Category: chlorides-buliding-blocks

Kodolov, V. I. published the artcileMechanism of the reaction of diethyl alkylphosphonates with hydroxyl-containing polyethers, Safety of Diethyltrichloromethylphosphonate, the publication is Vysokomolekulyarnye Soedineniya, Seriya A (1968), 10(11), 2541-9, database is CAplus.

Di-Et alkylor arylphosphonates are treated with OH-containing oligoethers to obtain products which are useful as additives possessing fire resistance in foamed plastics, glass reinforced plastics, and other materials. Di-Et phosphonate and methyl-, allyl-, trichloromethyl-, and phenylphosphonates are used, and the oligoethers are HO[CH2CH2O2CRCO]mOCH2CH2OH, where R = -CH2-CH2-, -CH:CH-, or -o-C6H4-, where m is 1-2. The compounds are heated at 160-80° under N. The quantity of condensate increases after 4-6 hrs. with the acid number increasing and the OH-group content decreasing. Chromatograms, kinetic data, and ir spectra are given for the products and discussed, and a mechanism for the reaction, based on the destruction of the oligoether by alcoholysis, followed by a proton-radical exchange between the oligoether and the Et Cellosolve formed is proposed.

Vysokomolekulyarnye Soedineniya, Seriya A published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Safety of Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cardenas, Mariel M. published the artcileCatalytic atroposelective dynamic kinetic resolutions and kinetic resolutions towards 3-arylquinolines via S_NAr, Computed Properties of 145349-62-8, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(78), 10087-10090, database is CAplus and MEDLINE.

Herein authors report the catalytic atroposelective syntheses of pharmaceutically relevant 3-arylquinolines via the nucleophilic aromatic substitution (SNAr) of thiophenols into 3-aryl-2-fluoroquinolines mediated by catalytic amounts of Cinchona alkaloid-derived ureas. These reactions displayed a spectrum of dynamic kinetic resolution (DKR) and kinetic resolution (KR) characters depending upon the stereochem. stability of the starting material. Low barrier substrates proceeded via DKR while higher barrier substrates proceeded via KR. On the other hand, substrates with intermediate stabilities displayed hallmarks of both DKR and KR. Finally, authors also show that they can functionalize the atropisomerically enriched quinolines into pharmaceutically privileged scaffolds with minimal observed racemization.

Chemical Communications (Cambridge, United Kingdom) published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Computed Properties of 145349-62-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bagherzadeh, Nastaran published the artcileGreen and efficient synthesis of thioureas, ureas, primary O-thiocarbamates, and carbamates in deep eutectic solvent/catalyst systems using thiourea and urea, Recommanded Product: 1-(4-Chlorophenyl)thiourea, the publication is New Journal of Chemistry (2021), 45(26), 11852-11858, database is CAplus.

An efficient and general catalysis process was developed for the direct preparation of various primary O-thiocarbamates/carbamates as well as monosubstituted thioureas/ureas by using thiourea/urea as biocompatible thiocarbonyl (carbonyl) sources. This procedure used choline chloride/tin(II) chloride [ChCl][SnCl₂]₂ with a dual role as a green catalyst and reaction medium to afford the desired products in moderate to excellent yields. Moreover, the DES can be easily recovered and reused for seven cycles with no significant loss in its activity. Besides, the method shows very good performance for synthesizing the desired products on a large scale.

New Journal of Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Recommanded Product: 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kalita, Pranjal published the artcileKIT-5 Supported Copper (II) Oxide Mesoporous Materials: An Efficient Catalyst for Regioselective Synthesis of 1,4- Disubstituted-1H-1,2,3-Triazoles in Water, HPLC of Formula: 620-20-2, the publication is Polycyclic Aromatic Compounds, database is CAplus.

We have synthesized copper-incorporated KIT-5 mesoporous materials which were characterized thoroughly by powder x-ray diffraction, N₂-sorption, UV-Vis, HR-SEM & EDS and HR-TEM techniques. The low angle PXRD with theta values of 0.609, 0.660, 0.704 and 0.746 confirmed the mesoporosity of the synthesized materials. In addition, the materials showed type-IV isotherms which are spherical in morphol. and fringes with pores of materials supporting the formation of mesoporous materials. The catalytic activity of synthesized materials was also investigated. We have used our materials as catalyst for the synthesis of 1,2,3-triazole derivatives via three component reaction of alkyl/aryl halide, terminal alkynes and sodium azide in water as a solvent. The desired triazole products were obtained in very good yields. This study indicates the importance of Cu element, solid support with uniformity of metal nanoparticles over the materials. The recyclability study with PXRD data of the catalyst confirmed the existence of the mesoporosity of the catalyst after the reaction and the yield decreased marginally from 98 to 91% over three cycles. This reaction has broad substrate scope and is compatible for aliphatic, aromatic, allyl substrates giving high yield of triazole products.

Polycyclic Aromatic Compounds published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, HPLC of Formula: 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sarmah, N. K. published the artcileSynthesis and antimicrobial evaluation of a novel series of some s-triazine moiety, Related Products of chlorides-buliding-blocks, the publication is Journal of Applicable Chemistry (Lumami, India) (2014), 3(5), 1936-1944, 9 pp., database is CAplus.

Some new 2-[N-(3,4,5-trimethoxybenzylidino)(benzoylhydrazinoyl)-amino-4-yl]-4-(4-cyclohexylamino)-6-(arylthioureido)-1,3,5-triazines I (R = 2-OMe, 2-Me, 2-Cl, etc.) were synthesized and evaluated for their in vitro antimicrobial activity against gram pos. and gram neg. strains using micro dilution procedure. Synthesized compounds proved to be effective with MIC (mg ml^-1), among them I (R = 4-OMe, 2-O₂N, 2,4-di-O₂N, R = 2-Cl-4-O₂N) showed excellent activity against a panel of microorganisms.

Journal of Applicable Chemistry (Lumami, India) published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Le Menn, J. C. published the artcileThe methoxy-iminium cation issued from DMF in organic electrosynthesis: an electrophile and a supporting-electrolyte cation, Related Products of chlorides-buliding-blocks, the publication is Electrochimica Acta (1991), 36(5-6), 819-23, database is CAplus.

Electrophilic reactivity of the methoxy-iminium cation (I), resulting from the reaction between dimethyl sulfate and DMF, has been investigated towards electrogenerated carbanions produced by electroreduction of activated polyhalo compounds Controlled potential reduction of di-Et trichloromethylphosphonate (II) in the presence of three equivalent of I in DMF leads to the expected adduct (EtO)₂P(O)CCl₂-CH(NMe₂)OMe (60% yield). Galvanostatic reduction of II in the presence of two equivalent of I leads to mixtures of the enamine (EtO)₂P(O)CCl=CH(NM₂) and the ynamine (EtO)₂P(O)CCNMe₂; when acetic acid is added, a mixture of the enamine and the enol-ether (EtO)₂P(O)CCl=CH(OMe) is obtained. Lastly, the enamine can be synthesized with a 80% yield by electroreducing II in the presence of four equivalent of I in the same way, enamines (MeO₂C)₂C=CH(NMe₂) (40% yield) and (EtO₂C)CCl=CH(NMe₂) (50% yield) are obtained from the electroreduction of di-Me dibromomalonate or Et trichloroacetate, resp.

Electrochimica Acta published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kedari, Chaitanya Kumar published the artcileBiarylmethoxy Nicotinamides As Novel and Specific Inhibitors of Mycobacterium tuberculosis, Computed Properties of 766549-26-2, the publication is ACS Medicinal Chemistry Letters (2014), 5(5), 491-495, database is CAplus and MEDLINE.

A whole cell based screening effort on a focused library from corporate collection resulted in the identification of biarylmethoxy nicotinamides as novel inhibitors of M. tuberculosis (Mtu) H37Rv. The series exhibited tangible structure-activity relationships, and during hit to lead exploration, a cellular potency of 100 nM was achieved, which is an improvement of >200-fold from the starting point. The series is very specific to Mtu and noncytotoxic up to 250 μM as measured in the mammalian cell line THP-1 based cytotoxicity assay. This compound class retains its potency on several drug sensitive and single drug resistant clin. isolates, which indicate that the compounds could be acting through a novel mode of action.

ACS Medicinal Chemistry Letters published new progress about 766549-26-2. 766549-26-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Phenol,Boronic Acids,Boronic acid and ester, name is 2-Chloro-4-hydroxyphenylboronic acid, and the molecular formula is C6H6BClO3, Computed Properties of 766549-26-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Vislohuzova, Tetiana published the artcileStudy of biodegradation, biocompatibility and bactericidal activity of film materials with tiamulin fumarate based on polyurethaneurea, Related Products of chlorides-buliding-blocks, the publication is Chemistry & Chemical Technology (2020), 14(3), 318-326, database is CAplus.

The influence of the model biol. medium 199 on the structure and properties of film materials with tiamulin fumarate based on polyurethaneurea containing in its structure the hydrophilic fragments of the copolymer of N-vinylpyrrolidone with vinyl acetate and vinyl alc. has been investigated. According to IR spectroscopy, under the influence of the biol. medium 199 there are processes of biodegradation of polymer materials which are accompanied by a decrease in the intensity of the absorption band νC=O of vinylpyrrolidone ring. It is established that the introduction of tiamulin fumarate into polyurethaneurea facilitates their biodegradation, as evidenced by a decrease of the tensile strength (1.28-2.38 times) and a relative elongation at break (1.36-1.82 times) after incubation in the biol. medium 199 by physico-mech. tests. The tissue culture method has established the biocompatibility of film materials with tiamulin fumarate. According to the results of microbiol. studies, bactericidal properties were observed in relation to the bacteria Staphylococcus aureus and Escherichia coli. It allows using them for production of drainage in abdominal surgery.

Chemistry & Chemical Technology published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C4H6O3, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Albuini-Oliveira, Nathalia M. published the artcileThe influence of ammonium and phosphonium salts on natural rubber vulcanization with experimental and commercial accelerators, Recommanded Product: N-Benzyl-N,N-dibutylbutan-1-aminium chloride, the publication is Polymer Bulletin (Heidelberg, Germany), database is CAplus.

The influence of eight different quaternary ammonium and phosphonium salts on the vulcanization of natural rubber was investigated. The central atom (P or N) of the cation was of minor importance, but the nature of the organic chains greatly affected the rheometrical parameters of the process and the mech. properties of the vulcanizates. Studies of rubber compositions containing binary mixtures of a quaternary salt and the com. accelerators ZDEC, TBBS, TMTD and MBTS showed a synergistic effect, mainly with TBBS and MBTS. With such binary systems, it is possible to reduce the amount of accelerator and improve the vulcanization parameters and the quality of the vulcanized rubber. The anionic complex bis(N-phenylsulfonyldithiocarbimato)zincate(II) (Z), one amine-free exptl. accelerator, was prepared and isolated as tetrabutylammonium (B₂Z) and benzyltriphenylphosphonium (H₂Z) salts. The H₂Z complex salt is a new substance and behaved as an ultra-accelerator, being faster than ZDEC and TMTD. B₂Z was a medium rate accelerator, being faster than TBBS and similar to MBTS. In addition, the tensile and tear strength of the specimens vulcanized with the zinc-dithiocarbimate salts were superior when compared to compositions containing the com. accelerators. The differences in the behavior of B₂Z and H₂Z showed that the zinc-dithiocarbimates are versatile accelerators for natural rubber as the process and the quality of the vulcanizate can be modulated by the choice of the cation.

Polymer Bulletin (Heidelberg, Germany) published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Recommanded Product: N-Benzyl-N,N-dibutylbutan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bodendiek, Silke B. published the artcileTriarylmethanes, a new class of Cx50 inhibitors, Category: chlorides-buliding-blocks, the publication is Frontiers in Pharmacology of Ion Channels and Channelopathies (2012), 3(June), 106, database is CAplus and MEDLINE.

The paucity of specific pharmacol. agents has been a major impediment for delineating the roles of gap junction (GJ) channels formed by connexin proteins in physiol. and pathophysiol. Here, we used the selective optimization of side activities (SOSA) approach, which has led to the design of high affinity inhibitors of other ion channels, to identify a specific inhibitor for channels formed by Cx50, a connexin subtype that is primarily expressed in the lens. We initially screened a library of common ion channel modulating pharmacophores for their inhibitory effects on Cx50 GJ channels and identified four new classes of compounds The triarlymethane (TRAM) clotrimazole was the most potent Cx50 inhibitor and we therefore used it as a template to explore the structure activity relationship (SAR) of the TRAMs for Cx50 inhibition. We describe the design of T122 (N-[(2-methoxyphenyl)diphenylmethyl]-1,3-thiazol-2-amine) and T136 (N-[(2-iodophenyl)diphenylmethyl]-1,3-thiazol-2-amine), which inhibit Cx50 with IC₅₀s of 1.2 and 2.4 μM. Both compounds exhibit at least 10-fold selectivity over other connexins as well as major neuronal and cardiac voltage-gated K⁺ and Na⁺ channels. The SAR studies also indicated that the TRAM pharmacophore required for connexin inhibition is significantly different from the pharmacophore required for blocking the calcium-activated KCa3.1 channel. Both T122 and T136 selectively inhibited Cx50 GJ channels in lens epithelial cells, suggesting that they could be used to further explore the role of Cx50 in the lens. In addition, our results indicate that a similar approach may be used to find specific inhibitors of other connexin subtypes.

Frontiers in Pharmacology of Ion Channels and Channelopathies published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics