Category: 98-60-2

《Cs2CO3-Mediated Vicinal Thiosulfonylation of 1,1-Dibromo-1-Alkenes with Thiosulfonates: An Expedient Synthesis of (E)-1,2-Thiosulfonylethenes》 was written by Reddy, Raju Jannapu; Kumari, Arram Haritha; Kumar, Jangam Jagadesh; Nanubolu, Jagadeesh Babu. Application of 98-60-2This research focused onthiosulfonylethene preparation diastereoselective; dibromoalkene thiosulfonate vicinal thiosulfonylation. The article conveys some information:

A new and highly efficient vicinal thiosulfonylation of 1,1-dibromo-1-alkenes ArCH=CBr2 (Ar = 3,4-dimethoxyphenyl, naphth-1-yl, furan-2-yl, etc.) with thiosulfonates R1S(O)2SR2 (R1 = Ph, 4-methylphenyl, naphth-2-yl, 4-chlorophenyl; R2 = Ph, 4-methylphenyl, naphth-2-yl, 4-chlorophenyl) in the presence of cesium carbonate has been developed. The metal-free diheterofunctionalization is operationally simple to access a wide range of (E)-1,2-thiosulfonylethenes (α-aryl-β-thioarylvinyl sulfones) ArC(S(O)2R1)=CHSR2 in moderate to high yields with high levels of stereoselectivities. Further, scalable reactions have been demonstrated for this transformation, thus illustrating its efficiency and practicality. In the experimental materials used by the author, we found 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Application of 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Application of 98-60-2 Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Quality Control of 4-Chlorobenzenesulfonyl chlorideIn 2021 ,《Structure based design, synthesis and evaluation of new thienopyrimidine derivatives as anti-bacterial agents》 was published in Journal of Molecular Structure. The article was written by Malasala, Satyaveni; Polomoni, Anusha; Ahmad, Naiyaz Md.; Shukla, Manjulika; Kaul, Grace; Dasgupta, Arunav; Chopra, Sidharth; Nanduri, Srinivas. The article contains the following contents:

A number of TrmD inhibitors including thienopyrimidines and fused thienopyrimidines were reported as potent antibacterial and anti-mycobacterial agents. A library of ∼200 structurally diverse thienopyrimidines were designed and subjected to preliminary in-silico studies. Among the library of compounds, 22 thienopyrimidines and fused thienopyrimidines compounds I [R = Ph,2-MeC6H4, 2,4-di-ClC6H3, etc.] II and III [R2 = benzyl, 3-nitrobenzyl, 2-(1H-indol-3-ylsulfanyl)acetyl, etc.] were selected, synthesized and were evaluated for their inhibitory activities against a panel of pathogens consisting E. coli, S. aureus, K. pneuminiae, A. baumannii and P. aeruginosa and M. tuberculosis (ATCC 27294). Among the tested compounds, II [R = 2-ClC6H4] III [R2 = benzyl, 3-nitrobenzyl, (2,4-dichlorophenyl)methyl, 2-oxo-2-(p-tolyl)ethyl, 2-(2-naphthyl)-2-oxo-ethyl] were found to inhibit M. tuberculosis (ATCC 27294) with the MIC of 16-32μg/mL. The compounds III [R2 = 3-nitrobenzyl, 2-(1H-indol-3-ylsulfanyl)acetyl] were found to be selective against S. aureus with the MIC of 4μg/mL and moderate activity against M. tuberculosis. The selected compounds were further subjected to docking, 3D-QSAR and ADMET studies to understand the mechanism of action and also their physico chem. profile. In the part of experimental materials, we found many familiar compounds, such as 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Quality Control of 4-Chlorobenzenesulfonyl chloride)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Quality Control of 4-Chlorobenzenesulfonyl chloride Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sankar, Rathinam; Bhattacharya, Debabrata; Arulananda Babu, Srinivasarao published their research in Asian Journal of Organic Chemistry in 2021. The article was titled 《Synthesis of 1-Naphthol-based Unsymmetrical Triarylmethanes: Heck-type Desulfitative Reaction of Arylsulfonyl Chlorides with Tetralone-derived Chalcones》.Name: 4-Chlorobenzenesulfonyl chloride The article contains the following contents:

Synthesis of 1-naphthol-based unsym. triarylmethanes via the Pd-catalyzed Heck-type desulfitative reaction and conjugate addition of arylsulfonyl chlorides with tetralone-derived chalcones was reported. Unsym. triarylmethanes were valuable mols. in organic-, medicinal and materials chem. Contributed towards enriching the library of unsym. triarylmethanes. The experimental part of the paper was very detailed, including the reaction process of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Name: 4-Chlorobenzenesulfonyl chloride)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Name: 4-Chlorobenzenesulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yang, Cai-Yun; Li, Xia; Liu, Bo; Huang, Guo-Li published an article in 2021. The article was titled 《I2-Promoted Direct C-H Sulfenylation of Isoquinolin-1(2H)-ones with Sulfonyl Chlorides》, and you may find the article in European Journal of Organic Chemistry.Application of 98-60-2 The information in the text is summarized as follows:

A simple, efficient, and green method for the iodine-promoted regioselective C-4 sulfenylation of isoquinolin-1(2H)-ones using com. available aryl sulfonyl chlorides as the sulfur source was described under metal- and solvent-free conditions. The reaction proceeded smoothly under simple conditions to obtain 4-arylthioisoquinolin-1(2H)-ones, e.g. I, in moderate to good yields, and showed high regioselectivity, broad substrate scope, and good functional group tolerance. A radical reaction mechanism involving ArS. radicals as key intermediates is proposed for the present transformation. In the part of experimental materials, we found many familiar compounds, such as 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Application of 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application of 98-60-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Modified and Scalable Synthesis of N-Tosyl-4-Chlorobenzenesulfonimidoyl Fluoride (SulfoxFluor): Direct Imidation of Sulfinyl Chlorides with Chloramine-T Trihydrate》 was written by Liu, Renxiang; Zhou, Xiao-Cong; He, Xin-Yi; Li, Yuan-Qiang; Zheng, Weiqin; Wang, Xiu; Guo, Junkai; Ni, Chuanfa; Hu, Jinbo. Application In Synthesis of 4-Chlorobenzenesulfonyl chlorideThis research focused ontosyl chlorobenzenesulfonimidoyl fluoride preparation. The article conveys some information:

A general and practical method for the preparation of N-Tosyl-4-chlorobenzenesulfonimidoyl fluoride (SulfoxFluor) and its adaptation to a large scale was disclosed. Starting from readily available 4-chlorobenzenesulfonyl chloride, chloramine-T trihydrate and potassium fluoride, SulfoxFluor was prepared on a hectogram scale in 63% overall yield with simple purification techniques. The use of chloramine-T trihydrate (instead of anhydrous chloramine-T) was a significant improvement over previous work, which streamlined the process and avoided the risk of explosion during drying or heating. This research not only established a reliable method for the scale-up synthesis of SulfoxFluor but also provided an insight into the imidation of sulfinyl chlorides with chloramine-T in the presence of water. In the experiment, the researchers used many compounds, for example, 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Application In Synthesis of 4-Chlorobenzenesulfonyl chloride)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Application In Synthesis of 4-Chlorobenzenesulfonyl chloride Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Nale, Sagar D.; Datta Khanal, Hari; Rok Lee, Yong published an article in European Journal of Organic Chemistry. The title of the article was 《Palladium(II)-Catalyzed Direct Arylations of Quinoxalin-2(1H)-ones with Arylsulfonyl Chlorides》.Recommanded Product: 98-60-2 The author mentioned the following in the article:

A palladium-catalyzed desulfitative coupling of quinoxalin-2(1H)-ones with arylsulfonyl chlorides is described. C3-Arylquinoxalin-2(1H)-ones are readily accessible by reacting various arylsulfonyl chloride derivatives with quinoxalin-2(1H)-ones. The arylsulfonyl chloride undergoes palladium-catalyzed C-S and S-Cl bond cleavage, which leads to direct desulfitative cross-coupling with the quinoxalin-2(H)-one. Chloro- and fluoro-aryl sulfonyl chlorides are successfully coupled with quinoxalin-2(1H)-ones without carbon-halogen bond cleavage. The results came from multiple reactions, including the reaction of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Recommanded Product: 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 98-60-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Angewandte Chemie, International Edition included an article by Yuan, Si-Wen; Han, Hui; Li, Yan-Lin; Wu, Xueli; Bao, Xiaoguang; Gu, Zheng-Yang; Xia, Ji-Bao. Quality Control of 4-Chlorobenzenesulfonyl chloride. The article was titled 《Intermolecular C-H Amidation of (Hetero)arenes to Produce Amides through Rhodium-Catalyzed Carbonylation of Nitrene Intermediates》. The information in the text is summarized as follows:

Amide bond formation is one of the most important reactions in organic chem. because of the widespread presence of amides in pharmaceuticals and biol. active compounds Existing methods for amides synthesis are reaching their inherent limits. Described herein is a novel rhodium-catalyzed three-component reaction to synthesize amides from organic azides, carbon monoxide, and (hetero)arenes via nitrene-intermediates and direct C-H functionalization. Notably, the reaction proceeds in an intermol. fashion with N2 as the only byproduct, and neither directing groups nor additives are required. The computational and mechanistic studies show that the amides are formed via a key Rh-nitrene intermediate. Thus, e.g., 1-methylindole + CO + TsN3 → 1-methyl-N-tosylindole-3-carboxamide (92%, 88% isolated) in presence of [Rh(cod)Cl]2 in MeCN. The results came from multiple reactions, including the reaction of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Quality Control of 4-Chlorobenzenesulfonyl chloride)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Quality Control of 4-Chlorobenzenesulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Roy, Bibhisan; Maisuls, Ivan; Zhang, Jianyu; Niemeyer, Felix C.; Rizzo, Fabio; Wolper, Christoph; Daniliuc, Constantin G.; Tang, Ben Zhong; Strassert, Cristian A.; Voskuhl, Jens published an article in Angewandte Chemie, International Edition. The title of the article was 《Mapping the Regioisomeric Space and Visible Color Range of Purely Organic Dual Emitters with Ultralong Phosphorescence Components: From Violet to Red Towards Pure White Light》.Synthetic Route of C6H4Cl2O2S The author mentioned the following in the article:

We mapped the entire visible range of the electromagnetic spectrum and achieved white light emission (CIE: 0.31, 0.34) by combining the intrinsic ns-fluorescence with ultralong ms-phosphorescence from purely organic dual emitters. We realized small mol. materials showing high photoluminescence quantum yields (ΦL) in the solid state at room temperature, achieved by active exploration of the regioisomeric substitution space. Chromophore stacking-supported stabilization of triplet excitons with assistance from enhanced intersystem crossing channels in the crystalline state played the primary role for the ultra-long phosphorescence. This strategy covers the entire visible spectrum, based on organic phosphorescent emitters with versatile regioisomeric substitution patterns, and provides a single mol. source of white light with long lifetime (up to 163.5 ms) for the phosphorescent component, and high overall photoluminescence quantum yields (up to ΦL=20 %). In the experiment, the researchers used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Synthetic Route of C6H4Cl2O2S)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Synthetic Route of C6H4Cl2O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Falconnet, Alban; Arndt, Jan-Dirk; Hashmi, A. Stephen K.; Schaub, Thomas published an article in 2022. The article was titled 《Triflic-Acid-Catalyzed Friedel-Crafts Reaction for the Synthesis of Diaryl Sulfones》, and you may find the article in European Journal of Organic Chemistry.Related Products of 98-60-2 The information in the text is summarized as follows:

The Friedel-Crafts sulfonylation for the synthesis of diaryl sulfones derivatives was achieved by using triflic acid (TfOH) as the acidic catalyst with aryl sulfonyl chlorides and arenes at elevated temperatures Different sulfones could be synthesized with this method in good to excellent yield and with high selectivity. In contrast to the previous methodol. reported for this sulfonylation, the catalyst and the excess of arene could be easily recovered and re-used in further batches. The experimental process involved the reaction of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Related Products of 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Related Products of 98-60-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Murthy, Indraganti Sreenivasa; Sireesha, Reddymasu; Deepti, Kolli; Srinivasa Rao, P.; Ramesh Raju, R. published their research in Chemical Data Collections in 2021. The article was titled 《Design, synthesis and biological evaluation of sulphonamide derivatives of benzofuran-imidazopyridines as anticancer agents》.Electric Literature of C6H4Cl2O2S The article contains the following contents:

A novel library of sulfonamide derivatives of benzofuran-imidazopyridines I [R = 4-methoxyphenyl, 4-bromophenyl, 2,6-dimethylpyridine-4-yl, etc.] were designed, synthesized and screened for their anticancer activity against four human cancer cell lines such as breast cancer (MCF-7), lung cancer (A549), colon cancer (Colo-205) and ovarian cancer (A2780) by employing MTT assay. The results were expressed with IC50 μM, which indicated that all of the compounds I showed good to moderate activity on tested cell lines. Among them, compound I [R = 4-methoxyphenyl] showed potent anticancer activities against MCF-7, A549, Colo-205 and A2780 cell lines with IC50 values of 0.011 ± 0.0075μM, 0.073 ± 0.0012μM, 0.10 ± 0.19μM and 0.034 ± 0.0041μM resp. In the experimental materials used by the author, we found 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Electric Literature of C6H4Cl2O2S)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Electric Literature of C6H4Cl2O2S However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics