Category: chlorides-buliding-blocks

Munteanu, Charissa published the artcilePd- and Ni-Based Systems for the Catalytic Borylation of Aryl (Pseudo)halides with B₂(OH)₄, COA of Formula: C12H15ClO3, the publication is Journal of Organic Chemistry (2020), 85(16), 10334-10349, database is CAplus and MEDLINE.

Despite recent advancements in metal-catalyzed borylations of aryl (pseudo)halides, there is a continuing need to develop robust methods to access both early-stage and late-stage organoboron intermediates amendable for further functionalization. In particular, the development of general catalytic systems that operate under mild reaction conditions across a broad range of electrophilic partners remains elusive. Herein, it is reported the development and application of three catalytic systems (two Pd-based and one Ni-based) for the direct borylation of aryl (pseudo)halides using tetrahydroxydiboron (B₂(OH)₄). For the Pd-based catalyst systems, it was identified general reaction conditions that allow for the sequestration of halide ions through simple precipitation that results in catalyst loadings as low as 0.01 mol % (100 ppm) and reaction temperatures as low as room temperature It is also described a complementary Ni-based catalyst system that employs simple unligated Ni(II) salts as an inexpensive alternative to the Pd-based systems for the borylation of aryl (pseudo)halides. Extrapolation of all three systems to a one-pot tandem borylation/Suzuki-Miyaura cross-coupling is also demonstrated on advanced intermediates and drug substances.

Journal of Organic Chemistry published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, COA of Formula: C12H15ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Niggemyer, Allison published the artcileIsolation and characterization of a novel As(V)-reducing bacterium: implications for arsenic mobilization and the genus Desulfitobacterium, Recommanded Product: 3-Chloro-4-hydroxyphenylacetic acid, the publication is Applied and Environmental Microbiology (2001), 67(12), 5568-5580, database is CAplus and MEDLINE.

Dissimilatory arsenate-reducing bacteria have been implicated in the mobilization of arsenic from arsenic-enriched sediments. An As(V)-reducing bacterium, designated strain GBFH, was isolated from arsenic-contaminated sediments of Lake Coeur d’Alene, Idaho. Strain GBFH couples the oxidation of formate to the reduction of As(V) when formate is supplied as the sole carbon source and electron donor. Addnl., strain GBFH is capable of reducing As(V), Fe(III), Se(VI), Mn(IV) and a variety of oxidized sulfur species. 16S ribosomal DNA sequence comparisons reveal that strain GBFH is closely related to Desulfitobacterium hafniense DCB-2^T and Desulfitobacterium frappieri PCP-1^T. Comparative physiol. demonstrates that D. hafniense and D. frappieri, known for reductively dechlorinating chlorophenols, are also capable of toxic metal or metalloid respiration. DNA-DNA hybridization and comparative physiol. studies suggest that D. hafniense, D. frappieri, and strain GBFH should be united into one species. The isolation of an Fe(III)- and As(V)-reducing bacterium from Lake Coeur d’Alene suggests a mechanism for arsenic mobilization in these contaminated sediments while the discovery of metal or metalloid respiration in the genus Desulfitobacterium has implications for environments cocontaminated with arsenious and chlorophenolic compounds

Applied and Environmental Microbiology published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Recommanded Product: 3-Chloro-4-hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Vilsmaier, Elmar published the artcileHaloalkyl thio ethers. II. Reaction of dichloroiodides with thio ethers, Synthetic Route of 1002-41-1, the publication is Justus Liebigs Annalen der Chemie (1971), 62-7, database is CAplus.

Reaction of alkyl thio ethers with 3-(dichloroiodo)pyridine (I) gave 69-72% (α-chloroalkyl) thio ethers. The mechanism of this reaction was investigated. Reaction of I with ethylene sulfide or thietane gave only (ClCH2CH2)2S2 and [Cl(CH2)3]2S2, resp.

Justus Liebigs Annalen der Chemie published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C19H14Cl2, Synthetic Route of 1002-41-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ramesh, Perla published the artcileRecyclable Aliphatic Nitrile-Template Enabled Remote meta-C-H Functionalization at Room Temperature, Synthetic Route of 51656-68-9, the publication is Journal of Organic Chemistry, database is CAplus and MEDLINE.

This article describes the development of a new aliphatic nitrile-template-directed remote meta-selective C-H olefin functionalization reaction of arenes. Remarkably, unlike the previous reports, this process was feasible at room temperature and enabled the formation of products with excellent regio-selectivity. The present protocol encompasses a broad spectrum of substituted dihydrocinnamic acids and olefins, producing meta-C-H olefinated products (up to 96% yield). In addition, the efficacy of the present method was showcased by the synthesis of various drug analogs (e.g., cholesterol, estrone, ibuprofen, and naproxen). Significantly, the robustness of meta-olefination was also demonstrated by gram-scale synthesis. The new nitrile-based meta-directing template, in particular, could be easily synthesized in two steps and recycled under mild conditions. A, B, and C represent the Intrinsic Reaction Curves (IRCs) for the meta-C-H activation, Alkene Insertion, and β-Hydride elimination, resp., along with the corresponding transition states. CYL view software was used for showing transition state structures.

Journal of Organic Chemistry published new progress about 51656-68-9. 51656-68-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene, name is 3-(2,6-Dichlorophenyl)propanoic acid, and the molecular formula is C9H8Cl2O2, Synthetic Route of 51656-68-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Salvino, Joseph M. published the artcileNovel small molecule guanidine Sigma1 inhibitors for advanced prostate cancer, Related Products of chlorides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry Letters (2017), 27(10), 2216-2220, database is CAplus and MEDLINE.

Prostate cancer is the most frequently diagnosed malignancy and the leading cause of cancer related death in men. First line therapy for disseminated disease relies on androgen deprivation, leveraging the addiction of these tumors on androgens for both growth and survival. Treatment typically involves antagonizing the androgen receptor (AR) or blocking the synthesis of androgens. Recurrence is common and within 2-3 years patients develop castration resistant tumors that become unresponsive to AR-axis targeted therapies. To provide a more effective treatment, the authors are utilizing an approach that targets a key scaffolding protein, Sigma1 (also known as sigma-1 receptor), a unique 26-kDa integral membrane protein that is critical in stabilizing the AR. Herein the authors report on a new series of Sigma1 compounds for lead optimization derived from a hybrid pharmacophore approach.

Bioorganic & Medicinal Chemistry Letters published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zolnowska, Beata published the artcileN-(2-Arylmethylthio-4-chloro-5-methylbenzenesulfonyl)amide derivatives as potential antimicrobial agents-synthesis and biological studies, Recommanded Product: 1-(Chloromethyl)-4-(trifluoromethyl)benzene, the publication is International Journal of Molecular Sciences (2020), 21(1), 210, database is CAplus and MEDLINE.

A series of N-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)amides I [R = Ph, 3-F₃CC₆H₄, 4–F₃CC₆H₄, 1-naphthyl, 2-naphthyl] and II was synthesized. The antimicrobial activity of compounds I and II was evaluated on Gram-pos., Gram-neg. bacteria and fungal species. Experiments took into account investigation of antibacterial activity against planktonic cells as well as biofilms. Compounds I and II showed high bacteriostatic activity against staphylococci, with the most active mols. I [R = 3-F₃CC₆H₄] and II [R = 3-F₃CC₆H₄] presenting low MIC values of 4-8μg/mL against reference methicillin-resistant S. aureus (MRSA) and methicillin-sensitive S. aureus (MSSA) strains as well as clin. isolates. Compounds I [R = 3-F₃CC₆H₄] and II [R = 3-F₃CC₆H₄] also showed an ability to inhibit biofilms formed by MRSA and MSSA. The potential of I [R = 3-F₃CC₆H₄] and II [R = 3-F₃CC₆H₄] as antibiofilm agents was supported by cytotoxicity assays that indicated no cytotoxic effect either on normal cells of human keratinocytes or on human cancer cells, including cervical, colon, and breast cancer lines.

International Journal of Molecular Sciences published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H9NOS, Recommanded Product: 1-(Chloromethyl)-4-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

van der Maaden, Koen published the artcileFluorescent Nanoparticle Adhesion Assay: a Novel Method for Surface pK_a Determination of Self-Assembled Monolayers on Silicon Surfaces, Related Products of chlorides-buliding-blocks, the publication is Langmuir (2012), 28(7), 3403-3411, database is CAplus and MEDLINE.

Since the computer industry enables one to generate smaller and smaller structures, silicon surface chem. is becoming increasingly important for (bio-)anal. and biol. applications. For controlling the binding of charged biomacromols. such as DNA and proteins on modified silicon surfaces, the surface pK_a is an important factor. Here the authors present a fluorescent nanoparticle adhesion assay as a novel method to determine the surface pK_a of silicon surfaces modified with weak acids or bases. This method is based upon electrostatic interactions between the modified silicon surface and fluorescent nanoparticles with an opposite charge. Silicon slides were modified with 3-aminopropyltriethoxysilane (APTES) and were further derivatized with succinic anhydride. Layer thickness of these surfaces was determined by ellipsometry. After incubating the surfaces with an amine-reactive fluorescent dye, fluorescence microscopy revealed that the silicon surfaces were successfully modified with amine- and carboxyl-groups. Two surface pK_a values were found for APTES surfaces by the fluorescent nanoparticle adhesion assay. The 1st surface pK_a (6.55 ± 0.73) was comparable with the surface pK_a obtained by contact angle titration (7.3 ± 0.8), and the 2nd surface pK_a (9.94 ± 0.19) was only found by using the fluorescent nanoparticle adhesion assay. The surface pK_a of the carboxyl-modified surface by the fluorescent nanoparticle adhesion assay (4.37 ± 0.59) did not significantly differ from that found by contact angle titration (5.7 ± 1.4). In conclusion, the authors have developed a novel method to determine the surface pK_a of modified silicon surfaces: the fluorescent nanoparticle adhesion assay. This method may provide a useful tool for designing pH-dependent electrostatic protein and particle binding/release and to design surfaces with a pH-dependent surface charge for (bio-)anal. lab-on-a-chip devices or drug delivery purposes.

Langmuir published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C23H28N2O4, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Allgeier, Alan M. published the artcileElectrochemically Controlling Ligand Binding Affinity for Transition Metals via RHLs: The Importance of Electrostatic Effects, HPLC of Formula: 1002-41-1, the publication is Journal of the American Chemical Society (1997), 119(3), 550-559, database is CAplus.

Redox-switchable hemilabile ligands (RHLs) were synthesized that incorporates ferrocene as the redox group and phosphine ether or phosphine thioether moieties as binding groups. These ligands, which complex to Rh(I) and Pd(II), yield electrochem. control over ligand binding affinity for transition metals in complexes of the following type: [M(η⁴-(η⁵-C₅H₄XCH₂CH₂PR₂)₂Fe)]^y+ (I: M = Rh, X = O, R = Ph (phenyl), y = 1; II: M = Rh, X = O, R = Cy (cyclohexyl), y = 1; III: M = Rh, X = S, R = Ph, y = 1; IV: M = Pd, X = O, R = Ph, y = 2; V: M = Pd, X = O, R = Cy, y = 2). In the case of V, ligand based oxidation decreases the ligand to metal binding constant by nearly ten orders of magnitude. An examination of the crystal structures of I, III, IV, and V and the electrochem. behavior of RHL-complexes and isoelectronic model complexes reveals that electrostatic effects play a significant role in the charge dependent behaviors of these complexes. Addnl., there is a correlation between the phosphine substituents and RHL-complex stability. As a general rule cyclohexyl groups stabilize the complexes in their oxidized states over Ph groups. RHLs provide a viable means of electrochem. controlling ligand binding affinity and thus the steric and electronic environment of bound transition metals.

Journal of the American Chemical Society published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, HPLC of Formula: 1002-41-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Timmers, Peer H. A. published the artcileImproved drinking water quality after adding advanced oxidation for organic micropollutant removal to pretreatment of river water undergoing dune infiltration near The Hague, Netherlands, SDS of cas: 637-07-0, the publication is Journal of Hazardous Materials (2022), 128346, database is CAplus and MEDLINE.

Introduction of AOP decreased the number and concentration of OMP that were introduced during MARR, which decreased the risk of neg. impacts on ecol. and groundwater. The many uncertainties, such as seasonal and annual fluctuations of the intake water and in the infltration ponds, made it diffcult to determine if factors were directly affected by the AOP introduction. However, AOP did increase the amount of easily biol. degradable compounds, but these were diluted with non-AOP treated infltration water and degraded during transport to the dunes, making the effects on MARR negligible. Several OMP that were not removed during AOP, were removed during MARR. The overall OMP concentrations in resulting drinking water therefore decreased after introduction of AOP, without showing a measurable neg. effect on other water quality parameters.

Journal of Hazardous Materials published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C16H12N2O2, SDS of cas: 637-07-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Van Tilborg, W. J. M. published the artcileThe electrochemical Wittig-Horner reaction; evidence of a stepwise cleavage of a four-membered ring Wittig intermediate, Application In Synthesis of 866-23-9, the publication is Recueil des Travaux Chimiques des Pays-Bas (1980), 99(6), 202-6, database is CAplus.

Electroreduction of diethyl(trichloromethyl)phosphonate in the presence of aldehydes or ketones replaces the O atom of the carbonyl group by a dichloromethylene group. The yield of 1,1-dichloroethene product decreases substantially if the carbonyl compound carries strongly acidic hydrogen. In several cases the conversion of the 4-membered ring Wittig intermediate into its corresponding carbanion by heterolytic P-C bond cleavage was observed The intermediate carbanion is sufficiently stable to be intercepted by proton abstraction. These observations suggest that the decomposition of the Wittig 4-membered ring intermediate occurs along a 2-step pathway.

Recueil des Travaux Chimiques des Pays-Bas published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C24H20Ge, Application In Synthesis of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics