Category: 98-60-2

Product Details of 98-60-2In 2021 ,《Photoredox-catalyzed synthesis of N-unsubstituted enaminosulfones from vinyl azides and sulfinates》 was published in Tetrahedron Letters. The article was written by Mulina, Olga M.; Ilovaisky, Alexey I.; Opatz, Till; Terent’ev, Alexander O.. The article contains the following contents:

A metal-free visible light photoredox-catalyzed synthesis of N-unsubstituted enaminosulfones from vinyl azides and sodium sulfinates in moderate to high yields were described. The reaction proceeded in ethanol and used Eosin Y as a readily available photocatalyst in combination with nitrobenzene as an electron shuttle. Took into account the number of steps involved (generation of the sulfonyl radical, its addition to the double bond, elimination of mol. nitrogen with formation of an iminyl radical, followed by its reduction and protonation) as well as the number of redox-active reaction partners involved, the selectivity of the process was quite impressive. In the experimental materials used by the author, we found 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Product Details of 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Product Details of 98-60-2 However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

SDS of cas: 98-60-2In 2022 ,《Boron-promoted reductive deoxygenation coupling reaction of sulfonyl chlorides for the C(sp3)-S bond construction》 was published in Chinese Chemical Letters. The article was written by Chen, Shuo; Wen, Qingru; Zhu, Yanqing; Ji, Yanru; Pu, Yu; Liu, Zhengli; He, Yun; Feng, Zhang. The article contains the following contents:

Herein, authors report a borane-promoted reductive deoxygenation coupling reaction to synthesize sulfides. This reaction features excellent functional group compatibility, high efficiency, broad substrate scope, and application in late-stage functionalization of biomols. Preliminary mechanistic studies suggest diaryl sulfides are the intermediates of this reaction. Moreover, the real active aryl sulfide anions may be generated in situ with the aid of B2pin2 and react with alkyl tosylates through a concerted SN2 pathway. The experimental part of the paper was very detailed, including the reaction process of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2SDS of cas: 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.SDS of cas: 98-60-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Alkene versus alkyne reactivity in unactivated 1,6-enynes: regio- and chemoselective radical cyclization with chalcogens under metal- and oxidant-free conditions》 was written by Mutra, Mohana Reddy; Kudale, Vishal Suresh; Li, Jing; Tsai, Wu-Hsun; Wang, Jeh-Jeng. Application of 98-60-2 And the article was included in Green Chemistry in 2020. The article conveys some information:

Herein, we have developed metal and oxidant-free visible light-promoted alkene vs. alkyne regio- and chemoselective radical cascade cyclization of electronically unbiased 1,6-enynes with chalcogens to synthesize substituted pyrrolidines bearing chalcogens. The reaction generated three new bonds, namely, C-SO2, C-C, and C-Se under extremely mild conditions. Furthermore, we achieved regio- and chemoselective mono-addition of aromatic thiophenols with unactivated 1,6-enynes. The key features of this protocol are broad substrate scope, environment-friendly conditions, operational simplicity, atom economy, and amenability to gram-scale synthesis. The mechanistic studies corroborate that the reaction proceeds via a radical pathway. In the part of experimental materials, we found many familiar compounds, such as 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Application of 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Application of 98-60-2 Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Recommanded Product: 98-60-2In 2019 ,《Visible-Light-Catalyzed C-C Bond Difunctionalization of Methylenecyclopropanes with Sulfonyl Chlorides for the Synthesis of 3-Sulfonyl-1,2-dihydronaphthalenes》 was published in Journal of Organic Chemistry. The article was written by Liu, Yu; Wang, Qiao-Lin; Chen, Zan; Zhou, Quan; Li, Hua; Zhou, Cong-Shan; Xiong, Bi-Quan; Zhang, Pan-Liang; Tang, Ke-Wen. The article contains the following contents:

A novel visible-light-catalyzed sulfonylation/arylation of carbon-carbon σ-bond with sulfonyl chlorides for the synthesis of 3-sulfonylated 1,2-dihydronaphthalenes is developed. This difunctionalization proceeds via a sequence of C=C bond sulfonylation, C-C σ-bond cleavage, and intramol. cyclization, and the experiment result shows that the C-C σ-bond difunctionalization reaction includes a radical process. This strategy provides a simple and convenient route for difunctionalization of C-C bonds with an aromatic carbon and a sulfonyl radical by one-pot construction of a C-S bond and a new C-C bond. In the experiment, the researchers used many compounds, for example, 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Recommanded Product: 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Recommanded Product: 98-60-2 Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Sabita, G.; Savitha, R.; Divya, K.; Bhaskar, K. published an article in Chemical Data Collections. The title of the article was 《Synthesis and biological evaluation of aryl sulfonyl linked isoxazol(pyridin-4-yl)pyrazolo[1,5-a]pyrimidines as cytotoxicity agents》.Computed Properties of C6H4Cl2O2S The author mentioned the following in the article:

A new bunch of aryl sulfonyl linked isoxazol(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine compounds I [R = 4-Me, 3,4-di-Cl, 3,4,5-tri-MeO, etc.] was designed, developed and their structure were characterized by anal. techniques. Further, compounds I were tested for their cytotoxicity activities towards human cancer cell lines like SiHa (cervix cancer), A549 (Lung cancer), MCF-7 (Breast cancer) and Colo-205 (colon cancer) using MTT assay and compared with standard drug, etoposide. Among all, compounds, compounds I [R = 3,4,5-tri-MeO, 3,4-di-MeO, 4-MeO, 4-O2N, 4-MeO-3,5-di-O2N] demonstrated good cytotoxicity effects as standard drug. Specifically, two compounds I [R = 3,4,5-tri-MeO, 4-MeO-3,5-di-O2N] displayed more potent activity.4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Computed Properties of C6H4Cl2O2S) was used in this study.

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C6H4Cl2O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Exploration of certain 1,3-oxazole- and 1,3-thiazole-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents》 was written by Anh, Duong Tien; Hai, Pham-The; Huong, Le-Thi-Thu; Park, Eun Jae; Jun, Hye Won; Kang, Jong Soon; Kwon, Joo-Hee; Dung, Do Thi Mai; Anh, Vu Tran; Hue, Van Thi My; Han, Sang-Bae; Nam, Nguyen-Hai. Reference of 4-Chlorobenzenesulfonyl chloride And the article was included in Bioorganic Chemistry in 2020. The article conveys some information:

Several novel series of hydroxamic acids bearing 2-benzamido-1,3-oxazole/1,3-thiazole I (R = H, 4-Cl, 4-Me, etc.; R1 = C(O); X = O, S) or 2-phenylsulfonamido-1,3-thiazole I (R = H, 4-Cl, 4-Me; R1 = SO2; X = S) were designed and synthesized. The compounds I were obtained straightforward via a two step pathway, starting from com. available Et 2-aminooxazole-4-carboxylate or Et 2-aminothiazole-4-carboxylate. Biol. evaluation showed that these hydroxamic acids I generally exhibited good cytotoxicity against three human cancer cell lines (SW620, colon; PC-3, prostate; NCI-H23, lung cancer), with IC50 values in low micromolar range and comparable to that of SAHA. These compounds I also comparably inhibited HDACs with IC50 values in sub-micromolar range (0.010-0.131μM) and some compounds (e.g., I (R = 4-Me; R1 = C(O); X = O), IC50, 0.010μM) were even more potent than SAHA (IC50, 0.025μM) in HDAC inhibition. Representative compounds I (R = H, R1 = C(O), X = O; R = H, R1 = SO2, X = S) appeared to arrest the SW620 cell cycle at G2 phase and significantly induced both early and late apoptosis of SW620 colon cancer cells. Docking experiments on HDAC2 and HDAC6 isoenzymes revealed favorable interactions at the tunnel of the HDAC active site which pos. contributed to the inhibitory activity of synthesized compound The binding affinity predicted by docking program showed good correlation with the exptl. IC50 values. This study demonstrates that simple 1,3-oxazole- and 1,3-thiazole-based hydroxamic acids I are also promising as antitumor agents and HDAC inhibitors and these results should provide valuable information for further design of more potent HDAC inhibitors and antitumor agents. In the experimental materials used by the author, we found 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Reference of 4-Chlorobenzenesulfonyl chloride)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Reference of 4-Chlorobenzenesulfonyl chloride The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Structural optimization of imidazothiazole derivatives affords a new promising series as B-Raf V600E inhibitors; synthesis, in vitro assay and in silico screening》 was written by Ammar, Usama M.; Abdel-Maksoud, Mohammed S.; Ali, Eslam M. H.; Mersal, Karim I.; Ho Yoo, Kyung; Oh, Chang-Hyun. COA of Formula: C6H4Cl2O2S And the article was included in Bioorganic Chemistry in 2020. The article conveys some information:

In this study, based on structural optimization of previously reported inhibitors (3-fluro substituted derivatives of imidazo[2,1-b]thiazole-based scaffold), sixteen new imidazo[2,1-b]thiazole derivatives with m-nitrophenyl group at position 6 I (n = 1, 2; Ar = 3-fluorophenyl, 4-chlorophenyl, 1-naphthyl, etc.) were designed and synthesized. The electron withdrawing properties were reserved while the polarity was modified in comparison to the previously synthesized compounds (-F). Furthermore, the new substituted group (-NO2) provided an addnl. H-bond acceptor(s) which may bind with the target enzyme through addnl. interaction(s). In vitro cytotoxicity evaluation was performed against human cancer cell line (A375). In addition, in vitro enzyme assay was performed against mutated B-Raf (B-Raf V600E). Compounds I (n = 2; Ar = 3-fluorophenyl, 4-fluorophenyl, 4-bromophenyl) showed highest activity on mutated B-Raf with IC50 0.021, 0.035 and 0.020μM. All target compounds were tested for in vitro cytotoxicity against NCI 60 cell lines. Compounds (n = 2; Ar = 3-fluorophenyl, 4-fluorophenyl) were selected for 5 doses test mode. Moreover, in silico mol. simulation was explored in order to explore the possible interactions between the designed compounds and the B-Raf V600E active site. The experimental process involved the reaction of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2COA of Formula: C6H4Cl2O2S)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. COA of Formula: C6H4Cl2O2S Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Design and Synthesis of Sulfonamide-Attached 2-(Isoxazol-3-yl)-1H-imidazoles as Anticancer Agents》 was written by Dende, Satheesh Kumar; Korupolu, Raghu Babu; Leleti, Krishnakanth Reddy. Quality Control of 4-Chlorobenzenesulfonyl chloride And the article was included in ChemistrySelect in 2020. The article conveys some information:

Library of 2-(isoxazol-3-yl)-1H-imidazole sulfonamides I [R = H, 4-Me, 3,4-di-Cl, etc.] were synthesized and structures were confirmed by 1HNMR, 13CNMR and mass spectral anal. Further these compounds I were tested for their anticancer activity against four human cancer cell lines, such as MCF-7 (breast cancer), A549 (lung cancer), Colo-205 (colon cancer) and A2780 (ovarian cancer) by MTT assay and etoposide used as pos. control. Among them, compounds I [R = 2,3,5-tri-MeO, 3,5-di-Cl, 4-MeO, 4-Cl, 4-CN, 4-NO2, 3-NO2] showed more potent anticancer activity against human cancer cell lines.4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Quality Control of 4-Chlorobenzenesulfonyl chloride) was used in this study.

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Quality Control of 4-Chlorobenzenesulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Computed Properties of C6H4Cl2O2SIn 2022 ,《Palladium-catalyzed cascade Heck-type thiocarbonylation for the synthesis of functionalized thioesters》 was published in Organic Chemistry Frontiers. The article was written by Xu, Ren-Rui; Wang, Wei; Qi, Xinxin; Wu, Xiao-Feng. The article contains the following contents:

A palladium-catalyzed cascade Heck-type cyclization and carbonylation reaction has been developed for the synthesis of functionalized thioesters. With arylsulfonyl chlorides as odorless and readily available sulfur sources, a variety of thioesters were obtained in moderate to good yields with good functional group compatibility. In this system, Mo(CO)6 acts as both a convenient CO surrogate and a suitable reductant. After reading the article, we found that the author used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Computed Properties of C6H4Cl2O2S)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Computed Properties of C6H4Cl2O2S Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhou, Liwei; Liu, Xiaodong; Lu, Haiyan; Deng, Guobo; Liang, Yun; Yang, Yuan; Li, Jin-Heng published their research in Organic Chemistry Frontiers in 2021. The article was titled 《Copper-catalyzed [3+2]/[3+2] carboannulation of dienynes and arylsulfonyl chlorides enabled by Smiles rearrangement: access to cyclopenta[a]indene-fused quinolinones》.Related Products of 98-60-2 The article contains the following contents:

A radical Smiles rearrangement strategy for allowing an unprecedented [3+2]/[3+2] carboannulation of dienynes 2-CCR3-R1C6H3N(R2)C(O)C(=CH2)CH=CH2 (R1 = H, 4-OMe, 4-Br, 5-F, etc.; R2 = Me, Bn; R3 = Ph, thiophen-2-yl, 4-chlorophenyl, etc.) with arylsulfonyl chlorides 2-R4-3-R5-4-R6C6H2S(O)2Cl (R4 = H, Me; R5 = H; R4R5 = -CH=CH-CH=CH-; R6 = H, OMe, Me, Cl, Br, I; R7 = H, 3-OMe, 3-Br, 2-F, etc.) using cheap copper catalysis was described. This cascade method represents a novel cycloaddition mode for dienyne chem., which occurs by the sequence of addition of arylsulfonyl radical to a dienyne, and a Smiles rearrangement and radical annulation to access cyclopenta[a]indene-fused quinolinones I with excellent diastereoselectivity. The experimental process involved the reaction of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Related Products of 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Related Products of 98-60-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics