《Crystal structure and anti-inflammatory activity of (3E,5E)-1-((4-chlorophenyl)sulfonyl)-3-(pyridin-4-ylmethylene)-5-(2-(trifluoromethyl)benzylidene)piperidin-4-one, C25H18ClF3N2O3S》 was published in Zeitschrift fuer Kristallographie – New Crystal Structures in 2020. These research results belong to Zhou, Yan-Qiu; Hou, Gui-Ge; Meng, Qing-Guo; Hou, Yun. Safety of 4-Chlorobenzenesulfonyl chloride The article mentions the following:
C25H18ClF3N2O3S, monoclinic, P21/n (number 14), a = 9.9087(5) Å, b = 21.7843(10) Å, c = 10.2512(6) Å, β = 94.749(5)°, V = 2205.2(2) Å3, Z = 4, Rgt(F) = 0.0448, wRref(F2) = 0.1028, T = 100 K. CCDC number: 1868651. 2-(Trifluoromethy)benzaldehyde (1.74 g, 10.0 mmol), 4-pyridinecarboxaldehyde (1.07 g, 10.0 mmol) and 4-piperidone hydrate hydrochloride (1.35 g, 10.0 mmol) were dissolved in dilute acetic acid (25 mL). This mixture was passed through by dry HCL gas for 30 min. After stirring at room temperature for about 24 h (monitored by thin layer chromatog. (TLC)), the precipitate was collected and washed with cold acetone. The precipitates were added into 100 mL water, and then aqueous Na2CO3 solution was added until the pH value was adjusted to about 7. The precipitates were filtered, subsequently washed by water, and purified on silica gel by column using methanol/petroleum ether/EtOAc (1:10:10, volume/volume/v) as the eluent to afford a yellow intermediate. Next, the intermediate (0.69 g, 2.0 mmol), and 4-chlorobenzenesulfonyl chloride (0.46 g, 2.2 mmol) were dissolved in dichloromethane (50 mL). Two drops of pyridine were added. After stirring for about 6 h at room temperature, the precipitate was collected, washed with water and recrystallized from dichloromethane/methanol (1:1, volume/volume) to get light yellow crystals of the title compound In the experiment, the researchers used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Safety of 4-Chlorobenzenesulfonyl chloride)
4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Safety of 4-Chlorobenzenesulfonyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics