Category: chlorides-buliding-blocks

Izzo, Patrick T. published the artcilePreparation of 1-aryl-1,2-cyclopropanedicarboximides. An application of dimethylsulfoxonium methylide, Formula: C3H9ClOS, the publication is Journal of Organic Chemistry (1963), 1713-15, database is CAplus.

1-Aryl-1,2-cyclopropanedicarboximides (I) were prepared in the presence of dimethylsulfoxonium methylide (II). Trimethylsulfoxonium chloride (III) was prepared by the method of Kuhn and Trischmann (CA 52, 14523g),m. 215-16°. III(1.5g.) added to a suspension of 0.29 g. NaH in 150 ml. tetrahydrofuran (THF), the mixture refluxed with evolution of H, stirred under reflux 45-60 min., and 0.012 mole N-methyl-2-arylmaleimide added to the solution (containing II), the mixture refluxed 2 hrs., cooled, alc. added, solvent removed in vacuo, the residue taken up in CH₂Cl₂, and the solution washed, dried, and evaporated gave I (R, R¹, m.p., % yield given): Ph, H, 55-7°, 21; Ph, Et, 113-146deg;, 81; 3,4,5-trimethoxyphenyl, H, 136-86°, 21. The structure of I was supported by infrared and ultraviolet spectra, elementary analyses, and unsaturation tests. N-Methyl-2-phenylsuccinimide (37.8 g.), 39.2 g. N-bromosuccinimide, 0.4 g. Bz₂O₂, and 800 ml. CCl₄ refluxed 24 hrs., stored 16 hrs. at room temperature, the succinimide removed, and the filtrate evaporated gave 49.2 g. 2-bromo-N-methyl2-phenylsuccinimide (IV), m. 110.5-12°. IV (7.5 g.) in 75 ml. C₆H₆ and 3 g. NEt₃ kept 1 hr. at room temperature and the product separated gave 3.7 g. N-methyl-2-phenylmaleimide (V), m. 147-8°. Arylation of maleimide with 3,4,5-trimethoxyphenyldiazonium chloride gave 27% 2-chloro-3-(3,4,5-trimethoxyphenyl)succinimide (VI), m. 207-8° (decomposition). VI (2 g.) heated 0.5 hr. with 8 ml. 2,6-lutidine gave 1.5 g. 2-(3,4,5-trimethoxyphenyl)maleimide (VII), m. 211-13°. VII (2.8 g.) in 75 ml. THF brought to reflux with 0.24 g. NaH, then treated in 45 min. under reflux with 7 g. MeI in 10 ml. THF, the mixture refluxed 1.75 hrs., evaporated, and the residue taken up in CHCl₈ gave 2 g. N-methyl-2-(3,4,5-trimethoxyphenyl)maleimide, m. 155-66deg;. V (8.9 g.) in 150 ml. CH₂Cl₂ treated in one lot with 0.054 mole MeCHN₂ in Et₂O gave 11.6 g. N,5-dimethyl-3-phenyl-1-pyrazoline-3,4-dicarboximide (VIII), m. 106-76deg; (decomposition). VIII (5.1 g.) in 50 ml. alc. was heated 0.5 hr., evapd, in vacuo, and the 4.4 g. of oil subjected to partition chromatography. Evaporation of material from the first peak gave 5% N-methyl-2-ethyl-3phenylmaleimide, m. 69-70°. The 2nd and slower moving component was obtained as the chief yield, 4 g., of N,3-dimethyl-1-phenyl-1,2-cyclopropanedicarboximide.

Journal of Organic Chemistry published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Formula: C3H9ClOS.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jones, F. William published the artcileFiber-reactive insecticides for wool: organophosphorus esters of nitrogen heterocycles, Formula: C3H3Br2ClO, the publication is Journal of Agricultural and Food Chemistry (1983), 31(2), 190-4, database is CAplus.

O,O-Di-Et phosphorothionate esters and O-Et S-Pr phosphorothiolothionate esters of some pyridazine and 1,2,4-triazole compounds containing a 2-bromoacryloyl ester substituent were synthesized and screened for insecticidal activity against the wool-digesting insects Tineola bisselliella and Anthrenus flavipes. O,O-Diethyl O-[1-(2-hydroxyethyl)-5-methylthio-3-(1,2,4-triazolyl)] phosphorothiolothionate (I) was most active. These compounds were found to be hydrolytically unstable when applied to wool from a boiling acidic dye bath. The extent of this hydrolysis has been determined by the development of a method for estimating organophosphorus esters that are covalently bound to the wool.

Journal of Agricultural and Food Chemistry published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Formula: C3H3Br2ClO.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jurga, Stefan published the artcileNuclear magnetic relaxation studies in solids, COA of Formula: C3H9ClOS, the publication is Ser. Fiz. (Uniw. im. Adama Mickiewicza Poznaniu) (1980), 58 pp., database is CAplus.

Spin-lattice relaxation times in the laboratory and in the rotating frame are reported for trimethyloxosulfonium fluoride, chloride, bromide and iodide as well as for Me₂SO and Me₂SO₂ over a wide temperature range. A model was developed that makes it possible to analyze the exptl. data on the basis of 4 independent reorientations around 3 3-fold axis and around center of gravity . The following conclusions consistent with the 2nd moment and spin-lattice relaxation results are drawn about reorientational state of cations and mols. The Me group is reorienting about its 3-fold axis at random between 3 equilibrium positions separated by 120° in all the compounds A 3-fold reorientation of all cations around the C₃ axis (designed by S → O bond) occurs. There is dynamical inequivalence of Me groups within the Me₂SO mol. and trimethyloxosulfonium chloride with 1:2 ratio. There is observed translational diffusion in Me₂SO₂. The activation energies for C₃ and C‘₃ reorientations decrease with an increase of an anion ionic radius (with exception of the iodide salt for the last motion).

Ser. Fiz. (Uniw. im. Adama Mickiewicza Poznaniu) published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, COA of Formula: C3H9ClOS.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Klevay, Leslie M. published the artcileCholesterotropic and cuprotropic chemicals, Name: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, the publication is Journal of the Science of Food and Agriculture (2020), 100(10), 4057, database is CAplus and MEDLINE.

A review. A dozen or so chems. modify both cholesterol and copper metabolism Ascorbic acid and cadmium, etc., inhibit copper metabolism and raise cholesterol. Calcium and clofibrate, etc., enhance copper and lower cholesterol. Perhaps the doses of dietary cholesterol and fructose in this experiment were too severe to permit fenofibrate to lower cholesterol in a manner similar to clofibrate. 2020 Society of Chem. Industry.

Journal of the Science of Food and Agriculture published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Name: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kozakiewicz, Irena published the artcileReactions of 2-(4-chloro-2-mercapto-5-methylbenzenesulfonamido)-5-methylimidazoline with some (dialkylamino)alkyl chlorides, Name: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Annales Academiae Medicae Gedanensis (1995), 367-70, database is CAplus.

Reactions of 2-(4-chloro-2-mercapto-5-methylbenzenesulfonamido)-5-methylimidazoline with some (dialkylamino)alkyl chlorides were described. Thus, treating mercaptobenzenesulfonamido derivative I (R = H) with RCl·HCl [R = CH₂CH₂NR’₂, R’ = Me, Bu, Pr; R = (CH₂)₃NMe₂, CH₂CH₂NR”₂, NR”₂ = morpholino; R = CH₂CMe₂NMe₂, CHMeCH₂NMe₂] in Me₂CHOH containing Me₂CHONa gave 23-72% alkylated I (same R).

Annales Academiae Medicae Gedanensis published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Name: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Changchun published the artcileSynthesis and fungicidal activity of (2-chloropyridin-5-yl)methyl carbamates, Safety of 3-Chloro-4-fluoronitrobenzene, the publication is Nongyaoxue Xuebao (2015), 17(1), 97-100, database is CAplus.

Eleven novel (2-ehloropyridin-S-yl)methyl carbamates were synthesized by Pd-Fe/TiO₂ catalyzed carbonylation of aromatic nitro-compounds and (2-chloropyridin-S-yl) methanol with carbon monoxide. Their structures were confirmed by ¹H NMR and MS. Preliminary fungicidal activity tests indicated that some of the target compounds exhibited certain degree of inhibiting effect against four tested strains at the concentration of 50 mg/L. The inhibition rate against Gibberella zeae was over 77.3% for compound I [(2-chloropyridin-5-yl)methyl (4-methoxyphenyl) carbamate], II [(2-chloropyridin-5-yl)methyl (2,4-dichlorophenyl) carbamate] and III [(2-ehloropyridin-S-yl)methyl (3,4-dichlorophenyl) carbamate]. Compound I showed 82.5% of inhibition rate against Physalospora piricola, that was almost equal to carbendazim. All compounds showed better fungicidal activities against Botrytis cinerea than carbendazim.

Nongyaoxue Xuebao published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Safety of 3-Chloro-4-fluoronitrobenzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lopatnikova, E. published the artcileIntramolecular transformations of silylenes in the gas phase, Quality Control of 14799-94-1, the publication is Doklady Akademii Nauk SSSR (1983), 268(1), 108-11 [Chem.], database is CAplus.

Treatment of RCH₂CH₂SiMeCl₂ [R = (CH₂)_nH, n = 0, 1-4] with K/Na (7:1) in a tubular continuous reactor at 300-340° and 0.1-1.0 mm gave, after trapping of the products in N(l) followed by gas chromatog-mass spectrometric identification, 30-50% RCH:CH₂. A mechanism involving intramol. β-attack by silylene (RCH₂CH₂SiMe) to give a 3-membered ring and subsequent elimination of the silylene group was proposed.

Doklady Akademii Nauk SSSR published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Quality Control of 14799-94-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mangte, Anvita D. published the artcileSynthesis and antimicrobial evaluation of protected lactosyl isothiourea derivatives, COA of Formula: C7H7ClN2S, the publication is Asian Journal of Chemical and Environmental Research (2014), 7(1-4), 50-54, database is CAplus.

Protected lactosyl isothiourea were synthesized by nucleophilic addition of per-O-acetyl lactosyl aryl isothiourea to tolyl isothiocyanate. Structures of these compounds were confirmed on the basis of IR, NMR, Mass spectra and elemental anal. These compounds were also screened for their in vitro antimicrobial activities against bacteria S. aureus, E. coli, P. vulgaris, P. aeruginosa and fungi A. niger, Penicillium.

Asian Journal of Chemical and Environmental Research published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, COA of Formula: C7H7ClN2S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mao, Faming published the artcileSynthesis of reactive scarlet 3G, Category: chlorides-buliding-blocks, the publication is Ranliao Yu Ranse (2010), 47(1), 19-20, database is CAplus.

Reactive scarlet 3G was prepared from sodium 2,4-diaminobenzenesulfonate, 2,3-dibromopropanoyl chloride and γ acid by acylation, diazotization, coupling and salting-out. The two steps of acylation were studied emphatically. The complete reaction conditions were obtained by experiments: the temperature of acylation was 0-15°C, pH was controlled between 5-7.5; the molar ratio of 2, 3-dibromopropanoyl chloride and sodium 2,4-diaminobenzenesulfonate was 1.05: 1,2,3-dibromopropanoyl chloride and γ acid molar ratio was 1.05: 1. The yield of acylation was above 90%.

Ranliao Yu Ranse published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Maristany, Jose M. Millet published the artcileDerivatives of N-methyl-4-phenylpiperidine-4-carboxylic and 2,2-diphenyl-4-dimethytaminovaleric acids, Category: chlorides-buliding-blocks, the publication is Rev. real acad. cienc. exact., fís. y nat. Madrid (1961), 59-103, database is CAplus.

N-Carboxyalkylamides of the title acids (I and II, resp.), analogs of dolatin and methadone, were prepared and tested. Derivatives of II had comparable spasmolytic activity, derivatives of I had low activity, and none had analgesic activity. The total syntheses of the chlorides (III and IV) of I and II were described with minor modifications of literature preparations Attempted condensations of III and IV with Et (V), Pr (VI), iso-Pr (VII), allyl (VIII), and Bu carbamates in the presence of Na and C₆H₆ at reflux, Na and Et₂O at reflux, EtMgBr (i.e., MgBr salt of the carbamate), Na and C₅H₅N, and alone gave poor results and the following method was adopted. To 10 g. NaH (50% dispersed in mineral oil) in 150 ml. anhydrous C₆H₆ was added 0.2 mole NH₂CO₂R in 250 ml. anhydrous C₆H₆ with cooling and stirring at a rate to maintain the temperature at 6-7°. Stirring was continued 30 min., during addition of 27.4 g. III.HCl (freshly prepared) in 150 ml. anhydrous C₆H₆, 2 hrs. more at 6-7°, 4 hrs. while the mixture warmed to room temperature, and 1 day longer. Workup yielded CH₂.CH₂.NMe.CH₂.CH₂.C(Ph)CONHCO₂R (X): (R in X, g. crude yield, m.p., and g. recovered acid given): Et, 16, 140-1.5° (Me₂CO), 9.5; Pr, 18.5, 138-9.5° (Me₂CO), 7; iso-Pr, 15, 136-8o (Me₂CO), 6; allyl, 16, 112-13.5° (Me₂CO), 8; Bu (XI), 15, 99.5-100.5° (Me₂CO) [picrate m. 163-4.5° (EtOH); HCl salt m. 108-10° (decomposition)], 6. X were very soluble in Me₂CO and EtOH, slightly soluble in Et₂O, and soluble in C₆H₅, 5% NaOH, and acids. Me₂NCHMeCH₂CPh₂CONHCO₂R (XII) were prepared similarly from 6.9 g. Na sand and 0.3 mole NH₂CO₂R (R in XII, g. pure yield, and m.p. given): Et, 10, 153-4.5° (Me₂CO); Pr, 10, 158-9° (Me₂CO); iso-Pr, 10, 140-1° (Me₂CO); allyl, 13.8, 139-9.5° (Me₂CO); and Bu (XIII), 12, 97-7.5° (Me₂CO) [picrate m. 128° (indefinite); HCl salt, liquid]. XII had the same solubilities as X, but were insoluble in dilute NaOH. XI was hydrolyzed by acid to the corresponding starting acid and by aqueous NH₃ and NaOEt in EtOH to the corresponding amide, whereas XIII was hydrolyzed by all three reagents to its corresponding amide. V (81 g.), 66 g. VI, and 60 g. VIII were prepared by heating 100 g. (NH₂)₂CO and 600 ml. of the appropriate alc. in an autoclave 60 hrs. at 160°, distilling the mixture to 150°, and distilling the residue in vacuo. Urea nitrate (200 g.) and 1 l. iso-PrOH refluxed 100 hrs. and the mixture worked up similarly gave 89 g. VII.

Rev. real acad. cienc. exact., fís. y nat. Madrid published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics