Category: chlorides-buliding-blocks

Application of 13726-14-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 13726-14-2 as follows.

This was prepared from MA1-012 (0.531 g) and 3-methoxy-4-chloroaniline (0.473 g) using procedure A (reaction time, 16 h) to give the title compound as a white solid (0.202 g, 23%). Mp: 143-144 C. lH NMR (400 MHz, DMSO-ifc): delta 8.93 (s, IH, disappeared on D20 shake), 8.07 (s, IH), 7.53 (d, / = 2.3 Hz, IH), 7.37 (d, / = 8.6 Hz, IH), 7.31 (dd, / = 8.6, 2.3 Hz, IH), 3.83 (s, 3H), 2.61 (q, J = 7.4 Hz, 2H), 1.17 (t, / = 7.4 Hz, 3H). HPLC-MS (ESI+): m/z 300.1 [70%, (M37C135C1+H)+], m/z 298.1 [100%, (M35C135C1+H)+]. Further elution gave the bis- adddition side product MA1-025B (109 mg, 9%) as a yellow solid, Mp: 201 C (dec). HPLC: 99% [tR = 8.1 min, 65% MeOH, 35% water (with 0.1% TFA), 20 min]. lH NMR (400 MHz, DMSO-ifc): delta 9.20 (s, IH, disappeared on D20 shake), 8.48 (s, IH, 40% reduced on D20 shake), 7.97 (s, IH), 7.56 (d, / = 2.3 Hz, IH), 7.43 (d, / = 2.3 Hz, IH), 7.38 (dd, / = 8.6, 2.3 Hz, IH), 7.32 (d, / = 8.7 Hz, IH) 7.29 (dd, / = 8.6, 2.3 Hz, IH), 7.15 (d, / = 8.7 Hz, IH), 3.74 (s, 3H), 3.60 (s, 3H), 2.57 (q, / = 7.4 Hz, 2H), 1.18 (t, / = 7.4 Hz, 3H). HPLC-MS (ESI+): m/z 421.1 [70%, (M37C135C1+H)+], 419.2 [100%, (M35C135C1+H)+]. LC-MS (ESI+): 421.1 [70%, (M37C135C1+H)+], 419.1 [100%, (M35C135C1+H)+]. HRMS (ESI+): m/z calcd for C20H20CI2N4O2 (M+H)+ 1035.Pr ocedure A: A mixture of substituted 2,4-dichloropyrimidine (1.0 equiv.) and substituted aniline (1.15 equiv.) in MeOH/water (1 : 1.5, 0.2 M) was stirred at 45 C. The reaction time is indicated below. Upon cooling to ambient temperature, the desired product precipitated and was filtered, washed with MeOH/water (1 : 1.5, 20 mL), and dried. 2,5-Dichloro-/Y4-(4-[/Y-(l,l-dimethylethyl)sulfamoyl]phenyl)pyrimidin-4-amine (SG1-182): This was prepared from 2,4,5-trichloropyrimidine (0.500 g) and SG1-177 (0.715 g) using procedure A (stirred for 4 d). The crude solid was purified via flash chromatography (S1O2) eluting with hexanes/EtOAc (0: 10 to 4:6 v/v) to provide the title compound as a tangerine-colored solid (0.590 g, 58%). Mp: 180-181 C. NMR (400 MHz, DMSO-ifc): delta 9.73 (s, IH, disappeared on D20 shake), 8.46 (s, IH), 7.80 (s, 4H), 7.48 (s, IH, disappeared on D20 shake), 1.09 (s, 9H). HPLC-MS (ESI+): m/z 773.1 [10%, (MCl35Cl37+M35Cl35Cl+Na)+], 379.1 [10%, (MC137C137+H)+], 377.1 [70%, (MC135C137+H)+], 375.1 [100%, (M35C135C1+H)+].

According to the analysis of related databases, 13726-14-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, INC.; SCHOeNBRUNN, Ernst; LAWRENCE, Nicholas J.; LAWRENCE, Harshani R.; (293 pag.)WO2017/66428; (2017); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 118-69-4, These common heterocyclic compound, 118-69-4, name is 2,6-Dichlorotoluene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5 g of the following catalyst particles, as described in examples 3 and 4, were loaded in the reactor along with the diluent corundum particles (1: 1 by weight) and tested the influence of addition of ethyl bromide (2 % VN) in presence and absence of water vapour. The reaction was performed under the following conditions. A reaction temperature of 350 to [400C] was used. The mole ratio 2,6-DCT : H20 : NH3: air: N2 was 1: 15: 3-4: 21: 0-29. Molar concentration of 2,6-DCT is 1.4 to 3.8 %.

Statistics shows that 2,6-Dichlorotoluene is playing an increasingly important role. we look forward to future research findings about 118-69-4.

Reference:
Patent; TESSENDERLO CHEMIE S.A.; WO2003/101939; (2003); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 4584-46-7,Some common heterocyclic compound, 4584-46-7, name is 2-Chloro-N,N-dimethylethanamine hydrochloride, molecular formula is C4H11Cl2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (2 g, 10.31 mmol), cesium carbonate (6.72 g, 20.61 mmol) and 2-chloro-N,N-dimethylethanamine hydrochloride (2.227 g, 15.46 mmol) were suspended in acetonitrile (30 mL) and the mixture was heated at reflux for 5 h, then cooled to room temperature, diluted with Et2O and filtered. The filtrate was concentrated in vacuo to give N,N-dimethyl-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]ethanamine dimethyl{2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]ethyl}amine (2.61 g, 9.84 mmol, 95% yield) as an amber oil which was used in the next step without further purification

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloro-N,N-dimethylethanamine hydrochloride, its application will become more common.

Reference:
Patent; Demont, Emmanuel Hubert; Garton, Neil Stuart; Gosmini, Romain Luc Marie; Hayhow, Thomas George Christopher; Seal, Jonathan; Wilson, David Matthew; Woodrow, Michael David; US2012/208798; (2012); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 823-57-4,Some common heterocyclic compound, 823-57-4, name is 2-Bromo-5-chloroaniline, molecular formula is C6H5BrClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(1H-indol-2-yl)boronic acid ((1H-indol-2-yl) boronic acid) (100 g, 0.621 mol) 2-Bromo-5-chloroaniline (2-bromo-5-chloroaniline) (115 g, 0.558 mol) Was dissolved in toluene (Toluene), EtOH, H2O 1000 mL: 200 mL: 200 mL , Pd (PPh3) 4 (35.8 g, 0.031 mol) and NaHCO3 (156.5 g, 1.863 mol) were added and stirred at 100 ° C for 3 hours. After completion of the reaction, MC and distilled water are added to the reaction solution to be extracted. After drying with anhydrous MgSO 4, the solvent was removed using a rotary evaporator to obtain Compound 1-1 (110 g, 74percent) in liquid form.

The synthetic route of 823-57-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; L Ti Material Co., Ltd.; Ji Hye-su; Oh Han-guk; Lee Yun-ji; Jeong Won-jang; Choi Jin-seok; Choi Dae-hyeok; (217 pag.)KR2019/33911; (2019); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 50638-46-5, name is 4-Bromo-3-chloroanisole, A new synthetic method of this compound is introduced below., COA of Formula: C7H6BrClO

Under an argon atmosphere, 1-bromo-2-chloro-4-methoxybenzene (44.3 g) was dissolved in toluene (220 ml), ethyl 2-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)benzoate (60.8 g), water (132 ml), sodium hydrogen carbonate (33.6 g) and dichlorobis(triphenylphosphine)palladium(II) (2.8 g) were added, and the mixture was stirred at an oil bath temperature of 120 C. for 7 hr. To the reaction mixture was added ethyl 2-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)benzoate (5.2 g), and the mixture was further stirred for 2 hr. The reaction mixture was cooled to room temperature, toluene (100 ml) and water (200 ml) were added, and the mixture was stirred overnight. To the reaction mixture was added activated carbon (3 g), and the mixture was further stirred for 1 hr. The insoluble material was filtered off through celite, and the insoluble material was washed with toluene (100 ml) and water (200 ml). The obtained filtrates were combined to allow for layer separation. The obtained organic layer was washed with water (100 ml), and the solvent was evaporated to give the title compound (67.7 g). [0120] 1H-NMR (400 MHz, DMSO-D6) delta: 7.88-7.86 (1H, m), 7.63 (1H, td, J=7.6, 1.4 Hz), 7.51 (1H, td, J=7.6, 1.4 Hz), 7.27 (1H, dd, J=7.6, 0.9 Hz), 7.18 (1H, d, J=8.6 Hz), 7.06 (1H, d, J=2.6 Hz), 6.95 (1H, dd, J=8.6, 2.6 Hz), 4.01 (2H, m), 3.80 (3H, s), 0.96 (3H, t, J=7.1 Hz)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; JAPAN TOBACCO INC.; Motomura, Takahisa; Shomi, Gakujun; US2014/296315; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 627-42-9, name is 2-Methoxyethyl chloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 627-42-9, Recommanded Product: 627-42-9

Example 23. 3-[4-tert-Butyl-2-(2-methoxy-ethoxy)-phenyl]-N-(3-fluoro-4- methanesulfonylamino-5-vinyl-benzyl)-acrylamideStep 1 : 4-tert-Butyl-1-iodo-2-(2-methoxyethoxy)benzeneNaH (21.0mg, 0.5250mmol, 60% disp.oil , 5eq) and tert-Butyl-2-iodo-phenol (29.0 mg, 0.105 mmol, 1eq) were added DMF. Chloroethyl methyl ether (23.96^, 0.26mmol, 2.5eq) was added into the mixture. The reaction mixture was stirred overnight at 90 C. The reaction mixture was quenched by adding H2O. After DMF was removed in vacuo, the residue was extracted with EtOAc. A combined organic layer was washed by H2O and brine, dried with Na2SO4, and then concentrated in vacuo. The residue was purified with column chromatography (n-Hexane :EtOAc = 20:1 ) to give liquid (32.0mg, 91.2%).1H NMR (400MHz, CDCI3) : delta 7.58(d, J=8.4Hz, 1H), 6.82(d, J=2.0Hz, 1H), 6.69(dd, J=8.4, 2.4Hz, 1H), 4.10(t, J=4.8Hz, 2H), 3.75(dd, J=4.8, 4.4Hz, 2H), 3.43(s, 3H), 1.22(s, EPO 9H); IR(NaCI Neat, crtau1) : 2960, 2871 , 1713, 1628, 1607, 1165.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methoxyethyl chloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AMOREPACIFIC CORPORATION; WO2006/101318; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 54932-72-8, A common heterocyclic compound, 54932-72-8, name is 4-Bromo-1-chloro-2-methylbenzene, molecular formula is C7H6BrCl, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[0422] A mixture of 2-chloro-5-methyl-pyrimidin-4-ylamine (0.34 g, 2.34 mmol), 4- bromo-l-chloro-2-methyl-benzene (0.58 g, 2.8 ?1), Pd2(dba)3 (0.21 g, 0.23 mmol), Xantphos (0.47 g, 0.47 mmol) and cesium carbonate (2.3 g, 7 mmol) were suspended in dioxane (9 mL) microwaved at 160 0C for 20 min. The reaction mixture was cooled to room temperature and centrifuged down. Solvents were then decanted and evaporated. Resulting residue was purified by flash chromatography on silica gel to afford title compound as yellow solids (0.24 g, 38%).

The synthetic route of 54932-72-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TARGEGEN, INC.; WO2007/53452; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 4863-91-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4863-91-6 name is 3-Chloro-5-fluoroaniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

a) 4-Bromo-3-chloro-5-fluoroaniline3- Chloro-5-fluoroaniline (2061 mmol, 300 g) was dissolved in ACN (3000 ml) and the solution cooled to 0C. NBS (2061 mmol, 367 g) was added to the reaction mixture in small portions keeping the temperature below 10 C. Reaction mixture was stirred at 10 +/- 5 C for 3.5 h. 10 % Aqueous NaHS03 was added and the reaction mixture was concentrated under vacuum to remove organic solvents. Water and DCM was added, stirred for 15 min and the phases were separated. The water phase was extracted with DCM. The combined organics were washed with water. The organic phase was evaporated. 2-Propanol was added to the residue and distilled until the steam temperature was 80 C. Water was added and the temperature was kept at 40 +/- 10 C. The mixture was cooled to 5 C and stirred for 4 h. The precipitate was removed by filtration, washed with water and dried under vacuum. 440.7 g of the title compound was obtained. 1 H-NMR (400 MHz, DMSO-c/6): delta 5.87 (s, 2H), 6.42-6.49 (m, 1H), 6.62-6.66 (m, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Chloro-5-fluoroaniline, and friends who are interested can also refer to it.

Reference:
Patent; ORION CORPORATION; TOeRMAeKANGAS, Olli; WOHLFAHRT, Gerd; SALO, Harri; RAMASUBRAMANIAN, Rathna, Durga; PATRA, Pranab, Kumar; MARTIN, Arputharaj, Ebenezer; HEIKKINEN, Terhi; VESALAINEN, Anniina; MOILANEN, Anu; KARJALAINEN, Arja; WO2012/143599; (2012); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6223-78-5, name is 2,5-Dichloro-2,5-dimethylhexane, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C8H16Cl2

For comparison in the biological evaluation (Fig. 1 and 2) of compounds 1 – 3, [8 and 9] and 30-32, [8b and 9b] an authentic sample of bexarotene and its ketone analog (33a) were synthesized, following the reported route (Boehm, et al. “Synthesis and Structure-Activity Relationships of Novel Retinoid X Receptor-Selective Retinoids.” J. Med. Chem. 1994, 37, 2930-2941 ): a seven step, convergent synthesis that gave a 29% overall yield of bexarotene. The first sequence of steps to bexarotene concerned the SN1 conversion of 2,5-dimethyl-2,5-hexanediol (33b) to 2,5-dichloro-2,5- dimthylhexane (34) by HCI, and the subsequent aluminum trichloride catalyzed Friedel-Crafts alkylation of toluene to give 1 ,2,3,4-tetrahydro-l .l A4,6-pentamethylnapthalene (35) in 68% yield over two steps (Scheme 1 ).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 6223-78-5.

Reference:
Patent; ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY; WAGNER, Carl E.; JURUTKA, Peter W.; MARSHALL, Pamela A.; VAN DER VAART, Arjan; WO2011/103321; (2011); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6940-78-9, name is 1-Bromo-4-chlorobutane, A new synthetic method of this compound is introduced below., Safety of 1-Bromo-4-chlorobutane

General procedure: K2C03 (1.0 eq.) and the dihaloalkane (XIII, 1.0 eq.) were added to a solution of the appropriatethio-derivative XIV (1.0 eq.) in DMF (0.5 mL per mmcl XIII). The reaction mixture was stirred under nitrogen atmosphere for 5 h at rt. The crude reaction mixture was filtered and concentrated under reduced pressure. Sat. aq. NaHCO3 solution (1.0 mL per mmol XIII) was added and the mixture extracted with Et20 (3 x 1.0 mL per mmol XIII). The combined organic layers were evaporated on silica. Pure compound XV was obtained by column chromatography using theTeledyne ISCO apparatus (cyclohexane:EtOAc). The title compound was obtained according to the General Procedure VIII (Step 1) starting from1-bromo-4-chlorobutane (8.57 g, 50.0 mmol) and thiophenol (5.51 g, 50.0 mmol). Colorless liquid(8.06 g, 80%). 1H NMR (400 MHz, CDCI,) 6 1.79 – 1.88 (m, 2H), 1.91 – 1.99 (m, 2H), 2.98 (t, i = 7.1Hz, 2H), 3.57 (t, J = 6.5 Hz, 2H), 7.17 – 7.24 (m, 1H), 7.28 – 7.34 (m, 2H), 7.35 – 7.39 (m, 2H). MS(ESI) m/z: non-ionizable compound under routine conditions used.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; UNIVERSITA’ DEGLI STUDI DI PARMA; PIOMELLI, Daniele; PIZZIRANI, Daniela; BACH, Anders; SCARPELLI, Rita; MELZIG, Laurin; MOR, Marco; (72 pag.)WO2015/173169; (2015); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics