Category: chlorides-buliding-blocks

Yang, Guangqian published the artcileStudy of the in vivo antiviral activity against TMV treated with novel 1-(t-butyl)-5-amino-4-pyrazole derivatives containing a 1,3,4-oxadiazole sulfide moiety, SDS of cas: 620-20-2, the publication is Pesticide Biochemistry and Physiology (2021), 104740, database is CAplus and MEDLINE.

A series of new 1-tert-butyl-5-amino-4-pyrazole bioxadiazole sulfide derivatives containing a 1,3,4-oxadiazole moiety were designed and synthesized. The bioactivity results showed that some title compounds exhibited excellent protective activity against TMV and certain insecticidal activity. Among the tested compounds, the EC₅₀ values of 5d, 5j, 5k and 5l were 165.8, 163.2, 159.7 and 193.1 mg/L, resp., which are better than the EC₅₀ value of ningnanmycin (271.3 mg/L). The chlorophyll contents and the defense enzyme activities of the tobacco leaves after treatment with 5j were significantly increased, which indicated that this series of title compounds may induce the systemic acquired resistance of host to defend against diseases. Further in vivo protective activity research on 5j using TMV with a GFP gene tag found that it can effectively inhibit the spread of TMV in inoculated tobacco. A morphol. study with TEM revealed that title compound 5h can cause a distinct break of the rod-shaped TMV. Moreover, the insecticidal activity revealed that the fatality rates of 5a, 5b and 5m against aphidoidea were 85%, 83% and 87%, resp., which indicated that the title compounds can effectively block the common carrier of plant viruses, thereby effectively reducing the TMV infection risk of tobacco. This series of synergistic effects provide key information for the research and development of antiviral agents.

Pesticide Biochemistry and Physiology published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C15H10O2, SDS of cas: 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yang, Guangqian published the artcileStudy of the in vivo antiviral activity against TMV treated with novel 1-(t-butyl)-5-amino-4-pyrazole derivatives containing a 1,3,4-oxadiazole sulfide moiety, Quality Control of 939-99-1, the publication is Pesticide Biochemistry and Physiology (2021), 104740, database is CAplus and MEDLINE.

A series of new 1-tert-butyl-5-amino-4-pyrazole bioxadiazole sulfide derivatives containing a 1,3,4-oxadiazole moiety were designed and synthesized. The bioactivity results showed that some title compounds exhibited excellent protective activity against TMV and certain insecticidal activity. Among the tested compounds, the EC₅₀ values of 5d, 5j, 5k and 5l were 165.8, 163.2, 159.7 and 193.1 mg/L, resp., which are better than the EC₅₀ value of ningnanmycin (271.3 mg/L). The chlorophyll contents and the defense enzyme activities of the tobacco leaves after treatment with 5j were significantly increased, which indicated that this series of title compounds may induce the systemic acquired resistance of host to defend against diseases. Further in vivo protective activity research on 5j using TMV with a GFP gene tag found that it can effectively inhibit the spread of TMV in inoculated tobacco. A morphol. study with TEM revealed that title compound 5h can cause a distinct break of the rod-shaped TMV. Moreover, the insecticidal activity revealed that the fatality rates of 5a, 5b and 5m against aphidoidea were 85%, 83% and 87%, resp., which indicated that the title compounds can effectively block the common carrier of plant viruses, thereby effectively reducing the TMV infection risk of tobacco. This series of synergistic effects provide key information for the research and development of antiviral agents.

Pesticide Biochemistry and Physiology published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C4H7BrO2, Quality Control of 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Guo, Haichang published the artcilePreparation of sub-microspherical Fe₃O₄@PDA-Pd NPs catalyst and application in catalytic hydroreduction reaction of halogenated aromatic nitro compounds to prepare halogenated aromatic amines, Category: chlorides-buliding-blocks, the publication is BMC Chemistry (2019), 13(1), 1-7, database is CAplus and MEDLINE.

A promising method for preparation of the superparamagnetic and strongly magnetic Fe₃O₄@PDA core-shell sub-microsphere-supported nano-palladium catalyst for catalyzing the hydrogenation reduction of halogenated aromatic nitro compds was reported. The catalyst showed a high selectivity of greater than 96% and effectively inhibited the occurrence of the side reactions of dehalogenation and C-N coupling. The optimum condition of the hydroredn. reaction was when THF is used as solvent and the reaction occurred at 50° for 5 h. The selectivity of the chlorinated aromatic amine and the fluorinated aromatic amine products exceeded 99% and the yield exceeds 90%. Only a small amount of dehalogenated products and C-N coupling byproducts were produced in the brominated aromatic compound and the iodinated aromatic compound

BMC Chemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Han, Shuaiyuan published the artcileReversible Complexation Mediated Living Radical Polymerization Using Tetraalkylammonium Chloride Catalysts, Category: chlorides-buliding-blocks, the publication is Macromolecular Rapid Communications, database is CAplus and MEDLINE.

The paper reports the first use of organic chloride salts as catalysts for reversible complexation mediated living radical polymerization Owing to the strong halogen-bond forming ability of Cl^–, the studied four tetraalkylammonium chloride catalysts (R₄N⁺Cl^–) successfully control the polymerizations of Me methacrylate, yielding polymers with low dispersities up to high monomer conversion (>90%). Benzyldodecyldimethylammonium chloride is further exploited to other methacrylates and yields low-dispersity block copolymers. Advantages of the chloride salt catalysts are wide monomer scope, good livingness, accessibility to block copolymers, and good solubility in organic media. Because of the good solubility, the use of the chloride salt catalysts can prevent agglomeration of catalysts on reactor walls in organic media, which is an industrially attractive feature. Among halide anions, chloride anion is the most abundant and least expensive halide anion, and therefore, the use of the chloride salt catalysts may lower the cost of the polymerization

Macromolecular Rapid Communications published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chen, Shuming published the artcileArylketone π-Conjugation Controls Enantioselectivity in Asymmetric Alkynylations Catalyzed by Centrochiral Ruthenium Complexes, Product Details of C8H4ClF3O, the publication is Journal of the American Chemical Society (2018), 140(15), 5146-5152, database is CAplus and MEDLINE.

The origin of enantioselectivity in the asym. alkynylation of trihalomethyl ketones catalyzed by octahedral stereogenic-at-ruthenium complexes has been investigated through d. functional theory calculations Computational results support a mechanism involving formation of a ruthenium acetylide, followed by pre-coordination of the trihalomethyl ketone through the carbonyl oxygen and intramol. attack of the acetylide via a compact four-membered transition state. Differences in computed free energies of activation for the formation of the major and minor propargyl alc. enantiomers are in good agreement with the exptl. observed levels of asym. induction. Anal. of fragment distortion energies shows that disfavored transition states are destabilized due to the more severe distortion and loss of π-conjugation in the coordinated arylketone fragments. Examination of the different substitution patterns in the ketone substrate and the catalyst reveals the key steric factors that control the enantioselectivity. Finally, calculations indicate promising directions for the simplification of the catalyst scaffold while preserving the high levels of enantioselectivity of these alkynylation reactions.

Journal of the American Chemical Society published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, Product Details of C8H4ClF3O.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yao, Si published the artcileMethylene violet 3RAX-conjugated porphyrin for photodynamic therapy: synthesis, DNA photocleavage, and cell study, Application In Synthesis of 4569-86-2, the publication is RSC Advances (2018), 8(8), 4472-4477, database is CAplus.

A methylene violet 3RAX-conjugated porphyrin has been designed and synthesized as a potential photosensitizer in photodynamic therapy because of its high DNA binding constant and the efficacy in inhibiting cancer cells with subcellular localization. At 400μM, the DNA photocleavage activities of compound 1 and2 were 80% and 20%, resp. The results fromphotophys. studies and cell experiments suggest porphyrin-methylene violet 3RAX conjugate could be developed as potential photosensitizers for mitochondrial targeting action in PDT.

RSC Advances published new progress about 4569-86-2. 4569-86-2 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, and the molecular formula is C17H14N2O2, Application In Synthesis of 4569-86-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Dai, Ali published the artcileA 1,3,4-Oxadiazole Contained Sesquiterpene Derivatives: Synthesis and Microbiocidal Activity for Plant Disease, Category: chlorides-buliding-blocks, the publication is Frontiers in Chemistry (Lausanne, Switzerland) (2022), 854274, database is CAplus and MEDLINE.

A series of 1,3,4-oxadiazole contained sesquiterpene derivatives were synthesized, and the activity of the target compounds against Xanthomonas oryzae pv. oryzae (Xoo), Xanthomonas axonopodis pv. citri (Xac), and tobacco mosaic virus (TMV) were evaluated. The biol. activity results showed that the EC₅₀ values of compounds H4, H8, H11, H12, H14, H16, and H19 for Xac inhibitory activity were 33.3, 42.7, 56.1, 74.5, 37.8, 43.8, and 38.4 μg/mL, resp. Compounds H4, H8, H15, H19, H22, and H23 had inhibitory effects on Xoo, with EC₅₀ values of 51.0, 43.3, 43.4, 50.5, 74.6, and 51.4 μg/mL, resp. In particular, the curative and protective activities of compound H8 against Xoo in vivo were 51.9 and 49.3%, resp. In addition, the EC₅₀ values of the inactivation activity of compounds H4, H5, H9, H10, and H16 against TMV were 69.6, 58.9, 69.4, 43.9, and 60.5 μg/mL, resp. The results of mol. docking indicated that compound H10 exhibited a strong affinity for TMV-coat protein, with a binding energy of -8.88 kcal/mol. It may inhibit the self-assembly and replication of TMV particles and have an anti-TMV effect, which supports its potential usefulness as an antiviral agent.

Frontiers in Chemistry (Lausanne, Switzerland) published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lunagariya, Jignesh published the artcileDesign and synthesis of analogues of marine natural product galaxamide, an N-methylated cyclic pentapeptide, as potential anti-tumor agent in vitro, HPLC of Formula: 42074-68-0, the publication is Marine Drugs (2016), 14(9), 161/1-161/22, database is CAplus and MEDLINE.

Herein, we report design and synthesis of novel 26 galaxamide analogs with N-methylated cyclo-pentapeptide, and their in vitro anti-tumor activity towards the panel of human tumor cell line, such as, A549, A549/DPP, HepG2 and SMMC-7721 using MTT assay. We have also investigated the effect of galaxamide and its representative analogs on growth, cell-cycle phases, and induction of apoptosis in SMMC-7721 cells in vitro. Reckon with the significance of conformational space and N-Me aminoacid (aa) comprising this compound template, we designed the analogs with modification in N-Me-aa position, change in aa configuration from l to d aa and substitute one Leu-aa to d/l Phe-aa residue with resp. to the parent structure. The efficient solid phase parallel synthesis approach is employed for the linear pentapeptide residue containing N-Me aa, followed by solution phase macrocyclisation to afford target cyclo pentapeptide compounds In the present study, all galaxamide analogs exhibited growth inhibition in A549, A549/DPP, SMMC-7721 and HepG2 cell lines. Compounds 6, 18, and 22 exhibited interesting activities towards all cell line tested, while Compounds 1, 4, 15, and 22 showed strong activity towards SMMC-7221 cell line in the range of 1-2 μg/mL IC50. Flow cytometry experiment revealed that galaxamide analogs namely Compounds 6, 18, and 22 induced concentration dependent SMMC-7721 cell apoptosis after 48 h. These compounds induced G0/G1 phase cell-cycle arrest and morphol. changes indicating induction of apoptosis. Thus, findings of our study suggest that the galaxamide and its analogs 6, 18 and 22 exerted growth inhibitory effect on SMMC-7721 cells by arresting the cell cycle in the G0/G1 phase and inducing apoptosis. Compound 1 showed promising anti-tumor activity towards SMMC-7721 cancer cell line, which is 9 and 10 fold higher than galaxamide and reference DPP (cisplatin), resp.

Marine Drugs published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, HPLC of Formula: 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Guan, Zhipeng published the artcileSelective radical cascade (4+2) annulation with olefins towards the synthesis of chroman derivatives via organo-photoredox catalysis, Related Products of chlorides-buliding-blocks, the publication is Chemical Science (2022), 13(21), 6316-6321, database is CAplus and MEDLINE.

Here a new (4 + 2) radical annulation approach for the construction of these functional six-membered frameworks I (R = ethoxycarbonyl, N-methyl-N-phenylcarbamoyl, benzenesulfonyl, (2,2,6,6-tetramethylpiperidin-1-yl)carbonyl, etc.; R¹ = H, Me, methoxycarbonyl; R² = H, Me, OMe; R³ = H, F, Ph, 2,2-dichlorocyclopropyl, etc.; R²R³ = -CH=CH-CH=CH-; R⁴ = H, Me, OMe, CF₃; R⁵ = H, Me;) via photocatalysis was reported. Featuring mild reaction conditions, the protocol allows readily available N-hydroxyphthalimide esters II and electron-deficient olefins RCH=CHR¹ to be converted into a wide range of valuable chromans I in a highly selective manner. Moreover, the present strategy can be used in the late-stage functionalization of natural product derivatives and biol. active compounds, which demonstrated the potential application. This method is complementary to the traditional Diels-Alder [4 + 2] cycloaddition reaction of ortho-quinone methides II and electron-rich dienophiles, since electron-deficient dienophiles were smoothly transformed into the desired chromans I.

Chemical Science published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zheng, Yue published the artcileStructure-activity relationship studies of c-di-AMP synthase inhibitor, bromophenol-thiohydantoin, Formula: C7H4BrClO2, the publication is Tetrahedron (2016), 72(25), 3554-3558, database is CAplus.

C-di-AMP, a bacterial second messenger, regulates various processes in Gram-pos. bacteria and mycobacteria. Small mol. inhibitors of c-di-AMP metabolic enzymes could affect bacterial growth and viability. A medium throughput screening identified bromophenol-thiohydantoin (BTH) as the first inhibitor of c-di-AMP synthase, DisA. Herein, the authors performed SAR studies of bromophenol-thiohydantoin to identify the salient features on BTH that are important for DisA inhibition. Seemingly minor substitution changes (e.g., aromatic bromo to chloro substitutions) resulted in dramatic changes in ligand potency. Bromophenol TH is specific for c-di-AMP synthase and did not inhibit RocR (c-di-GMP PDE), YybT (c-di-AMP PDE) or WspR (c-di-GMP synthase).

Tetrahedron published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C14H14, Formula: C7H4BrClO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics