Category: chlorides-buliding-blocks

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 63624-28-2 as follows. Recommanded Product: 2,4-Dimethoxybenzene-1-sulfonyl chloride

General procedure: A mixture of norfloxacin (a) or ciprofloxacin (b) (1 mmol) (refPreviewPlaceHolderScheme 1) and K2CO3 (152 mg, 1.1 mmol) was stirred in acetone (20 mL) at room temperature for 20 min. To the resulted mixture, the appropriate arenesulfonyl chloride (1.2 mmol) in acetone (5 mL) was added dropwise over a period of 20 min. The reaction mixture was further stirred at room temperature for 24 h. The separated solid was then filtered, washed with cold water, dried and crystallized from the appropriate solvent.

According to the analysis of related databases, 63624-28-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Abdel-Aziz, Alaa A.-M.; Asiri, Yousif A.; Al-Agamy, Mohamed H.M.; European Journal of Medicinal Chemistry; vol. 46; 11; (2011); p. 5487 – 5497;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 2533-69-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2533-69-9, name is Methyl 2,2,2-trichloroacetimidate belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 7; Synthesis of Compounds According to Formula (4); [00528] 5-bromo-2-(trichloromethyl)-lH-benzimidazole 2; To a solution of 4- bromo-o-phenylenediamine 1 (2.52Og, 13.5 mmol) in acetic acid (35mL) cooled to 0 0C was added methyl trichloroacetimidate (2.64Og, 15 mmol) under N2 atmosphere and resulting reaction mixture was stirred at room temperature for 3h. Diluted with water (200 mL) and resulting precipitate was filtered , washed with water (100 mL), dried in vacuum oven at 40 0C to give 5-bromo-2-(trichloromethyl)-lH-benzimidazole (4.1g, 97%). 1H NMR (300 MHz, DMSOd6) : 57.48 (d, J= 6.0 Hz, 1 H), 7.63 (d, J= 6.0 Hz, 1 H), 7.88 (s, 1 H); LCMS mlz 315 (M + H+), ELSD 100%. Reference: Louvet, P.; Lallement, G.; Pernot-Marino, L; Luu- Duc, C; Blanchet, G. Eur. J.Med.Chem. 1993, 28, 71-75.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2,2,2-trichloroacetimidate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CHEMBRIDGE RESEARCH LABORATORIES, INC.; WO2007/56155; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 2732-80-1, name is 2-Bromo-1-chloro-4-methoxybenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2732-80-1, name: 2-Bromo-1-chloro-4-methoxybenzene

4-Chloro-3-(4-fluorophenoxy)phenol; 2-Bromo-1-chloro-4-methoxybenzene (200 mg, 0.9 mmol), cesium carbonate (588 mg, 1.8 mmol), 4-fluorophenol (202 mg, 1.8 mmol), CuI (17 mg, 0.09 mmol) and N-methylpyrrolidine (1 mL) were sealed in a microwave vessel and heated in a microwave at 200 C. for 1800 s. The crude reaction mixture was purified by chromatography on silica gel. Elution with 10:90 ethyl acetate:heptane with a gradient to 30:70 ethyl acetate:heptane afforded 1-chloro-2-(4-fluorophenoxy)-4-methoxybenzene (112 mg, 0.44 mmol, 49%). 1-Chloro-2-(4-fluorophenoxy)-4-methoxybenzene (110 mg, 0.44 mmol) prepared above, was dissolved in DCM (5.00 mL) and stirred under argon at -78 C. Boron tribromide (1.0M in DCM, 2.20 mL) was then added and the reaction stirred at -78 C. for 1 h. The reaction was allowed to warm to ambient temperature overnight, quenched with saturated Na2CO3 (aq) and then the aqueous and organic layers were separated. The solvent was removed in vacuo and the crude product was purified by chromatography on silica gel. Elution with 2:98 ethyl acetate:heptane with a gradient to 20:80 ethyl acetate:heptane afforded 4-chloro-3-(4-fluorophenoxy)phenol (92 mg, 0.38 mmol, 87%). M.S. (ESI) (m/z): 237, 239 [M-H]-

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; N.V. Organon; US2007/185156; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 26487-67-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 26487-67-2, name is 1-(2-Chloroethyl)azepane hydrochloride, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Commercially available 5-chloro benzoxazoles or benzothiazoles(5 mmol) and K2CO3 (15 mmol) were added to 50 mL of DMF.The mixture was heated at 60 C and 1-(2-chloroethyl)hexahydro-1H-azepine hydrochloride (6.5 mmol) was added. The mixture was maintained at 60 C under stirring for 3 h, then was cooled to room temperature, poured into water, and extracted with diethyl ether(3 50 mL). The organic layer was washed with brine, dried overan hydrous Na2SO4 and evaporated under reduced pressure to give are sidue, which was purified by flash column chromatography oversilica gel using ethyl acetate/methanol 8:2 v/v as eluent. Immediately after solvent evaporation, free bases were converted into hydrochlorides by dissolving the corresponding amine in diethyl ether and treating with a 1.25MHCl ethanol solution (pH 1e2). The precipitate was filtered off, washed with diethyl ether, and dried under nitrogen. The following compounds were obtained using this procedure:

The chemical industry reduces the impact on the environment during synthesis 1-(2-Chloroethyl)azepane hydrochloride. I believe this compound will play a more active role in future production and life.

Reference:
Article; Romeo, Giuseppe; Prezzavento, Orazio; Intagliata, Sebastiano; Pittala, Valeria; Modica, Maria N.; Marrazzo, Agostino; Turnaturi, Rita; Parenti, Carmela; Chiechio, Santina; Arena, Emanuela; Campisi, Agata; Sposito, Giovanni; Salerno, Loredana; European Journal of Medicinal Chemistry; vol. 174; (2019); p. 226 – 235;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2106-02-7, name is 2-Chloro-4-fluoroaniline, A new synthetic method of this compound is introduced below., HPLC of Formula: C6H5ClFN

fd”) 4-Chloro-A^-(2-chloro-4-fluorophenvDpyra2ole-3-carboxamide A mixture of 3,8-dichlorodipyrazolo[l55-a;r95′-d]pyrazine-4,9-dione (0.20 mmol, 51 mg) and 2-chloro-4-fluoroaniline (1.0 mmol, 146 mg) was heated at 12O0C for I h, cooled to ambient temperature and diluted with pentane (5 mL). The precipitate was filtered off and washed with pentane (30 mL). Crystallisation from EtOH:water (4:1, 20 mL) gave 84 mg (77 %) of the title compound as a white solid. 1H NMR (DMSO-d6, 400 MHz) delta 13.8 (br s, IH), 9.65 (s, IH), 8.20 (s, IH), 7.96 (dd, IH), 7.57 (dd, IH), 7.28 (ddd, IH).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; BIOLIPOX AB; WO2007/45868; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

932-32-1, name is 2-Chloro-N-methylaniline, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 2-Chloro-N-methylaniline

General procedure: Dichloromethane (20 mL) and phenylpropynoic acid (11 mmol) were added into a 50 mL round bottom glass flask, and then N-alkylaniline (10 mol) was added at 0 C. Thereafter, a solution of DCC (15 mol), DMAP (0.5 mmol) and dichloromethane (20 mL) was slowly added dropwise with stirring. The reaction mixture was allowed to warm to room temperature and then stirred overnight. The mixture was washed with 5 mL saturated NaCO3 solution, 5 mL saturated NaCl solution, and 5 mL water. The organic phase was dried over Na2SO4, filtered and concentrated. The residue was purified by column chromatography on silica gel (petroleum ether/ethyl acetate as the eluent) affording the corresponding N-phenylpropynamide 1.

The synthetic route of 932-32-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Chen, Yuan; Chen, Yu-Jue; Guan, Zhi; He, Yan-Hong; Tetrahedron; vol. 75; 51; (2019);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 29671-92-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 29671-92-9 name is Carbamimidic chloride hydrochloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 3; 2-Amino-6- (4-methoxyphenoxymethyl)benzonitrile mg; 0.2 mmol) and chloroformamidine hydrochloride (34.0 mg, 0.30 mmol) were heated at 140 C in diglyme for 3 hours. The reaction mixture was diluted with water, stirred for 2 hours, filtered, washed with water and dried. Purification by silica gel chromatography (5% methanol in dichloromethane) yielded 30 mg of 5-(4- methoxyphenoxymethyl) quinazoline-2,4-diamine.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Carbamimidic chloride hydrochloride, and friends who are interested can also refer to it.

Reference:
Patent; DECODE CHEMISTRY, INC.; SINGH, Jasbir; GURNEY, Mark E.; WO2005/123724; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 1940-29-0,Some common heterocyclic compound, 1940-29-0, name is 4-Bromo-3,5-dichloroaniline, molecular formula is C6H4BrCl2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 4-bromo-3,5-dichloroaniline (1.00 g, 4.18 mmol) in Ac20 (5 mL) was added pyridine (0.1 mL). The reaction was stirred at room temperature for 2 h. The mixture was poured into 50 mL ice water and extracted with EA (20 mL X 3). The organic layer was washed with brine (50 mL), dried with Na2S04, and concentrated in vacuo to afford product (1 g, 85%). ESI-MS m/z calcd for [CsHeBrCkNOf [M+H]+: 2820; found: 282.0.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromo-3,5-dichloroaniline, its application will become more common.

Reference:
Patent; GALECTO BIOTECH AB; ZETTERBERG, Fredrik; LEFFLER, Hakon; NILSSON, Ulf; (131 pag.)WO2018/11093; (2018); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 6579-54-0, name is 2,6-Dichlorobenzenesulfonyl chloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6579-54-0, SDS of cas: 6579-54-0

General procedure: To a suspension of 2.5 mmol (2.5 equiv) of NaH (60% in oil) in 5 mL of anhydrous THF was added asolution of 188 mg (1 mmol) of 4-nitro-1-naphthylamine in 1 mL of THF. The mixture was stirred for 10 min at 0C,and 1 mmol of the appropriate benzenesulfonyl chloride was added. The mixture was stirred for 12 h at 25C, quenched with saturated NaHCO3 and extracted with EtOAc. The combined organic layers were washed with brine, dried over anhydrous MgSO4 and concentrated. The crude products were purified by recrystallization and/or chromatography as noted below.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Kril, Liliia M.; Vilchez, Valery; Jiang, Jieyun; Turcios, Lilia; Chen, Changguo; Sviripa, Vitaliy M.; Zhang, Wen; Liu, Chunming; Spear, Brett; Watt, David S.; Gedaly, Roberto; Bioorganic and Medicinal Chemistry Letters; vol. 25; 18; (2015); p. 3897 – 3899;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 30273-47-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 30273-47-3, name is 4-Bromo-5-chloro-2-methylaniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Under ice-bath cooling, acetic anhydride (1.553 mL, 16.46 mmol), was added to a solution of 4-bromo-5-chloro-2-methylaniline (1.815 g, 8.23 mmol) in chloroform (20 mL), Potassium acetate (0.889 g, 9.05 mmol), a solution of 18-crown-6 (0.435 g, 1 ,646 mmol) in chloroform (5 mL) and then t-butyl nitrite (2.282 mL, 17.29 mmol) were then added sequentially and the mixture was refluxed at 78C for 16 h. The reaction mixture was cooled and stirred (under ice bath cooling) with saturated aqueous sodium bicarbonate solution (20 mL). The aqueous layer was separated and extracted with DCM (3 x 20 mL) and the organics combined and reduced. The resulting residue was purified twice by chromatography on silica gel, eluting with a gradient of 0-20% ethyl acetate in isohexane to afford the title compound as an orange solid (1.52 g). H NMR (CDCI3, 400MHz) delta ppm: 2.79 (3H, s), 8.03 (1 H, s), 8.06 (1 H, d, J 1 Hz), 8.64 (1 H, m).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-5-chloro-2-methylaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLAXO GROUP LIMITED; BAILEY, James; KING, Nigel Paul; LIN, Xichen; REN, Feng; TAN, Kheng-Chuan; MAK, Sing Yeung; WO2011/72488; (2011); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics