Category: 98-60-2

In 2022,Zhang, Tianyuan; Zheng, Shumin; You, Shuyan; Huang, Danling; Cheng, Yong-Xian published an article in Medicinal Chemistry Research. The title of the article was 《Design and synthesis of potential fungicidal compounds derived from natural products, (-)-menthol and (-)-borneol》.Product Details of 98-60-2 The author mentioned the following in the article:

Twelve Novel compounds I[ R1=R2 = H, CH3, Cl etc], II[ R1= R2 = H, CH3, Cl etc] derived from (-)-menthol and (-)-borneol were designed, synthesized and characterized by 1H NMR, 13C NMR, and HRMS. The fungicidal activities of these novel compounds I and II against Botrytis cinerea, Curvularia lunata and Alternaria alternata were evaluated. The results indicated that II[ R1 = R2 = F] displayed potential fungicidal activities against B. cinerea and C. lunata. Especially, II[ R1 = R2 = F] exhibited IC50 value of 22.9 mg/L against C. lunata, which was higher fungicidal activity than com. product hymexazol and amicarthiazol. In addition, the superficial structure-activity relationship were discussed. This study provided a structural template for the design of novel fungicides. In addition to this study using 4-Chlorobenzenesulfonyl chloride, there are many other studies that have used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Product Details of 98-60-2) was used in this study.

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Product Details of 98-60-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Category: chlorides-buliding-blocksIn 2021 ,《Design, synthesis, in vitro determination and molecular docking studies of 4-(1-(tert-butyl)-3-phenyl-1H-pyrazol-4-yl)pyridine derivatives with terminal sulfonamide derivatives in LPS-induced RAW264.7 macrophage cells》 was published in Medicinal Chemistry Research. The article was written by Mersal, Karim I.; Abdel-Maksoud, Mohammed S.; Ali, Eslam M. H.; Ammar, Usama M.; Zaraei, Seyed-Omar; Kim, Jae-Min; Kim, Su-Yeon; Lee, Kyung-Tae; Lee, Kwan Hyi; Kim, Si-Won; Park, Hyun-Mee; Ji, Mi-Jung; Oh, Chang-Hyun. The article contains the following contents:

In the present work, a new series of 4-(1-(tert-butyl)-3-phenyl-1H-pyrazol-4-yl)pyridine possessing terminal Et or Pr sulfonamides I (R = H, F; n = 2,3; Ar = Ph, 4-FC6H4, 1-naphthyl, etc.) was designed and synthesized. The cytotoxic effect of the final compounds was measured by applying MTT assay in LPS-Induced RAW264.7 macrophage cells. The final target compounds were screened for their anti-inflammatory effect through their ability to inhibit NO and PGE2 production and cytokines production (TNF-α, IL-6, IL-1β) in LPS-induced RAW264.7 macrophage at 10μM concentration Compounds I (R = H; n = 3; Ar = 1-naphthyl), I (R = F; n = 3; Ar = 4-BrC6H4), and I (R = F; n = 3; Ar = 1-naphthyl) showed the highest inhibitory effect on NO production Compounds I (R = H, F; n = 3; Ar = 1-naphthyl) exhibited high PGE2 inhibition with IC50 values of 3.47, 2.54μM, resp. Compounds I (R = H, F; n = 3; Ar = 1-naphthyl) exhibited high cytokines inhibition >/= 60%. The most potent compounds I (R = H, F; n = 3; Ar = 1-naphthyl) were tested to determine their effect on iNOS and COX-2 mRNA expression level. Compound I (R = F; n = 3; Ar = 1-naphthyl) were activity on iNOS and COX-2 proteins level, pro-inflammatory mediators and cytokines was determined and showed remarkable inhibition for both proteins level. Compounds I (R = H, F; n = 3; Ar = 1-naphthyl) showed high binding affinity to COX-2 active site and exhibited similar binding interactions of the native ligand celecoxib. In addition to this study using 4-Chlorobenzenesulfonyl chloride, there are many other studies that have used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Category: chlorides-buliding-blocks) was used in this study.

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Xu, Zekun; Jiang, Jun; Lu, Qianqian; Chen, Jingyun; Chen, Shufang; Shi, Liyang; Yimei Zhao published an article in Journal of Organometallic Chemistry. The title of the article was 《Photoredox Catalyzed Sulfonylation of Multisubstituted Allenes with Ru(bpy)3Cl2 or Rhodamine B》.COA of Formula: C6H4Cl2O2S The author mentioned the following in the article:

A highly regio- and stereoselective sulfonylation of allenes was developed that provided direct access to α,β-substituted unsaturated sulfones I [R1 = Ph, 4-ClC6H4, 4-MeC6H4, etc.; R2 = H, Ph; R3 = Ph, 4-MeC6H4, 4-ClC6H4, etc.; R4 = Me, CH2C(O)OEt]. By means of visible-light photoredox catalysis, the free radicals produced by p-toluenesulfonic acid reacted with multisubstituted allenes to obtain Markovnikov-type vinyl sulfones with Ru(bpy)3Cl2 or Rhodamine B as photocatalyst. The yield of this reaction could reach up to 91%. A series of unsaturated sulfones would be used for further transformation to some valuable compounds After reading the article, we found that the author used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2COA of Formula: C6H4Cl2O2S)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. COA of Formula: C6H4Cl2O2S However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Gong, Bozhen; Zhu, Haibo; Yang, Liu; Wang, Haifeng; Fan, Qiangwen; Xie, Zongbo; Le, Zhanggao published an article in Organic & Biomolecular Chemistry. The title of the article was 《Base-promoted synthesis of diarylsulfones from sulfonyl hydrazines and diaryliodonium salts》.Related Products of 98-60-2 The author mentioned the following in the article:

An efficient and concise method for the synthesis of diaryl sulfones ArS(O)2Ar1 [Ar = Ph, 4-MeC6H4, 4-NCC6H4, etc.; Ar1 = Ph, 4-FC6H4, 3-MeC6H4, etc.] via metal-free sulfonylation from sulfonyl hydrazines with sym. or unsym. diaryliodonium salts using n-PrOH as the solvent was developed with high selectivity. Using n-PrOH as the solvent, diaryl sulfones are formed even on a gram scale. After reading the article, we found that the author used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Related Products of 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Related Products of 98-60-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cellnik, Torsten; Healy, Alan R. published an article in 2022. The article was titled 《Sulfonyl Chlorides as Thiol Surrogates for Carbon-Sulfur Bond Formation: One-Pot Synthesis of Thioethers and Thioesters》, and you may find the article in Journal of Organic Chemistry.Safety of 4-Chlorobenzenesulfonyl chloride The information in the text is summarized as follows:

A method to synthesize thioethers and thioesters directly from readily available sulfonyl chlorides was reported. A transient intermediate formed during phosphine-mediated deoxygenation of sulfonyl chlorides was trapped in situ by activated alcs. or carboxylic acids to effect carbon-sulfur bond formation. The method is operationally simple and tolerates a broad range of functional groups. Special attention was focused on the late-stage diversification of densely functionalized natural products and pharmaceuticals. The experimental part of the paper was very detailed, including the reaction process of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Safety of 4-Chlorobenzenesulfonyl chloride)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Safety of 4-Chlorobenzenesulfonyl chloride Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Firoozi, Somayeh; Hosseini-Sarvari, Mona published their research in Journal of Organic Chemistry in 2021. The article was titled 《Nanosized CdS as a Reusable Photocatalyst: The Study of Different Reaction Pathways between Tertiary Amines and Aryl Sulfonyl Chlorides through Visible-Light-Induced N-Dealkylation and C-H Activation Processes》.Name: 4-Chlorobenzenesulfonyl chloride The article contains the following contents:

The final products of the reaction of sulfonyl chlorides and tertiary amines in the presence of cadmium sulfide nanoparticles under visible light irradiation are highly dependent on the applied reaction conditions. Interestingly, with the change of a reaction condition, different pathways were conducted (visible-light-induced N-dealkylation or sp3 and sp2 C-H activation) that lead to different products such as secondary amines and various sulfonyl compounds Remarkably, all of these reactions were performed under visible light irradiation and an air atm. without any additive or oxidant in benign solvents or under solvent-free conditions. During this study, the CdS nanoparticles as affordable, heterogeneous, and recyclable photocatalysts were designed, successfully synthesized, and fully characterized and applied for these protocols. During these studies, intermediates resulting from the oxidation of tertiary amines are trapped during the photoinduced electron transfer (PET) process. The reaction was carried out efficiently with a variety of substrates to give the corresponding products at relatively short times in good to excellent yields in parallel with the use of the visible light irradiation as a renewable energy source. Most of these processes are novel or are superior in terms of cost effectiveness, safety, and simplicity to published reports. In addition to this study using 4-Chlorobenzenesulfonyl chloride, there are many other studies that have used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Name: 4-Chlorobenzenesulfonyl chloride) was used in this study.

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Name: 4-Chlorobenzenesulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Palladium-Catalyzed ortho-Benzoylation of Sulfonamides through C-H Activation: Expedient Synthesis of Cyclic N-Sulfonyl Ketimines》 was published in Advanced Synthesis & Catalysis in 2020. These research results belong to Ojha, Subhadra; Panda, Niranjan. Recommanded Product: 98-60-2 The article mentions the following:

The ortho-carbonylation of sulfonylarenes by non-hazardous aryl aldehydes as a carbonyl precursor was reported. In this method, the sulfonamide group served as a directing group for C-H activation in the presence of a Pd catalyst under ligand-free conditions. The scope of this strategy was extended to the one-pot two-step synthesis of cyclic N-sulfonyl ketimines under mild reaction conditions. Our approach could be considered as an alternative by circumventing the use of highly reactive organolithium or Grignard reagents to access a wide range of biol. potent cyclic N-sulfonyl ketimines. In the part of experimental materials, we found many familiar compounds, such as 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Recommanded Product: 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 98-60-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Synthesis of unsymmetrical disulfides via PPh3-mediated reductive coupling of thiophenols with sulfonyl chlorides》 was written by Wang, Dungai; Liang, Xiao; Xiong, Mingteng; Zhu, Heping; Zhou, Yifeng; Pan, Yuanjiang. Recommanded Product: 98-60-2This research focused onunsym disulfide preparation; thiophenol aryl sulfonyl chloride reductive coupling triphenylphosphine mediated. The article conveys some information:

A facile and rapid synthesis of unsym. aryl disulfides R1-S-S-R2 [R1 = 4-MeC6H4, 4-FC6H4, 2-naphthyl, etc.; R2 = 4-MeOC6H4, 2-NCC6H44, 4-ClC6H4, etc.] using PPh3-mediated reductive coupling of thiophenols with aryl sulfonyl chlorides under catalyst- and base-free conditions in moderate to excellent isolated yields was described. Good functional group tolerance and scalability were achieved in this strategy. The experimental process involved the reaction of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Recommanded Product: 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Recommanded Product: 98-60-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Black TiO2 nanoparticles with efficient photocatalytic activity under visible light at low temperature: regioselective C-N bond cleavage toward the synthesis of thioureas, sulfonamides, and propargylamines》 was written by Koohgard, Mehdi; Hosseini-Sarvari, Mona. HPLC of Formula: 98-60-2This research focused onthiourea sulfonamide propargylamine preparation regioselective photochem; tertiary amine carbon nitrogen bond cleavage black titanium dioxide; black titanium dioxide nanoparticle catalyst preparation. The article conveys some information:

Several different colored forms of TiO2 were prepared through the easy treatment of white TiO2 and NaBH4 as a safe hydrogen source. These types of modified TiO2 showed a quite acceptable visible light response. Then, tertiary amines were harnessed toward the regioselective synthesis of three prominent scaffolds, namely sulfonamides, thioureas, and propargylamines, using black TiO2 under visible light. For the first time, this type of modified TiO2 was easily prepared and exploited to handle organic transformations under visible light. Black TiO2-catalyzed oxidative C-N cleavage of tertiary amines was the key point of these transformations. Herein, the first report of the visible-light-driven synthesis of unsym. thioureas and propargylamines from tertiary amines has been presented. In the experiment, the researchers used many compounds, for example, 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2HPLC of Formula: 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.HPLC of Formula: 98-60-2 Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Yuan, Ye; Guo, Dou; Liu, Yibo; Wan, Congcong; Lu, Dongbiao; Yang, Hongxiang; Lu, Yufan; Meng, Wei; Wang, Hongling; Zhang, Xiang published an article in European Journal of Organic Chemistry. The title of the article was 《Iron(III)-Mediated Nucleophilic Halogenation of Phenols Using an Amido Directing Group》.Application In Synthesis of 4-Chlorobenzenesulfonyl chloride The author mentioned the following in the article:

A regioselective and nucleophilic halogenation of electron-rich amidophenols was realized in the presence of Fe(III) reagents and amido-directing groups. Halides could be sequentially introduced to specific positions to form mono-, di- and mixed di- halogenated amidophenols I [R = 3-NHC(O)Ph, 2-NHC(O)Ph, 2-NHC(O)Cy, etc.; X = 4-Cl, 4-Br, 2-Br-4-Cl, etc.] using using ferric chloride/bromide . Furthermore, this protocol provided new methods for the syntheses of IKK2 inhibitor (IMD-0354), muscle relaxant (Chlorzoxazone) and related derivatives The results came from multiple reactions, including the reaction of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Application In Synthesis of 4-Chlorobenzenesulfonyl chloride)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Application In Synthesis of 4-Chlorobenzenesulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics