Category: chlorides-buliding-blocks

Saheb Sharif-Askari, Narjes published the artcileEffect of common medications on the expression of SARS-CoV-2 entry receptors in kidney tissue, Formula: C12H15ClO3, the publication is Clinical and Translational Science (2020), 13(6), 1048-1054, database is CAplus and MEDLINE.

Besides the respiratory system, severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection was shown to affect other essential organs such as the kidneys. Early kidney involvement during the course of infection was associated with worse outcomes, which could be attributed to the direct SARS-CoV-2 infection of kidney cells. In this study, the effect of commonly used medications on the expression of SARS-CoV-2 receptor, angiotensin-converting enzyme (ACE)2, and TMPRSS2 protein in kidney tissues was evaluated. This was done by in silico analyses of publicly available transcriptomic databases of kidney tissues of rats treated with multiple doses of commonly used medications. Of 59 tested medications, 56% modified ACE2 expression, whereas 24% modified TMPRSS2 expression. ACE2 was increased with only a few of the tested medication groups, namely the renin-angiotensin inhibitors, such as enalapril, antibacterial agents, such as nitrofurantoin, and the proton pump inhibitor, omeprazole. The majority of the other medications decreased ACE2 expression to variable degrees with allopurinol and cisplatin causing the most noticeable downregulation. The expression level of TMPRSS2 was increased with a number of medications, such as diclofenac, furosemide, and dexamethasone, whereas other medications, such as allopurinol, suppressed the expression of this gene. The prolonged exposure to combinations of these medications could regulate the expression of ACE2 and TMPRSS2 in a way that may affect kidney susceptibility to SARS-CoV-2 infection. Data presented here suggest that the authors should be vigilant about the potential effects of commonly used medications on kidney tissue expression of ACE2 and TMPRSS2.

Clinical and Translational Science published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Formula: C12H15ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sharma, Prabodh Chander published the artcileDesign, Synthesis and Molecular Docking Studies of Some Thiazole Clubbed Heterocyclic Compounds as Possible Anti-infective Agents, HPLC of Formula: 3696-23-9, the publication is Letters in Organic Chemistry (2018), 15(8), 716-726, database is CAplus.

{[(Chlorophenyl)thiazolyl]arylpyrazolylmethylene}(arylimino)thiazolidinones I (R = 4-ClC₆H₄, 2-ClC₆H₄, Ph, 3-Cl-2-FC₆H₃, 4-FC₆H₄, 2,4-Cl₂C₆H₃, 2-ClC₆H₄, 4-MeOC₆H₄, 4-O₂NC₆H₄; R¹ = H, F, Cl, Br) were prepared and tested as antibacterial, antifungal, antimalarial, and antihelminthic agents. Potential binding modes of selected compounds with 14α-sterol demethylase and DNA gyrase subunit A were determined using mol. docking calculations The tested compounds exhibited moderate to significant antimicrobial activities. I (R = 4-O₂NC₆H₄; R¹ = Br) showed significant antimalarial activity with an IC₅₀ value of 0.59 μg/mL [as compared to chloroquine (IC₅₀ = 0.020 μg/mL) and quinine (IC₅₀ = 0.268 μg/mL)]. I (R = 2,4-Cl₂C₆H₃; R¹ = Cl) showed antihelminthic activity in earthworms with a mean time to paralysis of 19.2 ± 0.9 min and mean time to death of 31.7 ± 2.5 min.

Letters in Organic Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C15H14O3, HPLC of Formula: 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yoshida, Masahito published the artcileStructure-activity relationship study on Col-003, a protein-protein interaction inhibitor between collagen and Hsp47, Recommanded Product: 5-Bromo-3-chloro-2-hydroxybenzaldehyde, the publication is Chemical & Pharmaceutical Bulletin (2020), 68(3), 220-226, database is CAplus and MEDLINE.

This study demonstrates the structure-activity relationship of Col-003, a potent collagen-heat-shock protein 47 (Hsp47) interaction inhibitor. Col-003 analogs were successfully synthesized by Pd(0)-catalyzed cross-coupling reactions of 5-bromosalicylaldehyde derivatives with alkyl-metal species, and the inhibitory activities of the synthetic analogs were evaluated using surface plasmon resonance anal. (BIAcore). We succeeded in discovering two potent inhibitors that showed 85 and 81% inhibition at a concentration of 1.9μM against the collagen-Hsp47 interaction. This indicates that elongation of an alkyl linker between two aromatic rings could considerably improve inhibitory activity due to the adjustment of a pendant Ph moiety to an appropriate position, in addition to the hydrophobic interaction with an alkyl linker moiety.

Chemical & Pharmaceutical Bulletin published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C4H10O2, Recommanded Product: 5-Bromo-3-chloro-2-hydroxybenzaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Somawardhana, C. W. published the artcileSynthesis of 2-[¹²³I and ¹²⁴I]-iodoisonicotinic acid hydrazide-potential radiotracers for tuberculosis, SDS of cas: 6313-54-8, the publication is Applied Radiation and Isotopes (1991), 42(3), 215-20, database is CAplus and MEDLINE.

The radiochem. syntheses of Me 2-[¹²³I]-iodoisonicotinate, 2-[¹²³I]-iodoisonicotinic acid hydrazide (I) and 2-[¹²⁴I]-iodoisonicotinic acid hydrazide was accomplished. Iodine-123 was incorporated in the Me ester mol. by an exchange reaction in glacial acetic acid. The average efficiency of iodine exchange reaction was (92.6%). This radiotracer was extracted with ether and the solvent was evaporated The residue was re-dissolved in anhydrous ethanol and treated with hydrazine under anhydrous conditions to obtain I. The overall radiochem. yield was 69%. Biodistribution data of both radio-tracers in male Sprague-Dawley rats were collected. This is the first report of SPECT radiopharmaceuticals which may be useful for differential diagnosis of intracranial masses (tuberculoma vs. glioma), and CNS tuberculosis in immunosuppressed subjects.

Applied Radiation and Isotopes published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C9H10O4, SDS of cas: 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Beppu, Teruo published the artcileHydrosilane synthesis via catalytic hydrogenolysis of halosilanes using a metal-ligand bifunctional iridium catalyst, Quality Control of 14799-94-1, the publication is Journal of Organometallic Chemistry (2018), 75-80, database is CAplus.

Hydrogenolysis of various halosilanes was catalyzed by Ir amido complexes to produce hydrosilanes. Selective monohydrogenolysis of di- and trichlorosilanes similarly proceeded, giving chlorohydrosilanes (R₂SiHCl or RSiHCl₂) as synthetically important building blocks for various organosilicon compounds A mechanistic study supported the in-situ formation of an Ir hydride species as a key intermediate, which could transfer the hydride to the Si atom through a metal-ligand bifunctional mechanism. One-pot hydrotrimethylsilylation of olefins was achieved via successive hydrogenolysis and hydrosilylation reactions starting from Me₃SiCl.

Journal of Organometallic Chemistry published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Quality Control of 14799-94-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Naganawa, Yuki published the artcileA General and Selective Synthesis of Methylmonochlorosilanes from Di-, Tri-, and Tetrachlorosilanes, Application of Dichloro(hexyl)(methyl)silane, the publication is Organic Letters (2021), 23(2), 601-606, database is CAplus and MEDLINE.

Direct catalytic transformation of chlorosilanes into organosilicon compounds remains challenging due to difficulty in cleaving the strong Si-Cl bond(s). Herein, it is reported the palladium-catalyzed cross-coupling reaction of chlorosilanes with organoaluminum reagents. A combination of [Pd(C₃H₅)Cl]₂ and DavePhos ligand catalyzed the selective methylation of various dichlorosilanes, trichlorosilanes, and tetrachlorosilane to give the corresponding monochlorosilanes.

Organic Letters published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Application of Dichloro(hexyl)(methyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Schlapbach, Achim published the artcileN-aryl-piperidine-4-carboxamides as a novel class of potent inhibitors of MALT1 proteolytic activity, Formula: C6H3ClFNO2, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(12), 2153-2158, database is CAplus and MEDLINE.

Starting from a weak screening hit, potent and selective inhibitors of the MALT1 protease function were elaborated. Advanced compounds displayed high potency in biochem. and cellular assays. Compounds showed activity in a mechanistic Jurkat T cell activation assay as well as in the B-cell lymphoma line OCI-Ly3, which suggests potential use of MALT1 inhibitors in the treatment of autoimmune diseases as well as B-cell lymphomas with a dysregulated NF-κB pathway. Initially, rat pharmacokinetic properties of this compound series were dominated by very high clearance which could be linked to amide cleavage. Using a rat hepatocyte assay a good in vitro-in vivo correlation could be established which led to the identification of compounds with improved PK properties.

Bioorganic & Medicinal Chemistry Letters published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Formula: C6H3ClFNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fallah Fini, Mojtaba published the artcileExperimental and QSPR Studies on the Effect of Ionic Surfactants on n-Decane-Water Interfacial Tension, COA of Formula: C19H34ClN, the publication is Journal of Surfactants and Detergents (2012), 15(4), 477-484, database is CAplus.

A quant. structure property relationship approach was performed to find the relation between the surfactant structure and its effect on water-oil interfacial tension. As a result, a new database has been developed measuring the interfacial tension between n-decane as the model oil and different aqueous solutions of some ionic compounds In spite of other reports we selected surfactants by a scientific method that covers all structural information. Twenty four different compounds were selected by the principal component anal. method and their interfacial tensions were measured at their critical micelle concentrations The geometrical optimization of surfactants was performed at the B3LYP/6-311G** level and quantum chem. and structural descriptors were calculated using relevant computer software programs. The best fitted descriptors were selected using the variable selection of the genetic algorithm (GA-MLR). The predictive test was performed for an external prediction set of 6 compounds, chosen out of 24 compounds The resulted GA-MLR model can reasonably predict the interfacial tension using only three selected descriptors. The deviation between predicted and measured values was found to be <7%.

Journal of Surfactants and Detergents published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, COA of Formula: C19H34ClN.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hasanebrahimi, Gholamreza published the artcileExploring beneficial structural features of ionic surfactants for wettability alteration of carbonate rocks using QSPR modeling technique, Related Products of chlorides-buliding-blocks, the publication is Journal of Molecular Liquids (2017), 196-208, database is CAplus.

Surfactant induced wettability alteration of reservoir rocks is an efficient process that enhances oil recovery of carbonate reservoirs. Finding a suitable surfactant for such a process is an interesting challenge in petroleum industry. To this purpose, generating a database of surfactant properties would be a good idea but property measurement of hundreds of surfactants and then screening them is a highly time consuming and expensive method. Therefore, the application of a math. model for prediction of surfactant properties may well be so helpful for our purpose. Quant. structure-property relationship (QSPR) is a math. model that relates a specific property of materials to their structural characteristics. For the sake of QSPR modeling a dataset of 24 structurally different surfactants was created through the measurement of contact angles (as the most important surfactant characteristic in the wettability alteration process). Contact angle measurement was carried out through imaging a drop of n-decane as the model oil resting on a carbonate rock which has spent 2 days immersed in surfactant solution For this dataset a linear QSPR model of oil contact angle on carbonate rocks was derived using genetic algorithm based on multi-linear regression (GA-MLR) and verified by internal and external validation metrics. From a descriptive point of view, descriptors of the proposed model have a mechanistic interpretation and give an insight to the desired structural features enhancing wettability alteration ability of surfactants.

Journal of Molecular Liquids published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Geer, B. W. published the artcileThe growth effects of carnitine, deoxycarnitine, and sulfocholine for Drosophila, Neurospora, and Saccharomyces, Related Products of chlorides-buliding-blocks, the publication is Growth (1965), 29(4), 405-13, database is CAplus.

The physiol. activities of choline (I) were studied in Saccharomyces carlsbergensis, a I-requiring strain of Neurospora crassa, and Drosophila melanogaster. The related compounds deoxycarnitine (II), carnitine (III), and sulfocholine (IV) were then substituted for dietary I. IV was more effective than I in inhibiting the growth response of S. carlsbergensis to inositol, was slightly less effective than I in promoting the growth of I-requiring N. crassa, and was ∼50% as effective as I in stimulating the growth of D. melanogaster larvae. II and III were ineffective in the Neurospora and Saccharomyces systems, but were nearly as effective as I in the Drosophila system. Thus, the Neurospora and Saccharomyces systems are fundamentally similar in their responses to the test compounds The ability to utilize dietary II and III effectively for growth in place of I apparently evolved within the insect order Diptera.

Growth published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics