Category: chlorides-buliding-blocks

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 93765-83-4, name is 1-Bromo-5-chloro-2-fluoro-4-methylbenzene, This compound has unique chemical properties. The synthetic route is as follows., Formula: C7H5BrClF

A mixture of 1-bromo-5-chloro-2-fluoro-4-methylbenzene (500 mg, 2.3 mmol), N-bromosuccinimide (481 mg, 2.7 mmol) and azobisisobutyronitrile (38 mg, 0.23 mmol) in CCl4 (10 mL) was stirred at 90 C for 16 h. The mixture was diluted with DCM (20 ml) and water (20 ml). The organic layer was separated, dried over Na2S04, filtered and evaporated to get crude product. The residue was purified by silica column chromatography (eluting with petroleum ether/ethyl acetate = 50/1) to give 1-bromo-4-(bromomethyl)-5-chloro-2-fluorobenzene as a solid (324 mg, 47%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 93765-83-4.

Reference:
Patent; GENENTECH, INC.; XENON PHARMACEUTICALS INC.; CHEN, Chien-An; CHOWDHURY, Sultan; DEHNHARDT, Christoph Martin; SUN, Shaoyi; WO2014/144545; (2014); A2;,
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Related Products of 108-37-2, A common heterocyclic compound, 108-37-2, name is 1-Bromo-3-chlorobenzene, molecular formula is C6H4BrCl, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A flask containing (l,5-cyclooctadiene)(methoxy)-iridium(I) dimer (84 mg, 0.13 mmol), 4,4′-di-tert butyl-2-2′-dipyridyl (69 mg, 0.26 mmol) and bis(pinacolato)diboron (1.29 g, 5.11 mmol) was purged with Ar, then hexanes (26 mL) and l-bromo-3- chlorobenzene (1 mL, 8.51 mmol) were added sequentially. The solution was stirred at RT for 18 h. The reaction mixture was concentrated in vacuo, re-dissolved in acetone (26 mL), then oxone (5.23 g, 8.51 mmol) in water (26 mL) added [Caution: exotherm observed]. After 10 min, the reaction mixture was diluted with DCM. The layers separated, and the aqueous layer extracted with DCM. The combined organics were washed with brine, dried and concentrated in vacuo to give the title compound (1.43 g, 81%). LCMS (Method 3): Rt 3.74 min, m/z 205, 207 [M-H+].

The synthetic route of 108-37-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CHIESI FARMACEUTICI S.P.A.; ALCARAZ, Lilian; HURLEY, Christopher; CRIDLAND, Andrew, Peter; JENNINGS, Andrew, Stephen, Robert; WO2014/195402; (2014); A1;,
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Related Products of 4535-90-4,Some common heterocyclic compound, 4535-90-4, name is 2-Chloro-N-methylethanamine hydrochloride, molecular formula is C3H9Cl2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(ii) The white crystal 3 (1.0 g, 7.69 mmol) and sodium thiosulfate pentahydrate (1.91 g, 7.69 mmol) were added into 100 mL flask. MilliQ water (10 mL) was then added into the flask, and the reaction mixture was stirred at 120 C for 24 h under argon atmosphere. The reaction was then cooled to room temperature and the solvent was removed under reduced pressure. Hydrochloric acid (6.0 M, 25 mL) was added into the flask and the solution was stirred at 85 C for 3 h under argon atmosphere. The solvent was then removed, and 100 mL of dichloromethane and 15 mL of ethanol were added to extract the product. Sodium chloride and sulfate salts were precipitated from the solution. The salts were then filtered and the filtrate was concentrated to give product as a white solid (0.55 g, yield: 56.1%). The B monomer was extremely hygroscopic, which was needed to be stored in a dry oven. The 1H NMR and 13C NMR spectra of B monomer were shown in Fig. S4.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloro-N-methylethanamine hydrochloride, its application will become more common.

Reference:
Article; Xu, Chao-Ran; Zhang, Ze; Pan, Cai-Yuan; Hong, Chun-Yan; Polymer; vol. 172; (2019); p. 294 – 304;,
Chloride – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2163-00-0, name is 1,6-Dichlorohexane, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C6H12Cl2

EXAMPLE 2A 1,6-Bis(4-cyanomethylmorpholinium)hexane Dichloride (HDMMA) 100 ml of morpholine (1.147 mole) and 150 ml ethylacetate (EtOAc) were added to 500 ml Morton flask equipped with reflux condenser, thermometer, mechanical stirrer, and heating mantel. 25 ml of 1,6-dichlorohexane (0.172 mole) was added slowly to flask at room temperature. This was refluxed for 48 hours. Gas chromatogram showed 90% completion of the reaction. The product 1,6-bismorpholinohexane was purified from reaction mixture by vacuum filtration to remove the morpholine hydrochloride, and the light yellow filtrate was purified by adsorption chromatography. 13 C NMR showed a spectrum consistent with structure with very minor impurities. Gas chromatography showed an approximate purity of 98.2% based upon peak areas. The collected amount of 1,6-bismorpholinehexane was 30.0 g, which corresponds to a yield of 66.6%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2163-00-0.

Reference:
Patent; The Clorox Company; US5739327; (1998); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 81927-55-1, name is Benzyl 2,2,2-trichloroacetimidate belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: Benzyl 2,2,2-trichloroacetimidate

To a solution of Scheme 5-7 compound SI (24 g, 0. 136 mol) and benzyl 2,2,2- trichloroacetimidate (51.3 g, 0.204 mol) in cychexane/dichloromethane (600 mL/120 niL) at room temperature was added triiluoromeihanesulfomc anhydride (cat. L2 mi..) dropwise. The reaction mixture was stirred at room temperature overnight and filtered. The filtrate was washed with sat. NaHC03 and brine, dried over anhydrous Na2Si, filtered and concentrated. The residue was purified by column chromatography on silica gel (eluted with petroleum ether: ethyl acetate =10: 1) to afford the title compound (S2) (35 g, 93.3% yield) as a yellow oil.

The synthetic route of 81927-55-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAL, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; GREENLEE, William; (333 pag.)WO2017/35401; (2017); A1;,
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Application of 110407-59-5,Some common heterocyclic compound, 110407-59-5, name is 2-Chloro-4-fluorobromobenzene, molecular formula is C6H3BrClF, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Preparation 27:4-(2-CHLORO-4-FLUOROPHENYL)PYRIDINETo a mixture of l-bromo-2-chloro-4-fluorobenzene (2.0 g, 9.5 mmol), l-pyridyl-4-boronic acid (1.3 g, 10.5 mmol), sodium carbonate (2.0 g, 23.9 mmol) and triphenylphosphine (0.5 g, 1.9 mmol) in toluene/ethanol (1 : 1, 60 ml) under nitrogen, was added tris(dibenzylideneacetone)dipalladium(0) (0.22 g , 2.5 mol%). The mixture was heated at reflux for 48 h, cooled to ambient temperature and diluted with water (50 ml) and ethyl acetate (100 ml). The organic layer was separated and the aqueous phase was extracted with ethyl acetate (2×50 ml). The combined organic phases was evaporated to dryness and dissolved in aqueous hydrochloric acid (10%, 50 ml). The solution was washed with diethyl ether (2×40 ml), basified with aqueous sodium hydroxide (2M) and extracted with ethyl acetate (2×50 ml). The combined organic phases was dried (MgSO4) and evaporated to dryness to give the title compound (1.16 g). MS m/z (rel. intensity, 70 eV) 209 (33), 207 (M+, bp), 208 (14), 172 (24), 145 (16).

The synthetic route of 110407-59-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; A. CARLSSON RESEARCH AB; WO2007/65655; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 33863-76-2, name is 1-Bromo-3-chloro-5-fluorobenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 1-Bromo-3-chloro-5-fluorobenzene

1-fluoro-3-(methylsulfonyl)benzene A stirred mixture of 1-bromo-3-fluorobenzene (10.0 g, 57.1 mmol), sodium methanesulfinate (7.00 g, 68.6 mmol), CuI (1.08 g, 5.71 mmol), L-proline (1.31 g, 11.4 mmol) and sodium hydroxide (0.456 g, 11.4 mmol) was heated in DMSO (135 mL) at 95 C. overnight (~18 h). The reaction was cooled, diluted with water, and then extracted with ethyl acetate (2*150 mL). The extracts were dried with MgSO4 and concentrated in vacuo. Chromatography on silica gel eluding with 25/75 ethyl acetate/hexane gave the title compound as a colorless solid (6.21 g). MS (ES) m/z 175.1. Intermediates 3, 12 by Third ApproachPrepared according to a procedure similar to that described for Intermediate 8, using the appropriate halogenated thiophenol and alkylating agent R-LG (where LG was a leaving group such as a bromine, iodide, chloride, or tosylate), and eluting with an appropriate eluent. Intermediate 31,3-difluoro-5-(methylsulfonyl)benzene; MS (EI) m/z 192.

The synthetic route of 33863-76-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bernotas, Ronald Charles; Ullrich, John William; Travins, Jeremy Mark; Wrobel, Jay Edward; Unwalla, Rayomand Jal; US2010/273816; (2010); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 54932-72-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 54932-72-8, name is 4-Bromo-1-chloro-2-methylbenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Take 4-bromo-2-methylchlorobenzene 100kg, dissolved in 300kg of chloroform, add 90kg of NBS, add BPO 6kg, heat up to 70 C reflux reaction 4h, after the reaction is completed, cooled to room temperature, filtered, the filtrate decompression recovery of chloroform, petroleum Ethyl ether: Ethyl acetate (1:1) was recrystallized to give 128 kg of a white solid with a yield of 92%.

The synthetic route of 4-Bromo-1-chloro-2-methylbenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jiangsu Engineering Polytechnic College; Feng Chengliang; Yan Bin; (12 pag.)CN107652276; (2018); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 54932-72-8, These common heterocyclic compound, 54932-72-8, name is 4-Bromo-1-chloro-2-methylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under argon, a 250 mL three-necked flask was charged with 19.7 g of 2-chloro-5-bromotoluene (I), 11.7 g of o-aminothiophenol (n), 0.5 g of cuprous chloride, 36.5 g of tetramethylethylenediamine and 50 mL of water,Mechanical stirring, oil bath 130 C, the reaction 18 h.The reaction mixture was cooled to room temperature, extracted with 50 1111> 3 ethyl acetate, 12.5 mL * 3 aqueous ammonia and extracted with 25 mL * 3 purified water three times. The combined ethyl acetate phases were washed with 50 mL of purified water and 15 mL of aqueous ammonia, Brine, dried over anhydrous sodium sulfate. The dried ethyl acetate layer was dried, after adding 25 mL of petroleum ether dissolved, rapidly cooled to -5–10 C under stirring, and accompanied by a large amount of solid precipitation, vacuum filtration, the filter cake with petroleum ether leaching wash. The filter cake was collected and dried under reduced pressure at 40 C to give 2- (2-methyl-4-bromo-phenylmercapto) aniline(1Pi) 16.39 g, yield 83.2%, purity 90.1%.

The synthetic route of 54932-72-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jiangsu Ji Bell Pharmaceutical Co., Ltd.; Ding Deping; Li Zhaoguang; Feng Qi; Tang Zhiqun; Liu Jun; Jiang Bin; (10 pag.)CN107513048; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 14862-52-3, name is 3,5-Dibromochlorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14862-52-3, Application In Synthesis of 3,5-Dibromochlorobenzene

In a 250ml round bottom flask, carbazole borate (0.02mol), 2-chloro-4,6-dibromobenzene (0.012mol) and tetrakis(triphenylphosphine) palladium (0.0006mol) added into 15ml of tetrahydrofuran THF, added 10ml 2M K2CO3 solution and stir at a certain speed, the obtained mixed solution reactant was heated and reflux at a reaction temperature of 80 C for 18h; after the reaction is completed, cool to room temperature and add 100ml of water, the resulting mixture was filtered and washed three times in 25 ml of dichloroethane, finally it was dried over anhydrous magnesium sulfate. The resulting residue was further separated and purified on a silica gel column, and then obtained intermediate product M14

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Reference:
Patent; Shanghai Tianma Organic Shine Display Co., Ltd.; Zhang Lei; Wang Xiangcheng; Gao Wei; Niu Jinghua; Lu Yan; Fan Changxuan; Huang Gaojun; An Ping; (26 pag.)CN108997336; (2018); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics