Category: chlorides-buliding-blocks

Sanin, P. I. published the artcileInteraction of antiwear additives with friction surfaces, Product Details of C5H10Cl3O3P, the publication is Wear (1974), 30(2), 249-56, database is CAplus.

A study of the effects of phosphonic acid esters on frictional wear under diverse loads and sliding speeds indicated that the efficiency of such phosphonates (I) as antiwear additives depends on their structure and varies with the frictional modes. Principal I were grouped as esters which are ineffective under both high and low loads (esters with no Cl atoms); esters effective under both high and low loads (CCl3-group containing esters); and esters effective under high or low loads. The interaction of I with steel has been studied. Dissimilarity in the efficiency of esters as lubricating oil additives is explained by their different adsorption and chem. actions.

Wear published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Product Details of C5H10Cl3O3P.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Corley, L. S. published the artcileHaloaldehyde polymers. 16. Stabilization of anionically-prepared polychloral by end-capping with decomposable cations and other additives, Formula: C3H9ClOS, the publication is Polymer (1979), 20(12), 1535-47, database is CAplus.

Completely or partially stable polychloral [25154-92-1] was obtained by anionic cryotachensic polymerization of Cl₃CCHO in the presence of alkylating or acylating agents, e.g. Me₂SO₄ [77-78-1]. Stabilization was also effected by polymerization using salts with easily decomposed cations as anionic initiators. Sulfonium salts, e.g. Me₃S⁺Cl^– [3086-29-1] and [Me₂S⁺CH₂Ph]Br^– [14182-15-1], and iodonium salts, e.g. Ph₂I⁺Cl^– [1483-72-3], were effective although quant. stabilization was not achieved. Polychloral with improved stability was also obtained using certain amide acetals, e.g. Me₂NCH(OMe)₂ [4637-24-5], as initiators.

Polymer published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Formula: C3H9ClOS.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Roedl, Carmen B. published the artcileMulti-dimensional target profiling of N,4-diaryl-1,3-thiazole-2-amines as potent inhibitors of eicosanoid metabolism, Recommanded Product: 1-(4-Chlorophenyl)thiourea, the publication is European Journal of Medicinal Chemistry (2014), 302-311, database is CAplus and MEDLINE.

Eicosanoids like leukotrienes and prostaglandins play a considerable role in inflammation. Produced within the arachidonic acid (AA) cascade, these lipid mediators are involved in the pathogenesis of pain as well as acute and chronic inflammatory diseases like rheumatoid arthritis and asthma. With regard to the lipid cross-talk within the AA pathway, a promising approach for an effective anti-inflammatory therapy is the development of inhibitors targeting more than one enzyme of this cascade. Within this study, thirty N-4-diaryl-1,3-thiazole-2-amine based compounds with different substitution patterns were synthesized and tested in various cell-based assays to investigate their activity and selectivity profile concerning five key enzymes involved in eicosanoid metabolism (5-, 12-, 15-lipoxygenase (LO), cyclooxygenase-1 and -2 (COX-1/-2)). With compound ST-1355, 2-(4-phenylthiazol-2-ylamino)phenol, a multitarget ligand targeting all tested enzymes is presented, whereas compound ST-1705, 2-(4-(4-chlorophenyl)thiazol-2-ylamino)phenol, represents a potent and selective 5-LO and COX-2 inhibitor with an IC₅₀ value of 0.9±0.2 μM (5-LO) and a residual activity of 9.1±1.1% at 10 μM (COX-2 product formation). The promising characteristics and the addnl. noncytotoxic profile of both compounds reveal new lead structures for the treatment of eicosanoid-mediated diseases.

European Journal of Medicinal Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Recommanded Product: 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yaremchuk, A. A. published the artcileDevelopment of novel pharmaceutical forms of decamethoxin, Quality Control of 38146-42-8, the publication is Fiziologicheski Aktivnye Veshchestva (1991), 40-2, database is CAplus.

Decamethoxin, a quaternary ammonium compound, displayed high antibacterial activity against gram-pos. and gram-neg. pathogenic bacteria as well as anaerobic microorganisms, including Clostridium species. Decamethoxin was more active than other surface-active agents such as ethonium, thionium, dodecylpyridinium, cetylpyridinium, dodecylbenzalkonium, and cetylbenzalkonium. Decamethoxin may be used in the form of ointment and aerosol for treatment of skin and mucous membrane infections.

Fiziologicheski Aktivnye Veshchestva published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C9H21NO3, Quality Control of 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gadakh, Bharat published the artcileBase substituted 5′-O-(N-isoleucyl)sulfamoyl nucleoside analogs as potential antibacterial agents, HPLC of Formula: 42074-68-0, the publication is Bioorganic & Medicinal Chemistry (2014), 22(10), 2875-2886, database is CAplus and MEDLINE.

Aminoacyl-sulfamoyl adenosines are well-known nano-molar inhibitors of the corresponding prokaryotic and eukaryotic tRNA synthetases in vitro. Inspired by the aryl-tetrazole containing compounds of Cubist Pharmaceuticals and the modified base as found in the natural antibiotic albomycin, the selectivity issue of the sulfamoylated adenosines prompted us to investigate the pharmacophoric importance of the adenine base. We therefore synthesized and evaluated several isoleucyl-sulfamoyl nucleoside analogs with either uracil, cytosine, hypoxanthine, guanine, 1,3-dideaza-adenine (benzimidazole) or 4-nitro-benzimidazole as the heterocyclic base. Based on the structure and antibacterial activity of microcin C, we also prepared their hexapeptidyl conjugates in an effort to improve their uptake potential. We further compared their antibacterial activity with the parent isoleucyl-sulfamoyl adenosine (Ile-SA), both in in vitro and in cellular assays. Surprisingly, the strongest in vitro inhibition was found for the uracil containing analog. Unfortunately, only very weak growth inhibitory properties were found as of low uptake. The results are discussed in the light of previous literature findings.

Bioorganic & Medicinal Chemistry published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, HPLC of Formula: 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rodrigues, Elsa T. published the artcileCell-based assays as an alternative for the study of aquatic toxicity of pharmaceuticals, Formula: C12H15ClO3, the publication is Environmental Science and Pollution Research (2020), 27(7), 7145-7155, database is CAplus and MEDLINE.

An increasing number and amount of pharmaceuticals for human and veterinary use currently reach the aquatic environment, and the determination of their effects on aquatic organisms becomes of major importance. The 96-h fish lethal test is one of the conventional assays required for environmental hazardous assessment, but it is extremely time-consuming and costly, and it raises ethical concerns. In a broad study, we compared the ability of cell-based assays to detect, in absolute terms, lethal toxicity in fish due to pharmaceuticals in order to select sensitive cell lines to be posteriorly used as an alternative to fish testing. This study also explored the sensitivity of the rat cardiomyoblast H9c2(2-1) cell line and the suitability of the sulforhodamine B colorimetric assay regarding 15 pharmaceuticals belonging to 9 different therapeutic classes. The relation between in vivo and in vitro data was expressed as LC_50,96h/EC₅₀ ratios, and 66% of concordant data were attained. Accordingly, it was possible to conclude that cell-based assays could be considered a suitable alternative to fish lethal testing for pharmaceuticals, which, after validation, may dramatically reduce the number of fish required for environmental hazardous assessment. Several cell lines were selected as promising alternatives, but H9c2(2-1), HepG2, PLHC-1, and RTG-2 could be considered suitable starting cell types for further studies, as relevant results were obtained with low exposure times.

Environmental Science and Pollution Research published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Formula: C12H15ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lisetski, L. N. published the artcileEffects of membranotropic agents on mono- and multilayer structures of dipalmitoylphosphatidylcholine, SDS of cas: 38146-42-8, the publication is European Biophysics Journal (2002), 31(7), 554-558, database is CAplus and MEDLINE.

We have studied the action of some membranotropic agents (MTAs) on the parameters of mono- and multilayers of dipalmitoylphosphatidylcholine (DPPC). The MTAs used included an antimicrobial drug, decamethoxinum, the model amphiphilic agent stearoyl-L-α-alanine, and cholesterol as a reference substance. Using differential scanning calorimetry and the Langmuir monolayer technique, we measured the temperature and enthalpy of the main phase transition of DPPC, the mean mol. area, the collapse pressure and the free energy of the mixed monolayers of DPPC and MTA. A good correlation has been obtained between the structure of the MTA used and changes in the parameters of both mono- and multilayers. Thus, for cholesterol, its well-known condensing effect in the L_α phase correlates with its behavior in the mixed monolayers. The disturbing action of decamethoxinum (depression of the phase transition in DPPC multilayers and relatively high free energy of mixing in monolayers) is presumably connected with interaction of its charged ammonium moieties with polar phospholipid heads. At the same time, stearoyl-L-α-alanine condensed the lipid layers and increased the m.p. of DPPC, owing to its interaction with both polar and non-polar lipid moieties. One can conclude that the three MTAs used can really be considered as representative examples of three different types of behavior in mono- and multilayers.

European Biophysics Journal published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, SDS of cas: 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ghosh, Harisadhan published the artcileSynthesis of axially chiral 1,8-diarylnaphthalene ligands and application in asymmetric catalysis: an intriguing fluorine effect, HPLC of Formula: 21286-54-4, the publication is Tetrahedron: Asymmetry (2015), 26(2-3), 79-84, database is CAplus.

A fluorinated and a non-fluorinated axially chiral 1,8-diarylnaphthalene ligand have been synthesized through an Ullmann and Suzuki coupling reaction based strategy. A practical methodol. for the successful chiral resolution of the newly synthesized catechol based moiety is presented. The authors also disclose the preliminary application of these axially chiral mols. as ligands in asym. transformation reactions. The synthesis of the target compounds was achieved by a reaction of 1,8-diiodonaphthalene with 1,2,3,4,5-pentafluoro-6-(iodo)benzene and formation of 1-iodo-8-(pentafluorophenyl)naphthalene. A Suzuki coupling of this aryl iodide with (2,3,6-trimethoxyphenyl)boronic acid gave a biaryl which was deprotected and resolved to deliver axially chiral biaryls 4-methoxy-3-[(1S)-8-(pentafluorophenyl)-1-naphthalenyl]-1,2-benzenediol and 4-methoxy-3-[(1R)-8-(pentafluorophenyl)-1-naphthalenyl]-1,2-benzenediol which was transformed into chiral titanium complexes.

Tetrahedron: Asymmetry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, HPLC of Formula: 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Presa, Andreu published the artcilePhotoactivation of the Cytotoxic Properties of Platinum(II) Complexes through Ligand Photoswitching, Application of 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Inorganic Chemistry (2018), 57(7), 4009-4022, database is CAplus and MEDLINE.

The development of photoactivatable metal complexes with potential anticancer properties is a topical area of current investigation. Photoactivated chemotherapy (PACT) using coordination compounds is typically based on photochem. processes occurring at the metal center. In the present study, an innovative approach is applied that takes advantage of the remarkable photochem. properties of diarylethenes. Following a proof-of-concept study with two complexes, namely C1 and C2, a series of addnl. platinum(II) complexes from dithienylcyclopentene-based ligands have been designed and prepared Like C1 and C2, these new coordination compounds exhibit two thermally stable, interconvertible photoisomers that display distinct properties. The photochem. behavior of ligands L3-L7 has been analyzed by 1H NMR and UV-vis spectroscopy. Subsequently, the corresponding platinum(II) complexes C3-C7 have been synthesized and fully characterized, including by X-ray diffraction for some of them. Next, the interaction of each photoisomer (i.e., containing the open or closed ligand) of the metal complexes with DNA has been examined thoroughly using various techniques, revealing their distinct DNA-binding modes and affinities, as observed for the earlier compounds C1 and C2. The antiproliferative activity of the two forms of the complexes has then been assessed with five cancer cell lines and compared with that of C1 and C2, which supported the use of such diarylethene-based systems for the generation of a new class of potential photochemotherapeutic metallodrugs.

Inorganic Chemistry published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Application of 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

de Lucas, Ana I. published the artcileScaffold Hopping to Imidazo[1,2-a]pyrazin-8-one Positive Allosteric Modulators of Metabotropic Glutamate 2 Receptor, Computed Properties of 1860005-05-5, the publication is ACS Omega (2021), 6(35), 22997-23006, database is CAplus and MEDLINE.

Glutamate hyperfunction is implicated in multiple neurol. and psychiatric diseases. Activation of the mGlu2 receptor results in reduced glutamate release and decreased excitability representing a promising novel therapeutic agent for the treatment of disorders such as epilepsy, schizophrenia, mood, anxiety, and other neuropsychiatric disorders. We have previously reported substantial efforts leading to potent and selective mGlu2 PAMs from different chem. series. Herein, the discovery and optimization of a novel series of imidazopyrazinone mGlu2 PAMs are reported. This new scaffold originated from computational searching of fragment databases and comparison with our previously explored scaffolds. Optimization guided by our robust understanding of SAR from former series led to potent, selective, and brain-penetrant compounds

ACS Omega published new progress about 1860005-05-5. 1860005-05-5 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronate Esters,Boronate Esters, name is 2-(3-Chloro-4-(cyclopropylmethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C16H22BClO3, Computed Properties of 1860005-05-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics