Category: chlorides-buliding-blocks

Application of 202925-07-3, A common heterocyclic compound, 202925-07-3, name is 2-Chloro-1-fluoro-4-methoxybenzene, molecular formula is C7H6ClFO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: As a typical experiment, the reaction of the 2-halopyridine (1 mmol), fluorobenzene derivative (2.5 mmol) and PivOK (0.154 g, 1.1 mmol) at 150 C during 16 h in DMA (3 mL) in the presence of PdCl(C3H5)(dppb) (12 mg, 0.02 mmol) (see tables or schemes) under argon affords the arylation product after evaporation of the solvent and filtration on silica gel

The synthetic route of 202925-07-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Boyaala, Rabab; Touzani, Rachid; Guerchais, Veronique; Soule, Jean-Francois; Doucet, Henri; Tetrahedron Letters; vol. 58; 33; (2017); p. 3205 – 3208;,
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Reference of 6940-78-9, These common heterocyclic compound, 6940-78-9, name is 1-Bromo-4-chlorobutane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 1, 5,6, 7-TETRAHYDROINDOL-4-ONE (10.0 g) in DMSO (100 mL) was added powdered sodium hydroxide (3.26 g) and the mixture was stirred at ambient temperature for 0.25 hours. 1-BROMO-4-CHLOROBUTANE (9. 38 mL) was then added and the resulting mixture stirred at ambient temperature for 7 hours after which time TLC (ethyl acetate: dichloromethane 1: 1) showed complete reaction. The reaction was poured into ice cold water (250 mL) and stirred for 0.5 hours. An oil separated and was isolated with a separatory funnel. The aqueous layer was extracted with dichloromethane (50 ML). The oil was dissolved with dichloromethane (25 mL) and the combined organics were dried with sodium sulfate, filtered and the solvent removed under vacuum. Flash chromatography (ethyl acetate: hexane, 1: 1 to 2: 1) yielded an oil (6.0 g) as the titled compound.

The synthetic route of 6940-78-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CENOMED, INC.; WO2005/30148; (2005); A2;,
Chloride – Wikipedia,
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Application of 7006-52-2,Some common heterocyclic compound, 7006-52-2, name is N-Methyl-3-chloroaniline, molecular formula is C7H8ClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Chlorosulfonic acid (75 ml, 1130 mmol) was cooled to 0° C. and stirred during the slow addition of N-methyl-3-chloroaniline (10.0 g, 70.6 mmol). The reaction mixture was heated between 118-135° C. for 4.5 hours and allowed to stand at room temperature overnight. The mixture was slowly poured into a bath of ice water and the resulting semi-solid was extracted with hot chloroform (2.x.200 mL). The combined organic extractes were dried over MgSO4, and the solvent removed to near dryness under reduced pressure. The product was used in the next step without purification or analysis.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route N-Methyl-3-chloroaniline, its application will become more common.

Reference:
Patent; NitroMed, Inc.; US2006/189603; (2006); A1;,
Chloride – Wikipedia,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2533-69-9 as follows. COA of Formula: C3H4Cl3NO

Cl3CC(NH)OMe (1 eq.) was added slowly to a solution of compound (Ql) in AcOH (0.8 M) at 00C, then the reaction mixture was stirred at RT for 2 h. The reaction mixture was diluted with EtOAc, and the resulting organic phase was washed The with sat. aq. NaHCO3 and dried(Na2SO4). Evaporation of the solvent under reduced pressure afforded (75%) the title compound.MS (ES+) C8H4Cl3FN2 required: 252, 254, found: 253, 255 (M+H)+.

According to the analysis of related databases, 2533-69-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.; DESSOLE, Gabriella; JONES, Philip; BUFI, Laura, Llauger; MURAGLIA, Ester; ONTORIA ONTORIA, Jesus, Maria; TORRISI, Caterina; WO2010/13037; (2010); A1;,
Chloride – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2687-12-9, name is Cinnamyl chloride, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of Cinnamyl chloride

General procedure: Aryl, benzyl or allyl halides (1.0mmol), arylboronic acid (1.2mmol), K2CO3 (1.5mmol), C1 (5×10-6 mol%) and H2O (2.0mL) were added into a sealed tube and the mixture was stirred at 60C for a few hours. After the reaction, the aqueous phase was extracted with ethyl acetate for 3 times (3×7mL). Then the combined organic layers were dried over anhydrous Na2SO4, concentrated under vacuum and purified by column chromatography.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2687-12-9.

Reference:
Article; Luo, Kaixiu; Zhang, Lu; Yang, Rui; Jin, Yi; Lin, Jun; Carbohydrate Polymers; vol. 200; (2018); p. 200 – 210;,
Chloride – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 14752-66-0, name is Sodium 4-chlorobenzenesulfinate, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14752-66-0, name: Sodium 4-chlorobenzenesulfinate

In a dry test tube, add 34mg pyrazoleAnd 198mg of chlorobenzene sulfinateSodium, then add 336mg of NIS. 2mL ethyl acetate was then added to dissolve the solid, the reaction solution was stirred at 25 12 hours. After completion of the reaction, ethyl acetate and water extraction, the resulting organic phase was concentrated on a rotary evaporator, silica gel column (ethyl acetate and petroleum ether, the volume ratio of 1: 3) to give the product 155mg, yield 84% , the following reaction formula:

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Sodium 4-chlorobenzenesulfinate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Wenzhou Medical College; Xia, Qinqin; Fu, Lili; Bao, Xiaodong; Liu, Zhiguo; Liang, Guang; (11 pag.)CN105693621; (2016); A;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 112-26-5, name is 1,2-Bis(2-chloroethoxy)ethane, This compound has unique chemical properties. The synthetic route is as follows., Safety of 1,2-Bis(2-chloroethoxy)ethane

At a temperature 20 C with stirring, 15.42 g (100 mmol) dimethoxyphenol and 8.42 g (45 mmol) of 1,2- (dichloroethanyl) ethane were added to 100 ml N,N-dimethylformamide, potassium hydroxide was added thereto 6.06g (108mmol), warmed to 153 C, the reaction at 40 h, the solvent was distilled off, the solvent was distilled off can be used directly for the next reaction to give brown Yellow turbid liquid; The above brown turbid liquid is added in 100 ml dichloromethane, filters the insoluble substance, using 50 ml 1 M sodium hydroxide solution washing 3 times, then 50 ml saturated sodium chloride solution (20 C) washing 2 times, water-free magnesium sulfate drying, atmospheric dryness dichloromethane, to obtain yellow oily liquid; To the above-mentioned yellow oily liquid by adding 25 ml ethyl ether, up to 35 C, filtering to remove the insoluble matter, cooling to -15 C, cooling 3 h, liquid layered, taking the upper light yellow solution, cooling to -15 C, cooling 48 h, filtering solution, to obtain 15.26 g of powder of white solid 1,2-bis(2-(2,6-dimethoxyphenoxy)ethoxy)ethane, yield 80.27%, purity 98.42%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 112-26-5.

Reference:
Patent; Xi’an Modern Chemical Institute; Lu Tingting; Lu Xianming; Mo Hongchang; Wang Yinglei; Ji Yueping; Xu Minghui; Gao Fulei; Liu Weixiao; (6 pag.)CN107011128; (2017); A;,
Chloride – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 4152-90-3, name is (3-Chlorophenyl)methanamine, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4152-90-3, Computed Properties of C7H8ClN

General procedure: To a solution of benzylamine (0.6 mmol), indole (1.0 mmol) and CuI (0.1 mmol ) in CH3CN (1 mL) was added TEMPO (0.15 mmol) under atmosphere and the mixture was stirred at room temperature for overnight. The reaction mixture was concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel (eluent: EtOAc/PE = 1:4) to yield the corresponding product.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Liao, Meixiang; Zhang, Xiaoyun; Yue, Pengfei; Synthetic Communications; vol. 48; 13; (2018); p. 1694 – 1700;,
Chloride – Wikipedia,
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These common heterocyclic compound, 41965-95-1, name is 3-Chloro-4-methoxybenzylamine Hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C8H11Cl2NO

Preparation of Compound IV:3-Chloro-4-methoxybenzylamine hydrochloride III (25.00 g, 0.12 mol)Suspended in 75mL acetonitrile,Add sodium bicarbonate (23.21 g, 0.27 mol),Compound II (22.02 g, 0.11 mol) was added,Stir at 40 degrees for 2.5 hours.The reaction solution was suction filtered,The filter cake was washed once with 10 mL of acetonitrile.Wash once with 10 mL of water.After the filter cake is dried by phosphorus pentoxide,32.01g of white solid compound IV,The yield was 87.37%.

The synthetic route of 3-Chloro-4-methoxybenzylamine Hydrochloride has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Tierxi (Nanjing) Pharmaceutical Research And Development Co., Ltd.; Wu Wenchao; Song Dandan; Zhang Chi; Cui Xilin; (10 pag.)CN110117274; (2019); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 309721-44-6, name is 2-Bromo-1-chloro-3-fluorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 309721-44-6, COA of Formula: C6H3BrClF

A mixture of 146.1 g (1.36 mol) of p-toluidine, 12.6 g (0.02 mol) of (+-)-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl, 261.9 g (2.73 mol) of sodium t-butoxide, 314.1 g (1.50 mol) of 2-bromo-3-fluoro-chlorobenzene and 6.3 g (0.0069 mol) of tris(dibenzylideneacetone)dipalladium(0) in 3000 ml of toluene is heated to 110 over 30 minutes and stirred an additional 4 hours at this temperature. The mixture is cooled to room temperature and a solution of 680 ml 37% hydrochloric acid and 680 ml of water is added over 15 minutes. The mixture is stirred for 20 minutes and filtered through a pad of Celite. The layers are separated and the organic phase is washed twice with 680 ml of water and once with a solution of 225 g of sodium chloride in 680 ml of water. The solvents are evaporated under reduced pressure to give N-(2′-chloro-6′-fluorophenyl)-4-methylaniline as an oil, b.p. 129-131/0.5 mm Hg.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-1-chloro-3-fluorobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Novartis AG; US6291523; (2001); B1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics