Category: chlorides-buliding-blocks

Chen, Zhi-wei published the artcileSynthesis of 3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarbonyl chloride, Application of 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, the publication is Zhongguo Xiandai Yingyong Yaoxue (2008), 25(4), 308-309, database is CAplus.

A method for the synthesis of the title compound [i.e., 3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarbonyl chloride] is reported here. The synthesis of the target compound was achieved by a synthetic sequence involving an oximation reaction, chlorination, cyclization, hydrolysis, acyl chlorination using 2-chloro-6-fluorobenzaldehyde as starting material. The structure was determined by IR, NMR, ¹³C-NMR, MS (overall yield 60.2%). This is a practical and low-cost synthetic route. The above-mentioned target compound is an intermediate for flucloxacillin [i.e., (2S,5R,6R)-6-[[[3-(2-Chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid].

Zhongguo Xiandai Yingyong Yaoxue published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, Application of 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liang, Chunhui published the artcileEnhanced cellular uptake and nuclear accumulation of drug-peptide nanomedicines prepared by enzyme-instructed self-assembly, Formula: C19H14Cl2, the publication is Journal of Controlled Release (2020), 109-117, database is CAplus and MEDLINE.

Subcellular delivery of nanomedicines has emerged as a promising approach to enhance the therapeutic efficacy of anticancer drugs. Nuclear accumulation of anticancer drugs are essential for its therapeutic efficacy because their targets are generally located within the nucleus. However, strategies for the nuclear accumulation of nanomedicines with anticancer drugs rarely reported. In this study, we reported a promising nanomedicine, comprising a drug-peptide amphiphile, with enhanced cellular uptake and nuclear accumulation capability for cancer therapy. The drug-peptide amphiphile consisted of the peptide ligand PMI (TSFAEYWNLLSP), which was capable of activating the p53 gene by binding with the MDM2 and MDMX located in the cell nucleus. Peptide conformations could be finely tuned by using different strategies including heating-cooling and enzyme-instructed self-assembly (EISA) to trigger mol. self-assembly at different temperatures Due to the different peptide conformations, the drug-peptide amphiphile self-assembled into nanomedicines with various properties, including stabilities, cellular uptake, and nuclear accumulation. The optimized nanomedicine formed by EISA strategy at a low temperature of 4 C showed enhanced cellular uptake and nuclear accumulation capability, and thus exhibited superior anticancer ability both in vitro and in vivo. Overall, our study provides a useful strategy for finely tuning the properties and activities of peptide-based supramol. nanomaterials, which may lead to optimized nanomedicines with enhanced performance.

Journal of Controlled Release published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Formula: C19H14Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Qu, Renyu published the artcileDesign, synthesis and bioactivity of new pyrimidyl-salicylate inhibitors, Recommanded Product: 3-Chloro-4-fluoronitrobenzene, the publication is Youji Huaxue (2019), 39(8), 2303-2310, database is CAplus.

Acetohydroxyacid synthase (AHAS) was one of important herbicidal targets. However, the issue of weed resistance to com. AHAS inhibitors has become one of the largest obstacles for their application. Therefore, there is a high demand to design new anti-resistance AHAS inhibitors. Herein, based on the reported low resistance AHAS inhibitors, a series of pyrimidyl-salicylates with “double oxygen bridge” utilized the “conformation flexibility anal.” strategy were designed. All the synthesized compounds were characterized by ¹H NMR, ¹³C NMR and HRMS. The bioactivity results showed that most of the derivatives displayed good inhibitory activities against P197L mutant. Especially, 2-((4,6-dimethoxypyrimidin-2-yl)oxy)-6-(2-fluoro-4-nitrophenoxy)-4-methylbenzoic acid (6l) was identified as the most potent anti-resistance AHAS inhibitor. In addition, some compounds showed good weed control for resistant Descurainia sophia (P197L AHAS). Most importantly, 2-((4,6-dimethoxypyrimidin-2-yl)oxy)-6-(2-fluorophenoxy)-4-methylbenzoic acid (6b) showed 80% herbicidal activities against sensitive and resistant Descurainia sophia at the dosage of 150 g ai/ha. These results indicated that this type of compounds worth of the further investigation.

Youji Huaxue published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Recommanded Product: 3-Chloro-4-fluoronitrobenzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Feng, Yanli published the artcilePhotochromic thiophene oligomers based on bisthienylethene: syntheses, photochromic and two-photon properties, Application of 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Journal of Materials Chemistry (2006), 16(37), 3685-3692, database is CAplus.

A series of novel, functional sym. and unsym. photochromic thiophene oligomers based on bisthienylethenes (BTEs) were synthesized via control of the reaction condition with a Suzuki coupling method. Their optical, photochromic quantum yields, two-photon and electrochem. properties in THF as well as in poly(Me methacrylate) (PMMA) films were measured and discussed. The fluorescence emission can be tuned reversibly by alternating irradiation with UV and visible light. These BTEs could be used as nanowires, fluorescent switch and electrochem. switch.

Journal of Materials Chemistry published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Application of 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Du, Daohai published the artcileStructure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction, Name: 1-(Chloromethyl)-4-(trifluoromethyl)benzene, the publication is Journal of Medicinal Chemistry (2021), 64(12), 8194-8207, database is CAplus and MEDLINE.

The cocrystal structure of EZH2-embryonic ectoderm development (EED) in complex with astemizole at 2.15 Å was reported. The structure elucidated the detailed binding mode of astemizole to EED and provided a structure-guided design for the discovery of a novel EZH2-EED interaction inhibitor, DC-PRC2in-01 I, with an affinity Kd of 4.56μM. DC-PRC2in-01 I destabilized the PRC2 complex, thereby leading to the degradation of PRC2 core proteins and the decrease of global H3K27me3 levels in cancer cells. The proliferation of PRC2-driven lymphomas cells was effectively inhibited, and the cell cycle was arrested in the G0/G1 phase. Together, these data demonstrated that DC-PRC2in-01 I could be an effective chem. probe for investigating the PRC2-related physiol. and pathol. and providing a promising chem. scaffold for further development.

Journal of Medicinal Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Name: 1-(Chloromethyl)-4-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xu, Zhian published the artcileCuSO₄ nanoparticles loaded on carboxymethylcelulose/polyaniline composites: A highly efficient catalyst with enhanced catalytic activity in the synthesis of propargylamines, benzofurans, and 1,2,3-triazoles, Recommanded Product: 3-Chlorobenzylchloride, the publication is Applied Organometallic Chemistry (2021), 35(10), e6349, database is CAplus.

A novel and efficient heterogeneous CuSO₄ nanoparticles (CuSO₄ NPs) immobilized on CM-cellulose/polyaniline (CuSO₄NPs@CMC/PANI) composites were prepared via one-pot and one-step interfacial oxidative polymerization of aniline with sodium CM-cellulose (CMC) as soft template and CuSO₄ as catalyst. The in situ formed CuSO₄ NPs were dispersed uniformly and firmly on the resultant composites and stabilized by complexation with hydroxyl groups (OH), carboxylate groups (COO^–), nitrogen atoms, and delocalized π-π conjugate benzenoid and quinoid moieties of CMC/PANI composites. The morphol., composition, and structure of the as-fabricated composites were systematically characterized by XPS, transmission electron microscopy (TEM), SEM (SEM), energy-dispersive X-ray spectroscopy (EDS), Fourier transform IR spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetric anal. (TGA), and derivative thermogravimetry (DTG) techniques. The CuSO₄NPs@CMC/PANI composites were successfully applied as catalysts in aldehyde-alkyne-amine (A³) coupling reactions, A³-cycloisomerization tandem reactions, and Cu-catalyzed azide-alkyne cycloaddition (CuAAC) reactions. All reactions proceeded smoothly and afforded the desired products in excellent yields. Moreover, no significant decrease in catalytic ability was observed in A³ model reaction after 15 recycles, indicating CuSO₄NPs@CMC/PANI composites exhibited easy separability and high reusability. Tolerance of wide scope of substrate, excellent catalytic activity, easy operation, recycling of catalyst, and environmental benign are the salient features of these catalytic process.

Applied Organometallic Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C13H10O3, Recommanded Product: 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Mingjuan published the artcileCopper immobilized on biomimetic assembled calcium carbonate/carboxymethylcellulose hybrid: a highly active recoverable catalyst for CuAAC reactions, Formula: C7H6Cl2, the publication is Research on Chemical Intermediates (2021), 47(9), 3883-3898, database is CAplus.

A novel copper immobilized on biomimetic assembled CM-cellulose/calcium carbonate hybrid (Cu^II@CMC/CaCO₃) as an efficient heterogeneous catalyst for the synthesis of 1,2,3-triazoles has been described herein. The fabrication of Cu^II@CMC/CaCO₃ is accomplished through a bioinspired mineralization process using sodium CM-cellulose (CMC-Na) as the template and ion exchange agent, while the metathesis, nucleation, assemble, hybridization, and immobilization of Cu(II) occurred by successful treatment with CaCl₂, Na₂CO₃, and CuSO₄ in water at room temperature The resultant Cu^II@CMC/CaCO₃ hybrid was well characterized by various analyses such as FT-IR, XRD, SEM, EDX, EDX-mapping, TEM, and TGA techniques. In the presence of low copper loading of Cu^II@CMC/CaCO₃ hybrid, benzylic halides, azide, and alkynes proceeded smoothly to afford 1,4-disubstituted 1,2,3-triazoles in high yields. The catalyst can be conveniently recovered from the reaction mixture by filter and reused for at least 5 consecutive runs with a slight drop in its catalytic activity. The remarkable activity and stability of the catalyst may be attributed to the coordination of both carboxyl and hydroxyl groups of the hybrid of CMC/CaCO₃.

Research on Chemical Intermediates published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C9H7NO4, Formula: C7H6Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Maiti, Rakesh published the artcileCarbene-catalyzed selective addition of isothioureas to enals for access to sulphur-containing 5,6-dihydropyrimidin-4-ones, HPLC of Formula: 3696-23-9, the publication is Organic Chemistry Frontiers (2021), 8(4), 743-747, database is CAplus.

A carbene-catalyzed addition reaction between isothioureas and enals under oxidative conditions was reported. The key steps of these reactions was the formation of two carbon-nitrogen bonds in a highly regioselective manner. A variety of sulfur-containing 5,6-dihydropyrimidin-4-ones were obtained with high optical purity.

Organic Chemistry Frontiers published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, HPLC of Formula: 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Guanghui published the artcileDouble N,B-Type Bidentate Boryl Ligands Enabling a Highly Active Iridium Catalyst for C-H Borylation, Computed Properties of 929626-16-4, the publication is Journal of the American Chemical Society (2015), 137(25), 8058-8061, database is CAplus and MEDLINE.

Boryl ligands hold promise in catalysis due to their very high electron-donating property. In this communication double N,B-type boryl anions were designed as bidentate ligands to promote an sp² C-H borylation reaction. A sym. pyridine-containing tetraaminodiborane(4) compound was readily prepared as the ligand precursor that could be used, in combination with [Ir(OMe)(COD)]₂, to in situ generate a highly active catalyst for a broad range of (hetero)arene substrates including highly electron-rich and/or sterically hindered ones. This work provides the 1st example of a bidentate boryl ligand in supporting homogeneous organometallic catalysis.

Journal of the American Chemical Society published new progress about 929626-16-4. 929626-16-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronate Esters, name is 2-(3-Chloro-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C14H21BO2, Computed Properties of 929626-16-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

He, Weixuan published the artcileα-Elimination of diethyl dichlorolithiomethanephosphonate, Recommanded Product: Diethyltrichloromethylphosphonate, the publication is Huaxue Xuebao (1987), 45(3), 291-4, database is CAplus.

The α-elimination of (EtO)₂P(O)C^–Cl₂ Li⁺ generates dichlorocarbene, in which the leaving group is diethyl phosphite anion not Cl^–. A discussion on the reaction is given.

Huaxue Xuebao published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Recommanded Product: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics