixture of 68 g. of 5- and 6-tetralinsulfonyl chlorides; this product (20 g.) added to 14.5 g. ClCH₂CO₂H on 12 g. NaOH in 250 ml. H₂O and the mixture heated 1 hr. on a water bath, cooled, and acidified precipitated 25 g. of an acid mixture (X). X (20 g.) in 80 ml. 5% KOH was added to 40 ml. 40% KOH. The acidified precipitate gave 9.2 g. (6-tetralylthio)acetic acid, m. 78.5-79. Acidification of the filtrate gave 9.0 g. of (5-tetralylthio)acetic acid, m. 133-4°.

Journal of the Chemical Society published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics