Category: 939-99-1

Yang, Zaibo published the artcileDesign, synthesis, and biological evaluation of novel pyrethrin derivatives containing 1,3,4-oxadiazole and thioether moieties as active insecticidal agents, Recommanded Product: 1-(Chloromethyl)-4-(trifluoromethyl)benzene, the publication is Chemical Papers (2020), 74(5), 1621-1632, database is CAplus.

To discover and develop novel active mols., in this study, a series of novel pyrethrin derivatives containing 1,3,4-oxadiazole and thioether moieties were I [R = Ph, 5-chloro-thienyl, 2-fluorophenyl, etc.] designed and synthesized. Bioassay results revealed that some of the target compounds I possessed good insecticidal activities against Plutella xylostella (P. xylostella), Vegetable aphids (V. aphids), and Empoasca vitis (E. vitis), resp., which were even better than those of the com. insecticidal agents chlorpyrifos, beta cypermethrin, spinosad, and azadirachtin. The results favored this rational design intention and provide a new class of small-mol. inhibitors available for the development of active insecticidal agents targeting P. xylostella, V. aphids, and E. vitis.

Chemical Papers published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C9H5ClO4S, Recommanded Product: 1-(Chloromethyl)-4-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yang, Zaibo published the artcileNovel pyrethrin derivatives containing an 1,3,4-oxadiazole thioether moiety: Design, synthesis, and insecticidal activity, Recommanded Product: 1-(Chloromethyl)-4-(trifluoromethyl)benzene, the publication is Journal of Heterocyclic Chemistry (2020), 57(1), 81-88, database is CAplus.

In this study, a series of novel pyrethrin derivatives containing an 1,3,4-oxadiazole thioether moiety, I (R = Ph, 2-ClC₆H₄, 6-chloropyridinyl, etc.), were designed and synthesized. Bioassay results revealed that some of the target compounds possessed excellent insecticidal activities against Plutella xylostella (P. xylostella), Vegetable aphids (V. aphids), and Empoasca vitis (E. vitis), resp. In particular, compound I (R = 4-F₃CC₆H₄) revealed the best insecticidal activities against P. xylostella and V. aphids, with the 50% lethal concentration (LC₅₀) values of 1.78 and 1.61 mg/L, resp.; meanwhile, compound I (R = 5-chlorothiadiazol-2-yl) revealed the best insecticidal activity against E. vitis, with the LC₅₀ value of 1.06 mg/L, which were superior to those of the com. insecticidal agents of chlorpyrifos, beta cypermethrin, spinosad, and azadirachtin. These results indicated that novel pyrethrin derivatives containing an 1,3,4-oxadiazole thioether moiety could effectively inhibit P. xylostella, V. aphids, and E. vitis.

Journal of Heterocyclic Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C4H6N2, Recommanded Product: 1-(Chloromethyl)-4-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Chen-Gang published the artcileCarbon Dioxide Mediated Cellulose Dissolution and Derivatization to Cellulose Carbonates in a Low-pressure System, Synthetic Route of 939-99-1, the publication is Carbohydrate Polymer Technologies and Applications (2022), 100186, database is CAplus.

An effective switchable solvent system using carbon dioxide (CO₂) and 2-tert-butyl-1,1,3,3-tetramethylguanidine (BTMG) for cellulose dissolution and derivatization was developed. High concentration cellulose solution (up to 10 wt%) could be achieved by dissolving microcrystalline cellulose rapidly, within 5 min, into DMSO in presence of BTMG and 1 atm CO₂ at room temperature The cellulose-carbonate anion intermediate was characterized by ¹H and ¹³C NMR spectroscopies, emphasizing the generation of cellulose carbonate anions and protonated BTMG. Addition of organochlorides into the cellulose solution triggers a nucleophilic substitution with cellulose-carbonate anions, producing various cellulose benzyl carbonates and a cellulose-carbonate-ester with degree of substitution (DS) up to 1.83 at 1 atm CO₂ pressure and room temperature The activation energy (Ea) and Gibbs free energy change (ΔG) of CO₂-mediated dissolution and nucleophilic substitution were calculated by d. functional theory. The results showed that the nucleophilic substitution is the rate-limiting step.

Carbohydrate Polymer Technologies and Applications published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C9H8BNO2, Synthetic Route of 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhou, Yan published the artcileDesign, synthesis, and evaluation of dihydropyranopyrazole derivatives as novel PDE2 inhibitors for the treatment of Alzheimer’s disease, HPLC of Formula: 939-99-1, the publication is Molecules (2021), 26(10), 3034, database is CAplus and MEDLINE.

In this study, (R)-LZ77 was obtained as a hit compound with moderate PDE2 inhibitory activity (IC₅₀ = 261.3 nM) using a high-throughput virtual screening method based on mol. dynamics. Then, 28 dihydropyranopyrazole derivatives I [R¹ = H, CH₃O, Cl; R² = H, CH₃, CH₃O, etc.; R³ = H, CH₃, C₆H₅; R⁴ = H, CH₃O, Cl, etc; R⁵ = NH₂, (CH₃)₂N; n = 1, 2, 3] and II [R⁶ = Cl, CF₃; n = 0, 2, 3] were designed and synthesized as PDE2 inhibitors. Among them, compound (+)-I [R¹ = H; R² = CH₃O; R³ = CH₃; R⁴ = CF₃; R⁵ = NH₂; n = 1] was the most potent PDE2 inhibitor, with an IC₅₀ value of 41.5 nM. The mol. docking of PDE2-(+)-I [R¹ = H; R² = CH₃O; R³ = CH₃; R⁴ = CF₃; R⁵ = NH₂; n = 1] revealed that the 4-(trifluoromethyl)benzyloxyl side chain of the compound enters the H-pocket and forms strong hydrophobic interactions with L770/L809/F862, which improves inhibitory activity. The above results may provide insight for further structural optimization of highly potent PDE2 inhibitors and may lay the foundation for their use in the treatment of AD.

Molecules published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C4H3ClN2O, HPLC of Formula: 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xiao, Yulong published the artcileDesign, Synthesis, and Antifungal Activity of Sulfoximine Derivatives Containing Nitroguanidine Moieties, HPLC of Formula: 939-99-1, the publication is Chemistry & Biodiversity (2022), 19(3), e202100839, database is CAplus and MEDLINE.

To discover novel pesticide candidates, a series of sulfoximine derivatives were designed and synthesized via the oxidation coupling reaction of sulfides and N-alkyl nitroguanidines. The compounds were evaluated for their antifungal activity against six phytopathogenic fungi. Most of them exhibited a broad spectrum of fungicidal activity in vitro. Compound 8IV-b displayed good fungicidal activity against Sclerotinia sclerotiorum, Rhizoctonia solani, Botrytis cinerea, Fusarium graminearum, and Phytophthora capsici, with EC50 value of 12.82, 12.50, 17.25, 31.08, and 30.11 mg/L, resp. In addition, compounds 8III-c and 8IV-e had EC50 values of 22.23 and 20.67 mg/L against P. capsic, which were significantly better than that of the com. procymidone (118.15 mg/L). Strikingly, 8IV-d exhibited satisfactory fungicidal activity against B. cinerea, which was comparable to control procymidone in terms of their EC50 values (7.42 vs. 10.83 mg/L), and the bioassays in vivo further confirmed that 8IV-d possessed potent protective effect against B. cinerea at 200 mg/L (72.2 %). These present findings will facilitate the design and development of novel potent fungicides.

Chemistry & Biodiversity published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C10H18BNO2, HPLC of Formula: 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Korvorapun, Korkit published the artcileLate-Stage Diversification by Selectivity Switch in meta-C-H Activation: Evidence for Singlet Stabilization, Product Details of C8H6ClF3, the publication is ACS Catalysis (2020), 10(1), 435-440, database is CAplus.

The full control of site selectivity in C-H activation is paramount for the programmed late-stage functionalization of structurally complex structures. During the past decade, directing groups have revolutionized mol. synthesis in terms of ortho-selective C-H activation. In sharp contrast, a selectivity switch that guides the typical ortho- to remote meta-C-H activation has thus far proven elusive. Herein, we describe the realization of such a concept for a robust selectivity control in ruthenium catalysis. The distal C-H transformation was guided by key mechanistic insights into the mild, synergistic action of carboxylates and phosphines in ruthenium(II) catalysis. Our findings allowed remote selectivity in broadly effective late-stage diversification of structurally complex drugs and natural product mols., tolerating sensitive fluorescent dyes, drugs, lipids, peptides, nucleosides and carbohydrates.

ACS Catalysis published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Product Details of C8H6ClF3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kumar, Sourav published the artcilePyrazine Based Type-I Sensitizing Assemblies for Photoreduction of Cu(II) in ‘One-Pot Three-Component’ CuAAC Reaction Under Aerial Conditions, Category: chlorides-buliding-blocks, the publication is Chemistry – An Asian Journal (2021), 16(23), 3944-3950, database is CAplus and MEDLINE.

Photosensitizing assemblies of pyrazine derivative PDA have been developed which exhibit a high photostability, ‘lighted’ excited state, balanced redox potential, high transportation potential and activate oxygen via type-I pathway only. These PDA assemblies in combination with Cu(II) ions catalyze the CuAAC reaction via in situ reduction of Cu(II) ions without any reducing or stabilizing agent. The present protocol has wide substrate scope with recyclability of the catalytic system up to six catalytic cycles and is applicable to gram-scale synthesis.

Chemistry – An Asian Journal published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Dreas, Agnieszka published the artcileDiscovery of indazole-pyridinone derivatives as a novel class of potent and selective MNK1/2 kinase inhibitors that protecting against endotoxin-induced septic shock, Quality Control of 939-99-1, the publication is European Journal of Medicinal Chemistry (2021), 113057, database is CAplus and MEDLINE.

The mitogen-activated protein kinase (MAPK)-interacting kinases 1 and 2 (MNKs 1/2) and their downstream target eIF4E, play a role in oncogenic transformation, progression and metastasis. These results provided rationale for development of first MNKs inhibitors, currently in clin. trials for cancer treatment. Inhibitors of the MNKs/eIF4E pathway are also proposed as treatment strategy for inflammatory conditions. Here we present results of optimization of indazole-pyridinone derived MNK1/2 inhibitors among which compounds I and II, selective and metabolically stable derivatives Both compounds decreased levels of eIF4E Ser206 phosphorylation (pSer209-eIF4E) in MOLM16 cell line. When administered in mice compounds I and II significantly improved survival rates of animals in the endotoxin LD challenge model, with concomitant reduction of proinflammatory cytokine levels – TNFα and IL-6 in serum. Identified MNK1/2 inhibitors represent a novel class of immunomodulatory compounds with a potential for the treatment of inflammatory diseases including sepsis.

European Journal of Medicinal Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Quality Control of 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Saini, Parul published the artcileExternal Catalyst-Free Oxidation of Benzyl Halides to Benzoic Acids Using NaOH/TBHP in Water, Recommanded Product: 1-(Chloromethyl)-4-(trifluoromethyl)benzene, the publication is Asian Journal of Organic Chemistry (2021), 10(9), 2355-2359, database is CAplus.

An efficient and metal-free methodol. for the oxidation of benzyl halides to benzoic acids using an inexpensive and green oxidant (TBHP) in aqueous basic medium has been developed. This protocol offers an excellent way to avoid adding catalysts and involves the use of an in-situ generated halide ion as catalyst. It is also the first report on the oxidation of benzyl iodides to benzoic acids. A series of carboxylic acids were prepared from benzyl halides in high yields under mild reaction conditions by this method which does not require chromatog. purification Gram scale reactions for the synthesis of the carboxylic acids in good yields have been successfully carried out using benzyl chloride, bromide and iodide. As an industrial application, the synthesis of a key monomer used for the synthesis of polyethylene terephthalate (PET), i. e., terephthalic acid (PTA), has also been accomplished in good yields.

Asian Journal of Organic Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Recommanded Product: 1-(Chloromethyl)-4-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Struwe, Julia published the artcilePhoto-Induced Ruthenium-Catalyzed C-H Benzylations and Allylations at Room Temperature, Name: 1-(Chloromethyl)-4-(trifluoromethyl)benzene, the publication is Chemistry – A European Journal (2021), 27(65), 16237-16241, database is CAplus and MEDLINE.

The ruthenium-catalyzed synthesis of diarylmethane compounds was realized under exceedingly mild photoredox conditions without the use of exogenous photocatalysts. The versatility and robustness of the ruthenium-catalyzed C-H benzylation was reflected by an ample scope, including multifold C-H functionalizations, as well as transformable pyrazoles, imidates and sensitive nucleosides. Mechanistic studies were indicative of a photoactive cyclometalated ruthenium complex, which also enabled versatile C-H allylations.

Chemistry – A European Journal published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C17H14O5, Name: 1-(Chloromethyl)-4-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics