Category: 98-60-2

《Synthesis, characterization and biological activities of sulfonamide tagged 1,2,3-triazoles》 was published in Synthetic Communications in 2020. These research results belong to Kaushik, C. P.; Chahal, Manisha; Luxmi, Raj; Kumar, Devinder; Kumar, Ashwani; Kumar, Mukesh; Singh, Dharmendra. Recommanded Product: 4-Chlorobenzenesulfonyl chloride The article mentions the following:

The synthesis of a series of sulfonamide containing 1,4-disubstituted 1,2,3-triazoles I [R1 = H, F, Cl, Br; R2 = Ph, 3-pyridinyl, 1-naphthyl, etc.] through click reaction of terminal alkynes with aromatic azides was reported. The synthesized triazoles I were characterized by FTIR, 1H NMR,13C NMR and HRMS techniques. Further, the structures of synthesized compounds I [R1 = Cl, R2 = 4-chlorophenyl] (CCDC 1954932) and I [R1 = Br, R2 = 4-chlorophenyl] (CCDC 1954931) were also confirmed by X-ray crystallog. The synthesized triazoles I were evaluated for in-vitro antibacterial activity against S. aureus, B.subtilis, E. coli and K. pneumoniae by serial dilution method. Among the series, compounds I [R1 = Br, R2 = 4-bromophenyl, 1-naphthyl] (MIC = 0.025μM/mL) and (MIC = 0.027μM/mL) resp. exhibited the appreciable antibacterial activity against Staphylococcus aureus and Bacillus subtilis. Further, the mol. docking studies of above potent analogs with dihydropteroate synthase was performed to have an insight for binding interactions. Synthesized mols. I were also explored for antioxidant activity, reflecting compound I [R1 = F, R2 = 4-chlorophenyl] as better radical scavenging agent with IC50 value of 1.96μM/mL. In the part of experimental materials, we found many familiar compounds, such as 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Recommanded Product: 4-Chlorobenzenesulfonyl chloride)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Recommanded Product: 4-Chlorobenzenesulfonyl chloride The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Arylsulfochlorination of β-aminopropioamidoximes giving 2-aminospiropyrazolylmorpholine-ammonium arylsulfonates》 was published in Russian Chemical Bulletin in 2020. These research results belong to Kayukova, L. A.; Praliyev, K. D.; Myrzabek, A. B.; Kainarbayeva, Zh. N.. Synthetic Route of C6H4Cl2O2S The article mentions the following:

The reaction of P-(morpholin-1-yl)propioamidoxime with aromatic sulfonyl chlorides (p-XC6H4SO2Cl; X = CH3O, CH3, H, Br, Cl, NO2) in chloroform in the presence of triethylamine does not produce expected O-arylsulfonyl-β-(morpholin-1-yl)propioamidoximes; instead, this reaction affords isomers of the latter compounds, 2-amino-8-oxa-l,5-diazaspiro[4.5]dec-1-ene-5-ammonium arylsulfonates. The structures of the reaction products were established by physicochem. methods, spectroscopy, and X-ray diffraction. In the experiment, the researchers used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Synthetic Route of C6H4Cl2O2S)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Synthetic Route of C6H4Cl2O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Synthesis, evaluation of thymidine phosphorylase and angiogenic inhibitory potential of ciprofloxacin analogues: Repositioning of ciprofloxacin from antibiotic to future anticancer drugs》 was published in Bioorganic Chemistry in 2020. These research results belong to Shahzad, Sohail Anjum; Sarfraz, Ayesha; Yar, Muhammad; Khan, Zulfiqar Ali; Naqvi, Syed Ali Raza; Naz, Sadia; Khan, Nazeer Ahmad; Farooq, Umar; Batool, Razia; Ali, Muhammad. Computed Properties of C6H4Cl2O2S The article mentions the following:

Discovery of potent inhibitors of thymidine phosphorylase (TP) can offer appropriate approach in cancer treatment. A series of ciprofloxacin derivatives has been synthesized and inhibitory activity of these ciprofloxacin derivatives against thymidine phosphorylase enzyme was assessed. Out of these twelve analogs of ciprofloxacin, nine analogs exhibited good inhibitory activity against thymidine phosphorylase. Inhibitory activity as presented by their IC50 values was found in the range of 39.71 ± 1.13 to 161.89 ± 0.95μM. The 7-deazaxanthine was used as a standard inhibitor with IC50 = 37.82 ± 0.93μM. Furthermore, the chick chorionic allantoic membrane (CAM) assay was used to investigate anti-angiogenic activity of the most active ciprofloxacin-based inhibitor compound I. To enlighten the important binding interactions of ciprofloxacin derivatives with target enzyme, the structure activity relationship and mol. docking studies of chosen ciprofloxacin analogs was discussed. Docking studies revealed key π-π stacking, π-cation and hydrogen bonding interactions of ciprofloxacin analogs with active site residues of thymidine phosphorylase enzyme. In the experiment, the researchers used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Computed Properties of C6H4Cl2O2S)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Computed Properties of C6H4Cl2O2S Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Discovery of novel 1,3,5-triazine derivatives as potent inhibitor of cervical cancer via dual inhibition of PI3K/mTOR》 was written by Hu, Junbo; Zhang, Yanli; Tang, Na; Lu, Yanju; Guo, Peng; Huang, Ziming. Quality Control of 4-Chlorobenzenesulfonyl chlorideThis research focused ontriazine preparation cervical antitumor activity enzyme inhibitor SAR; 1,3,5-triazine; Apoptosis; Cell cycle; Cell viability; Cervical cancer; PI3K; mTOR. The article conveys some information:

This study describes the synthesis of novel 1,3,5-triazine derivatives I (R = H, 2-OMe, 3-NO2, 4-Cl, etc.) as potent inhibitors of cervical cancer. The compounds I were initially tested for inhibition of PI3K/mTOR, where they showed significant inhibitory activity. The top-ranking mol. [compound I (R = 4-OH) (II)] was further tested against class I PI3K isoforms, such as PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, where it showed the most significant activity against PI3Kα. Compound II was then tested for anti-cancer activity against triple-neg. breast cancer cells (MDA-MB321), human breast cancer cells (MCF-7), human cervical cancer cells (HeLa) and human liver cancer cells (HepG2), and it showed the greatest potency against HeLa cells. The effects of compound II were further evaluated against the HeLa cells, where it showed significant attenuation of cell viability by inducing cell cycle arrest in the G1 phase. Compound II induced apoptosis and reduced migration and invasion of HeLa cells. Western blotting anal. showed that II inhibited PI3K and mTOR with pos. modulation of Bcl-2 and Bax levels in HeLa cells. The effects of compound II were also investigated in a tumor xenograft mouse model, where it showed reduction of tumor volume and weight It also inhibited the PI3K/Akt/mTOR signaling cascade in xenograft tumor tissues, as evidenced by western blotting anal. The results of the present study suggest the possible utility of the designed 1,3,5-triazine derivative I as a potent inhibitor of cervical cancer. After reading the article, we found that the author used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Quality Control of 4-Chlorobenzenesulfonyl chloride)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Quality Control of 4-Chlorobenzenesulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application In Synthesis of 4-Chlorobenzenesulfonyl chlorideIn 2019 ,《KI-catalyzed synthesis of S-Thiocarbamates by cross-coupling of cyclohexyl isocyanide with sulfonyl chlorides》 was published in Journal of Chemical Research. The article was written by Lin, Liangwei; Fang, Zhengjun; Li, Yajun; Wu, Feng; Au, Chaktong; Luo, Sai. The article contains the following contents:

A simple and efficient process for direct generation of various S-thiocarbamates I (Ar = Ph, 4-MeC6H4, 4-ClC6H4, etc.) is developed by cross-coupling of readily available sulfonyl chlorides with cyclohexyl isocyanide. The yields are excellent and the structures of the generated S-thiocarbamates are characterized by NMR spectroscopy, IR spectroscopy, and high-resolution mass spectrometry together with X-ray crystallog. anal. The protocol has the advantages of using easily available reagents, employs inexpensive KI as the reagent, demonstrates good functional group tolerance, and utilizes mild reaction conditions. The results came from multiple reactions, including the reaction of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Application In Synthesis of 4-Chlorobenzenesulfonyl chloride)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application In Synthesis of 4-Chlorobenzenesulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yuan, Pan-Feng; Huang, Tao; He, Jian; Huang, Xie-Tian; Jin, Xiao-Ling; Sun, Chunlin; Wu, Li-Zhu; Liu, Qiang published an article in 2021. The article was titled 《Controllable Z/E-selective synthesis of α-amino-ketoximes from N-nitrososulfonamides and aryl alkenes under neutral conditions》, and you may find the article in Organic Chemistry Frontiers.COA of Formula: C6H4Cl2O2S The information in the text is summarized as follows:

Design of a photosensitization strategy to generate the unique triplet state reactivity of N-nitrososulfoximides, specifically N-methyl-N-nitroso-p-toluenesulfonamides (NANS1) and the subsequent installation of both N-centered sulfonamidyl radical and nitric oxide functionalities into aryl alkene feedstocks were reported, which was mild and completely atom economical, exhibited broad functional group tolerance and occur readily under neutral conditions. Furthermore, this newly developed methodol. was also compatible with both terminal and internal 1,3-dienes to afford solely 1,2-amidoximation products in a remarkable regio- and Z/E-selective manner. Compared with traditional methods that are based on the steric hindrance of the substrates to control the reaction selectivity, both the (E)- and (Z)-isomers of α-amino-ketoximes was obtained selectively by the switch of sensitizers in this protocol. The key photophys. properties of NANS1 and DFT calculations were investigated in detail, providing the fact that the reaction proceeded through a sensitized triplet energy transfer pathway. In the experimental materials used by the author, we found 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2COA of Formula: C6H4Cl2O2S)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.COA of Formula: C6H4Cl2O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Non-directed copper-catalyzed regioselective C-H sulfonylation of phenothiazines》 were Liu, Caiyan; Shen, Yongli; Yuan, Kedong. And the article was published in Organic & Biomolecular Chemistry in 2019. Name: 4-Chlorobenzenesulfonyl chloride The author mentioned the following in the article:

A simple and general method for the synthesis of phenothiazinyl sulfones I [R = n-Bu, Ph, Bn, etc.; R1 = cyclopropyl, 4-MeC6H4, 2-naphthyl, etc.; R2 = H, SMe, Cl; R3 = H, Cl] was developed via copper-catalyzed regioselective C-H sulfonylation of phenothiazines with sulfonyl chlorides. The broad scope of aryl/alkyl sulfonyl chlorides was applicable to produce C3 sulfonylation products of phenothiazines in moderate to good yields. The further transformation of the sulfonylation products was successful, which afforded valuable polyheterocycles. The experimental part of the paper was very detailed, including the reaction process of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Name: 4-Chlorobenzenesulfonyl chloride)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Name: 4-Chlorobenzenesulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Design and synthesis of β-carboline linked aryl sulfonyl piperazine derivatives: DNA topoisomerase II inhibition with DNA binding and apoptosis inducing ability》 was published in Bioorganic Chemistry in 2020. These research results belong to Lakshmi Manasa, Kesari; Thatikonda, Sowjanya; Sigalapalli, Dilep Kumar; Sagar, Arpita; Kiranmai, Gaddam; Kalle, Arunasree M.; Alvala, Mallika; Godugu, Chandraiah; Nagesh, Narayana; Nagendra Babu, Bathini. COA of Formula: C6H4Cl2O2S The article mentions the following:

A series of new β-carboline linked aryl sulfonyl piperazine congeners I (R = H, Ph, 3,4,5-trimethoxyphenyl, 4-fluorophenyl, etc.; R1 = H, OMe, Me, Cl, t-Bu) have been synthesized by coupling various β-carboline acids II with substituted aryl sulfonyl piperazines III. Evaluation of their anticancer activity against a panel of human cancer cell lines such as colon (HT-29), breast (MDA-MB-231), bone osteosarcoma (MG-63), brain (U87 MG), prostate (PC- 3) and normal monkey kidney (Vero) cell line has been done. Among the series, compound I (R = Ph, R1 = Cl) and I (R = Ph, R1 = H) has shown most potent cytotoxicity with IC50 values of 2.80 ± 0.10μM and 0.59 ± 0.28μM resp. against MG-63 cell line and also potent on other cell lines tested. Compounds I (R = Ph, R1 = Cl) and I (R = Ph, R1 = H) were found to inhibit Topo II that is confirmed by specific Topo II inhibition assay. DNA binding studies, cell cycle anal., Annexin V study indicate that these compounds have potential anticancer activity. Mol. docking studies for compound I (R = Ph, R1 = Cl) and I (R = Ph, R1 = H) are incorporated to understand the nature of interaction with topoisomerase IIα and dsDNA. In the part of experimental materials, we found many familiar compounds, such as 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2COA of Formula: C6H4Cl2O2S)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. COA of Formula: C6H4Cl2O2S The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《The organocatalytic synthesis of perfluorophenylsulfides via the thiolation of trimethyl(perfluorophenyl)silanes and thiosulfonates》 was written by Luo, Jinyun; Lin, Muze; Wu, Leifang; Cai, Zhihua; He, Lin; Du, Guangfen. Product Details of 98-60-2This research focused ontrimethyl perfluorophenyl silane thiosulfonate phosphazene catalyst thiolation green chem; perfluorophenylsulfide preparation. The article conveys some information:

The organic superbase t-Bu-P4-catalyzed direct thiolation of trimethyl(perfluorophenyl)silanes and thiosulfonates was developed. Yields of perfluorophenylsulfides of up to 97% under catalysis of 5 mol% t-Bu-P4 were achieved. This method was shown to provide an efficient way to construct the perfluorophenyl-sulfur bond under mild metal-free reaction conditions. The experimental process involved the reaction of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Product Details of 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Product Details of 98-60-2 Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Korkmaz, Adem; Bursal, Ercan published an article in Journal of Molecular Structure. The title of the article was 《Benzothiazole sulfonate derivatives bearing azomethine: Synthesis, characterization, enzyme inhibition and molecular docking study》.Name: 4-Chlorobenzenesulfonyl chloride The author mentioned the following in the article:

Enzyme inhibition is one of the most applied ways to find new diagnostic facilities for the prevention and treatment of many health problems. For example, tyrosinase and pancreatic lipase inhibition have been used for the treatment of skin pigmentation problems and obesity, resp. This study mainly focused on evaluating inhibition of tyrosinase and pancreatic lipase by newly synthesized sulfonate derivatives I [R = 2,4,6-Me3C6H2, 2-naphthyl, 4-BrC6H4, etc.]. The structural characterizations of the compounds were performed by 1H NMR, 13C NMR and HR-MS analyses. According to the in-vitro enzyme inhibition methods, compound I [R = 4-FC6H4] had the highest tyrosinase inhibitory activity (46.9 ± 3.6μM IC50 value). On the other hand, effective pancreatic lipase inhibitory activities of I [R = 4-MeOC6H4, 4-FC6H4, 4-MeC6H4] were determined from their low IC50 values 58.3 ± 6.7μM, 59.5 ± 13.8μM and 64.8 ± 6.3μM, resp. Mol. docking studies were also conducted with tyrosinase and pancreatic lipase enzymes sep. Finally, the ADME studies were carried out to determine the pharmacokinetics, drug similarities and medicinal properties of the target compounds4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Name: 4-Chlorobenzenesulfonyl chloride) was used in this study.

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Name: 4-Chlorobenzenesulfonyl chloride Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics