Category: 98946-18-0

On December 19, 2016, Comba, Peter; Grimm, Laura; Orvig, Chris; Rueck, Katharina; Wadepohl, Hubert published an article.Safety of tert-Butyl trichloroacetimidate The title of the article was Synthesis and Coordination Chemistry of Hexadentate Picolinic Acid Based Bispidine Ligands. And the article contained the following:

The synthesis and CuII, NiII, ZnII, CoII and GaIII coordination chem. of the two isomeric hexadentate N5O ligands Hbispa1a and Hbispa1b (6-((9-hydroxy-1,5-bis(methoxycarbonyl)-7-methyl-6,8-di(pyridin-2-yl)-3,7-diazabicyclo[3.3.1]nonan-3-yl)methyl)picolinic acid and 6-((9-hydroxy-1,5-bis(methoxycarbonyl)-7-methyl-2,4-di(pyridin-2-yl)-3,7-diazabicyclo[3.3.1]nonan-3-yl)methyl)picolinic acid), picolinate-appended bispidines, are described. The two ligands are highly preorganized for octahedral coordination geometries and are particularly well suited for tetragonal symmetries, i.e. for Jahn-Teller labile ground states. This is confirmed by all data presented: the solid state structures, solution spectroscopy, electrochem. and the CuII complex stabilities. Differences in preorganization of the two isomers for the Jahn-Teller labile CuII centers are thoroughly analyzed from the crystal structures and an angular overlap model (AOM) based ligand field anal. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Safety of tert-Butyl trichloroacetimidate

The Article related to crystal structure transition metal picolinate bispidine complex, transition metal picolinate bispidine preparation spectroelectrochem, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.Safety of tert-Butyl trichloroacetimidate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On January 12, 2021, Hsu, Sheng-Hsin; Zhang, Shouqi; Huang, Sheng-Cih; Wu, Tung-Kung; Xu, Zhengren; Chang, Chin-Yuan published an article.Related Products of 98946-18-0 The title of the article was Characterization of enzymes catalyzing the formation of the nonproteinogenic amino acid L-Dap in capreomycin biosynthesis. And the article contained the following:

Capreomycin (CMN) and viomycin (VIO) are nonribosomal peptide antituberculosis antibiotics, the structures of which contain four nonproteinogenic amino acids, including L-2,3-diaminopropionic acid (L-Dap), β-ureidodehydroalanine, L-capreomycidine, and β-lysine. Previous bioinformatics anal. suggested that CmnB/VioB and CmnK/VioK participate in the formation of L-Dap; however, the real substrates of these enzymes are yet to be confirmed. We herein show that starting from O-phospho-L-Ser (OPS) and L-Glu precursors, CmnB catalyzes the condensation reaction to generate a metabolite intermediate N-(1-amino-1-carboxyl-2-ethyl)glutamic acid (ACEGA), which undergoes NAD+-dependent oxidative hydrolysis by CmnK to generate L-Dap. Furthermore, the binding site of ACEGA and the catalytic mechanism of CmnK were elucidated with the assistance of three crystal structures, including those of apo-CmnK, the NAD+-CmnK complex, and CmnK in an alternative conformation. The CmnK-ACEGA docking model revealed that the glutamate α-hydrogen points toward the nicotinamide moiety. It provides evidence that the reaction is dependent on hydride transfer to form an imine intermediate, which is subsequently hydrolyzed by a water mol. to produce L-Dap. These findings modify the original proposed pathway and provide insights into L-Dap formation in the biosynthesis of other related natural products. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Related Products of 98946-18-0

The Article related to capreomycin biosynthesis amino acid diaminopropionic acid enzyme structure saccharothrix, Enzymes: Separation-Purification-General Characterization and other aspects.Related Products of 98946-18-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On July 31, 2022, Clemens, Jennifer; Bell, Emily L.; Londregan, Allyn T. published an article.Product Details of 98946-18-0 The title of the article was Selective N2-Alkylation of 1H-Indazoles and 1H-Azaindazoles. And the article contained the following:

A general and selective procedure for the N2-alkylation of 1H-indazoles and 1H-azaindazoles is presented. Promoted by either trifluoromethanesulfonic acid or copper(II) triflate, diverse 1H-indazoles/azaindazoles are selectively alkylated with varied primary, secondary, and tertiary alkyl 2,2,2-trichloroacetimidates at the N2-nitrogen to afford the corresponding 2-alkyl-2H-indazoles/azaindazoles. Forty-one examples are included along with a discussion of reaction optimization, scope, and mechanism. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Product Details of 98946-18-0

The Article related to alkyl indazole azaindazole preparation regioselective, indazole azaindazole primary secondary tertiary alkyl trichloroacetimidate alkylation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Product Details of 98946-18-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On July 2, 2020, Oyama, Ryoko; Abe, Manabu published an article.HPLC of Formula: 98946-18-0 The title of the article was Reactivity and Product Analysis of a Pair of Cumyloxyl and tert-Butoxyl Radicals Generated in Photolysis of tert-Butyl Cumyl Peroxide. And the article contained the following:

Alkoxyl radicals play important roles in various fields of chem. Understanding their reactivity is essential to applying their chem. for industrial and biol. purposes. Hydrogen-atom transfer and C-C β-scission reactions have been reported from alkoxyl radicals. The ratios of these two processes were investigated using cumyloxyl (CumO•) and tert-butoxyl radicals (t-BuO•), resp. However, the products generated from the pair of radicals have not been investigated in detail. In this study, CumO• and t-BuO• were simultaneously generated from the photolysis of tert-Bu cumyl peroxide to understand the chem. behavior of the pair of radicals by analyzing the products and their distribution. ESR and/or transient absorption spectroscopy analyses of radicals, including CumO• and t-BuO•, provide more information about the radicals generated during the photolysis of tert-Bu cumyl peroxide. Furthermore, the photoproducts of (3-(tert-butylperoxy)pentane-3-yl)benzene demonstrated that the ether products were formed in in-cage reactions. The triplet-sensitized reaction induced by acetophenone, which is produced from CumO•, clarified that the spin state did not affect the product distribution. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).HPLC of Formula: 98946-18-0

The Article related to cumyloxyl tertbutoxyl radical formation reactivity peroxide photolysis, Physical Organic Chemistry: Degradation Reactions, Including Mass Spectral Fragmentation and other aspects.HPLC of Formula: 98946-18-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Schnell, Simon D.; Hoff, Lukas V.; Panchagnula, Advaita; Wurzenberger, Maximilian H. H.; Klapotke, Thomas M.; Sieber, Simon; Linden, Anthony; Gademann, Karl published an article in 2020, the title of the article was 3-Bromotetrazine: labelling of macromolecules via monosubstituted bifunctional s-tetrazines.Application In Synthesis of tert-Butyl trichloroacetimidate And the article contains the following content:

Synthesis and first characterization of the novel chem. probe 3-bromotetrazine and establish its reactivity toward nucleophiles was reported. This led to the synthesis of several novel classes of 3-monosubstituted s-tetrazines, e.g., I. A remarkable functional group selectivity was observed and was utilized to site-selectively functionalize different complex mols. The stability of 3-bromotetrazine under the reaction conditions facilitated the development of a protocol for protein functionalization, which enabled a “minimal”, bifunctional tetrazine unit as a bio-orthogonal handle for inverse electron demand Diels-Alder reactions. Addnl., a novel tetrazine-based chem. probe was developed and its application in the context of thiol-targeted natural product isolation and labeling of mammalian cells was demonstrated. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Application In Synthesis of tert-Butyl trichloroacetimidate

The Article related to chem probe bromotetrazine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Three Or More Hetero Atoms and other aspects.Application In Synthesis of tert-Butyl trichloroacetimidate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 15, 2021, Lu, Ronghua; Yang, Tilong; Chen, Xin; Fan, Wenzheng; Chen, Pinhong; Lin, Zhenyang; Liu, Guosheng published an article.Name: tert-Butyl trichloroacetimidate The title of the article was Enantioselective Copper-Catalyzed Radical Cyanation of Propargylic C-H Bonds: Easy Access to Chiral Allenyl Nitriles. And the article contained the following:

The first enantioselective copper-catalyzed cyanation of propargylic C-H bonds via radical relay was established using novel BoxOTMS ligands, providing an efficient and straightforward tool for the construction of structurally diverse chiral allenyl nitriles in good yields with excellent enantioselectivities. This reaction features high functional group tolerance and mild conditions. In addition, the chiral allene products can be readily converted to other chiral compounds via axis-to-center chirality transfer. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Name: tert-Butyl trichloroacetimidate

The Article related to trimethylsilyl cyanide aralakyl alkyne copper catalyst enantioselective chemoselective cyanation, aryl allenyl nitrile preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Name: tert-Butyl trichloroacetimidate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 17, 2017, Kondo, Hikaru; Kochi, Takuya; Kakiuchi, Fumitoshi published an article.Application of 98946-18-0 The title of the article was Selective Monoarylation of Aromatic Ketones and Esters via Cleavage of Aromatic Carbon-Heteroatom Bonds by Trialkylphosphine Ruthenium Catalysts. And the article contained the following:

We report here the ruthenium-catalyzed selective monoarylation of aromatic ketones bearing two ortho carbon-heteroatom (O or N) bonds. Under the newly developed catalyst system consisting of RuHCl(CO)(PiPr3)2, CsF, and styrene, the C-O arylation of 2′,6′-dimethoxyacetophenone with a phenylboronate gave the C-O monoarylation product selectively. The selective C-O monoarylation was applicable to a variety of arylboronates and aromatic ketones and proceeds with high regio- and chemoselectivities. A formal synthesis of altertenuol was also achieved using the C-O monoarylation of an aromatic ester as a key step. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Application of 98946-18-0

The Article related to regioselective monoarylation aromatic ketone ester trialkylphosphine ruthenium catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ketones and Derivatives, Including Quinones and Sulfur Analogs and other aspects.Application of 98946-18-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 6, 2015, Wallach, Daniel R.; Stege, Patrick C.; Shah, Jigisha P.; Chisholm, John D. published an article.Reference of tert-Butyl trichloroacetimidate The title of the article was Bronsted Acid Catalyzed Monoalkylation of Anilines with Trichloroacetimidates. And the article contained the following:

Trichloroacetimidates are useful alkylating agents for aromatic amines, requiring only a catalytic amount of a Bronsted acid to facilitate the reaction. Monoalkylation predominates under these conditions. E.g., in presence of camphorsulfonic acid in CH2Cl2 at room temperature, monoalkylation of 2,5-dichloroaniline with PhCHMeOC(:NH)CCl3 gave 97% I. Electron-poor anilines provide superior yields, with electron-rich anilines sometimes showing competitive Friedel-Crafts alkylation. A single flask protocol with formation of the imidate in situ is demonstrated, providing a convenient method for the direct substitution of alcs. with anilines. Reaction with a chiral imidate favors a mechanism that proceeds through a carbocation intermediate. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Reference of tert-Butyl trichloroacetimidate

The Article related to bronsted acid catalyst alkylation aniline trichloroacetimidate, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amines, Amine Oxides, Imines, and Quaternary Ammonium Compounds and other aspects.Reference of tert-Butyl trichloroacetimidate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 7, 2017, Adhikari, Arijit A.; Suzuki, Tamie; Gilbert, Reesheda T.; Linaburg, Matthew R.; Chisholm, John D. published an article.Recommanded Product: 98946-18-0 The title of the article was Rearrangement of Benzylic Trichloroacetimidates to Benzylic Trichloroacetamides. And the article contained the following:

The rearrangement of allylic trichloroacetimidates is a well-known transformation, but the corresponding rearrangement of benzylic trichloroacetimidates has not been explored as a method for the synthesis of benzylic amines. Conditions that provide the trichloroacetamide product from a benzylic trichloroacetimidate in high yield have been developed. Methods were also investigated to transform the trichloroacetamide product directly into the corresponding amine, carbamate, and urea. A cationic mechanism for the rearrangement is implicated by the available data. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Recommanded Product: 98946-18-0

The Article related to rearrangement benzylic trichloroacetimidate synthesis, benzylic trichloroacetamide preparation rearrangement benzyl trichloroacetimidate, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Recommanded Product: 98946-18-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bergamaschi, Greta; Lascialfari, Luisa; Pizzi, Andrea; Martinez Espinoza, Maria Isabel; Demitri, Nicola; Milani, Alberto; Gori, Alessandro; Metrangolo, Pierangelo published an article in 2018, the title of the article was A halogen bond-donor amino acid for organocatalysis in water.SDS of cas: 98946-18-0 And the article contains the following content:

Herein we report a halogen bond-donor amino acid, 4-iodotetrafluorophenylalanine, which behaves as a catalyst for the aqueous synthesis of bis-(heterocyclic)methanes. We also provide exptl. evidence that halogen bonding is a plausible explanation for the observed catalytic effect. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).SDS of cas: 98946-18-0

The Article related to halogen bond donor amino acid iodotetrafluorophenylalanine organocatalysis water, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.SDS of cas: 98946-18-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics