Category: chlorides-buliding-blocks

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3386-33-2, name is 1-Chlorooctadecane, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C18H37Cl

EXAMPLE 1 Preparation of a compound of formula (I) in which R1 is a stearyl radical, R2 is a hydroxypropyl radical, n=6.3 and p=14 52.5 g (173 mmol) of stearyl chloride were added dropwise for 20 minutes at 20 C. to a solution of 12.4 g (8.3 mmol) of hydroxypropyl-beta-cyclodextrin (n=6.3), sold by the company Aldrich, in 100 ml of anhydrous pyridine. After 5 hours’ stirring at ambient temperature, the reaction mixture was poured into 400 ml of ethanol. The solid obtained was filtered off and washed three times with 200 ml portions of hot ethanol. After drying, 40.5 g of a light-beige solid which had a melting point of 39 C. were obtained. Infrared: ester band at 1745 cm-1

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3386-33-2.

Reference:
Patent; L’Oreal; US5854225; (1998); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

These common heterocyclic compound, 622-86-6, name is (2-Chloroethoxy)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C8H9ClO

2-(4-Fluorophenyl)butanoic acid (250.3 mg, 1.4mmol) was suspended with stirring in trifluoroacetic anhydride (194.2 uL, 2.0mmol). Then (2-chloroethoxy)benzene (173 uL, 1.3 mmol) was added the resultingmixture was stirred at room temperature overnight. The reaction was quenchedwith saturated sodium bicarbonate solution (5 mL) and extracted with ethylacetate (2 x 15 mL). The combinedorganic layers were dried over anhydrous magnesium sulfate and concentrated ona rotary evaporator. The resultingresidue was purified by reverse-phased chromatography (C-10 column, gradient ofacetonitrile in water with 0.1% trifluoroacetic acid) to afford 105.2 mg (26%)of the desired product as a yellow solid.1H NMR (400 MHz, CDCl3) delta 7.90 (d, J=8.8 Hz, 2H), 7.50 (d,J=8.7 Hz, 2H), 7.23 (m, 2H), 6.95 (d, J=8.7 Hz, 2H), 4.25 (m, 3H), 3.86 (t,J=7.2 Hz, 2H), 2.18 (m, 1H), 1.60 (m, 1H), 0.90 (t, J=7.3 Hz, 3H); MS (ESI)(m/z) 321.1/323.1 (M+H)+.

The synthetic route of (2-Chloroethoxy)benzene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Childers, Wayne; Fan, Rong; Martinez, Rogelio; Colussi, Dennis J.; Melenski, Edward; Liu, Yuxiao; Gordon, John; Abou-Gharbia, Magid; Jacobson, Marlene A.; Bioorganic and Medicinal Chemistry Letters; vol. 30; 2; (2020);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 13745-86-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13745-86-3, name is 11-Chlorodibenzo[b,f][1,4]thiazepine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 2Preparation of 11-piperazinyl-Dibenzo[B,F][1,4]Thiazepine,DihydrochlorideDimethylsulfoxide (3.0 L); piperazine (2.45 Kg); toluene (3.0 L) were charged at room temperature under nitrogen and the mixture was heated to 50 C. to 60 C.; stirred at 50 C. to 60 C. till solid dissolves and cooled to 25 C. to 30 C. To it a solution of 11-chloro-dibenzo[b,f]1,4]thiazepine (1.0 Kg) in toluene (6.0 L) was charged at 25 C. to 30 C. and stirred for 3 hours at 25 C. to 30 C. and monitored to completion. The reaction mixture was charged slowly into DI water (45 L) at 25 C. to 30 C. and stirred for 30 minutes at 25 C. to 30 C. The layers were separated at room temperature and the organic layer was washed with DI water (3×3.0 L) at room temperature. The solvent was recovered from the organic layer under vacuum at 50 C. to 55 C. to obtain oil. Ethanol (5 L) was charged into the residue and stirred to dissolve at room temperature. Concentrated hydrochloric acid (0.72 L) was added slowly at 25 C. to 30 C. and stirred until the solid precipitated. The mixture was stirred for 10 hours at 25 C. to 30 C. after precipitation, cooled to 0 C. to 5 C. and stirred for 1 hour at 0 C. to 5 C. The solid was filtered and washed with ethanol (1 L) at 0 C. to 5 C. The solid was added to pre-cooled ethanol (5 L) at 0 C. to 5 C. and stirred for 15 minutes at 0 C. to 5 C. The solid was filtered at 0 C. to 5 C. and washed with ethanol (1 L) at 0 C. to 5 C. The wet cake was unloaded at room temperature under nitrogen atmosphere and dried under vacuum at 55 C. to 60 C. until the moisture content is NMT 5.0% to obtain the title compound.Yield: 1.10 Kg

The synthetic route of 11-Chlorodibenzo[b,f][1,4]thiazepine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; RANBAXY LABORATORIES LIMITED; US2012/71649; (2012); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 102-49-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 102-49-8, name is 3,4-Dichlorobenzylamine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: 2,2,2-Trichloro-1-(1H-pyrrol-2-yl)ethanone (2) (0.200 g, 0.94 mmol) and benzylamine (0.101 g, 0.11 mL, 0.94 mmol) were dissolved in acetonitrile (15.0 mL). Triethylamine (5 equiv, 0.65 mL) was added to the solution, and the reaction mixture stirred at 60 °C for 24 h. Solvent was removed from the reaction by rotary evaporation. The resulting yellow oil was purified using 5percent MeOH/CH2Cl2 to afford N-benzyl-1H-pyrrole-2-carboxamide (0.123 g, 65percent) as a white solid, mp 128?130 °C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,4-Dichlorobenzylamine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Dyson, Lauren; Wright, Anthony D.; Young, Kelly A.; Sakoff, Jennette A.; McCluskey, Adam; Bioorganic and Medicinal Chemistry; vol. 22; 5; (2014); p. 1690 – 1699;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 60811-21-4, name is 4-Bromo-2-chloro-1-fluorobenzene, A new synthetic method of this compound is introduced below., HPLC of Formula: C6H3BrClF

EXAMPLE 65 6-(3-Chloro-4-fluoro-phenyl)-4,4-dimethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one Prepared from 6-bromo-4,4-dimethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one and 1-bromo-3-chloro-4-fluorobenzene according to Procedure A. White solid: mp 211-212 C.; 1H-NMR (DMSO-d6) delta10.4 (s, 1H), 7.92 (dd, 1H, J=7.13, 2.19 Hz), 7.71-7.66 (m, 1H), 7.60-7.57 (m, 2H), 7.49 (t, 1H, J=8.95 Hz), 6.96 (d, 1J=8.01 Hz), 1.67 (s, 6H); MS (EI) m/z 305 ([M +H]+, 20%); Anal. Calc. For C16H13ClFNO2: C, 62.86, H, 4.29, N, 4.58. Found: C, 62.52, H, 4.45, N, 4.42.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Wyeth; Ligand Pharmaceuticals, Inc.; US6444668; (2002); B1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 918538-05-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 918538-05-3 name is 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 2,4-dichloropyrrolo[1,2-f][1,2,4]triazine (4a) (0.5 g, 2.7 mmol) in 2-Propanol (6 mL) was added (S)-pyrrolidin-2-ylmethanol (0.39 mL, 4.0 mmol), DIPEA (1.39 mL, 8.0 mmol) and heated at 90 C for 1 hr. The reaction was cooled to room temperature and solid obtained was collected by filtration to afford (S)-(l-(2-chloropyrrolo[2,l-f][l,2,4]triazin-4- yl)pyrrolidin-2-yl)methanol (96a) (0.49 g, 73 % yield) as a white solid; NMR (300 MHz, DMSO-i/e): delta 7.70 (dd, J= 2.6, 1.4 Hz, 1H), 6.97 (dd, J= 4.7, 1.6 Hz, 1H), 6.80 – 6.57 (m, 1H), 5.15 (t, J = 5.7 Hz, 1H, D2O exchangeable), 4.87 (t, J= 5.7 Hz, 1H), 4.44 (d, J= 17.8 Hz, 1H), 4.05 – 3.82 (m, 1H), 3.72 – 3.39 (m, 2H), 2.22 – 1.84 (m, 4H). MS (ES+): 253.3, 255.3 (M+2); MS (ES-): 287.2, 289.2 (M+Cl).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine, and friends who are interested can also refer to it.

Reference:
Patent; BIOCRYST PHARMACEUTICALS, INC.; KOTIAN, Pravin, L.; BABU, Yarlagadda, S.; KUMAR, V., Satish; ZHANG, Weihe; LU, Peng-Cheng; RAMAN, Krishnan; (747 pag.)WO2018/232094; (2018); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 6223-78-5, name is 2,5-Dichloro-2,5-dimethylhexane, molecular formula is C8H16Cl2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 6223-78-5

(c) 1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene (2): To a 1000 mLround-bottomed flask fitted with water condenser were added compound 1(30.0 g, 165 mmol), toluene (35.1 mL, 330 mmol) and CH2Cl2 (150 mL). To thisvigorously stirred solution was added aluminum chloride (1.92 g, 1.4 mmol)slowly in portionwise, which resulted in rapid evolution of gaseoushydrochloride acid. The reaction mixture was stirred at RT for 30 minfollowed by additional aluminum chloride (400 mg). After the reactionmixture was stirred and heated to reflux for 15 min, it was cooled in an icebath and quenched with 20% HCl aqueous solution (150 mL). The mixture wasextracted with hexanes; the combined organic layers were washed with waterand brine, dried over anhydrous Na2SO4, filtered and concentrated in vacuo.The crude product was purified by column chromatography with hexanes toafford 2 as a white solid (28.3 g, 85%), mp 34-35 C (lit.2 34-36 C). 1H NMR(CDCl3): d 7.40 (d, J = 8.0 Hz, 1H), 7.31 (s, 1H), 7.14 (d, J = 8.0 Hz, 1H), 2.49 (s,3H), 1.87 (s, 4H), 1.48(s, 6H), 1.47 (s, 6H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6223-78-5, its application will become more common.

Reference:
Article; Wang, Min; Davis, Toni; Gao, Mingzhang; Zheng, Qi-Huang; Bioorganic and Medicinal Chemistry Letters; vol. 24; 7; (2015); p. 1742 – 1747;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 622-86-6, name is (2-Chloroethoxy)benzene, A new synthetic method of this compound is introduced below., name: (2-Chloroethoxy)benzene

Phenyl acetic acid (2.6 g, 19 mmol) wassuspended in trifluoroacetic anhydride (11 mL, 76 mmol). Chloroethyoxylbenzene(2.7 mL, 19 mmol) was added to the stirred suspension dropwise. The resultingmixture was allowed to stir overnight at room temperature. The reaction wasquenched with 40% aqueous sodium hydroxide solution and then extracted withethyl acetate (2 x 15 mL). The combinedorganic layers were dried over anhydrous magnesium sulfate and concentrated ona rotary evaporator. The resultingresidue was purified by chromatography on silica gel (ethyl acetate/hexane) toafford 3.56 g (68%) of the desired product as a yellow solid. 1H NMR (400 MHz, CDCl3)delta 7.93 (d, J = 6.8 Hz, 2H), 7.22 (m, 5H), 6.87 (d, J = 6.9 Hz, 2H), 4.21 (t, J=5.8 Hz, 2H), 4.17 (s, 2H), 3.76 (t, J = 5.8 Hz, 2H); MS (ESI) (m/z) 275.1/277.1(M+H)+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Childers, Wayne; Fan, Rong; Martinez, Rogelio; Colussi, Dennis J.; Melenski, Edward; Liu, Yuxiao; Gordon, John; Abou-Gharbia, Magid; Jacobson, Marlene A.; Bioorganic and Medicinal Chemistry Letters; vol. 30; 2; (2020);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

These common heterocyclic compound, 108-41-8, name is 1-Chloro-3-methylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 1-Chloro-3-methylbenzene

General procedure: Ethylbenzene (3a) (0.0531 g, 0.5 mmol), K2S2O8 (0.2703 g, 1.0 mmol), pyridine (0.0158 g, 0.2 mmol) and CH3CN (1.0 mL) were added to an oven-dried pressure vessel with a magnetic stir bar. Then the pressure vessel was filled with dioxygen and the reaction mixture was stirred at 80 C for 16 hours (oil bath). After the completion of the reaction, the solvent was evaporated and the reaction mixture was purified with column chromatography (eluenet: ethyl acetate/PE = 1/10) to give acetophenone (4a) (0.0535 g yield 89%).

The synthetic route of 1-Chloro-3-methylbenzene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Hu, Yixin; Zhou, Lihong; Lu, Wenjun; Synthesis; vol. 49; 17; (2017); p. 4007 – 4016;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 39226-96-5, name is (2-Chloro-3-(trifluoromethyl)phenyl)methanamine, A new synthetic method of this compound is introduced below., category: chlorides-buliding-blocks

Example 120 N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-5-oxo-1-(3-pyridinylmethyl)prolinamide (E120) 5-oxo-1-(3-pyridinylmethyl)proline (0.210 g, 1 mmol, prepared as described below), N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (0.383 g, 2 mmol), and 1-hydroxybenzotriazole (0.306 g, 2 mmol) were stirred together in dichloromethane (10 ml) at room temperature for 30 minutes. The mixture was then treated with {[2-chloro-3-(trifluoromethyl)phenyl]methyl}amine (0.314 g, 1.5 mmol) and the mixture was stirred overnight at room temperature. The mixture was concentrated and partitioned between ethyl acetate and saturated aqueous sodium hydrogen carbonate. The aqueous layer was separated and extracted with more ethyl acetate and then the combined ethyl acetate fractions were washed sequentially with 3 portions of water and then with saturated aqueous sodium chloride solution. Drying over magnesium sulphate and concentration gave a solid residue which was purified by mass-directed automated HPLC to give pure N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-5-oxo-1-(3-pyridinylmethyl)prolinamide (0.031 g). LC/MS [M+H]+=412/414, retention time=1.83 minutes.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; GLAXO GROUP LIMITED; US2008/9541; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics