Category: 98946-18-0

On December 6, 2019, Moreira, Ryan; Diamandas, Matthew; Taylor, Scott D. published an article.Safety of tert-Butyl trichloroacetimidate The title of the article was Synthesis of Fmoc-protected amino alcohols via the Sharpless asymmetric aminohydroxylation reaction using FmocNHCl as the nitrogen source. And the article contained the following:

The aminohydroxylation of various alkenes using FmocNHCl (9-fluorenylmethyl chlorocarbamate) as a nitrogen source is reported. In general, in the absence of a ligand, the reaction provided racemic Fmoc-protected amino alcs. with excellent regioselectivity but in low to moderate yields. However, in some instances, the yield of an amino alc. product and the regioselectivity could be altered by the addition of a catalytic amount of triethylamine (TEA). The Sharpless asym. variant of this reaction (Sharpless asym. aminohydroxylation (SAAH)), using (DHQD)2PHAL (DHQD) or (DHQ)2PHAL (DHQ) as chiral ligands, proceeded more readily and in higher yield compared to the same reaction in the absence of a chiral ligand. The enantiomeric ratios (er) of all but two examples exceeded 90:10 with many examples giving er values of 95:5 or higher, making FmocNHCl a highly practical reagent for preparing chiral amino alcs. The SAAH reaction using FmocNHCl was used for the preparation of D-threo-β-hydroxyasparagine and D-threo-β-methoxyaspartate, suitably protected for Fmoc solid phase peptide synthesis. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Safety of tert-Butyl trichloroacetimidate

The Article related to amino alc fmoc protected enantioselective regioselective synthesis hydroxyasparagine methoxyaspartate, sharpless asym aminohydroxylation fluorenylmethyl chlorocarbamate nitrogen source and other aspects.Safety of tert-Butyl trichloroacetimidate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On May 1, 2019, Huang, Yong; Liu, Song; Wu, Renbo; Zhang, Lifang; Zhang, Yan; Hong, Haiyan; Zhang, Aili; Xiao, Hao; Liu, Yajing; Wu, Zehui; Zhu, Lin; Kung, Hank F. published an article.Recommanded Product: tert-Butyl trichloroacetimidate The title of the article was Synthesis and preliminary evaluation of a novel glutamine derivative: (2S,4S)4-[18F]FEBGln. And the article contained the following:

We report the preparation of a novel glutamine derivative, (2S,4S)-2,5-diamino-4-(4-(2-fluoroethoxy)benzyl)-5-oxopentanoic acid, (2S, 4S)4-[18F]FEBGln ([18F]4), through efficient organic and radiosyntheses. In vitro assays of [18F]4 using MCF-7 cells showed that it entered cells via multiple amino acid transporter systems including system L and ASC2 transporters but not through the system A transporter. [18F]4 showed promising properties for tumor imaging and may serve as a lead compound for further optimizing and targeting the system L transporter associated with enhanced glutamine metabolism in cancer cells. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Recommanded Product: tert-Butyl trichloroacetimidate

The Article related to glutamine derivative tumor imaging agent diamino fluoroethoxybenzyl oxopentanoic acid, amino acid transporter system uptake chirality, amino acid, glutamine, radiosynthesis, synthesis, transporter and other aspects.Recommanded Product: tert-Butyl trichloroacetimidate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 3, 2021, Pascoe, Cameron A.; Engelhardt, Daniel B.; Rosana, Albert Remus R.; van Belkum, Marco J.; Vederas, John C. published an article.HPLC of Formula: 98946-18-0 The title of the article was Methylene analogs of neopetrosiamide as potential antimetastatic agents: solid-supported syntheses using diamino diacids for pre-stapling of peptides with multiple disulfides. And the article contained the following:

Neopetrosiamide, a 28-residue peptide from Neopetrosia sp., contains three disulfide bonds and hinders mammalian tumor cell invasion. Proper connectivity of disulfide bonds is crucial for activity. Synthetic replacement of single disulfide bridges with methylene bridges gives active analogs. Pre-stapling of one ring enhances the correct formation of the remaining disulfides by reducing isomeric possibilities and possibly initiating the correct 3D fold. Cloning and expression of neopetrosiamide in E. coli affords access to the natural linear peptide. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).HPLC of Formula: 98946-18-0

The Article related to cyclic peptide neopetrosiamide methylene analog synthesis antimetastatic antitumor agent, diamino acid solid phase peptide synthesis coupling oxidative cyclization, natural product neopetrosiamide and other aspects.HPLC of Formula: 98946-18-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 20, 2020, Soni, Arvind S.; Vacariu, Condarache M.; Chen, Jeff Y.; Tanner, Martin E. published an article.Quality Control of tert-Butyl trichloroacetimidate The title of the article was Synthesis of a meso-oxa-diaminopimelic acid containing peptidoglycan pentapeptide and coupling to the GlcNAc-anhydro-MurNAc disaccharide. And the article contained the following:

The syntheses of peptidoglycan (PG)-derived peptides containing meso-diaminopimelic acid (meso-Dap) are typically quite lengthy due to the need to prepare orthogonally protected meso-Dap. In this work, the preparation of the PG pentapeptide containing the isosteric analog meso-oxa-Dap is described. The synthesis relies on the ring opening of a peptide embedded aziridine via the attack of a serine residue. The pentapeptide was attached to a GlcNAc-anhydro-MurNAc disaccharide, to produce a putative substrate for the AmpG pore protein. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Quality Control of tert-Butyl trichloroacetimidate

The Article related to meso oxadiaminopimelic acid peptidoglycan pentapeptide synthesis coupling disaccharide, peptide cyclization coupling aziridine peptide ring opening heine reaction, ampg pore protein substrate and other aspects.Quality Control of tert-Butyl trichloroacetimidate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On June 3, 2022, Bolduc, Trevor G.; Lee, Cayo; Chappell, William P.; Sammis, Glenn M. published an article.Safety of tert-Butyl trichloroacetimidate The title of the article was Thionyl fluoride-mediated one-pot substitutions and reductions of carboxylic acids. And the article contained the following:

Thionyl fluoride (SOF2) is an underutilized reagent that is yet to be extensively studied for its synthetic applications. We previously reported that it is a powerful reagent for both the rapid syntheses of acyl fluorides and for one-pot peptide couplings, but the full scope of these nucleophilic acyl substitutions had not been explored. Herein, we report one-pot thionyl fluoride-mediated syntheses of peptides and amides (35 examples, 45-99% yields) that were not explored in our previous study. The scope of thionyl fluoride-mediated nucleophilic acyl substitutions was also expanded to encompass esters (24 examples, 64-99% yields) and thioesters (11 examples, 24-96% yields). In addition, we demonstrate that the scope of thionyl fluoride-mediated one-pot reactions can be extended beyond nucleophilic acyl substitutions to mild reductions of carboxylic acids using NaBH4 (13 examples, 33-80% yields). The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Safety of tert-Butyl trichloroacetimidate

The Article related to peptide amide one pot synthesis thionyl fluoride mediated thioester, carboxylic acid nucleophilic acyl substitution reduction thionyl fluoride mediated, amino acid peptide coupling protection and other aspects.Safety of tert-Butyl trichloroacetimidate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Peng, Lei; Li, Kai; Xie, Chuandong; Li, Shan; Xu, Da; Qin, Wenling; Yan, Hailong published an article in 2019, the title of the article was Organocatalytic Asymmetric Annulation of ortho-Alkynylanilines: Synthesis of Axially Chiral Naphthyl-C2-indoles.SDS of cas: 98946-18-0 And the article contains the following content:

A chiral Bronsted base catalyzed asym. annulation of ortho-alkynylanilines was developed to accessed axially chiral naphthyl-C2-indoles via vinylidene ortho-quinone methide intermediates. This strategy provided a unique organocatalytic atroposelective route to axially chiral aryl-C2-indole skeletons with excellent enantioselectivity and functional-group tolerance. This transformation was applicable to decagram-scale preparation (50.0g) with perfect enantioselectivity through simple recrystallization Moreover, the utility of this reaction was demonstrated by a variety of transformations towards chiral naphthyl-C2-indoles for a series of carbon-heteroatom bond formations. Furthermore, the prepared axially chiral naphthyl-C2-indoles were applied as a chiral skeleton for organocatalytic aza-Baylis-Hillman reaction and asym. formal [4+2] tandem cyclization to give the corresponding adducts in high yields with improved enantioselectivity and diastereoselectivity. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).SDS of cas: 98946-18-0

The Article related to anilinoethynyl naphthol cinchon alkaloid catalyst enantioselective heterocyclization, hydroxynaphthyl indole preparation, asymmetric catalysis, atroposelectivity, axially chirality, indoles, organocatalysis and other aspects.SDS of cas: 98946-18-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On July 16, 2021, Abad-Galan, Laura; Cieslik, Patrick; Comba, Peter; Gast, Michael; Maury, Olivier; Neupert, Lucca; Roux, Amandine; Wadepohl, Hubert published an article.Category: chlorides-buliding-blocks The title of the article was Excited State Properties of Lanthanide(III) Complexes with a Nonadentate Bispidine Ligand. And the article contained the following:

EuIII, TbIII, GdIII and YbIII complexes of the nonadentate bispidine derivative L2 (bispidine=3,7-diazabicyclo[3.3.1]nonane) were successfully synthesized and their emission properties studied. The X-ray crystallog. reveals full encapsulation by the nonadentate ligand L2 that enforces to all LnIII cations a common highly sym. capped square antiprismatic (CSAPR) coordination geometry (pseudo C4v symmetry). The well-resolved identical emission spectra in solid state and in solution confirm equal structures in both media. As therefore expected, this results in long-lived excited states and high emission quantum yields ([EuIIIL2]+, H2O, 298 K, τ=1.51 ms, φ=0.35; [TbIIIL2]+, H2O, 298 K, τ=1.95 ms, φ=0.68). Together with the very high kinetic and thermodn. stabilities, these complexes are a possible basis for interesting biol. probes. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Category: chlorides-buliding-blocks

The Article related to lanthanide nonadentate bispidine complex preparation luminescence, crystal structure lanthanide nonadentate bispidine complex, lanthanides, luminescence, nonadentate ligand, photophysics, quantum yield and other aspects.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Dowman, Luke J.; Agten, Stijn M.; Ripoll-Rozada, Jorge; Calisto, Barbara M.; Pereira, Pedro Jose Barbosa; Payne, Richard J. published an article in 2021, the title of the article was Synthesis and evaluation of peptidic thrombin inhibitors bearing acid-stable sulfotyrosine analogs.Formula: C6H10Cl3NO And the article contains the following content:

Tyrosine sulfation is an important post-translational modification of peptides and proteins which underpins and modulates many protein-protein interactions. In order to overcome the inherent instability of the native modification, we report the synthesis of two sulfonate analogs and their incorporation into two thrombin-inhibiting sulfopeptides. The effective mimicry of these sulfonate analogs for native sulfotyrosine was validated in the context of their thrombin inhibitory activity and binding mode, as determined by X-ray crystallog. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Formula: C6H10Cl3NO

The Article related to peptide thrombin inhibitor synthesis sulfotyrosine, sulfonated aryl iodide negishi cross coupling iodoalanine, solid phase peptide synthesis microwave, thrombin crystal structure inhibitor mol docking and other aspects.Formula: C6H10Cl3NO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 2, 2018, Patel, Nitinchandra D.; Sieber, Joshua D.; Tcyrulnikov, Sergei; Simmons, Bryan J.; Rivalti, Daniel; Duvvuri, Krishnaja; Zhang, Yongda; Gao, Donghong A.; Fandrick, Keith R.; Haddad, Nizar; Lao, Kendricks So; Mangunuru, Hari P. R.; Biswas, Soumik; Qu, Bo; Grinberg, Nelu; Pennino, Scott; Lee, Heewon; Song, Jinhua J.; Gupton, B. Frank; Garg, Neil K.; Kozlowski, Marisa C.; Senanayake, Chris H. published an article.Formula: C6H10Cl3NO The title of the article was Computationally Assisted Mechanistic Investigation and Development of Pd-Catalyzed Asymmetric Suzuki-Miyaura and Negishi Cross-Coupling Reactions for Tetra-ortho-Substituted Biaryl Synthesis. And the article contained the following:

Metal-catalyzed cross-coupling reactions are extensively employed in both academia and industry for the synthesis of biaryl derivatives for applications to both medicine and material science. Application of these methods to prepare tetra-ortho-substituted biaryls leads to chiral atropisomeric products that introduce the opportunity to use catalyst control to develop asym. cross-coupling procedures to access these important compounds Asym. Pd-catalyzed Suzuki-Miyaura and Negishi cross-coupling reactions to form tetra-ortho-substituted biaryls were studied employing a collection of P-chiral dihydrobenzooxaphosphole (BOP) and dihydrobenzoazaphosphole (BAP) ligands. Enantioselectivities of up to 95:5 and 85:15 enantiomeric ratios were identified for the Suzuki-Miyaura and Negishi cross-coupling reactions, resp. Unique ligands for the Suzuki-Miyaura reaction vs the Negishi reaction were identified. A computational study on these Suzuki-Miyaura and Negishi cross-coupling reactions enabled an understanding in the differences between the enantiodiscriminating events between these two cross-coupling reactions. These results support that enantioselectivity in the Negishi reaction results from the reductive elimination step, whereas all steps in the Suzuki-Miyaura catalytic cycle contribute to the overall enantioselection with transmetalation and reductive elimination providing the most contribution to the observed selectivities. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Formula: C6H10Cl3NO

The Article related to computationally assisted mechanistic investigation, palladium catalyst asym suzuki miyaura negishi cross coupling, tetra ortho substituted biaryl synthesis, palladium, asymmetric, catalysis, cross-coupling, phosphines and other aspects.Formula: C6H10Cl3NO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Roesner, Stefan; Saunders, George J.; Wilkening, Ina; Jayawant, Eleanor; Geden, Joanna V.; Kerby, Paul; Dixon, Ann M.; Notman, Rebecca; Shipman, Michael published an article in 2019, the title of the article was Macrocyclization of small peptides enabled by oxetane incorporation.Product Details of 98946-18-0 And the article contains the following content:

Cyclic peptides are an important source of new drugs but are challenging to produce synthetically. We show that head-to-tail peptide macrocyclizations are greatly improved, as measured by isolated yields, reaction rates and product distribution, by substitution of one of the backbone amide C:O bonds with an oxetane ring. The cyclization precursors are easily made by standard solution- or solid-phase peptide synthesis techniques. Macrocyclizations across a range of challenging ring sizes (tetra-, penta- and hexapeptides) are enabled by incorporation of this turn-inducing element. Oxetane incorporation is shown to be superior to other established amino acid modifications such as N-methylation. The positional dependence of the modification on cyclization efficiency is mapped using a cyclic peptide of sequence LAGAY. We provide the first direct exptl. evidence that oxetane modification induces a turn in linear peptide backbones, through the observation of dNN (i, i + 2) and dαN (i, i + 2) NOEs, which offers an explanation for these improvements. For cyclic peptide, cLAGAY, a combination of NMR derived distance restraints and mol. dynamics simulations are used to show that this modification alters the backbone conformation in proximity to the oxetane, with the flexibility of the ring reduced and a new intramol. H-bond established. Finally, we incorporated an oxetane into a cyclic pentapeptide inhibitor of Aminopeptidase N, a transmembrane metalloprotease overexpressed on the surface of cancer cells. The inhibitor, cCNGRC, displayed similar IC50 values in the presence or absence of an oxetane at the glycine residue, indicating that bioactivity is fully retained upon amide C:O bond replacement. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Product Details of 98946-18-0

The Article related to cyclic peptide synthesis md simulation hydrogen bond safety, oxetane peptide coupling macrocyclization solid phase synthesis cyclization kinetics, peptide cyclic oxetane aminopeptidase n inhibiting structure activity and other aspects.Product Details of 98946-18-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics