Category: chlorides-buliding-blocks

Han, Ying published the artcileSynthesis and Bioactivity of Coumarin-6-sulfonylureas, Category: chlorides-buliding-blocks, the publication is Zhongguo Yaoke Daxue Xuebao (2002), 33(2), 93-97, database is CAplus.

Twenty-one coumarin-6-sulfonylureas {N-[4-R¹-7-R²-benzopyran-2(2H)-one-6-sulfonyl]-N’-R³-urea; R¹ and/or R² = H or methyl; R³ = cyclohexyl, allyl, Pr, heptyl, iso-Pr, Bu, or isobutyl} were synthesized to search for new antidiabetic drugs. Sulfonylurea functional groups were introduced into the structure of coumarin, and the hypoglycemic activity of the target compounds was measured. Their structures were identified by IR, ¹H NMR, and MS spectra. The pharmacol. study showed that compounds SU-1 (R¹ = R² = H, R³ = cyclohexyl), SU-8 (R¹ = H, R² = Me, R³ = cyclohexyl), SU-11 (R¹ = H, R² = Me, R³ = butyl), SU-12 (R¹ = H, R² = Me, R³ = heptyl), and SU-13 (R¹ = H, R² = Me, R³ = isopropyl) exhibited evident hypoglycemic activities (P <0.01) at the dose of 50 mg kg^-1.

Zhongguo Yaoke Daxue Xuebao published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Qi, Gang published the artcileSynthesis of coumarin-propanedioic acid dimethyl esters, Synthetic Route of 10543-42-7, the publication is Hecheng Huaxue (2007), 15(4), 466-467, 470, database is CAplus.

Three new coumarin-propanedioic acid di-Me esters were designed and synthesized by matching principle from coumarin and propanedioic acid di-Me ester. The structures were identified by ¹H NMR, IR and MS.

Hecheng Huaxue published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Synthetic Route of 10543-42-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shi, Peng published the artcileRegio- and Stereoselective Chloro Sulfoximidations of Terminal Aryl Alkynes Enabled by Copper Catalysis and Visible Light, Recommanded Product: Sodium chloro(tosyl)amide trihydrate, the publication is Advanced Synthesis & Catalysis (2021), 363(10), 2552-2556, database is CAplus.

By visible-light photoredox catalysis with copper complexes, sulfoximidoyl chlorides add to terminal aryl alkynes to gave the corresponding (E)-β-chlorovinyl sulfoximines I [R = 2-thienyl, Ph, 2-naphthyl, etc.; R¹ = n-Pr, Ph, 4-MeC₆H₄, etc.] with exclusive regio- and stereoselectivities in high yields. Two representative products I [R = 4-BrC₆H₄, 4-t-BuC₆H₄; R¹ = Ph] had been characterized by X-ray crystal structure anal. Radicals appear was decisive intermediates. As demonstrated by two subsequent reactions, the products could be derivatized.

Advanced Synthesis & Catalysis published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C9H21NO3, Recommanded Product: Sodium chloro(tosyl)amide trihydrate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shi, Peng published the artcileVisible Light-Promoted Synthesis of β-Keto Sulfoximines from N-Tosyl-Protected Sulfoximidoyl Chlorides, Related Products of chlorides-buliding-blocks, the publication is Journal of Organic Chemistry, database is CAplus and MEDLINE.

Under visible light, N-tosyl-protected sulfoximidoyl chlorides RSO(NTs)Cl (R = 4-CH₃C₆H₄, 4-CH₃OC₆H₅, 1-naphthyl, etc.) react with aryl alkynes R¹C₆H₄CC (R¹ = 4-Cl, 3-Br, 3-Me, etc.) to give β-keto sulfoximines I. The reaction is characterized by a high functional group tolerance and good yields. It can be improved by the presence of a ruthenium photocatalyst. Air is the source of the ketonic oxygen in the products.

Journal of Organic Chemistry published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H10BNO4S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jiang, Wanlong published the artcileArylpropionylpiperazines as antagonists of the human melanocortin-4 receptor, Recommanded Product: 3-(2,6-Dichlorophenyl)propanoic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2006), 16(17), 4674-4678, database is CAplus and MEDLINE.

A series of 3-arylpropionylpiperazines were synthesized as antagonists of the melanocortin-4 receptor. Their potency was increased by replacing the α-Me substituent of the initial lead with a larger s-Bu or i-Bu group. Further potency enhancement was observed when a glycine or β-alanine was incorporated onto the benzylamine. Some compounds demonstrated good potency, moderate selectivity, and oral bioavailability.

Bioorganic & Medicinal Chemistry Letters published new progress about 51656-68-9. 51656-68-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene, name is 3-(2,6-Dichlorophenyl)propanoic acid, and the molecular formula is C9H8Cl2O2, Recommanded Product: 3-(2,6-Dichlorophenyl)propanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zawadowski, Teodor published the artcileSynthesis of the 2-[4-hydroxy-7-methyl-5-oxo-5H-furo[3,2-g][1]benzopyran-9-yloxy]acetic and -propionic acid derivatives with expected activity on the circulatory system, Safety of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Acta Poloniae Pharmaceutica (1989), 46(4), 305-12, database is CAplus and MEDLINE.

Etherification of 4,9-didemethylkhellin (I) with ClCH₂CO₂Et and MeCHClCO₂Et in Me₂CO containing K₂CO₃ gave the furobenzopyranyloxyacetic acid derivatives II (R = H, R² = OEt, R¹ = H, Me, resp.), subsequently hydrolyzed with H₂SO₄ to the corresponding II (R² = OH, III). II (R = H, R² = OR³; R¹ = H, Me, R³ = 2-(1-piperidinyl)ethyl and 2-(4-morpholinyl)ethyl; R¹ = Me, R³ = Me₂NCH₂CHMe) were prepared in the reaction of III with appropriate R³Cl.HCl in a MeOH-Me₂CHOH solution of NaOH. II (R = R¹ = H, R² = NH₂, 2-pyridylamino, IV) were prepared by direct etherification of I with the corresponding ClCH₂COR²; further reaction with MeI gave II (R = Me, R¹ = H, R² = 2-pyridylamino), and with 2-chloroacetylaminopyridine, the ethers V (R¹ = H, R⁴ = H₂NCO and 2-pyridylcarbamoyl). In a similar reaction, 4-demethylkhellin gave V (R¹ = R⁴ = H). IV was comparable with propranolol in antiarrhythmic activity and effect on heart bioelec. action with LD₅₀ as low as 250 mg/kg i.v.

Acta Poloniae Pharmaceutica published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C6H8O6, Safety of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ferrier, Robert J. published the artcileUnsaturated carbohydrates, part 28. Synthesis and photolysis of some carbohydrate 1,6-dienes, Related Products of chlorides-buliding-blocks, the publication is Carbohydrate Research (1985), 249-58, database is CAplus.

Several attempts to abbreviate author’s earlier syntheses of the prostaglandin intermediates I and II by photocyclization of carbohydrate-based 1,6-dienes III [R = R¹ = Cl, Br; RR¹ = S(CH₂)₃S; R = cyano, R¹ = NEt₂] and IV (R² = Me, OEt) did not yield the required bicyclo[3.2.0]heptane derivatives Photolysis of IV caused migration of the conjugated alkene bond.

Carbohydrate Research published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Murphy, Jaclyn M. published the artcileOne-Pot Synthesis of Arylboronic Acids and Aryl Trifluoroborates by Ir-Catalyzed Borylation of Arenes, HPLC of Formula: 929626-16-4, the publication is Organic Letters (2007), 9(5), 757-760, database is CAplus and MEDLINE.

The synthesis of arylboronic acids and aryl trifluoroborates in a one-pot sequence by Ir-catalyzed borylation of arenes is reported. To prepare the arylboronic acids, the Ir-catalyzed borylation is followed by oxidative cleavage of the boronic ester with NaIO₄ and to prepare the aryltrifluoroborate, the Ir-catalyzed borylation is followed by displacement of pinacol by KHF₂. These two-step sequences give products that are more reactive toward subsequent chem. than the initially formed pinacol boronates.

Organic Letters published new progress about 929626-16-4. 929626-16-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronate Esters, name is 2-(3-Chloro-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C13H18BClO3, HPLC of Formula: 929626-16-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Birgul, Kaan published the artcileSynthesis and molecular modeling of MetAP2 of thiosemicarbazides, 1,2,4-triazoles, thioethers derived from (S)-Naproxen as possible breast cancer agents, Recommanded Product: 3-Chlorobenzylchloride, the publication is Journal of Molecular Structure (2022), 132739, database is CAplus.

New thiosemicarbazides, 1,2,4-triazoles and thioethers I (R¹ = Ph, 4-FC₆H₄, Bn, etc.; R² = Bn, 3-FC₆H₄CH₂, 4-MeOC₆H₄CH₂, etc.) from derived (S)-Naproxen were synthesized in this study. The mol. binding of the compounds on MetAP-2 was performed. Anticancer effects of the synthesized compounds were studied by using MTT assay method on MCF-7 (includes estrogen and progesterone receptors) and MDA-MB-231 (lacks estrogen and progesterone receptors) adenocarcinoma cell lines at 0, 10, 25, 50, 75 and 100μM concentrations for 24 h. The IC₅₀ values of novel (S)-Naproxen derivatives were determined between from 5 to 100μM on MCF-7 breast cancer cell line and MDA-MB-231 cell lines. The apoptotic activity of selected compounds I (R¹ = 4-ClC₆H₄; R² = 3-FC₆H₄CH₂) and I (R¹ = Ph; R² = 4-MeC₆H₄CH₂) were first analyzed by Annexin V staining using Tali Image-Based Cytometer. Mitochondrial membrane potential changes determined in fluorescence plate reader following JC-1 stain for compounds I (R¹ = 4-ClC₆H₄; R² = 3-FC₆H₄CH₂) and I (R¹ = Ph; R² = 4-MeC₆H₄CH₂) in MCF-7 and MDA-MB-231 cells. The effect of these compounds on the cell viability 4T1 mouse mammary tumor cell line was tested at 1 to 5 times of calculated IC₅₀ value (IC₅₀x1, IC₅₀x2, IC₅₀x3, IC₅₀x4, and IC₅₀x5). Next in order to determine the toxicity of the combination of compound I (R¹ = Bn; R² = 3-FC₆H₄CH₂) and Docetaxel, WST-1 cell viability and proliferation assay was performed with 4T1.

Journal of Molecular Structure published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Recommanded Product: 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Akazawa, Masako published the artcilePhotoresponsive dithienylethene-urea-based organogels with “reversed” behavior, HPLC of Formula: 219537-97-0, the publication is Organic & Biomolecular Chemistry (2008), 6(9), 1544-1547, database is CAplus and MEDLINE.

Dithienylperhydrocyclopentene-bisurea-based low mol. weight gelators are described that function as photoresponsive organogels that show a remarkable gel-to-liquid transition upon irradiation The two series of derivatives, with and without alkyl spacers between the urea hydrogen bonding groups and the photochromic unit, show different gelation behavior. Upon UV irradiation of the gels, a gel liquefied at only 1.4% conversion of the photochromic unit. Transmission electron microscopy (TEM) shows that the gel fibers consist of thin ribbons. Semi-empirical (PM3) calculations indicate that the hydrogen bonding between the open-ring isomer (o) mols. is weak, and that formation of the closed-ring isomer (c) destabilizes the hydrogen bonding further. The results indicate that a small amount of the closed-ring isomer will disrupt the intermol. hydrogen-bonding, leading to disintegration of the gel fiber ribbons and hence reversible liquefication.

Organic & Biomolecular Chemistry published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, HPLC of Formula: 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics