Category: chlorides-buliding-blocks

Li, He published the artcileAn improved method for the synthesis of phenylacetic acid derivatives via carbonylation, HPLC of Formula: 620-20-2, the publication is Journal of Chemical Research (2019), 43(11-12), 548-552, database is CAplus.

A series of phenylacetic acid derivatives RCH₂CO₂H [R = 2-ClC₆H₄, 4-MeC₆H₄, 2,4-Cl₂C₆H₃, etc.] was synthesized via bistriphenylphosphine palladium dichloride catalyzed carbonylation reaction of benzyl chloride derivatives in presence of tetraethylammonium chloride and sodium hydroxide as reagents and xylene as solvent at 80°C under a CO atm. 2,4-Dichlorophenylacetic acid was obtained in a maximum yield of 95% from 2,4-dichlorobenzyl chloride using the same reaction system.

Journal of Chemical Research published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, HPLC of Formula: 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Leimbacher, Markus published the artcileDiscovery of Small-Molecule Interleukin-2 Inhibitors from a DNA-Encoded Chemical Library, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Chemistry – A European Journal (2012), 18(25), 7729-7737, S7729/1-S7729/120, database is CAplus and MEDLINE.

Libraries of chem. compounds individually coupled to encoding DNA tags (DNA-encoded chem. libraries) hold promise to facilitate exceptionally efficient ligand discovery. We constructed a high-quality DNA-encoded chem. library comprising 30 000 drug-like compounds; this was screened in 170 different affinity capture experiments High-throughput sequencing allowed the evaluation of 120 million DNA codes for a systematic anal. of selection strategies and statistically robust identification of binding mols. Selections performed against the tumor-associated antigen carbonic anhydrase IX (CA IX) and the pro-inflammatory cytokine interleukin-2 (IL-2) yielded potent inhibitors with exquisite target specificity. The binding mode of the revealed pharmacophore against IL-2 was confirmed by mol. docking. Our findings suggest that DNA-encoded chem. libraries allow the facile identification of drug-like ligands principally to any protein of choice, including mols. capable of disrupting high-affinity protein-protein interactions.

Chemistry – A European Journal published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Yuanfeng published the artcileAsymmetric Epoxidation of α,β-Unsaturated Ketones Catalyzed by Chiral Iron Complexes of (R,R)-3,4-Diaminopyrrolidine Derived N4-Ligands with Camphorsulfonyl Sidearms, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Asian Journal of Organic Chemistry (2020), 9(4), 616-621, database is CAplus.

Three (R,R)-3,4-diaminopyrrolidine-based chiral N₄ ligands and corresponding iron complexes were synthesized. The complexes were applied to the asym. epoxidation of various α,β-unsaturated ketones with H₂O₂ as an oxidant and carboxylic acid as an auxiliary. Good to excellent enantioselectivity (up to 97%) was achieved in the case of 2,2-dimethylbutyric acid as an auxiliary.

Asian Journal of Organic Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Du, Qiuyao published the artcileSimultaneous determination and quantitation of hypolipidemic drugs in fingerprints by UPLC-Q-TRAP/MS, Formula: C12H15ClO3, the publication is Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences (2021), 122496, database is CAplus and MEDLINE.

An ultra-performance liquid chromatog. tandem triple quadrupole compound linear ion trap mass spectrometry (UPLC-Q-TRAP/MS) method was developed and validated for the detection of hypolipidemic drugs in fingerprints. 13 Hypolipidemic drugs were well separated by the gradient elution of 0.01% formic acid in water and methanol at a flow rate of 0.4 mL/min within 11 min. The analytes were detected in pos. (ESI⁺) and neg. (ESI^–) modes and scanned using scheduled multiple reaction monitoring-information dependent acquisition-enhanced product ion (SMRM-IDA-EPI) for best selectivity and sensitivity. The calibration curves showed good linearity in the range of 0.050-50.000 ng/patch with coefficients (r²) higher than 0.9904 for all analytes. Meantime, the LODs and LLOQs were in ranges of 0.001-0.034 and 0.003-0.050 ng/patch. The accuracies, intra-day and inter-day precision ranged from -13.3 to 0.3%, 1.1-10.4% and 3.7-14.5%, resp. The recoveries ranged from 79.9 to 114.8%, while the absolute and relative matrix effects were in the range of 83.0-107.2% and 2.2-9.7%. By comparing the non-spiked fingerprints from healthy volunteers with the fingerprints obtained from patients, demonstrated that the method was competent for determination and quantitation of hypolipidemic drugs in fingerprints.

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Formula: C12H15ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lin, Runfeng published the artcileThe development of HEC-866 and its analogues for the treatment of idiopathic pulmonary fibrosis, Name: 3-Chloro-4-fluoronitrobenzene, the publication is RSC Medicinal Chemistry (2021), 12(7), 1222-1231, database is CAplus and MEDLINE.

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with a typical survival time between three to five years. Two drugs, pirfenidone and nintedanib have been approved for the treatment of IPF, but they have limited efficacy. Thus, the development of new drugs to treat IPF is an urgent medical need. In this paper we report the discovery of a series of orally active pyrimidin-4(3H)-one analogs which exhibit potent activity in in vitro assays. Among them, HEC-866 showed promising efficacy in rat IPF models. Since HEC-866 also had good oral bioavailability, a long half-life and favorable long-term safety profiles, it was selected for further clin. evaluation.

RSC Medicinal Chemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Name: 3-Chloro-4-fluoronitrobenzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fu, Jun-Hao published the artcileEnantioselective vinylogous aldol/lactonization cascade reaction between β,γ-unsaturated amides and trifluoromethyl ketones: facile access to chiral trifluoromethyl dihydropyranones, Safety of 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, the publication is Organic & Biomolecular Chemistry (2020), 18(39), 7848-7851, database is CAplus and MEDLINE.

An efficient asym. vinylogous aldol/lactonization cascade reaction between β,γ-unsaturated amides I (R¹ = C₆H₅, 2-thienyl, 1-naphthyl, etc.) and trifluoromethyl ketones has R²C(O)CF₃ (R² = C₆H₅, 2-ClC₆H₄, CH=CHC₆H₅, etc.) been developed. Using a chiral cyclohexanediamine-based tertiary amine-thiourea catalyst II [Ar = 3,5-(CF₃)₂C₆H₃], optically active trifluoromethyl dihydropyranones (S)-III have been constructed in moderate-to-excellent yields (up to 99%) with excellent stereoselectivities (96-> 99.5% ee).

Organic & Biomolecular Chemistry published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, Safety of 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wu, Jie published the artcileDesign, synthesis, and screening of novel ursolic acid derivatives as potential anti-cancer agents that target the HIF-1α pathway, Computed Properties of 620-20-2, the publication is Bioorganic & Medicinal Chemistry Letters (2019), 29(6), 853-858, database is CAplus and MEDLINE.

The transcription factor hypoxia-inducible factor-1α (HIF-1α) plays an important role in tumor angiogenesis, growth, and metastasis and is recognized as an important potential therapeutic target for cancer. Here, we designed and synthesized three novel series of ursolic acid derivatives containing an aminoguanidine moiety and evaluated them as HIF-1α inhibitors and anticancer agents using human cancer cell lines. Most of the compounds exhibited significant inhibition of HIF-1α transcriptional activity, as measured using a Hep3B cell-based luciferase reporter assay. Among these compounds, I was the most potent inhibitor of HIF-1α expression under hypoxic conditions (IC₅₀ 4.0 μM) and did not display significant cytotoxicity against any cell lines tested. The mechanism of action of I was investigated, we found that I downregulated HIF-1α protein expression, possibly by suppressing its synthesis, reduced production of vascular endothelial growth factor, and inhibited the proliferation of cancer cells.

Bioorganic & Medicinal Chemistry Letters published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C12H10FeO4, Computed Properties of 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Calvo, Roxan published the artcileFacile access to nitroarenes and nitroheteroarenes using N-nitrosaccharin, Safety of Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, the publication is Nature Communications (2019), 10(1), 1-8, database is CAplus and MEDLINE.

Nitroaroms. and nitroheteroaroms. serve as key building blocks and intermediates in synthesis, and form the core scaffold of a vast number of materials, dyes, explosives, agrochems. and pharmaceuticals. However, their synthesis relies on harsh methodologies involving excess mineral acids, which present a number of critical drawbacks in terms of functional group compatibility and environmental impact. Modern, alternative strategies still suffer from significant limitations in terms of practicality, and a general protocol amenable to the direct C-H functionalization of a broad range of aromatics has remained elusive. Herein, author introduces a bench-stable, inexpensive, easy to synthesize and recyclable nitrating reagent based on saccharin. This reagent acts as a controllable source of the nitronium ion, allowing mild and practical nitration of both arenes and heteroarenes displaying an exceptional functional group tolerance.

Nature Communications published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Safety of Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhu, Bang-Chang published the artcilep-Arsanilic acid stabilizing titanium-oxo clusters with various core structures and light absorption behaviours, Related Products of chlorides-buliding-blocks, the publication is Inorganic Chemistry Communications (2017), 14-17, database is CAplus.

P-Arsanilic acid stabilizing polyoxo-titanium clusters (PTCs) were successfully synthesized through solvothermal method, which present {Ti₄}, {Ti₅} and {Ti₆} cores functionalized by different carboxylic acid ligands. PTC-111 displays a {Ti₄} core structure which is stabilized by glycolic acid and esterified p-arsanilic acid. PTC-112, PTC-113 and PTC-114 have isostructural {Ti₆} structures, functionalized by isonicotinic acid, 2-chloroisonicotinic acid and HOBz, resp. The {Ti₅} core of PTC-115 is functionalized by m-nitrobenzoic acid. It is interesting that the light absorption behaviors of these PTCs are dependent on their core structures and the functionalizing ligands.

Inorganic Chemistry Communications published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C15H15OP, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Nan published the artcileAnalysis of long chain sulphur mustard and related compounds by gas chromatography-mass spectrometry, Related Products of chlorides-buliding-blocks, the publication is Fenxi Shiyanshi (2003), 22(1), 86-89, database is CAplus.

The identification of sulfur-containing mustards was studied by gas chromatog.-mass spectrometry. Under the applied conditions, the anal. species were separated effectively with the capillary columns coated with SE-54 stationary phases from the mixture solution Electron-impact pos.-ion mass spectral cleavage mechanisms of sulfur-mustards were discussed in detail. From the mass spectra, general fragmentation pathways of these compounds were derived.

Fenxi Shiyanshi published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics