Hamprecht, Dieter published the artcileIsoindolone derivatives, a new class of 5-HT2C antagonists: Synthesis and biological evaluation, COA of Formula: C9H9ClO2, the main research area is isoindolone aryl derivative preparation 5HT2C receptor inhibitory activity.
Two independent approaches resulted in the identification of a series of isoindolone derivatives, e.g., I, as potent and selective 5-HT2C antagonists. From a Medicinal Chem. perspective this template was considered interesting as it allowed the incorporation of the carbon-carbon double bond of an earlier dihydropyrrolone series in an aromatic system within a comparatively simple and compact motif. Addnl. an in silico screening approach of the corporate database using a 5-HT2C pharmacophore model resulted in the identification of a related structure containing this template. The strategy used to optimize potency at the target receptor and to improve the pharmacokinetic profile is described, resulting in mols. combining high potency with good selectivity and oral bioavailability.
Bioorganic & Medicinal Chemistry Letters published new progress about 5-HT2A receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 99585-12-3 belongs to class chlorides-buliding-blocks, name is Methyl 4-chloro-2-methylbenzoate, and the molecular formula is C9H9ClO2, COA of Formula: C9H9ClO2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics