Category: 939-99-1

Wang, Jiabao published the artcileNickel-catalyzed reductive benzylation of tertiary alkyl halides with benzyl chlorides and chloroformates, Product Details of C8H6ClF3, the publication is Organic Chemistry Frontiers (2021), 8(12), 2944-2948, database is CAplus.

Ni-Catalyzed reductive cross-coupling of tertiary alkyl halides with benzyl chlorides and chloroformates has been developed, which provides an efficient method for the construction of benzylated all-carbon quaternary centers in moderate to excellent yields with high functional group tolerance.

Organic Chemistry Frontiers published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C3H9ClOS, Product Details of C8H6ClF3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sebastian-Perez, Victor published the artcileDeciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools, COA of Formula: C8H6ClF3, the publication is Journal of Enzyme Inhibition and Medicinal Chemistry (2020), 35(1), 511-523, database is CAplus and MEDLINE.

A previous phenotypic screening campaign led to the identification of a quinazoline derivative with promising in vitro activity against Schistosoma mansoni. Follow-up studies of the antischistosomal potential of this candidate are presented here. The in vivo studies in a S. mansoni mouse model show a significant reduction of total worms and a complete disappearance of immature eggs when administered concomitantly with praziquantel in comparison with the administration of praziquantel alone. This fact is of utmost importance because eggs are responsible for the pathol. and transmission of the disease. Subsequently, the chem. optimization of the structure in order to improve the metabolic stability of the parent compound was carried out leading to derivatives with improved drug-like properties. Addnl., the putative target of this new class of antischistosomal compounds was envisaged by using computational tools and the binding mode to the target enzyme, aldose reductase, was proposed.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C9H5ClO4S, COA of Formula: C8H6ClF3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Dungai published the artcileUnsymmetrical Disulfides Synthesis via Cs₂CO₃-Catalyzed Three-Component Reaction in Water, Synthetic Route of 939-99-1, the publication is Advanced Synthesis & Catalysis (2020), 362(22), 4991-4995, database is CAplus.

An unsym. disulfide synthesis by Cs₂CO₃-catalyzed three-component coupling reaction of thioacetates RSC(O)Me (R = 4-CH₃OC₆H₄, CH₂C₆H₅, oxolan-2-ylmethyl, etc.), sodium thiosulfate, and benzyl halide R¹CH₂Cl (R¹ = C₆H₅, 4-BrC₆H₄, 1-naphthyl, etc.) in water has been described. The safe, stable, and non-toxic Na₂S₂O₃ was invoked as the sulfur-source, successfully avoiding the odor generation in the process of S-S bond formation. A wide range of substrate suitability and appropriate functional group tolerance were observed for the transformation. Notably, the approach reported here was compatible with various biomols. including glucose, coumarin, and quinolinone.

Advanced Synthesis & Catalysis published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C26H41N5O7S, Synthetic Route of 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Zi-Hao published the artcileN-Hydroxyphthalimide/benzoquinone-catalyzed chlorination of hydrocarbon C-H bond using N-chlorosuccinimide, Synthetic Route of 939-99-1, the publication is Organic & Biomolecular Chemistry (2019), 17(13), 3403-3408, database is CAplus and MEDLINE.

The direct chlorination of C-H bonds has received considerable attention in recent years. In this work, a metal-free protocol for hydrocarbon C-H bond chlorination with com. available N-chlorosuccinimide (NCS) catalyzed by N-hydroxyphthalimide (NHPI) with 2,3-dicyano-5,6-dichlorobenzoquinone (DDQ) functioning as an external radical initiator is presented. Aliphatic and benzylic substituents and also heteroaromatic ones were found to be well tolerated. Both the experiments and theor. anal. indicate that the reaction goes through a process wherein NHPI functions as a catalyst rather than as an initiator. On the other hand, the hydrogen abstraction of the C-H bond conducted by a PINO species rather than the highly reactive N-centered radicals rationalizes the high chemoselectivity of the monochlorination obtained by this protocol as the latter is reactive towards the C(sp³)-H bonds of the monochlorides. The present results could hold promise for further development of a nitroxy-radical system for the highly selective functionalization of the aliphatic and benzylic hydrocarbon C-H.

Organic & Biomolecular Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Synthetic Route of 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Donzel, Maxime published the artcileBioinspired Photoredox Benzylation of Quinones, SDS of cas: 939-99-1, the publication is Journal of Organic Chemistry (2021), 86(15), 10055-10066, database is CAplus and MEDLINE.

3-Benzylmenadiones were obtained in good yield by using a blue-light-induced photoredox process in the presence of Fe(III), oxygen, and γ-terpinene acting as a hydrogen-atom transfer agent. This methodol. is compatible with a wide variety of diversely substituted 1,4-naphthoquinones as well as various cheap, readily available benzyl bromides with excellent functional group tolerance. The benzylation mechanism was investigated and supports a three-step radical cascade with the key involvement of the photogenerated superoxide anion radical.

Journal of Organic Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, SDS of cas: 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fu, Duo published the artcileMethanesulfinylation of Benzyl Halides with Dimethyl Sulfoxide, Related Products of chlorides-buliding-blocks, the publication is Journal of Organic Chemistry (2020), 85(4), 2752-2758, database is CAplus and MEDLINE.

A phenyltrimethylammonium tribromide-mediated nucleophilic substitution/oxygen transformation reaction of benzyl halides with DMSO has been developed. In this transition-metal-free reaction, DMSO acts as not only a solvent but also a “S(O)Me” source, thus providing a convenient method for the efficient and direct synthesis of various benzyl Me sulfoxides.

Journal of Organic Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Heo, Seunga published the artcileBoosting photoredox catalysis using two-dimensional electride as persistent electron donor, Formula: C8H6ClF3, the publication is ACS Applied Materials & Interfaces (2021), 13(36), 42880-42888, database is CAplus and MEDLINE.

Electrides, which have excess anionic electrons, are solid-state sources of solvated electrons that can be used as powerful reducing agents for organic syntheses. However, the abrupt decomposition of electrides in organic solvents makes controlling the transfer inefficient, thereby limiting the utilization of their superior electron-donating ability. Here, we demonstrate the efficient reductive transformation strategy which combines the stable two-dimensional [Gd₂C]²⁺·2e^– electride electron donor and cyclometalated Pt(II) complex photocatalysts. Strongly localized anionic electrons at the interlayer space in the [Gd₂C]²⁺·2e^– electride are released via moderate alcoholysis in 2,2,2-trifluoroethanol, enabling persistent electron donation. The Pt(II) complexes are adsorbed onto the surface of the [Gd₂C]²⁺·2e^– electride and rapidly capture the released electrons at a rate of 10⁷ s^-1 upon photoexcitation. The one-electron-reduced Pt complex is electrochem. stable enough to deliver the electron to substrates in the bulk, which completes the photoredox cycle. The key benefit of this system is the suppression of undesirable charge recombination because back electron transfer is prohibited due to the irreversible disruption of the electride after the electron transfer. These desirable properties collectively serve as the photoredox catalysis principle for the reductive generation of the benzyl radical from benzyl halide, which is the key intermediate for dehalogenated or homocoupled products.

ACS Applied Materials & Interfaces published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Formula: C8H6ClF3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xu, Peng published the artcileNovel promising 4-anilinoquinazoline-based derivatives as multi-target RTKs inhibitors: Design, molecular docking, synthesis, and antitumor activities in vitro and vivo, Quality Control of 939-99-1, the publication is Bioorganic & Medicinal Chemistry (2019), 27(20), 114938, database is CAplus and MEDLINE.

4-Anilinoquinazoline derivatives I [R = 2-OBn, 3-OBn, 4-OBn, 2-O(4-NO₂Bn), etc.; n = 0, 1, 2] were designed and synthesized using a binding model with multi-target receptor tyrosine kinases and assessed their antitumor activity against five human tumor cell lines (HepG2, A549, MCF-7, DU145, SH-SY5Y). The majority of the compounds inhibited the proliferation of all the cancer cell types, with some compounds displaying selective inhibition. Compounds I [R = 3-OBn, n = 0], I [R = 4-O(4-NO₂Bn), n = 0] and I [R = 2-OBn, n = 1] displayed IC₅₀ values of 7.588, 8.619 and 6.936μM, resp., for A549 cells, which were much lower than that of Gefitinib (14.803μM). Compound I [R = 3-O(4-CF₃Bn), n = 1] displayed an IC₅₀ value of 2.756μM for DU145 cells. The representative compound I [R = 3-O(4-CF₃Bn), n = 1] had unexceptionable broad-spectrum inhibition for all cancer cell types, and demonstrate inhibition of vascular endothelial growth factor receptor 2 (VEGFR-2), platelet-derived growth factor receptor beta (PDGFR-β), and epidermal growth factor receptor (EGFR) with IC₅₀ values of 46.4, 673.6 and 384.8 nM, resp., which were similar to those of Sorafenib for VEGFR-2 and PDGFR-β (140.6 and 582.7 nM, resp.). Mol. docking results supported the mol. level assay results. Data for production of reactive oxygen species and assessment of matrix metalloproteinase corroborated the strong anti-proliferative effect of compound I [R = 3-O(4-CF₃Bn), n = 1]. The compound also displayed robust antitumor efficacy and relativity lower toxicity in a xenograft model. These attributes were similar to those of Sorafenib.

Bioorganic & Medicinal Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H15NO, Quality Control of 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Dachuan published the artcileDesign, synthesis and biological evaluation of benzo[d]thiazole with dimethylpyrazole derivatives, COA of Formula: C8H6ClF3, the publication is Asian Pacific Journal of Cancer Prevention (2019), 20(11), 3487-3495, database is CAplus and MEDLINE.

A series of new benzothiazole derivatives containing dimethylpyrazole I [R = H, n-pentyl, benzyl, etc.] were synthesized and evaluated for their anticonvulsant activity, neurotoxicity and cytotoxicity by using the maximal electroshock (MES), rotarod neurotoxicity (TOX) and MTT colorimetric assay. Among the compounds studied, four compounds I [R = Bu, n-pentyl, 2-fluorobenzyl, 2,6-dichlorobenzyl] showed better anticonvulsant than the others at 300 mg/kg and they also showed anticonvulsant activity at the dose of 100 mg/kg. All the synthetic compounds I showed lower neurotoxicity and little cytotoxicity, so that the compounds, which with better activities, also had higher protective index. In particular, the compound I [R = 2-fluorobenzyl] showed better activity with an ED₅₀ value of 160.4 mg/kg and higher protective index (PI) values of 2.74 in the MES test than the standard drugs sodium valproate, which used as pos. controls in this study. After that the compound I [R = 2-fluorobenzyl] demonstrated antagonistic activity against seizures induced by pentylenetetrazol, which proved compound I [R = 2-fluorobenzyl] may be exert activity through effecting GABAergic neurotransmission.

Asian Pacific Journal of Cancer Prevention published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, COA of Formula: C8H6ClF3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ning, Xiaoqin published the artcilePalladium-Catalyzed Carbene Coupling Reactions of Cyclobutanone N-Sulfonylhydrazones, SDS of cas: 939-99-1, the publication is Organic Letters (2021), 23(21), 8348-8352, database is CAplus and MEDLINE.

Described herein are the palladium-catalyzed cross-coupling reactions of cyclobutanone-derived N-sulfonylhydrazones with aryl or benzyl halides, suggesting that the metal carbene process and β-hydride elimination can smoothly occur in strained ring systems. Structurally diversified products including cyclobutenes, methylenecyclobutanes, and conjugated dienes are selectively afforded in good to excellent yields. Preliminary success in asym. carbene coupling reactions in strained ring systems has been achieved, providing a promising route for the synthesis of enantioenriched four-membered-ring mols.

Organic Letters published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, SDS of cas: 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics