Category: chlorides-buliding-blocks

Comstock, Lindsay R. published the artcileExpeditious synthesis of aziridine-based cofactor mimics, Name: 2,3-Dibromopropionylchloride, the publication is Tetrahedron (2002), 58(30), 6019-6026, database is CAplus.

S-Adenosyl-L-methionine mimics were synthesized in a linear fashion highlighting methodol. that bypasses the need for adenine base protection. These aziridine-based cofactor mimics are envisioned as useful biochem. tools and potential therapeutic agents whose mechanism of action hinges upon aberrant methyltransferase enzymes. Aziridination of the 5′ position of adenosine was effected by convergence of suitably protected 5′-aminoadenosine with various dibromopropionates. The economy and high yields for this route to said aziridine-based cofactors is highly amenable to large-scale chem. which no doubt will be vital to their development as therapeutics and biochem. tools.

Tetrahedron published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Name: 2,3-Dibromopropionylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Prasad, G. K. published the artcileSun light assisted photocatalytic decontamination of sulfur mustard using ZnO nanoparticles, Application of 1,2-Bis(2-chloroethyl)disulfane, the publication is Journal of Molecular Catalysis A: Chemical (2011), 349(1-2), 55-62, database is CAplus.

Sunlight-assisted photocatalytic decontamination of sulfur mustard (HD) was studied using ZnO nanoparticles and the data were compared with those carried out in the presence of UVA and visible light radiation. In the presence of sunlight, 100% of HD was decomposed in 12 h. Whereas, in the presence of UVA light 90%, and in visible light 80% of HD was decomposed in 12 h. GC-MS data indicated the formation of thiodiglycol, hemisulfur mustard, divinyl sulfide, 2-chloro Et vinyl sulfide, etc., on the surface of ZnO nanoparticles in the case of dark and visible light irradiation experiments However, in sunlight and UVA light irradiation experiments, GC-MS data indicated the formation of HD sulfoxide, HD sulfone, 1,3-dithiane, 2-chloro ethanol, acetaldehyde, CO₂, etc. along with hydrolysis and elimination products. Under the illumination of visible light and in dark hydrolysis, elimination and surface complexation reactions contributed to decontamination of HD. Whereas, in the presence of sunlight and UVA light, photocatalytic reactions like C-S bond cleavage, oxidation of C, S atoms were observed to have contributed to decontamination of HD in addition to hydrolysis and elimination reactions.

Journal of Molecular Catalysis A: Chemical published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Application of 1,2-Bis(2-chloroethyl)disulfane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

O’Hagan, Michael P. published the artcileVisible-light photoswitching of ligand binding mode suggests G-quadruplex DNA as a target for photopharmacology, Formula: C15H14Cl2S2, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(38), 5186-5189, database is CAplus and MEDLINE.

We report the selective targeting of telomeric G4 DNA with a dithienylethene ligand and demonstrate the robust visible-light mediated switching of the G4 ligand binding mode and G-tetrad structure in physiol.-relevant conditions. The toxicity of the ligand to cervical cancer cells is modulated by the photoisomeric state of the ligand, indicating for the first time the potential of G4 to serve as a target for photopharmacol. strategies.

Chemical Communications (Cambridge, United Kingdom) published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Formula: C15H14Cl2S2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ahn, Ki Chang published the artcileDetection of the Antimicrobial Triclosan in Environmental Samples by Immunoassay, Category: chlorides-buliding-blocks, the publication is Environmental Science & Technology (2016), 50(7), 3754-3761, database is CAplus and MEDLINE.

A sensitive, competitive ELISA for the detection of the antimicrobial triclosan (TCS) was developed. Novel immunizing haptens were synthesized by derivatizing at the 4-Cl position of the TCS mol. Compounds derived from substitutions at 4′-Cl and that replaced the 2′-OH with a Cl atom were designed as unique coating antigen haptens. Polyclonal rabbit antisera were screened against the coating antigen library to identify combinations of immunoreagents resulting in the most sensitive assays. The most sensitive assay identified was one utilizing antiserum number 1155 and a heterologous competitive hapten, where the 2′-OH group was substituted with a Cl atom. An IC₅₀ value and the detection range for TCS in assay buffer were 1.19 and 0.21-6.71 μg/L, resp. The assay was selective for TCS, providing low cross-reactivity (<5%) to the major metabolites of TCS and to brominated di-Ph ether-47. A 2nd assay using a competitive hapten containing Br instead of Cl substitutions was broadly selective for both brominated and chlorinated diphenylethers. Using the most sensitive assay combination, we measured TCS concentrations in water following dilution Biosolid samples were analyzed following the dilution of a simple solvent extract The immunoassay results were similar to those determined by LC-MS/MS. This immunoassay can be used as a rapid and convenient tool to screen for human and environmental exposure.

Environmental Science & Technology published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Darroudi, Mahdieh published the artcileSynthesis of Novel Triazole Incorporated Thiazolone Motifs Having Promising Antityrosinase Activity through Green Nanocatalyst CuI-Fe₃O₄@SiO₂ (TMS-EDTA), COA of Formula: C7H7ClN2S, the publication is Applied Organometallic Chemistry (2020), 34(12), e5962, database is CAplus.

In the present work, novel 5-((1-benzyl-1,2,3-triazol-4-yl)methoxybenzylidene)-2-(arylamino)thiazol-4-one thiazolone incorporated triazole derivatives I and II was designed as tyrosinase inhibitors. The compounds I and II were synthesized through click reaction in good yield. Moreover, the antityrosinas activity of the synthesized derivatives I and II was evaluated. In the search for establishing a click copper-catalyzed azide/alkyne cycloaddition (CuAAC) reaction under strict conditions, in terms of a novel air-stable, a recyclable and efficient magnetic catalyst was planned for new triazole derivatives as a well-organized copper iodide supported on the functionalized Fe₃O₄@SiO₂ core-shell (CuI/Fe₃O₄@SiO₂(TMS-EDTA) nanoparticles). The engineered nanocatalyst synthesized for the first time and characterized by different methods, including FT-IR spectroscopy, XRD, FESEM, EDX, TEM, TGA, and BET anal. The excellent catalytic performance in ethanol with high surface area (351.7 m²g^-1) and short reaction time for diverse functional groups (120-200 min), no use of toxic solvents, reusability of the catalyst, and using eco-friendly conditions were the advantageous of this work. Moreover,the nanocatalyst was used at least five times without any significant decrease in the yield of the reaction. The thiazolidine-triazole derivatives I [X=Y=Z = H, X=Y = H; Z = Br, X = 4-N; Y = H; Z = 2-Cl and X = 4-N; Y = H; 3,4-di-Cl] showed promising tyrosinase inhibitory activity with IC₅₀ values in the range of 5.90-9.81μM. The compounds I and II were found to be considerably more potent tyrosinase inhibitors than the reference inhibitor kojic acid (IC₅₀ = 18.36μM).

Applied Organometallic Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, COA of Formula: C7H7ClN2S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pragathi, Yazala Jyothsna published the artcileIodine promoted synthesis and construction of aromatic thioureas from amines, Synthetic Route of 3696-23-9, the publication is European Journal of Biomedical and Pharmaceutical Sciences (2018), 5(7), 1-3, database is CAplus.

A new facile methodol. for the synthesis of thioureas by desulfurization and addition reaction of the required amines, carbon disulfide and ammonia solution in the presence of DMF solvent using iodine at room temperature The structures of the synthesized compounds were confirmed by IR, and ¹H-NMR methods. The synthetic benefits were operational simplicity, mild reaction conditions, short reaction times, high purity and yield of the products. Considering the com. importance of thioureas, it should be emphasized that implementation of the optimal synthesis of thiourea determined good intermediate for the synthesis heterocyclic compounds having good biol. activity from amines using iodine as a reagent.

European Journal of Biomedical and Pharmaceutical Sciences published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Synthetic Route of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kalola, Anirudhdha G. published the artcileReduction of aliphatic, aromatic and heteroaromatic carboxylic acid derivatives to alcohol promoted by trityl resin under presence of copper sulphate and sodium borohydride catalytic system, COA of Formula: C19H14Cl2, the publication is Heterocyclic Letters (2022), 12(1), 87-99, database is CAplus.

An efficient, eco-friendly, mild protocol for the acid-alc. transformation is developed. Varied aliphatic, aromatic and heteroaromatic carboxylic acid derivatives RC(O)OH [R = n-heptadecan-1-yl, 1-naphthyl, furan-2-yl, etc.] loaded on to the 2-chloro trityl chloride resin under perseverance of DIPEA base followed by subsequent reduction into corresponding alcs. ROH using CuSO₄-NaBH₄ catalytic system have been achieved in excellent yield with easy product isolation technique. Facile recycling of the recovered resin is also associated to this methodol.

Heterocyclic Letters published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, COA of Formula: C19H14Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mal, Sanjib published the artcileFacile one pot synthesis of 8-chloro-[1,2,4]triazolo[4,3-a]pyrazines via oxidative cyclisation using chloramine T, Category: chlorides-buliding-blocks, the publication is Tetrahedron Letters (2015), 56(22), 2896-2901, database is CAplus.

A facile and expedient one pot synthesis of 8-chloro-[1,2,4]triazolo[4,3-a]pyrazine derivatives I [R¹ = H, Cl; R = Ph, 3-MeO-C₆H₄, 4-Br-C₆H₄, etc.] from 2-chloro-3-hydrazinylpyrazine and aldehydes is described using chloramine T trihydrate as a safe and convenient electrocyclisation (oxidising) agent. The presence of the chloro group on pyrazine enabled us to access versatile new synthetic scaffolds II [R¹ = Ph, 2-thiophenyl, 2,4-diCl-C₆H₃] by easy diversification using palladium catalyzed Suzuki-Miyaura and Sonogashira cross coupling reactions. The products are obtained in high yields in short reaction time under mild conditions without the need for chromatog. purification

Tetrahedron Letters published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fuson, Reynold C. published the artcileLevinstein mustard gas. IV. The bis(2-chloroethyl)polysulfides, Recommanded Product: 1,2-Bis(2-chloroethyl)disulfane, the publication is Journal of Organic Chemistry (1946), 487-98, database is CAplus and MEDLINE.

In the preparation of II according to the L. process, a considerable amount of products with a high S content is formed. These products are considered to consist of bis(2-chloroethyl) polysulfides (XXVII) (cf. Conant, et al., loc. cit.). XXVII are identified and synthesized. H₂O₂ (503 g., 30%) is slowly added over a period of 2 hrs. to 624 g. XX with stirring and cooling to maintain a temperature of 50-60°. The mixture is kept 2 hrs. and the H₂O distilled off in vacuo. Heating the crude (HOCH₂CH₂)₂S₂ (XXVIII) with 2800 cc. concentrated HCl on a steam bath for 0.5 hr. gives 94% III, b_0.4 97-8°, n_D²⁰ 1.5656. An apparatus for a continuous process for the preparation of III is described. When to Na₂S₃, prepared by dissolving 256 g. S and 960 g. Na₂S.9II₂O in 1300 cc. H₂O, 644 g. HOCH₂CH₂Cl (XXIX) is added over a period of 0.5 hr. with cooling with ice-H₂O, the mixture stirred an addnl. 4 hrs., the oily layer separated, and the H₂O and excess XXIX are distilled off in vacuo, 80% (HOCH₂CH₂)₂S₃ is obtained and is converted with SOCl₂ into crude IV which is purified by distillation at 0.01 mm. The fractions with n_D 1.59-1.62 are crystallized from absolute EtOH, giving pure IV, m. 30.5-1.5°, n_D²⁰ 1.6110. When 120 g. II from the Levinstein process is stirred with H₂O for 11 days and the H₂O frequently changed until the H ion concentration becomes negligible, 29.1% unhydrolyzed XXVII is obtained and dissolved in Cellosolve (XXX). S (77.5 g.) and a small amount of viscous oil are filtered off and the XXX is washed out with H₂O, leaving crude (ClCH₂CH₂)₂S₅ (XXXI), n_D²⁰ 1.6763. Calculated on the S recovered, the original XXVII has the composition (ClCH₂ CH₂)₂S_7.5. XXXI is further purified by steam distillation to remove any III and IV. The residual XXXI is treated again with XXX, washed with H₂O, taken up in ether, and the ether solution dried and evaporated, giving 70% pure XXXI, n_D²⁰ 1.6853, d_D²⁰ 1.5013. When IV is treated 6-36 hrs. at temps, ranging from 115-40° with various mol. amounts of S, homogeneous products are obtained. These compounds, when kept in the refrigerator for several days, deposit S in amounts equal to the amount used in excess of that required to form XXXI. Treatment of the products with XXX gives XXXI. III and S at 145-50° for 20-30 hrs. also give XXXI. On treatment of the hydrolysis products of II with XXX, a small amount of alc.-insoluble oil (the analysis of which agrees with C₄H₈Cl₂S₁₁), which slowly deposits S on standing, is obtained. Me₂S₄, b_1.5 68-70°, n_D²⁰ 1.6621, d₄²⁰ 1.3008, is prepared according to the method of Levi and Baroni (C.A. 23, 4927) in 25% yield. An attempt to sulfurize III with Me₂S₄ failed. When 0.14 mol. Me₂S₄ and 0.06 mol. IV are heated at 35-40° and 3-4 mm., Me₂S₃, n_D²⁰ 1.5999, slowly distills, and, on raising the temperature to 120° for 2 hrs., 50% XXXI, n_D²⁰ 1.6850, is obtained. Sulfurization of XXXI with Me₂S₄ 4 hrs. at 75° in a N atm. and finally at 130° several hrs., gives 97% (ClCH₂CH₂)₂S₇ (XXXII), n_D²⁰ > 1.74, which deposits S upon standing. When treated with NH₃, XXXII is reconverted into XXXI. When the sulfurization is carried out by using a large amount of Me₂S₄, higher polysulfides are formed which lose S rapidly upon standing. When XXXI is subjected to a steam distillation and the residue is allowed to stand for 1 week, no S is deposited. The residue, n_D²⁰ 1.702, has the composition (ClCH₂CH₂)₂S_5.5. When 10 g. XXXI is heated with 9 g. S at 110° for 3 days, (ClCH₂CH₂)₂S₁₂, red viscous oil, is obtained. IV, when shaken with finely divided S, dissolves 4.4% S, while XXXI dissolves 7.4%. In lieu of XXX, moist NH₃ can be used for the stripping of XXVII, resulting in the formation of XXXI. When the stripping is carried out with NH₃ in the presence of XXX or ether, IV is obtained. When XXXI is refluxed with Me₂CO for 2 days, a XXVII is obtained, corresponding approx. to a tetrasulfide, n_D²⁰ 1.6545. Steam distillation of XXXI gives an impure IV, m. 13°, n_D²⁰ 1.611. On heating of IV at 145-60° and 0.5 mm., III, n_D²⁰ 1.5690, distills, leaving a mixture of S and XXVII from which no IV can be isolated. III and IV are quite stable to hydrolysis with H₂O. By exhaustive hydrolysis of II from the L. process and stripping the residue with XXX, a mixture of III and XXXI, n_D²⁰ 1.6740, is obtained. From this n_D and on the basis of n_D²⁰ 1.6835 for XXXI and 1.5656 for III, a content of 1.8% III is calculated for the original II. When 3.1 g. III is slowly added to 5.5 g. com. 90% thiosalicylic acid and 2.6 g. NaOH in 150 cc. 95% EtOH, the mixture refluxed h 1 hr., and poured into 400 cc. H₂O, acidification of the solution with dilute HCl precipitates 5.1 g. of a compound, C₁₈H₁₈O₄S₄, crystals from EtOH, m. 185-6°. Heating 7 g. III in 50 cc. MeOH with 165 g. XXII in 125 cc. MeOH and 15 cc. H₂O 2 hrs. on a steam bath gives 92% of a compound, C₁₄H₂₄N₂O₂S₆, fine needles from 95% EtOH, m. 109-10°. III and piperidine give 53% bis[2-(1-piperidyl)ethyl] disulfide, oil, n_D²⁰ 1.5478 (di-HCl salt, crystals, m. 236°). The structure of XXVII is discussed and it is concluded that III and IV possess a linear structure rather than an angular one. Structure XXXIa is proposed for XXXI.

Journal of Organic Chemistry published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Recommanded Product: 1,2-Bis(2-chloroethyl)disulfane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fuson, Reynold C. published the artcileLevinstein mustard gas. I. 2-Haloalkylsulfenyl halides, SDS of cas: 1002-41-1, the publication is Journal of Organic Chemistry (1946), 469-74, database is CAplus and MEDLINE.

In the reaction mechanism postulated by Conant, et al. ( C.A. 14, 1677), ClCH₂CH₂SCl (I) is suggested as an intermediate in the formation of (ClCH₂CH₂)₂S (II) although I has never been obtained in a pure state. When 169 g. Cl is passed into 453 g. (ClCH₂CH₂)₂S₂ (III) in dry CCl₄ at such a rate that the temperature does not exceed 10° the solvent distilled off, and the residue fractionated, 57-79% I, b₁₅ 47-7.5° n_D²⁰ 1.5290, is obtained. I, orange liquid, is moderately stable when kept in a brown bottle in the refrigerator. The residue (173 g.) from the distillation, on further fractionation, gives III and a new compound, C₄H₇Cl₃S₂, yellow liquid, n_D^21.8 1.5768. When I is treated with KI, III is formed with liberation of iodine. When I is treated with H₂O, III, b₂ 83-8°, n_D²⁰ 1.5670, m. 1° is formed, in addition to an unidentified product, probably the thiosulfonic ester. When equal mols. I and S are heated for 3 h. at 60-5° and distilled, S₂Cl₂, III and (ClCH₂CH₂)₂S₃ (IV) are obtained. Oxidation of 4.8 g. I with 30 cc. HNO₃ (d. 1.42) on a steam bath, evaporation to dryness, dissolution of the residue in an excess of NH₄OH, and evaporation again give 79% ClCH₂CH₂SO₂ONH₄, m. 191-3°. When CH₂:CH₂ is passed into 10 g. I in 90 cc. CCl₄, the solution is decolorized with formation of 70% II, b₁ 54-5°, n_D²⁰ 1.5281. I and cydohexene (V) give 69% 2-chlorocyclohexyl 2-chloroethyl sulfide (VI), b_0.2 84-6° (p-tolylsulfonylsulfilimine, prepared by treating VI with Chloramine-T, m. 145.5-6° (preheated bath)). When 185 g. I is dropped into 1500 cc. AcOEt over a period of 2 h. saturated with CHCH at 0° with continuous introduction of CHCH, 56% 2-chloroethyl 2-chlorovinyl sulfide, b_0.15 30°, b_0.75 46°, m. -24° n_D²⁰ 1.5480 (p-tolylsulfonylsulfilimine m. 105-5.5° sulfone, platelets from petr. ether, m. 37.5-8°), is obtained. When 35 g. I and Me₂CO are allowed to react, HCl is evolved and the solution becomes colorless, giving acetonyl 2-chloroethyl sulfide, b_0.75 76-85° (semicarbazone m. 145-6°). When I and piperazine are allowed to react according to Rheinboldt and Mott (C.A. 33, 4959.4), 1,4-bis(2-chloroethylmercapto)piperazine, needles from EtOH, m. 117-18° is obtained. When III is treated with Br in 150 cc. CCl₄, ClCH₂CH₂SBr is obtained after distilling off the solvent in vacuo at room temperature It decomposes on distillation at 3 mm. When V is added to the bromination reaction mixture, 75% 2-bromocyclohexyl 2-chloroethyl sulfide is formed, decomposing slightly on distillation at 0.35 mm. (p-tolylsulfonylsulfilimine, crystals from EtOH, m. 145-6°).

Journal of Organic Chemistry published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, SDS of cas: 1002-41-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics