Category: chlorides-buliding-blocks

Bai, Ying published the artcileUse of functionalized PEG with 4-aminobenzoic acid stabilized platinum nanoparticles as an efficient catalyst for the hydrosilylation of alkenes, Synthetic Route of 14799-93-0, the publication is Journal of Colloid and Interface Science (2013), 428-433, database is CAplus and MEDLINE.

A catalyst containing functionalized polyethylene glycol with 4-aminobenzoic acid (PEG-AMB) stabilized Pt nanoparticles was synthesized and characterized, and its application in the hydrosilylation of alkenes studied. The functionalized PEG-stabilized Pt nanoparticles form a very efficient catalyst for the hydrosilylation of alkenes. The Pt nanoparticles can be fully immobilized in the PEG-AMB and recycled at least nine times without any obvious loss of catalytic activity.

Journal of Colloid and Interface Science published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Synthetic Route of 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bai, Ying published the artcileUse of functionalized PEG with 4-aminobenzoic acid stabilized platinum nanoparticles as an efficient catalyst for the hydrosilylation of alkenes, Name: Dichloro(hexyl)(methyl)silane, the publication is Journal of Colloid and Interface Science (2013), 428-433, database is CAplus and MEDLINE.

A catalyst containing functionalized polyethylene glycol with 4-aminobenzoic acid (PEG-AMB) stabilized Pt nanoparticles was synthesized and characterized, and its application in the hydrosilylation of alkenes studied. The functionalized PEG-stabilized Pt nanoparticles form a very efficient catalyst for the hydrosilylation of alkenes. The Pt nanoparticles can be fully immobilized in the PEG-AMB and recycled at least nine times without any obvious loss of catalytic activity.

Journal of Colloid and Interface Science published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Name: Dichloro(hexyl)(methyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yang, Hu published the artcileHydrosilylation of alkenes catalyzed by MCM-48 supported chitosan-platinum complex, Formula: C9H20Cl2Si, the publication is Hangzhou Shifan Daxue Xuebao, Ziran Kexueban (2012), 11(3), 217-221, database is CAplus.

A new Pt/CS-MCM-48 catalysts was prepared from chitosan supported on MCM-48. The catalyst was characterized by XRD, IR and TG. The results indicated that coordination bond between platinum and nitrogen atom of chitosan was formed. Pt/CS-MCM-48 catalyst has favorable catalytic performance for the hydrosilylation of alkenes, the regioselectivity of adduct is above 90%, and the catalyst can be reused for 14 times without noticeable loss of activity.

Hangzhou Shifan Daxue Xuebao, Ziran Kexueban published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C11H24O3, Formula: C9H20Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yao, Qi-Jun published the artcileAtroposelective Synthesis of Axially Chiral Biaryls by Palladium-Catalyzed Asymmetric C-H Olefination Enabled by a Transient Chiral Auxiliary, Name: 4-Chloro-2-methylphenylboronic acid, the publication is Angewandte Chemie, International Edition (2017), 56(23), 6617-6621, database is CAplus and MEDLINE.

Atroposelective synthesis of axially chiral biaryls by palladium-catalyzed C-H olefination, using tert-leucine as an inexpensive, catalytic, and transient chiral auxiliary, has been realized. This strategy provides a highly efficient and straightforward access to a broad range of enantioenriched biaryls, e.g., I (X-rays single crystal structure shown), in good yields (up to 98 %) with excellent enantioselectivities (95 to >99 % ee). Kinetic resolution of trisubstituted biaryls bearing sterically more demanding substituents is also operative, thus furnishing the optically active olefinated products with excellent selectivity (95 to >99 % ee, s-factor up to 600).

Angewandte Chemie, International Edition published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C10H14O, Name: 4-Chloro-2-methylphenylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhu, Feng published the artcileCatalytic and Photochemical Strategies to Stabilized Radicals Based on Anomeric Nucleophiles, Safety of 1-(Chloromethyl)-4-(trifluoromethyl)benzene, the publication is Journal of the American Chemical Society (2020), 142(25), 11102-11113, database is CAplus and MEDLINE.

Carbohydrates, one of the three primary macromols. of living organisms, play significant roles in various biol. processes such as intercellular communication, cell recognition, and immune activity. While the majority of established methods for the installation of carbohydrates through the anomeric carbon rely on nucleophilic displacement, anomeric radicals represent an attractive alternative because of their functional group compatibility and high anomeric selectivities. Herein, we demonstrate that anomeric nucleophiles such as C1 stannanes can be converted into anomeric radicals by merging Cu(I)-catalysis with blue light irradiation to achieve highly stereoselective C(sp3)-S cross-coupling reactions. Mechanistic studies and DFT calculations revealed that the C-S bond-forming step occurs via the transfer of the anomeric radical directly to a sulfur electrophile bound to Cu(II) species. This pathway complements a radical chain observed for metal-free conditions where a disulfide initiator can be activated by a Lewis base additive. Both strategies utilize anomeric nucleophiles as efficient radical donors and achieve a switch from an ionic to a radical pathway. Taken together, the stability of glycosyl nucleophiles, a broad substrate scope, and high anomeric selectivities observed for the thermal and photochem. protocols make this novel C-S cross-coupling a practical tool for late-stage glyco-diversification of bioactive natural products and drug candidates.

Journal of the American Chemical Society published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C4H5BN2O2, Safety of 1-(Chloromethyl)-4-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Jie-long published the artcileGreen synthesis of germicide Prochloraz, Category: chlorides-buliding-blocks, the publication is Huaxue Shiji (2010), 32(9), 856-858, database is CAplus.

Prochloraz is a broad-spectrum imidazole germicide. The synthesis of the target compound [i.e., N-propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]-1H-imidazole-1-carboxamide, Prochloraz, Mirage, Preclude, Sportake, etc.] was achieved using using 2,4,6-trichlorophenol, 1,2-ethanediol, imidazole and triphosgene as starting materials in an environmentally friendly synthetic sequence (green chem.).

Huaxue Shiji published new progress about 67747-01-7. 67747-01-7 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Ether,Benzene Compounds, name is N-(2-(2,4,6-Trichlorophenoxy)ethyl)propan-1-amine, and the molecular formula is C4H7F3O2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Xu-Jun published the artcileSynthesis and fungicidal activity of phenazine-1-carboxylic triazole derivatives, Computed Properties of 620-20-2, the publication is Journal of Asian Natural Products Research (2021), 23(5), 452-465, database is CAplus and MEDLINE.

A total of 15 novel-substituted 3-(benzylsulfanyl)-1H-1,2,4-triazol-5-ylamines I [R = 3-MeC₆H₄, 2-FC₆H₄, 2,4-Cl₂C₆H₃, etc.] and 10 novel-substituted 3-benzylmercapto-1,2,4-triazole derivatives II were synthesized based on the natural product phenazine-1-carboxylic acid (PCA). Their structures were confirmed by ¹H-NMR, ¹³C-NMR, HRMS and X-ray. Most substituted 3-benzylmercapto-1,2,4-triazole derivatives II displayed very strong fungicidal activity against one or multiple plant pathogens in vitro and in vivo. Compounds II [R = 4-MeC₆H₄, 4-iPrC₆H₄, 4-tBuC₆H₄, etc.] showed a broad spectrum of fungicidal activity. Further field experiments indicated that compounds II [R = 4-MeC₆H₄, 2-FC₆H₄, 4-iPrC₆H₄, etc.] displayed better efficacy against rice blast (Pyricularia oryzae) than PCA. These data demonstrated that compounds II [R = 4-MeC₆H₄, 2-FC₆H₄, 4-iPrC₆H₄, etc.] were promising fungicidal candidates, deserving further studies.

Journal of Asian Natural Products Research published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Computed Properties of 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhao, Xuelian published the artcileSynthesis and biological evaluation of isatin derivatives containing 1,3,4-thiadiazole as potent a-glucosidase inhibitors, Related Products of chlorides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry Letters (2021), 128447, database is CAplus and MEDLINE.

A series of isatin derivatives containing 1,3,4-thiadiazole derivatives I [R = 2-F, 3-CN, 4-Cl, etc.] were designed and synthesized. All newly synthesized compounds I were evaluated for their α-glucosidase inhibitory activity with resveratrol as pos. control in-vitro. Except for compounds I [R = 2-CN, 3-CN], all of the compounds I showed a potent inhibitory activity against α-glucosidase with IC₅₀ values in the range of 3.12 ± 1.25 to 45.95 ± 1.26μM and the purity of these compounds were greater than 95%. The IC₅₀ values were being compared to the standard resveratrol (IC₅₀ = 22.00 ± 1.15μM) and it was found that compounds I [R = H, 2-F, 2-Cl, 3-Cl, 4-Cl, 2-Br] were found to be more active than resveratrol. Specifically,I [R = 4-Cl] exhibited the most potent α-glucosidase inhibitory activity with IC₅₀ value of 3.12 ± 1.25μM. The kinetic anal. revealed that compound I [R = 4-Cl] was noncompetitive inhibitor. Structure activity relationship was established for all compounds I. Furthermore, the binding interactions of compound I [R = 4-Cl] with the active site of α-glucosidase were confirmed through mol. docking. This study was identified a new class of potent α-glucosidase inhibitors for further investigation.

Bioorganic & Medicinal Chemistry Letters published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C24H20Ge, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Ziyong published the artcileSynthesis and Properties of Photochromic Diarylethene Containing N-Salicylideneaniline Units, SDS of cas: 219537-97-0, the publication is Molecular Crystals and Liquid Crystals (2012), 557(1), 84-89, database is CAplus.

A sym. diarylethene containing N-salicylideneaniline (Schiff base) units was synthesized. The structure was well confirmed by NMR spectroscopy, mass spectrometry, and elemental anal. Its photochromism was investigated by UV/visible absorption spectra and NMR. The result displayed that diarylethene can well perform photoisomerization, but no obvious intramol. proton transfer was observed Furthermore, we checked the effects of metal cations for the properties of N-salicylideneaniline-based diarylethene, which indicated that Cu²⁺ and Fe³⁺ cations can significantly affect the UV/visible absorption spectra of diarylethene ring-open and ring-closed isomers.

Molecular Crystals and Liquid Crystals published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, SDS of cas: 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tian, Ze-Yu published the artcileVisible-light-initiated catalyst-free trifluoromethylselenolation of arylsulfonium salts with [Me₄N][SeCF₃], SDS of cas: 637-07-0, the publication is Organic Chemistry Frontiers (2022), 9(8), 2220-2227, database is CAplus.

The redox potential gap between arylsulfonium salts and [Me₄N][SeCF₃] has been clearly revealed by CV measurements. Construction of the carbon-selenium bond by overcoming this gap without using catalysts and additives is a challenging task. Here, the authors report an efficient visible-light-induced cross-coupling of arylsulfonium triflates, e.g., 5-[4-(4-cyanophenoxy)phenyl]-5H-thianthren-5-ium triflate, with [Me₄N][SeCF₃] by simply mixing these two species, which allowed the facile synthesis of various aryl trifluoromethyl selenoethers, e.g., ArSeCF₃ (Ar = 2-formyl-4-methoxyphenyl, N-methylcarbazol-6-yl, benzodioxol-5-yl, etc.) under catalyst- and additive-free conditions. The mechanistic study indicated that aryl and SeCF₃ radicals might be formed as key intermediates in the reactions. Merits of the reactions include operational simplicity, high efficiency, visible-light irradiation, good functional group tolerance, a wide range of substrates, excellent chemoselectivity, and good yields of (trifluoromethyl)selenolated products, which combined with a sulfenylation process enabled the selective and practical installation of SeCF₃ moieties onto complex arenes, including drug mols., via a formal C-H functionalization.

Organic Chemistry Frontiers published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C7H8O3, SDS of cas: 637-07-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics