Category: chlorides-buliding-blocks

Reference of 56961-77-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 56961-77-4, name is 1-Bromo-2,3-dichlorobenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

[Intermediate 5-1] 10 g of 30.2 mmol was dissolved in 100 mL of xylene, followed by the addition of 8.7 g of NatBuO, stirring at 180 C., and then 3.41 g of 1-bromo-2,3-dichlorobenzene and 0.37 g Give it in sequential order. After 12 h, the reaction was quenched with NH4Cl, extracted with EA, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure.This was columned with EA: Hx to obtain 7.2 g (Yield 62%) of [Intermediate 17-1].

The synthetic route of 1-Bromo-2,3-dichlorobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LG Chem, Ltd.; Gu Gi-dong; Yoon Jeong-min; Kim Gong-gyeom; Huh Nan-seul-a; Lee Gi-gon; Keum Su-jeong; (52 pag.)KR2018/112721; (2018); A;,
Chloride – Wikipedia,
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Electric Literature of 7464-11-1,Some common heterocyclic compound, 7464-11-1, name is 5,7-Dichloro-2-methylthiazolo[5,4-d]pyrimidine, molecular formula is C6H3Cl2N3S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A 50-mL round-bottom flask, was charged with a solution of intermediate 41.2 (111 mg, 0.49 mmol, 1.00 equiv) in CH3CN(10 mL), K3P04 (322 mg, 1.52 mmol, 3.07 equiv), and compound 23.1 (125 mg, 0.57 mmol, 1.15 equiv). The reaction was stirred overnight at 85 C in an oil bath. Solids were filtered out and solution was concentrated under vacuum. The crude product obtained was purified using flash column chromatography to yield 180 mg (89%) of intermediate 41.3 as a yellow solid.

The synthetic route of 7464-11-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NIMBUS IRIS, INC.; ROMERO, Donna L.; MASSE, Craig E.; ROBINSON, Shaughnessy; GREENWOOD, Jeremy Robert; HARRIMAN, Geraldine; WO2015/48281; (2015); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 81927-55-1, These common heterocyclic compound, 81927-55-1, name is Benzyl 2,2,2-trichloroacetimidate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of scheme 5-8 compound S1 (24 g, 0.136 mol) and benzyl 2,2,2-trichloroacetimidate (51.3 g, 0.204 mol) in cychexane/dichloromethane (600 mL/120 mL) at room temperature was added trifluoromethanesulfonic anhydride (cat.1.2 mL) dropwise. The reaction mixture was stirred at room temperature overnight and filtered. The filtrate was washed with sat. NaHCO3 and brine, dried over anhydrous Na2SO4, filtered and concentrated. The residue was purified by column chromatography on silica gel (eluted with petroleum ether: ethyl acetate =10: 1) to afford the title compound (35 g, 93.3% yield) as a yellow oil.

Statistics shows that Benzyl 2,2,2-trichloroacetimidate is playing an increasingly important role. we look forward to future research findings about 81927-55-1.

Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAL, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; GREENLEE, William; (508 pag.)WO2017/35409; (2017); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 821-10-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 821-10-3 as follows.

General procedure: K2CO3 (3a, 210 mg, 1.5 mmol) was added to a solution of b-ketoesters 5a-c (0.5 mmol) in acetone (10 mL) at 25 C. The reaction mixture was stirred at 25 C for 10 min. 1,4-Dichloro-2-butyne (2, 68 mg, 0.55 mmol) was added to the reaction mixture at reflux. The reaction mixture was stirred at 56 C for 8 h. The reaction mixture was cooled to 25 C and the solvent was concentrated. The residue was diluted with water (10 mL) and the mixture was extracted with CH2Cl2 (320 mL). The combined organic layers were washed with brine, dried, filtered and evaporated to afford crude product. Purification on silica gel (hexanes/EtOAc20/1e10/1) afforded 6a-c.

According to the analysis of related databases, 821-10-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Chan, Chieh-Kai; Lu, Yi-Ju; Chang, Meng-Yang; Tetrahedron; vol. 71; 51; (2015); p. 9544 – 9549;,
Chloride – Wikipedia,
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Synthetic Route of 33863-76-2, These common heterocyclic compound, 33863-76-2, name is 1-Bromo-3-chloro-5-fluorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 1-bromo-3-chloro-5-fluorobenzene (25 g, 120 mmol) in methanol (800 ml) was added sodium methoxide (64 g, 1180 mmol). The reaction was heated to reflux for 9 days. The reaction was then concentrated in vacuo to one fifth of the volume (150 ml), cooled, and water (1000 ml) added. The mixture was extracted with diethyl ether (3 x 150 ml). The combined organic extracts were washed with brine (2 x 100 ml), dried over Na2SO4 and evaporated to afford the title compound (24.6 g). 1HNMR (CDCI3): 3.80(s, 3H), 6.84(s, 1 H), 6.96(s, 1 H), 7.10 (s, 1 H)GCMS Rt=3.86min MS m/z 222 [MH]+

Statistics shows that 1-Bromo-3-chloro-5-fluorobenzene is playing an increasingly important role. we look forward to future research findings about 33863-76-2.

Reference:
Patent; PFIZER LIMITED; WO2008/135826; (2008); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4584-46-7 as follows. HPLC of Formula: C4H11Cl2N

A mixture of 4-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)phenol (0.22 g, 1 .00 mmol), 2-chloro-N,N-dimethylethanamine hydrochloride (0.17 g, 1.15 mmol) and cesium carbonate (1.3 g, 4.00 mmol) in tetrahydrofuran (4 mL) was heated at 130 00 for 2 hours under microwave irradiation. After cooling to room temperature the reactionmixture was partitioned between water and ethyl acetate. The organic phase was separated, washed with additional water and brine, dried over sodium sulfate and thesolvent was evaporated to dryness to yield the title compound (254 mg, 86%) as a brownish oil.LRMS (mlz): 291 (M+1).1H-NMR (300 MHz, CDCI3): 1.3 (s, 12H), 2.3 (s, 6H), 2.7 (t, 2H), 4.1 (t, 2H),6.8 – 7.0 (d, 2H), 7.6 – 7.9 (d, 2H).

According to the analysis of related databases, 4584-46-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ALMIRALL, S.A.; BACH TANA, Jordi; PEREZ CRESPO, Daniel; LLERA SOLDEVILA, Oriol; ESTEVE TRIAS, Cristina; TABOADA MARTINEZ, Lorena; WO2015/86693; (2015); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 51419-59-1, name is p-Tolylmethanesulfonyl chloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 51419-59-1, Recommanded Product: 51419-59-1

General procedure: A two-step one-pot method for preparing an abscisic acid receptor agonist:Add p-methylbenzyl mercaptan to acetonitrileAnd then adding a chlorinating reagent,Point plate monitoring, after the reaction, move into the ice water bath,Add 4 equivalents of an acid binding agent such as pyridine.After the addition, 7-amino-N-propylquinolinone in acetonitrile was slowly added dropwise.The plate is monitored for reaction, after the reaction, pickling, drying,Further, the abscisic acid receptor agonist can be obtained by column chromatography or recrystallization,

At the same time, in my other blogs, there are other synthetic methods of this type of compound, p-Tolylmethanesulfonyl chloride, and friends who are interested can also refer to it.

Reference:
Patent; Shaoyang University; Huang Zhiyou; (7 pag.)CN109678797; (2019); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 94-97-3,Some common heterocyclic compound, 94-97-3, name is 5-Chloro-1H-benzo[d][1,2,3]triazole, molecular formula is C6H4ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Styrene (1.0 equiv.) in anhydrous dichloromethane (5 mL) and NBS (2.0 equiv.) was taken into RB and reaction mixture was stirred at room temperature. After 30 min benzotriazole (2.0 equiv) dissolved in anhydrous DCM was added drop wise to the reaction mixture. After the completion of reaction as monitored by TLC, solvent was evaporated under vacuum. The reaction mixture was extracted with ethyl acetate and washed with hypo and brine solution. The organic layer obtained was dried over sodium sulphate, filtered and then evaporated under reduced pressure. Further purification was done by using flash column chromatography (SiO2).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Chloro-1H-benzo[d][1,2,3]triazole, its application will become more common.

Reference:
Article; Bose, Priyanka; Singh, Anoop S.; Singh, Mala; Tiwari, Vinod K.; Tetrahedron; (2020);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 367-22-6, name is 4-Chloro-3-fluoroaniline, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 367-22-6, Formula: C6H5ClFN

To a solution containing para- chloro-meta-fluoroaniline (10.0 g, 70.1 mmol) in 600 mL THF at 0 C was added Et3N (9.1 1 mL, 70.1 mmol) followed by ethyl oxalylchloride (7.70 mL, 70.1 mmol) dropwise over 15 minutes. The reaction mixture was warmed to room temperature and stirred for 18 hrs. The reaction mixture was filtered and the filter cake was washed with one-300 mL portion of ethyl acetate. The organic phase was washed with two- 100 mL portions of IM HCl, dried over MgSO4, filtered, and concentrated to give the product. Recrystallization from hot Et2theta gave the product as a colorless crystalline solid: yield 14.4 g (84%); 1H NMR (500 MHz, CDCl3): delta 1.43 (t, J = 7.0 Hz, 3H), 4.42 (q, J= 7.0 Hz, 2H), 7.25 (dq, J= 8.5, 1.0 Hz, 1H), 7.37 (t, J= 8.5 Hz, 1H), 7.72 (dd, J= 10.5, 2.5 Hz, 1H), 8.94 (br, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; DANA FARBER CANCER INSTITUTE; JOHNS HOPKINS UNIVERSITY; UNIVERSITY OF PENNSYLVANIA; SODROSKI, Joseph; MADANI, Navid; SCHON, Arne; LA LONDE, Judith, M.; COURTER, Joel, R.; SOETA, Takahiro; NG, Danny; FREIRE, Ernesto; SMITH, Amos, B.; WO2010/53583; (2010); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 13726-14-2, name is 4-Chloro-3-methoxyaniline, A new synthetic method of this compound is introduced below., category: chlorides-buliding-blocks

To a solution of 2-t-butoxycarbonylaminobenzoic acid (115 mg, 0.485 mmol) in DMF (2.0 mL) was added a solution of 4-chloro-3-methoxyaniline (82.2 mg, 0.522 mmol), HOBt (70.0 mg, 0.518 mmol), EDCI·HCl (104 mg, 0.542 mmol) and DIEA (90.0 muL, 0.522 mmol) in DMF (1.0 mL). The resulting mixture was stirred at r.t. overnight. After completion of the reaction, AcOEt was added. The organic layer was washed with water and brine, dried, and concentrated to give the title compound as a pale yellow paste, which was used for the next step without further purification.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Numadate, Akiyoshi; Mita, Yusuke; Matsumoto, Yotaro; Fujii, Shinya; Hashimoto, Yuichi; Chemical and Pharmaceutical Bulletin; vol. 62; 10; (2014); p. 979 – 988;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics