Category: 98-60-2

The author of 《Design, Synthesis, Acaricidal Activities, and Structure-Activity Relationship Studies of Novel Oxazolines Containing Sulfonate Moieties》 were Chen, Shilin; Zhang, Yu; Liu, Yuxiu; Wang, Qingmin. And the article was published in Journal of Agricultural and Food Chemistry in 2019. Category: chlorides-buliding-blocks The author mentioned the following in the article:

With the ultimate goal of addressing pest-related constraints on global agricultural production, combination principles were used to design and synthesize 2,4-diphenyl-1,3-oxazolines I (R = Me, Et, cyclohexyl, 2-FC6H4, 1-naphthyl, etc.) containing a sulfonate moiety at the para-position of the 4-Ph group. The target compounds, which have strong affinity for lipids and can be expected to traverse cell membranes, were characterized by 1H and 13C NMR spectroscopy and high-resolution mass spectrometry. Their activities against the larvae and eggs of carmine spider mites (Tetranychus cinnabarinus) were determined by a leaf-dipping method and compared with the activity of the com. acaricide etoxazole. Most of the test compounds displayed good ovicidal and larvicidal activities. In particular, the compound I (R = 4-t-BuC6H4) possessed better larvicidal activity (LC50 = 0.022 ± 0.009 mg/L) and ovicidal activity (0.044 ± 0.020 mg/L) than etoxazole (0.091 ± 0.051 and 0.095 ± 0.059 mg/L, resp.). Given its outstanding bioactivities, this compound deserves further attention as a pesticide candidate. After reading the article, we found that the author used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Category: chlorides-buliding-blocks)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Category: chlorides-buliding-blocks Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ali, Eslam M. H.; El-Telbany, Rania Farag A.; Abdel-Maksoud, Mohammed S.; Ammar, Usama M.; Mersal, Karim I.; Zaraei, Seyed-Omar; El-Gamal, Mohammed I.; Choi, Se-In; Lee, Kyung-Tae; Kim, Hee-Kwon; Lee, Kwan Hyi; Oh, Chang-Hyun published an article in 2021. The article was titled 《Design, synthesis, biological evaluation, and docking studies of novel (imidazol-5-yl)pyrimidine-based derivatives as dual BRAFV600E/p38α inhibitors》, and you may find the article in European Journal of Medicinal Chemistry.Computed Properties of C6H4Cl2O2S The information in the text is summarized as follows:

In the present work, a new series of (imidazol-5-yl)pyrimidine I ( Ar = C6H5, 4-ClC6H4, 4-BrC6H4 etc.; X = F, Cl; R = OCH3, OH) was designed and synthesized as dual inhibitors of BRAFV600E and p38α kinases which are considered as key regulators in mitogen-activated protein kinase signalling pathway. The target compounds were evaluated for dual kinase inhibitory activity. The tested compounds exhibited nanomolar scale IC50 values against BRAFV600E and low to sub-micromolar IC50 range against p38α. Compound I (Ar = 4-OHC6H4; X = F; R = OH) was identified as the most potent dual BRAFV600E/p38α inhibitor with IC50 values of 2.49 and 85 nM, resp. Further deep investigation revealed that Compound I (Ar = 4-OHC6H5; X = F; R = OH) possesses inhibitory activity of TNF-α production in lipopolysaccharide-induced RAW 264.7 macrophages with IC50 value of 96.3 nM. Addnl., the target compounds efficiently frustrated the proliferation of LOX-IMVI melanoma cell line. Compound I (Ar = 4-OHC6H5; X = F; R = OH) showed a satisfactory antiproliferative activity with IC50 value of 13μM, while, compound I (Ar = 3-FC6H4; X = F; R = OCH3) exhibited the highest cytotoxicity potency with IC50 value of 0.9μM. Compound I (Ar = 3-FC6H4; X = F; R = OCH3) is 11.11-fold more selective toward LOX-IMVI melanoma cells than IOSE-80PC normal cells. The results came from multiple reactions, including the reaction of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Computed Properties of C6H4Cl2O2S)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Computed Properties of C6H4Cl2O2S Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Unprecedented Reactivity of β-Iodovinyl Sulfones: An Efficient Synthesis of β-Keto Sulfones and β-Keto Thiosulfones》 were Reddy, Raju Jannapu; Kumar, Jangam Jagadesh; Kumari, Arram Haritha. And the article was published in European Journal of Organic Chemistry in 2019. Reference of 4-Chlorobenzenesulfonyl chloride The author mentioned the following in the article:

An unprecedented reactivity of (E)-β-iodovinyl sulfones in the presence of NaOAc is reported. The (E)-β-iodovinyl sulfones were treated with NaOAc in DMSO/H2O to yield β-keto sulfones in moderate to high yields. A novel oxidative difunctionalization of β-iodovinyl sulfones with thiosulfonates and NaOAc in DMF has been developed. This metal-free oxosulfenylation is an operationally simple to access a wide range of β-keto thiosulfones (α-thioaryl-β-keto sulfones) in moderate to high yields. The transformations were reliable at gram-scale, thus illustrating its efficiency and practicality. A plausible mechanism for the protocol is also proposed. In the experiment, the researchers used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Reference of 4-Chlorobenzenesulfonyl chloride)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Reference of 4-Chlorobenzenesulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Xie, Dandan; Hu, Xin; Ren, Xiaoli; Yang, Zaiping published an article in Frontiers in Chemistry (Lausanne, Switzerland). The title of the article was 《Synthesis and bioactivities of novel piperonylic acid derivatives containing a sulfonic acid ester moiety》.Formula: C6H4Cl2O2S The author mentioned the following in the article:

In order to develop efficient, broad-spectrum and structurally simple agricultural bactericide, the structure of piperonylic acid was modified and a series of novel piperonylic acid derivatives I [R = Ph, 2-naphthyl, benzyl, etc.] containing a sulfonic acid ester moiety was synthesized. Bioassay results indicated the compounds I exhibited significantly antibacterial activities. Among them, compound I [R = phenyl] exhibited excellent antibacterial activities against Pseudomonas syringae pv. Actinidiae (Psa), with inhibitory value 99 and 85% at 100μg/mL and 50μg/mL, resp., which was higher than that of thiodiazole-copper (84 and 77%) and bismerthiazol (96 and 78%). In addition, some compounds also showed moderate insecticidal activity against Spodoptera frugiperda. The above mentioned results confirm the broadening of the application of piperonylic acid, with reliable support for the development of novel agrochem. bactericide. The experimental process involved the reaction of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Formula: C6H4Cl2O2S)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Formula: C6H4Cl2O2S However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Category: chlorides-buliding-blocksIn 2019 ,《Anticancer profile of newly synthesized BRAF inhibitors possess 5-(pyrimidin-4-yl)imidazo[2,1-b]thiazole scaffold》 appeared in Bioorganic & Medicinal Chemistry. The author of the article were Abdel-Maksoud, Mohammed S.; Ammar, Usama M.; Oh, Chang-Hyun. The article conveys some information:

In this work, a new series of imidazo[2,1-b]thiazole was designed and synthesized. The new compounds are having 3-fluorophenyl at position 6 of imidazo[2,1-b]thiazole and pyrimidine ring at position 5. The pyrimidine ring containing either amide or sulfonamide moiety attached to a linker (Et or propyl) at position 2 of the pyrimidine ring. The final compounds were selected by NCI for in vitro cytotoxicity screening. Most derivatives showed cytotoxic activity against colon cancer and melanoma cell lines. In addition, IC50s of the target compounds were determined over A375 and SK-MEL-28 cell lines using sorafenib as pos. control. Compounds12b, 12c, 12e, 12f, 15a, 15d, 15f, 14g and 15h exhibited superior activity when compared to sorafenib. The most potent compounds were tested against wild type BRAF, v600e BRAF, and CRAF. Compound 15h exhibited a potential inhibitory effect againstV600EBRAF (IC50 = 9.3 nM). In the experimental materials used by the author, we found 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Category: chlorides-buliding-blocks)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Computed Properties of C6H4Cl2O2SIn 2022 ,《Synthesis and bioactivity of novel sulfonate scaffold-containing pyrazolecarbamide derivatives as antifungal and antiviral agents》 appeared in Frontiers in Chemistry (Lausanne, Switzerland). The author of the article were Lei, Zhi-Wei; Yao, Jianmei; Liu, Huifang; Ma, Chiyu; Yang, Wen. The article conveys some information:

Novel I [R = Ph, 4-methylphenyl, 2-chlorophenyl, etc] bearing a sulfonate fragment were synthesized to identify potential antifungal and antiviral agents. All the structures of the key intermediates and target compounds were confirmed by NMR and high-resolution mass spectrometry. The single-crystal X-ray diffraction of the compound I [R = 3-trifluoromethyl phenyl] showed that pyrazole carbamide is a sulfonate. The in vitro antifungal activities of the target compounds against Colletotrichum camelliae, Pestalotiopsis theae, Gibberella zeae, and Rhizoctonia solani were evaluated at 50μg/mL. Among the four pathogens, the target compounds exhibited the highest antifungal activity against Rhizoctonia solani. The compound I [R = phenylethyl] (EC50 = 0.45 mg/L) had higher antifungal activity than the com. fungicide hymexazol (EC50 = 10.49 mg/L) against R. solani, almost similar to bixafen (EC50 = 0.25 mg/L). Addnl., the target compounds exhibited protective effects in vivo against TMV. Thus, this study reveals that I. bearing a sulfonate fragment exhibited potential antifungal and antiviral activities. The experimental part of the paper was very detailed, including the reaction process of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Computed Properties of C6H4Cl2O2S)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Computed Properties of C6H4Cl2O2S Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nasrollahzadeh, Mahmoud; Nezafat, Zahra; Pakzad, Khatereh; Ahmadpoor, Fatemeh published an article in 2021. The article was titled 《Synthesis of magnetic chitosan supported metformin-Cu(II) complex as a recyclable catalyst for N-arylation of primary sulfonamides》, and you may find the article in Journal of Organometallic Chemistry.Recommanded Product: 4-Chlorobenzenesulfonyl chloride The information in the text is summarized as follows:

Immobilization of a copper complex on the magnetic chitosan bearing metformin ligand was developed through immobilizing structurally defined metformin with long tail of (3-chloropropyl)trimethoxysilane (TMOS). The synthesized Fe3O4-chitosan@metformin-Cu(II) complex (Fe3O4-CS@Met-Cu(II)) were used as an effective, reusable and magnetic catalyst in the N-arylation of different derivatives of primary sulfonamides with arylboronic acids in ethanol. The primary sulfonamides were prepared from the reaction of sulfonyl chlorides with sodium cyanate in water under ultrasonic irradiation Utilizing a wide variety of substrates in EtOH as a green solvent, high yields of the primary and secondary sulfonamides, easy work-up along with the excellent recovery and reusability of the catalyst, make this process a simple, economic and environmentally benign method. The synthesized Fe3O4-CS@Met-Cu(II) were characterized using various techniques such as XRD (X-ray diffraction), EDS (energy-dispersive X-ray spectroscopy), elemental mapping, TEM (transmission electron microscopy), FESEM (field emission SEM), VSM (vibrating sample magnetometer), ICP-MS (inductively coupled plasma mass spectroscopy), TGA (thermogravimetric anal.) and FT-IR (Fourier-transform IR spectroscopy) analyses. The catalyst was recycled and reused 5 times with no considerable loss of catalytic activity. The experimental process involved the reaction of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Recommanded Product: 4-Chlorobenzenesulfonyl chloride)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 4-Chlorobenzenesulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Murthy, Indraganti Sreenivasa; Sireesha, Reddymasu; Deepti, Kolli; Srinivasa Rao, P.; Ramesh Raju, R. published their research in Chemical Data Collections in 2021. The article was titled 《Design, synthesis and biological evaluation of sulphonamide derivatives of benzofuran-imidazopyridines as anticancer agents》.Electric Literature of C6H4Cl2O2S The article contains the following contents:

A novel library of sulfonamide derivatives of benzofuran-imidazopyridines I [R = 4-methoxyphenyl, 4-bromophenyl, 2,6-dimethylpyridine-4-yl, etc.] were designed, synthesized and screened for their anticancer activity against four human cancer cell lines such as breast cancer (MCF-7), lung cancer (A549), colon cancer (Colo-205) and ovarian cancer (A2780) by employing MTT assay. The results were expressed with IC50 μM, which indicated that all of the compounds I showed good to moderate activity on tested cell lines. Among them, compound I [R = 4-methoxyphenyl] showed potent anticancer activities against MCF-7, A549, Colo-205 and A2780 cell lines with IC50 values of 0.011 ± 0.0075μM, 0.073 ± 0.0012μM, 0.10 ± 0.19μM and 0.034 ± 0.0041μM resp. In the experimental materials used by the author, we found 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Electric Literature of C6H4Cl2O2S)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Electric Literature of C6H4Cl2O2S However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Design, Synthesis, Acaricidal Activities, and Structure-Activity Relationship Studies of Novel Oxazolines Containing Sulfonate Moieties》 were Chen, Shilin; Zhang, Yu; Liu, Yuxiu; Wang, Qingmin. And the article was published in Journal of Agricultural and Food Chemistry in 2019. Category: chlorides-buliding-blocks The author mentioned the following in the article:

With the ultimate goal of addressing pest-related constraints on global agricultural production, combination principles were used to design and synthesize 2,4-diphenyl-1,3-oxazolines I (R = Me, Et, cyclohexyl, 2-FC6H4, 1-naphthyl, etc.) containing a sulfonate moiety at the para-position of the 4-Ph group. The target compounds, which have strong affinity for lipids and can be expected to traverse cell membranes, were characterized by 1H and 13C NMR spectroscopy and high-resolution mass spectrometry. Their activities against the larvae and eggs of carmine spider mites (Tetranychus cinnabarinus) were determined by a leaf-dipping method and compared with the activity of the com. acaricide etoxazole. Most of the test compounds displayed good ovicidal and larvicidal activities. In particular, the compound I (R = 4-t-BuC6H4) possessed better larvicidal activity (LC50 = 0.022 ± 0.009 mg/L) and ovicidal activity (0.044 ± 0.020 mg/L) than etoxazole (0.091 ± 0.051 and 0.095 ± 0.059 mg/L, resp.). Given its outstanding bioactivities, this compound deserves further attention as a pesticide candidate. After reading the article, we found that the author used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Category: chlorides-buliding-blocks)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Category: chlorides-buliding-blocks Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ali, Eslam M. H.; El-Telbany, Rania Farag A.; Abdel-Maksoud, Mohammed S.; Ammar, Usama M.; Mersal, Karim I.; Zaraei, Seyed-Omar; El-Gamal, Mohammed I.; Choi, Se-In; Lee, Kyung-Tae; Kim, Hee-Kwon; Lee, Kwan Hyi; Oh, Chang-Hyun published an article in 2021. The article was titled 《Design, synthesis, biological evaluation, and docking studies of novel (imidazol-5-yl)pyrimidine-based derivatives as dual BRAFV600E/p38α inhibitors》, and you may find the article in European Journal of Medicinal Chemistry.Computed Properties of C6H4Cl2O2S The information in the text is summarized as follows:

In the present work, a new series of (imidazol-5-yl)pyrimidine I ( Ar = C6H5, 4-ClC6H4, 4-BrC6H4 etc.; X = F, Cl; R = OCH3, OH) was designed and synthesized as dual inhibitors of BRAFV600E and p38α kinases which are considered as key regulators in mitogen-activated protein kinase signalling pathway. The target compounds were evaluated for dual kinase inhibitory activity. The tested compounds exhibited nanomolar scale IC50 values against BRAFV600E and low to sub-micromolar IC50 range against p38α. Compound I (Ar = 4-OHC6H4; X = F; R = OH) was identified as the most potent dual BRAFV600E/p38α inhibitor with IC50 values of 2.49 and 85 nM, resp. Further deep investigation revealed that Compound I (Ar = 4-OHC6H5; X = F; R = OH) possesses inhibitory activity of TNF-α production in lipopolysaccharide-induced RAW 264.7 macrophages with IC50 value of 96.3 nM. Addnl., the target compounds efficiently frustrated the proliferation of LOX-IMVI melanoma cell line. Compound I (Ar = 4-OHC6H5; X = F; R = OH) showed a satisfactory antiproliferative activity with IC50 value of 13μM, while, compound I (Ar = 3-FC6H4; X = F; R = OCH3) exhibited the highest cytotoxicity potency with IC50 value of 0.9μM. Compound I (Ar = 3-FC6H4; X = F; R = OCH3) is 11.11-fold more selective toward LOX-IMVI melanoma cells than IOSE-80PC normal cells. The results came from multiple reactions, including the reaction of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Computed Properties of C6H4Cl2O2S)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Computed Properties of C6H4Cl2O2S Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics