Category: chlorides-buliding-blocks

Nishad, Ravi K. published the artcileDesign and Synthesis of 2-Substituted Benzothiazole Derivatives as Antioxidant and Antimicrobial Agents, Application of 1-(4-Chlorophenyl)thiourea, the publication is Current Bioactive Compounds (2020), 16(8), 1242-1248, database is CAplus.

An upsurge in the number of antibiotic-resistant microbial infections has warranted the discovery and development of new antibiotics. This is a matter of great concern for effective therapy for a search of novel antimicrobial agents. Literature has a number of reports of involvement of oxidative stress due to an imbalance between the generation and neutralization of free radicals in many diseases. Heterocyclic compounds have been involved in the treatment of various disorders. Benzothiazole is one such heterocyclic nucleus having benzene ring merged with the thiazole ring. Among the various substitutions possible in this nucleus, substitutions at position-2 have already been reported with potential bioactivities. Thus, different substituted compounds have been synthesized which could serve as antimicrobials and antioxidants. Benzothiazole derivatives (B₁-B₇) were synthesized by two-step reactions and the structures were confirmed through IR, mass and NMR spectroscopy. The compounds were evaluated for in vitro antioxidant and antimicrobial activities using standard methods. The results of antibacterial and antifungal activity showed that compound B₄ exhibited maximum activity against all the tested strains of microorganisms with the zone of inhibition 17.1-18.5 mm and MIC value 1.1-1.5μg/mL. Compound B₅ exhibited potent antioxidant activity. The compounds substituted with halogen on the aryl ring showed increased antimicrobial activity as seen in the case of compound B₄ (6-fluoro). The compounds substituted with a hydroxyl group (B₅) exhibited good antioxidant activity.

Current Bioactive Compounds published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Application of 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Shan published the artcileDiscovery of Hexahydrofuro[3,2-b]furans as New Kinase-Selective and Orally Bioavailable JAK3 Inhibitors for the Treatment of Leukemia Harboring a JAK3 Activating Mutant, COA of Formula: C6H3ClFNO2, the publication is Journal of Medicinal Chemistry (2022), 65(15), 10674-10690, database is CAplus and MEDLINE.

Janus kinase 3 (JAK3) is a potential target for the treatment of hematol. malignancies. Herein, we report the discovery of a series of new orally bioavailable irreversible JAK3 kinase inhibitors. The representative compound 12n (I) potently inhibited JAK3 kinase activity with an IC₅₀ value of 1.2 nM and was more than 900-fold selective over JAK1, JAK2, and Tyk2. Cell-based assays revealed that 12n significantly suppressed phosphorylation of JAK3 and the downstream effectors STAT3/5 and also robustly restrained proliferation of BaF3 cells transfected with JAK3^M511I activating mutation and human leukemia U937 cells harboring JAK3^M511I with IC₅₀ values of 22.9 and 20.2 nM, resp. More importantly, 12n showed reasonable pharmacokinetic (PK) properties, and oral administration of 12n at a dose of 50 mg/kg twice daily led to tumor regression in a U937 cell inoculated xenograft mouse model. Thus, 12n represents a promising lead compound for further optimization to discover new therapeutic agents for hematol. malignancies.

Journal of Medicinal Chemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, COA of Formula: C6H3ClFNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Aukland, Miles H. published the artcileMetal-free photoredox-catalysed formal C-H/C-H coupling of arenes enabled by interrupted Pummerer activation, Application of Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, the publication is Nature Catalysis (2020), 3(2), 163-169, database is CAplus.

An expedient, one-pot assembly of (hetero)biaryl motifs using photocatalysis and two non-prefunctionalized arene partners was reported. The approach was underpinned by the functionalization of a C-H bond in an arene coupling partner using the interrupted Pummerer reaction. A unique pairing of the organic photoredox catalyst and the intermediate dibenzothiophenium salts enables highly selective reduction in the presence of sensitive functionalities. The utility of the metal-free, one-pot strategy was exemplified by the synthesis of a bioactive natural product and the modification of complex mols. of societal importance.

Nature Catalysis published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Application of Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sahu, Meeta published the artcileDesign, synthesis and evaluation of newer 5,6-dihydropyrimidine-2(1H)-thiones as GABA-AT inhibitors for anticonvulsant potential, Synthetic Route of 3696-23-9, the publication is Bioorganic Chemistry (2017), 166-178, database is CAplus and MEDLINE.

Several new 5,6-dihydropyrimidine-2(1H)-thione derivatives have been prepared and investigated for their potencies for anticonvulsant activity against maximal electroshock (MES) and s.c. pentylenetetrazole (scPTZ) test in mice. The acute neurotoxicity was measured by rotarod test. Compounds 3c (1-(4-methoxyphenyl)-4,6-diphenyl-5,6-dihydropyrimidine-2(1H)-thione) and 3l (4-(4-hydroxyphenyl)-1-(2-nitrophenyl)-6-phenyl-5,6-dihydropyrimidine-2(1H)-thione) were found active in both of the animal models. Further, in vitro GABA-AT enzyme activity assay was carried out to investigate the possible mechanism of action through GABA-AT inhibition. The most potent compounds 3c and 3l showed inhibitory potency (IC₅₀) of 18.42 μM and 19.23 μM, resp. The mol. modeling was performed for all the synthesized compounds The docking results were found in concordant with the observed animal studies.

Bioorganic Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Synthetic Route of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Palii, G. K. published the artcileSensitivity of microflora isolated from babies with respiratory tract diseases to decamethoxin and antibiotics, Category: chlorides-buliding-blocks, the publication is Mikrobiologichnii Zhurnal (1934-1977) (1974), 36(3), 347-9, database is CAplus.

Staphylococcal strains, isolated from pharynx, skin, and feces of babies with respiratory tract diseases, were sensitive to decamethoxin (I) [38146-42-8] (0.12-7.8 μg/ml). However, most of the 118 strains were resistant to penicillin [1406-05-9], streptomycin [57-92-1], erythromycin [114-07-8], tetracycline [60-54-8], oxytetracycline [79-57-2], chlortetracycline [57-62-5], and levomycetin [56-75-7].

Mikrobiologichnii Zhurnal (1934-1977) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Volyanskii, Yu. L. published the artcileEffect of decametoxin on pathogenic staphylococci, Name: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Mikrobiologichnii Zhurnal (1934-1977) (1971), 33(4), 503-6, database is CAplus.

The bactericidal concentrations of decametoxin, a derivative of decamethylenediamine [646-25-3], tested on 648 pathogenic strains of staphylococci ranged between 0.125 and 50 μg/ml. At 2.5 and 25 μg/ml decametoxin decreased the activity of catalase and peroxidase in Staphylococcus aureus.

Mikrobiologichnii Zhurnal (1934-1977) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C7H5Br2F, Name: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Caiyan published the artcileNon-directed copper-catalyzed regioselective C-H sulfonylation of phenothiazines, Synthetic Route of 10543-42-7, the publication is Organic & Biomolecular Chemistry (2019), 17(20), 5009-5013, database is CAplus and MEDLINE.

A simple and general method for the synthesis of phenothiazinyl sulfones I [R = n-Bu, Ph, Bn, etc.; R¹ = cyclopropyl, 4-MeC₆H₄, 2-naphthyl, etc.; R² = H, SMe, Cl; R³ = H, Cl] was developed via copper-catalyzed regioselective C-H sulfonylation of phenothiazines with sulfonyl chlorides. The broad scope of aryl/alkyl sulfonyl chlorides was applicable to produce C3 sulfonylation products of phenothiazines in moderate to good yields. The further transformation of the sulfonylation products was successful, which afforded valuable polyheterocycles.

Organic & Biomolecular Chemistry published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Synthetic Route of 10543-42-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yao, Shengxin published the artcileSynthesis and spectroscopic properties of BODIPY-dithienylethene conjugates, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Journal of Porphyrins and Phthalocyanines (2021), 25(10/12), 930-936, database is CAplus.

Two red fluorescent triads containing photochromic dithienylethene moiety linked to two 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) via acetylene bond, 1a or single bond, 1b were synthesized and characterized. Although no evident absorption and NMR spectra changes were observed upon irradiation with visible light, the absorption and fluorescence spectra of 1a and 1b are remarkably solvent dependent, in contrast to those of the reference BODIPY-thienyl compounds 2a and 2b, which are essentially solvent independent. Fluorescence intensities of 1a and 1b decreased as the solvent polarity increased, and the fluorescence decay showed two exponentials in polar solvents other than n-hexane. DFT calculations have been carried out to elucidate the spectral behavior of investigated compounds

Journal of Porphyrins and Phthalocyanines published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C14H14, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Myannik, A. O. published the artcileSynthesis and properties of some esters of phosphoric, thiophosphoric, and phosphonic acids, Application In Synthesis of 866-23-9, the publication is Neftekhimiya (1964), 4(6), 899-905, database is CAplus.

The influence of the trichloromethyl group in different esters of phosphoric, thiophosphoric, and alkylphosphorous esters on their antiabrasive properties were studied. The following compounds prepared by known methods [b.p. (mm.), d₂₀, n²⁰_D), and MR_D given]: iso-AmOP(O)(OEt)₂, 85-8°(3), 1.0164, 1.4150, 55.21; CCl₃CH₂OP(O)(OEt)₂, 119-20°(4), 1.3473, 1.4490, 56.85; CCl₃CH₂OP(O)(OBu)₂, 126-7°(2), 1.2097, 1.4480, 75.48; CCl₃(CH₂)₄OP(O)(OEt)₂, 155-6°(2), 1.2685, 1.4850, 70.48; CCl₃(CH₂)₄OP(O)(OBu)₂, 196-7°(2), 1.1637, 1.4550, 89.39; AmSP(O)(OEt)₂, 145-6°(6), 1.0434, 1.4575, 62.73; Me(CH₂)₈SP(O)(OEt)₂, 177-8°(2), 0.9985, 1.4600, 81.19; CCl₃(CH₂)₄SP(O)(OEt)₂, 165-7°(2), 1.2892, 1.4940, 77.40; CCl₃(CH₂)₄SP(O)(OPr)₂, 186-7°(2), 1.2226, 1.4890, 87.45; CCl₃(CH₂)₄SP(O)(OBu-iso)₂, 183-4°(2), 1.1875, 1.4850, 96.42; CCl₃(CH₂)₈SP(O)(OEt)₂, 217- 18°(2), 1.1900, 1.4885, 96.80; EtOP(S)(OEt)₂, 88-9°(8), 1.0746, 1.4480, 49.33; BuOP(S)(OEt)₂, 120-1°(5), 1.0412, 1.4505, 58.40; CCl₃CH₂OP(S)(OEt)₂, 130-1°(3), 1.3414, 1.4840, 64.32; CCl₃(CH₂)₄OP(S)(OEt)₂, 153-4°(4), 1.2647, 1.4873, 78.14; MeP(O)(OEt)₂, 74-5°(10), 1.0685, 1.4140, 35.53; MeP(O)(OAm)₂, 98-9°(2), 0.9618, 1.4307, 63.33; CCl₃P(O)(OEt)₂, 88-9°(2), 1.3738, 1.4645, 51.30; CCl₃P(O)(OAm)₂, 123-4°(1), 1.1745, 1.4601, 79.01; MeP(O)OCH₂CCl₃)₂, –(m. 63-3.5°), –, –, –; MeP(O)[O(CH₂)₄CCl₃₂, 177-8°(1), 1.3838, 1.4941, 92.91; CCl₃P(O)(OCH₂CCl₃)₂ –(m. 94-94.5°),–, –, –.

Neftekhimiya published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Application In Synthesis of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Myannik, A. O. published the artcileThe effect of composition of some esters of phosphoric and phosphonic acids on their activity as mixtures, in decreasing friction wear, SDS of cas: 866-23-9, the publication is Teoriya Smazochnogo Deistviya i Novye Materialy (1965), 63-7, database is CAplus.

H₃PO₄ esters were synthesized from dialkylphosphoric acid chlorides and of alcs. Almost all the esters are liquids soluble in hydrocarbons and lubricating oils. The experiment was carried by adding 6 millimoles of ester to 100 g. oil (1.4-2.2%). Wear-load curves were constructed. H₃PO₄ esters considerably increase the critical load (80 kg.) for pure lubricating oil to 150 kg., after addition of diethyl isoamyl phosphate, and to 227 kg. after addition of diethyl trichloropentyl phosphate. Increasing wear resistance is seen after addition of compounds containing (RO₂)P(:S) S < (RO)₂P(:S)O < (RO)₂P(:O)S < (RO)₂P(:O)O groups. The addition of methyl- and trichloromethyl phosphonic acids increases the load to 300 kg.

Teoriya Smazochnogo Deistviya i Novye Materialy published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, SDS of cas: 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics