Category: chlorides-buliding-blocks

Ke, Jie published the artcileHexafluoroisopropanol-Enabled Copper-Catalyzed Asymmetric Halogenation of Cyclic Diaryliodoniums for the Synthesis of Axially Chiral 2,2′-Dihalobiaryls, Name: 4-Chloro-2-methylphenylboronic acid, the publication is Organic Letters (2021), 23(2), 329-333, database is CAplus and MEDLINE.

An efficient asym. halogenation of cyclic diaryliodonium salts was demonstrated, which gave access to a wide range of axially chiral 2,2′-dihalobiaryls in good to excellent yields and with excellent enantioselectivities. The use of CuX with chiral bisoxazoline ligand and tetrabutylammonium halides in the unique solvent of hexafluoroisopropanol (HFIP) led to the best results in the process. The axially chiral 2,2′-dihalobiaryls was transformed into a number of enantiopure chiral ligands that was potentially useful in asym. catalysis.

Organic Letters published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Name: 4-Chloro-2-methylphenylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

de Vasconcelos, Alana published the artcile2,4-Thiazolidinedione as Precursor to the Synthesis of Compounds with Anti-glioma Activities in C6 and GL261 Cells, Application of 3-Chlorobenzylchloride, the publication is Medicinal Chemistry (Sharjah, United Arab Emirates) (2021), 17(6), 601-610, database is CAplus and MEDLINE.

Thiazolidinediones (TZDs) represent an important class of heterocyclic compounds that have versatile biol. activities, including anticancer activity. Glioma is one of the most common primary brain tumors, and it is responsible for most of the deaths caused by primary brain tumors. In the present work, 2,4-thiazolidinediones were synthesized via a multicomponent microwave one-pot procedure. The cytotoxicity of compounds was analyzed in vitro using rat (C6) and mouse (GL261) glioblastoma cell lines and primary cultures of astrocytes. This study aims to synthesize and characterize 2,4-thiazolidinediones and evaluate their antitumor activity. TZDs were synthesized from three components: 2,4-thiazolidinedione, arene-aldehydes, and aryl chlorides. The reactions were carried out inside a microwave and monitored using thinlayer chromatog. (TLC). Compounds were identified and characterized using gas chromatog. coupled to mass spectrometry (CG-MS) and hydrogen (¹H-NMR) and carbon NMR spectroscopy (¹³C-NMR). The antitumor activity was analyzed using the 3-(4,5- dimethyl)-2,5-diphenyltetrazolium bromide (MTT) reduction test, in which cell viability was verified in the primary cultures of astrocytes and in rat and mouse glioblastoma cells exposed to the synthesized compounds The cytotoxicity of all derivatives was analyzed at the 100 μM concentration, both in astrocytes and in the mouse and rat glioblastoma cell lines. The compounds that showed the best results, 4CI and 4DI, were also tested at concentrations 25, 50, 100, 175, and 250 μM to obtain the IC₅₀. Seventeen TZD derivatives were easily obtained through one-pot reactions in 40 min with yields ranging from 12% to 49%. All compounds were cytotoxic to both glioblastoma cell lines without being toxic to the astrocyte primary cell line at 100 μM, thus demonstrating a selective activity. Compounds 4CI and 4DI showed the best results in the C6 cells: IC₅₀ of 28.51 μM and 54.26 μM, resp. The compounds were not cytotoxic in astrocyte culture, demonstrating selectivity for malignant cells. Changes in both rings are important for anti-glioma activity in the cell lines tested. TZD 4CI had the best anti-glioma activity.

Medicinal Chemistry (Sharjah, United Arab Emirates) published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Application of 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xiong, Feng published the artcileSynthesis of ortho-Phenolic Sulfilimines via an Intermolecular Sulfur Atom Transfer Cascade Reaction, Application In Synthesis of 209919-30-2, the publication is Organic Letters (2020), 22(10), 3799-3803, database is CAplus and MEDLINE.

A N-H sulfenylation/[2,3]-sigmatropic rearrangement cascade reaction was reported. This mild reaction enabled com. available thiols as the sulfenylation reagent and generated water as the sole byproduct. Moreover, the reaction showed a wide substrate scope and was conducted on a gram scale with excellent reaction efficiency.

Organic Letters published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C10H18O4, Application In Synthesis of 209919-30-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kharrasova, F. M. published the artcileReaction of phosphorus(III) acid esters with carbon tetrachloride, Name: Diethyltrichloromethylphosphonate, the publication is Zhurnal Obshchei Khimii (1974), 44(11), 2419-22, database is CAplus.

(RO)2(Cl3C)PO (R = C1-5 n-alkyl) were obtained in 52.9-87.5% yields by boiling P(OR)3 8 hr with CCl4. Addnl. obtained were the corresponding R(Cl3C)P(O)(OR). Treatment of PrP(O)(OEt)2 with CCl4 14 hr at 50-70° gave 61% R(Cl3C)P(O)(OR1) (I; R = Pr, R1 = Et). Analogously obtained were 39 and 75% I (R = Bu, R1 = pentyl; R = Ph, R1 = Et).

Zhurnal Obshchei Khimii published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Name: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Abd El-Aleem, Abd El-Aleem Hassan published the artcileReactions with coumarin-3,6-disulfonyl chloride, Application of Coumarin-6-sulfonyl chloride, the publication is Modelling, Measurement & Control, C: Energetics, Chemistry, Earth, Environmental & Biomedical Problems (1995), 47(1), 49-54, database is CAplus.

The reaction between coumarin-3,6-disulfonyl chloride (I) and amino compounds is investigated. The acid chloride reacts with aliphatic amines such as Et amine, ethanolamine, ethylenediamine or benzylamine to give the corresponding coumarin-6-sulfonamide derivatives While its reaction with secondary amines, aromatic amines or acid hydrazide gives the corresponding coumarin-3,6-disulfonamides. The reaction with hydrazine hydrate gives coumarin-6-sulfonylhydrazide or coumarin-3,6-disulfonylhydrazide, depends on the reaction conditions.

Modelling, Measurement & Control, C: Energetics, Chemistry, Earth, Environmental & Biomedical Problems published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Application of Coumarin-6-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Abd El-Meguid, Eman A. published the artcileSynthesis and antimicrobial evaluation of some novel sulfamoyl and triazole derivatives incorporating a 4-benzoimidazol-2-yl moiety, Related Products of chlorides-buliding-blocks, the publication is International Journal of Pharmacy and Technology (2015), 7(3), 10014-10028, database is CAplus.

In this study 15 novel benzoimidazole compounds were synthesized in order to investigate their possible antibacterial and antifungal activity. Two different Gram-pos. and two different Gram-neg. bacterial strains were used in antibacterial activity tests. Antifungal activity tests were also performed against two different fungal strains. Most of the test compounds found to be significantly effective against Gram-pos., Gram-neg. bacterial strains and antifungal strains.

International Journal of Pharmacy and Technology published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Abd El-Meguid, Eman Ali published the artcileDiscovery of some novel benzothiazole derivatives as VEGFR-2 inhibitors, Quality Control of 21286-54-4, the publication is International Journal of Pharmacy and Technology (2015), 7(3), 10040-10055, database is CAplus.

A series of benzothiazole derivatives were prepared by condensation of 5-amino-1-(4-benzothiazol-2-yl-benzoyl)-1H-pyrazole-4-carbonitrile (1) and/or 5-amino-1-(4-benzothiazol-2-yl-benzoyl)-1H-pyrazole-4-carboxylic acid hydrazide (6) with different electrophilic and nucleophilic reagents. All of the newly synthesized compounds have been evaluated for their potential cytotoxicity against breast cancer cell line (MCF-7); compounds 5c, 8b and 8c are more potent than tamoxifen while compounds 5b and 8a are equipotent to tamoxifen. These results were consistent with percentage of inhibition values against human VEGF compared with control untreated cells.

International Journal of Pharmacy and Technology published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Quality Control of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Abdel-Bary, Hamed M. published the artcileReactions with coumarin: synthesis and reactions of coumarin sulfonamides, Safety of Coumarin-6-sulfonyl chloride, the publication is Afinidad (1998), 55(473), 67-71, database is CAplus.

Coumarin-6-sulfonyl chloride was animated with different secondary amines to give the sulfonamides. Treatment of these with hydrazine under controlled conditions effected ring-opening of the lactone ring to afford the corresponding o-hydroxycinnamoyl hydrazides which were converted to hydrazones by reaction with various aldehydes. The hydrazones were cyclized using acetic anhydride to yield oxadiazolines. Reaction of the hydrazides with 4-toluoyl chloride afforded the corresponding N-toluoyl derivatives which cyclized with POCl₃ to the corresponding 1,3,4-oxadiazole derivatives Thiosemicarbazide derivatives were obtained by treatment of the hydrazides with PhNCS. Cyclization of the thiosemicarbazides using POCl₃ afforded the corresponding 1,3,4-thiadiazoles.

Afinidad published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Safety of Coumarin-6-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Abdel-Bary, Hamed M. published the artcileReactions with coumarin: synthesis and reactions of coumarinsulfonamides, COA of Formula: C9H5ClO4S, the publication is Mansoura Science Bulletin, A: Chemistry (1997), 24(1), 161-170, database is CAplus.

Coumarin-6-sulfonyl chloride was amidated with different secondary amines to give coumarin-6-sulfonamides. The latter with hydrazine under controlled conditions effected ring-opening of the lactone ring to afford the corresponding o-hydroxycinnamoyl hydrazides. Hydrazones were obtained by condensation of the latter with aldehydes. Some reactions of the hydrazones or hydrazides were examined

Mansoura Science Bulletin, A: Chemistry published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, COA of Formula: C9H5ClO4S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Abdulla, Riaz F. published the artcileMorpholines. V. Synthesis and properties of some 2-substituted 3-oxo-4H-1,4-oxazines, Computed Properties of 18791-02-1, the publication is Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie (1972), 27(12), 1465-70, database is CAplus.

Cyclodehydrochlorination of p-RC6H4N(COCHCl2)CH2COC6H4N-O2-p with Me3COK in Me2SO gave the title compounds (I; R = H or EtO2C; X = OH), which reacted with SOCl2 to give I (X = Cl) (II). Solvolysis with MeOH or amination of II with R21NH gave I (X = MeO or NR21, NR21 = ethyleneimino, 1-pyrrolidinyl, or piperidino).

Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Computed Properties of 18791-02-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics