Category: chlorides-buliding-blocks

Kobatake, Seiya published the artcileAcid-induced photochromic system switching of diarylethene derivatives between P- and T-types, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Chemical Communications (Cambridge, United Kingdom) (2007), 1698-1700, database is CAplus and MEDLINE.

Diethylamino-substituted diarylethenes can switch between P-type photochromism (P-type = thermally stable isomers) and T-type (thermally unstable isomers) photochromism upon addition of trifluoromethanesulfonic acid. The protonated closed-form photoinduced color isomers return to open-ring isomers at a fast rate at elevated temperature such as 160° C. The protonation and deprotonation of the open- and closed isomers was reversible. Such photochromic materials could be used as reversible switching materials for write-by-light/erase-by-heat recording.

Chemical Communications (Cambridge, United Kingdom) published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fushimi, Nobuhiko published the artcileDesign, synthesis, and structure-activity relationships of a series of 4-benzyl-5-isopropyl-1H-pyrazol-3-yl β-D-glycopyranosides substituted with novel hydrophilic groups as highly potent inhibitors of sodium glucose co-transporter 1 (SGLT1), Product Details of C19H34ClN, the publication is Bioorganic & Medicinal Chemistry (2013), 21(3), 748-765, database is CAplus and MEDLINE.

Sodium glucose co-transporter 1 (SGLT1) plays a dominant role in the absorption of glucose in the gut and is considered a promising target in the development of therapeutic options for postprandial hyperglycemia. Previously, we reported potent and selective SGLT1 inhibitors 1 and 2 showing efficacy in oral carbohydrate tolerance tests in diabetic rat models. In a pharmacokinetic (PK) study of glycoside I (R = OH), excessive systemic exposure to metabolites of I (R = OH) was observed, presumably due to the high permeability of its aglycon. To further improve SGLT1 inhibitory activity and reduce aglycon permeability, a series of 4-benzyl-5-isopropyl-1H-pyrazol-3-yl β-D-glycopyranoside derivatives, e.g. I (R = NH₂), bearing novel hydrophilic substitution groups on the Ph ring were synthesized and their inhibitory activity toward SGLTs was evaluated. Optimized compound II showed an improved profile satisfying both higher activity and lower permeability of its aglycon. Moreover, the superior efficacy of II in various carbohydrate tolerance tests in diabetic rat models was confirmed compared with acarbose, an α-glucosidase inhibitor (α-GI) widely used in the clinic.

Bioorganic & Medicinal Chemistry published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Product Details of C19H34ClN.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yamamoto, H. published the artcileOrally active cephalosporins. Part 3: synthesis, structure-activity relationships and oral absorption of novel C-3 heteroarylmethylthio cephalosporins, Synthetic Route of 75341-23-0, the publication is Bioorganic & Medicinal Chemistry (2001), 9(2), 465-475, database is CAplus and MEDLINE.

A series of 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]-3-(heteroarylmethylthio)cephalosporins was designed, synthesized and evaluated for antibacterial activity and oral absorption in rats. Antibacterial activity was markedly influenced by the structure of the heteroaromatic ring moiety. Oral absorption was influenced by the heteroaromatic ring moiety as well as by the arrangement of heteroatoms. Among these compounds, FK041, 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetamido]-3-[(pyrazol-3-yl)methylthio]-3-cephem-4-carboxylic acid, showed potent antibacterial activity against both Gram-pos. and Gram-neg. bacteria including Haemophilus influenzae. Further, it showed higher oral absorption than CFDN.

Bioorganic & Medicinal Chemistry published new progress about 75341-23-0. 75341-23-0 belongs to chlorides-buliding-blocks, auxiliary class Thiadiazole,Chloride, name is 2-(Chloromethyl)-5-methyl-1,3,4-thiadiazole, and the molecular formula is C17H14N2O2, Synthetic Route of 75341-23-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ciganek, M. published the artcileModification of glass capillary inner surface for chromatography, Product Details of C9H20Cl2Si, the publication is Chemical Papers (1991), 45(1), 81-9, database is CAplus.

Conditions of glass capillary (50 μm inner diameter) inner surface modification by an aqueous solution of ammonia were studied. The resulting silica gel porous layer was modified chem. by methyloctyldichlorosilane. Under given etching conditions (temperature 250-300° for 16 h), a 5-10 volume% aqueous solution of ammonia was optimal. The static way of silylation by 10 volume% silane solution in toluene for 16 h at 250-280° with the column filled to 50-70% of its volume is optimal. This method provides a mech. stable porous layer 1-10 μm thick.

Chemical Papers published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Product Details of C9H20Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jamal Ahamed, V. S. published the artcileRadical polymerization of methyl methacrylate (MMA) initiated by KHSO₅-BTBAC system – a kinetic study, Name: N-Benzyl-N,N-dibutylbutan-1-aminium chloride, the publication is Journal of Polymer Research (2012), 19(2), 1-8, database is CAplus.

Kinetics of free radical polymerization of Me methacrylate using potassium peroxomonosulfate as initiator in the presence of benzyltributylammonium chloride (BTBAC) as phase transfer catalyst was studied. The polymerization reactions were carried out under nitrogen atm. and unstirred conditions at a constant temperature of 60°C in Et acetate/water bi-phase system. The role of concentrations of monomer, initiator, catalyst, temperature, acid and ionic strength on the rate of polymerization (R_p) was ascertained. The orders with respect to monomer, initiator and phase transfer catalyst were found to be 1.5, 0.5 and 0.5 resp. The rate of polymerization (R_p) is independent of ionic strength and pH. Based on the kinetic results, a suitable mechanism is proposed.

Journal of Polymer Research published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Name: N-Benzyl-N,N-dibutylbutan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wyrebska, Lucja published the artcileSynthesis and characterization of new polisher agent used in electroplating, Synthetic Route of 4569-86-2, the publication is Technologia i Jakosc Wyrobow (2012), 56(1-2), 30-35, database is CAplus.

The paper presents results of research on the preparation of polisher agent used in copper electroplating (electropolisher) and intermediate required for the synthesis of N,N-diethylphenosafranine (I). The multi-step synthesis of the intermediate I comprises the nitrosation of N,N-diethylaniline, reduction of p-nitroso-N,N-diethylaniline, oxidation of the resulting N,N-diethyl-p-phenylenediamine and its condensation with aniline. The polisher agent was obtained by diazotization of N,N-diethylphenosafranine and by reacting the resulting diazo compound with N,N-dimethylaniline, to obtain the product with absorption maximum λ_max = 584 (300) nm. The usage tests of the newly developed product have shown very good application properties.

Technologia i Jakosc Wyrobow published new progress about 4569-86-2. 4569-86-2 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, and the molecular formula is C7H7IN2O, Synthetic Route of 4569-86-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Matsuo, Y. published the artcilePreparation and characterization of silylated graphite oxide, Quality Control of 14799-93-0, the publication is Carbon (2005), 43(14), 2875-2882, database is CAplus.

Graphite oxide was silylated by various alkylchlorosilanes in the presence of butylamine and toluene, and new intercalation compounds were obtained. The silylating reagents with two or three Cl atoms at Si in them reacted with graphite oxide, while no reaction occurred when silylating reagents with only one Cl atom was used. The silylating reagent mainly reacted with hydroxyl group of graphite oxide, forming Si-O bonding. The role of butylamine was not only exfoliating graphite oxide layer but also scavenging HCl mol. which caused the decomposition of silylated graphite oxide. The Si content was almost constant �.6 mol/graphite oxide for the samples silylated by alkyltrichlorosilane with shorter alkyl chain lengths. It increased with the increase of alkyl chain length and reached 1.7 mol/graphite oxide. The higher Si content could be ascribed to further silylation on hydroxyl groups formed at Si atoms of silylating reagent bonded to graphite oxide, bridging two silylating reagents.

Carbon published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Quality Control of 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Corpas-Lopez, Victoriano published the artcileO-Alkyl Hydroxamates Display Potent and Selective Antileishmanial Activity, Related Products of chlorides-buliding-blocks, the publication is Journal of Medicinal Chemistry (2020), 63(11), 5734-5751, database is CAplus and MEDLINE.

Leishmania (L.) infantum causes visceral, cutaneous, and mucosal leishmaniasis in humans and canine leishmaniasis in dogs. Herein, we describe that O-alkyl hydroxamate derivatives displayed potent and selective in vitro activity against the amastigote stage of L. infantum while no activity was observed against promastigotes. Compound PhNHCO(CH₂)₆CONHOCPh₃ (I)showed potent in vivo activity against L. infantum. Moreover, the combination of compound 5 supported on gold nanoparticles and meglumine antimoniate was also effective in vivo and improved the activity of these compounds compared to that of the individual treatment. Docking studies showed that compound 5 did not reach highly conserved pocket C and established interactions with the semiconserved residues V44, A45, R242, and E243 in pocket A of LiSIR2rp1. The surface space determined by these four amino acids is not conserved in human sirtuins. Compound I represents a new class of selective ligands with antileishmanial activity.

Journal of Medicinal Chemistry published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hideo, Endo published the artcileAntitumor activity of phenazine derivatives against S 180 and C 63 in mice I, Product Details of C22H23ClN4, the publication is Sci. Rept. Res. Inst., Tohoku Univ., Ser. C (1965), 12(1), 53-7, database is CAplus.

Phenazine and 68 derivatives of phenazine were screened for their antitumor activity against Sarcoma 180 and Carcinoma 63, transplanted in mice. The ratio of the average weights of tumors in the treated and the controls, and the ratio of body weight changes in the 2 groups were recorded for each compound 2-Methoxyphenazine, 3,7-diamino-2-methylphenazine and 3-morpholino-1,2-benzophenazine at doses of 50 mg./kg.-body weight/day, brought down the tumor weight to less than half in the carcinoma infected mice and 3-acetamido-7-amino-5-phenylphenazonium chloride at the same dosage caused a similar effect in the sarcoma-infected animals. No correlation was observed between tumor weight change and the change in body weight in the treated animals.

Sci. Rept. Res. Inst., Tohoku Univ., Ser. C published new progress about 4569-86-2. 4569-86-2 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, and the molecular formula is C22H23ClN4, Product Details of C22H23ClN4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yoshihira, Kunitoshi published the artcileStereochemistry. XL. Rearrangement and trans-elimination contrary to the Chugaev reaction rule. 4. Thermal treatment on thionobenzoates, Application of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Yakugaku Zasshi (1969), 89(9), 1225-35, database is CAplus and MEDLINE.

Thermal treatment of xanthates bearing an anchimeric group causes rearrangement to dithiocarbonates or trans elimination depending on their conformation (contrary to the Chugaev reaction). Thiobenzoates, e.g. I, were similarly treated and the analogous conclusion was reached concerning results and mechanisms. The identification of 2-(dialkylamino)alkanethiols produced in this series was reexamined and Hansen’s report on the same problem was corrected with respect to isothiuronium salt formation and desulfurization by Raney Ni.

Yakugaku Zasshi published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C11H11BFNO4, Application of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics