Category: 939-99-1

Spinnato, Davide published the artcileA Photochemical Organocatalytic Strategy for the α-Alkylation of Ketones by using Radicals, Formula: C8H6ClF3, the publication is Angewandte Chemie, International Edition (2020), 59(24), 9485-9490, database is CAplus and MEDLINE.

Reported herein is a visible-light-mediated radical approach to the α-alkylation of ketones. This method exploits the ability of a nucleophilic organocatalyst to generate radicals upon S_N2-based activation of alkyl halides and blue light irradiation The resulting open-shell intermediates are then intercepted by weakly nucleophilic silyl enol ethers, which would be unable to directly attack the alkyl halides through a traditional two-electron path. The mild reaction conditions allowed functionalization of the α position of ketones with functional groups that are not compatible with classical anionic strategies. In addition, the redox-neutral nature of this process makes it compatible with a cinchona-based primary amine catalyst, which was used to develop a rare example of enantioselective organocatalytic radical α-alkylation of ketones. Thus, e.g., treatment of acetophenone O-TBS silyl enol ether with chloroacetonitrile afforded I (91%) in presence of dithiocarbonyl catalyst II using blue LED irradiation and TFA or TBAF workup.

Angewandte Chemie, International Edition published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C9H10O3S, Formula: C8H6ClF3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bazzi, Sakna published the artcileElectrogenerated Sm(II)-Catalyzed CO₂ Activation for Carboxylation of Benzyl Halides, Quality Control of 939-99-1, the publication is Organic Letters (2019), 21(24), 10033-10037, database is CAplus and MEDLINE.

Sm(II)-catalyzed carboxylation of benzyl halides is reported through the electrochem. reduction of CO₂. The transformation proceeds under mild reaction conditions to afford the corresponding phenylacetic acids in good to excellent yields. This user-friendly and operationally simple protocol represents an alternative to traditional strategies, which usually proceeds through the C(sp³)-halide activation pathway.

Organic Letters published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Quality Control of 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Markushyna, Yevheniia published the artcileChromoselective Synthesis of Sulfonyl Chlorides and Sulfonamides with Potassium Poly(heptazine imide) Photocatalyst, Quality Control of 939-99-1, the publication is Angewandte Chemie, International Edition (2021), 60(37), 20543-20550, database is CAplus and MEDLINE.

Among external stimuli used to promote a chem. reaction, photocatalysis possesses a unique one-light. Photons are traceless reagents that provide an exclusive opportunity to alter chemoselectivity of the photocatalytic reaction varying the color of incident light. This strategy may be implemented by using a sensitizer capable to activate a specific reaction pathway depending on the excitation light. Herein, we use potassium poly(heptazine imide) (K-PHI), a type of carbon nitride, to generate selectively three different products from S-arylthioacetates simply varying the excitation light and otherwise identical conditions. Namely, arylchlorides are produced under UV/purple, sulfonyl chlorides with blue/white, and diaryl disulfides at green to red light (e.g., S-Ph thioacetate → benzenesulfonyl chloride (93%) under blue light irradiation using HCl in water/MeCN and O₂ as electron acceptor). A combination of the neg. charged polyanion, highly pos. potential of the valence band, presence of intraband states, ability to sensitize singlet oxygen, and multi-electron transfer is shown to enable this chromoselective conversion of thioacetates.

Angewandte Chemie, International Edition published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Quality Control of 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Krymov, Stepan K. published the artcileSynthesis, biological evaluation, and in silico studies of potential activators of apoptosis and carbonic anhydrase inhibitors on isatin-5-sulfonamide scaffold, Product Details of C8H6ClF3, the publication is European Journal of Medicinal Chemistry (2022), 113997, database is CAplus and MEDLINE.

Carbonic anhydrase IX is a promising target for the search for new antitumor compounds with improved properties. Using the mol. hybridization approach, on the basis of structures of a selective carbonic anhydrase IX inhibitor 3 and an activator of apoptosis 2 (1), a series of 1-substituted isatin-5-sulfonamides I [R = benzyl, 2-fluorobenzyl, 3-fluorobenzyl, etc.] were designed and synthesized. The study of the inhibitory activity of isatin-5-sulfonamides showed the ability to inhibit I, II, IX, XII isoforms at nano- and micromolar concentrations Docking of compounds 1-(3,5-Difluorobenzyl)-2,3-dioxoindoline-5-sulfonamide and 1-(2,4-Dichlorobenzyl)-2,3-dioxoindoline-5-sulfonamide into the active site of II and IX carbonic anhydrase isoforms showed the coordination of sulfonamidate anions with zinc cations, as well as a number of addnl. hydrophobic interactions. The trifluoromethylthio derivative2,3-Dioxo-1-(4-((trifluoromethyl)thio)benzyl)indoline-5-sulfonamide suppressed the growth of tumor cells at low micromolar concentrations, maintaining activity on resistant lines and under hypoxic conditions. Immunoblotting of MCF7 cells treated with the 2,3-Dioxo-1-(4-((trifluoromethyl)thio)benzyl)indoline-5-sulfonamide revealed its antiestrogenic activity and ability to activate apoptosis in tumor cells.

European Journal of Medicinal Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Product Details of C8H6ClF3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Wei published the artcilePalladium-Catalyzed Thiocarbonylation of Benzyl Chlorides with Sulfonyl Chlorides for the Synthesis of Arylacetyl Thioesters, Computed Properties of 939-99-1, the publication is Advanced Synthesis & Catalysis (2021), 363(10), 2541-2545, database is CAplus.

A convenient procedure for the synthesis of thioesters RCH₂C(O)SR¹ (R = Ph, 3,4-dimethylphenyl, naphthalen-1-yl, thiophen-3-yl, etc.; R¹ = Ph, 2,4,6-trimethylphenyl, naphthalen-1-yl, etc.) has been developed via a palladium-catalyzed thiocarbonylation of benzyl chlorides RCH₂Cl with sulfonyl chlorides R¹S(O)₂Cl. Various arylacetyl thioesters were produced in good yields by using sulfonyl chlorides as an odorless sulfur source. Furthermore, W(CO)₆ exhibited dual roles as both a solid CO surrogate and reductant here.

Advanced Synthesis & Catalysis published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C7H8BClO2, Computed Properties of 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Papastavrou, Argyro T. published the artcileUnprecedented Multicomponent Organocatalytic Synthesis of Propargylic Esters via CO₂ Activation, Application of 1-(Chloromethyl)-4-(trifluoromethyl)benzene, the publication is ChemCatChem (2019), 11(21), 5379-5386, database is CAplus.

An efficient and straightforward organocatalytic method for the direct, multicomponent carboxylation of terminal alkynes with CO₂ and organochlorides, towards propargylic esters, is reported for the first time. 1,3-Di-tert-butyl-1H-imidazol-3-ium chloride, a simple, widely-available, stable, and cost-efficient N-heterocyclic carbene (NHC) precursor salt was used as the (pre)catalyst. A wide range of phenylacetylenes, bearing electron-withdrawing or electron-donating substituents, react with allyl chlorides, benzyl chlorides, or 2-chloroacetates, providing the corresponding propargylic esters in low to excellent yields. DFT calculations on the mechanism of this transformation indicate that the reaction is initiated with the formation of an NHC-carboxylate, by addition of the carbene to a mol. of CO₂. Then, the nucleophilic addition of this species to the corresponding chlorides has been computed to be the rate limiting step of the process.

ChemCatChem published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Application of 1-(Chloromethyl)-4-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pravardhan Reddy, E. published the artcileBenzyl chlorides as aldehyde surrogates in the Prins cyclization: Direct access to 2-aryl-4-chlorotetrahydropyrans, Formula: C8H6ClF3, the publication is Tetrahedron Letters (2022), 153746, database is CAplus.

An efficient synthesis of 2-aryl-4-chloro-tetrahydropyrans was accomplished from benzyl chlorides and homoallylic alcs. using FeCl₃ as a promoter through a sequential oxidation/Prins cyclization in high yields. This was the first report on the use of benzyl chlorides as surrogates for aldehydes in the Prins cyclization.

Tetrahedron Letters published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Formula: C8H6ClF3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ma, Junjie published the artcileSemicarbazone derivatives bearing phenyl moiety: synthesis, anticancer activity, cell cycle, apoptosis-inducing and metabolic stability study, SDS of cas: 939-99-1, the publication is Chemical & Pharmaceutical Bulletin (2019), 67(4), 351-360, database is CAplus and MEDLINE.

A series of semicarbazone derivatives bearing Ph moiety I [R = Me, Et; R¹ = H, benzyloxidanyl, 2-(2H-1,3-benzodioxol-5-ylmethyl)-(1,3-thiazol-4-yl)-methyloxy, [(4-chlorophenyl)methyl]oxidanyl, etc.; R² = t-Bu, H, prop-2-en-1-yl; R³ = H, t-Bu] was synthesized and evaluated for the vitro anticancer activities in four human cancer cell lines (human colon cancer (HT29), human neuroblastoma (SK-N-SH), human breast cancer (MDA-MB-231), and human gastric cancer (MKN45)). Biol. evaluation led to the identification of I [(I) R = Me, R¹ H, R² = R³ = t-Bu; (II) R = Et, R¹ H, R² = R³ = t-Bu], which showed excellent anticancer activities against tested cancer cell lines with IC₅₀ values ranging from 0.32 to 1.57 μM, resp., while exhibiting weak cytotoxicity on the normal cells (human umbilical vein endothelial cell (HUVEC)). Flow cytometric assay for cell cycle and apoptosis revealed that (I) and (II) caused an arrest in the Sub-G1 cell cycle and inhibited proliferation of cancer cells by inducing apoptosis in a dose-dependent manner. Further enzymic assay suggested that (I) and (II) could significantly activated procaspase-3 to caspase-3. Metabolic stability study indicated that (I) and (II) showed moderate stability in vitro in human and rat liver microsomes. In view of promising pharmacol. activities of (I) and (II), which had emerged as the valuable lead for further development in the treatment for cancer.

Chemical & Pharmaceutical Bulletin published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, SDS of cas: 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yao, Yan published the artcileElectrochemical Synthesis of Quinazolinones by the Metal-Free and Acceptor-Free Dehydrogenation of 2-Aminobenzamides, Formula: C8H6ClF3, the publication is Synlett (2020), 31(18), 1795-1799, database is CAplus.

An efficient approach has been developed for the construction of quinazolin-4(3H)-ones by the selective anodic dehydrogenative oxidation/cyclization of benzylic chlorides and 2-aminobenzamides [e.g., 2-aminobenzamide + benzyl chloride → 2-phenylquinazolin-4(3H)-one I (80%) employing RVC as anode, Pt as cathode, Bu₄NBF₄ as electrolyte and MeCN as solvent in undivided cell at constant current of 10mA at 80°]. The method features acceptor-free and metal-free dehydrogenation of amines to imines; a subsequent intermol. addition provides the products in moderate to good yields.

Synlett published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C7H16ClNO2, Formula: C8H6ClF3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ferla, Salvatore published the artcileRational modifications, synthesis and biological evaluation of new potential antivirals for RSV designed to target the M2-1 protein, HPLC of Formula: 939-99-1, the publication is Bioorganic & Medicinal Chemistry (2020), 28(8), 115401, database is CAplus and MEDLINE.

Respiratory syncytial virus (RSV) is the main cause of lower respiratory tract diseases in infants and young children, with potentially serious and fatal consequences associated with severe infections. Despite extensive research efforts invested in the identification of therapeutic measures, no vaccine is currently available, while treatment options are limited to ribavirin and palivizumab, which both present significant limitations. While clin. and pre-clin. candidates mainly target the viral fusion protein, the nucleocapsid protein or the viral polymerase, our focus has been the identification of new antiviral compounds targeting the viral M2-1 protein, thanks to the presence of a zinc-ejecting group in their chem. structure. Starting from an anti-RSV hit we had previously identified with an in silico structure-based approach, we have designed, synthesized and evaluated a new series of dithiocarbamate analogs, with which we have explored the antiviral activity of this scaffold. The findings presented in this work may provide the basis for the identification of a new antiviral lead to treat RSV infections.

Bioorganic & Medicinal Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, HPLC of Formula: 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics