Category: 89-77-0

Komar, Mario; Kraljevic, Tatjana Gazivoda; Jerkovic, Igor; Molnar, Maja published an article in 2022, the title of the article was Application of Deep Eutectic Solvents in the Synthesis of Substituted 2-Mercaptoquinazolin-4(3H)-Ones: A Comparison of Selected Green Chemistry Methods.Electric Literature of 89-77-0 And the article contains the following content:

In this study, deep eutectic solvents (DESs) were used as green and eco-friendly media for the synthesis of substituted 2-mercaptoquinazolin-4(3H)-ones I [R1 = H, 6-I, 6-Br, 7-Cl, 6,8-dichloro; R2 = Me, Ph, Bn, etc.] from different anthranilic acids and aliphatic or aromatic isothiocyanates. A model reaction on anthranilic acid and Ph isothiocyanate was performed in 20 choline chloride-based DESs at 80 °C to find the best solvent. Based on the product yield, choline chloride:urea (1:2) DES was found to be the most effective, while DESs acted both as solvents and catalysts. Desired compounds were prepared with moderate to good yields using stirring, microwave-assisted, and ultrasound-assisted synthesis. Significantly higher yields were obtained with mixing and ultrasonication (16-76%), while microwave-induced synthesis showed lower effectiveness (13-49%). The structures of the synthesized compounds were confirmed by 1H and 13C NMR spectroscopy. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Electric Literature of 89-77-0

The Article related to mercaptoquinazolinone green preparation, anthranilic acid isothiocyanate microwave ultrasound choline chloride urea catalyst, 2-mercaptoquinazolin-4(3h)-one, deep eutectic solvents, green chemistry, microwave-assisted synthesis, ultrasound-assisted synthesis and other aspects.Electric Literature of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On June 3, 2020, Song, Bichao; Xie, Peipei; Li, Yingzi; Hao, Jiping; Wang, Lu; Chen, Xiangyang; Xu, Zhongliang; Quan, Haitian; Lou, Liguang; Xia, Yuanzhi; Houk, K. N.; Yang, Weibo published an article.COA of Formula: C7H6ClNO2 The title of the article was Pd-Catalyzed Decarboxylative Olefination: Stereoselective Synthesis of Polysubstituted Butadienes and Macrocyclic P-glycoprotein Inhibitors. And the article contained the following:

The efficient and stereoselective synthesis of polysubstituted butadienes, especially the multifunctional butadienes, represents a great challenge in organic synthesis. Herein, we wish to report a distinctive Pd(0) carbene-initiated decarboxylative olefination approach that enables the direct coupling of diazo esters with vinylethylene carbonates (VECs), vinyl oxazolidinones, or vinyl benzoxazinones to afford alc.-, amine-, or aniline-containing 1,3-dienes in moderate to high yields and with excellent stereoselectivity. This protocol features operational simplicity, mild reaction conditions, a broad substrate scope, and gram-scalability. Notably, a structurally unique allylic Pd(II) intermediate was isolated and characterized. DFT calculation and control experiments demonstrated that a rare Pd(0) carbene intermediate could be involved in this reaction. Moreover, the polysubstituted butadienes as novel building blocks were unprecedentedly assembled into macrocycles, which efficiently inhibited the P-glycoprotein and dramatically reversed multidrug resistance in cancer cells by 190-fold. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).COA of Formula: C7H6ClNO2

The Article related to vinylethylene carbonate diazo ester palladium decarboxylative olefination catalyst, vinyloxazolidinone diazo ester palladium decarboxylative olefination catalyst, vinylbenzoxazinone diazo ester palladium decarboxylative olefination catalyst, butadiene polysubstituted stereoselective preparation and other aspects.COA of Formula: C7H6ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On January 17, 2020, Chen, Kai-Chi; Barve, Indrajeet J.; Sun, Chung-Ming published an article.Formula: C7H6ClNO2 The title of the article was Catalyst-Controlled Regioselective Synthesis of Benzotriazolodiazepin-7-ones and Benzotriazolodiazocin-8-ones. And the article contained the following:

A catalyst-controlled highly chemoselective and regioselective intramol. cycloamidation of triazol-1-ylbenzamides toward the synthesis of scarcely known heterocycles is reported. In the presence of a palladium catalyst, this cycloisomerization reaction afforded substituted benzotriazolodiazepin-7-ones via intramol. insertion of a palladium into C-C triple bond in a 7-exo-dig way. Alternatively, the use of a silver catalyst in the reaction produced substituted benzotriazolodiazocin-8-ones in a highly regioselective manner through 8-endo-dig intramol. ring closure. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Formula: C7H6ClNO2

The Article related to palladium catalyst triazolylbenzamide diastereoselective chemoselective regioselective intramol cycloamidation, benzotriazolodiazepinone preparation, silver catalyst triazolylbenzamide diastereoselective chemoselective regioselective intramol cycloamidation, benzotriazolodiazocinone preparation and other aspects.Formula: C7H6ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 16, 2020, Wang, Peng-Fei; Jensen, Anders A.; Bunch, Lennart published an article.Related Products of 89-77-0 The title of the article was From Methaqualone and Beyond: Structure-Activity Relationship of 6-, 7-, and 8-Substituted 2,3-Diphenyl-quinazolin-4(3H)-ones and in Silico Prediction of Putative Binding Modes of Quinazolin-4(3H)-ones as Positive Allosteric Modulators of GABAA Receptors. And the article contained the following:

Methaqualone (2-methyl-3-(o-tolyl)-quinazolin-4(3H)-one, MTQ) is a moderately potent pos. allosteric modulator (PAM) of GABAA receptors (GABAARs). In a previous structure-activity relationship (SAR) study probing the importance of 2- and 3-substituents in the quinazolin-4(3H)-one scaffold, several potent GABAAR PAMs were identified, including 2,3-diphenylquinazolin-4(3H)-one (PPQ) and 3-(2-chlorophenyl)-2-phenylquinazolin-4(3H)-one (Cl-PPQ). Here, PPQ was applied as lead in a SAR study of 6-, 7-, and 8-substituents in the quinazolin-4(3H)-one by synthesis and functional characterization of 36 PPQ analogs at various GABAAR subtypes. While none of the new analogs were significantly more potent than PPQ or displayed pronounced subtype selectivity across the GABAARs tested, several interesting SAR observations were extracted from the study. In an in silico study, the putative binding modes of MTQ, PPQ, and Cl-PPQ in the transmembrane β2(+)/α1(-) interface of the α1β2γ2S GABAAR were predicted. Several plausible binding modes were identified for the three PAMs, and rationalization of the mol. basis for their different modulatory potencies was attempted. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Related Products of 89-77-0

The Article related to quinazolinone preparation gaba receptor allosteric modulator, structure quinazolinone binding selectivity gaba receptor, mol docking complex quinazolinone gabaa transmembrane domain, gabaa positive allosteric modulators (pams), gabaa receptors, docking, methaqualone, structure−activity relationship (sar) study, transmembrane domain and other aspects.Related Products of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 1, 2021, Kadaiahgari, Chandra Sekhar; Saha, Moumita; Ravuri, Srinath; Nandigama, Sandeep; Saha, Krishna Das; Banerji, Biswadip published an article.Formula: C7H6ClNO2 The title of the article was Sulphonamide-Containing Oxazoline Hybrids as New Class of Neuroprotective Agents and Lead Molecule as Autophagy Inducer. And the article contained the following:

In the present study, a series of sulfonamide containing oxazoline hybrids I [R1 = 2-NH2, 3-NH2, 4-NH2; R2 = H, Cl, MeO; R3 = H, MeO; R2R3 = HC=CHCH=CH] were synthesized and their neuroprotective efficacy in neuronal cell lines was explored. All the compounds I showed moderate to good neuroprotection against adrenal medulla cell lines (PC 12). Compound I [R1 = 4-NH2; R2R3 = HC=CHCH=CH] had good neuroprotective activity against PC 12 cell lines showing increased expression of autophagy regulatory proteins (ATG7, LC 3B, p62, Beclin-1) and anti-apoptotic proteins (Bcl-2) and also decreased expression of pro-apoptotic proteins (Bax and Bad). This study demonstrated clearly that compound I [R1 = 4-NH2; R2R3 = HC=CHCH=CH] showed neuroprotective effect through the induction of autophagy and opens up new avenues for a new class of compounds as neuroprotective therapeutic agents. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Formula: C7H6ClNO2

The Article related to amino dihydrooxazolyl aryl benzenesulfonamide preparation neuroprotective agent autophagy human, aminophenyl sulfonylamino hydroxyethyl aryl carboxamide preparation mitsunobu reaction, hydroxyethyl nitrophenyl sulfonylamino aryl carboxamide preparation reduction catalyst iron, nitrophenyl sulfonylamino aryl carboxylic acid preparation aminoethanol coupling and other aspects.Formula: C7H6ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 1, 2021, Kadaiahgari, Chandra Sekhar; Saha, Moumita; Ravuri, Srinath; Nandigama, Sandeep; Saha, Krishna Das; Banerji, Biswadip published an article.Formula: C7H6ClNO2 The title of the article was Sulphonamide-Containing Oxazoline Hybrids as New Class of Neuroprotective Agents and Lead Molecule as Autophagy Inducer. And the article contained the following:

In the present study, a series of sulfonamide containing oxazoline hybrids I [R1 = 2-NH2, 3-NH2, 4-NH2; R2 = H, Cl, MeO; R3 = H, MeO; R2R3 = HC=CHCH=CH] were synthesized and their neuroprotective efficacy in neuronal cell lines was explored. All the compounds I showed moderate to good neuroprotection against adrenal medulla cell lines (PC 12). Compound I [R1 = 4-NH2; R2R3 = HC=CHCH=CH] had good neuroprotective activity against PC 12 cell lines showing increased expression of autophagy regulatory proteins (ATG7, LC 3B, p62, Beclin-1) and anti-apoptotic proteins (Bcl-2) and also decreased expression of pro-apoptotic proteins (Bax and Bad). This study demonstrated clearly that compound I [R1 = 4-NH2; R2R3 = HC=CHCH=CH] showed neuroprotective effect through the induction of autophagy and opens up new avenues for a new class of compounds as neuroprotective therapeutic agents. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Formula: C7H6ClNO2

The Article related to amino dihydrooxazolyl aryl benzenesulfonamide preparation neuroprotective agent autophagy human, aminophenyl sulfonylamino hydroxyethyl aryl carboxamide preparation mitsunobu reaction, hydroxyethyl nitrophenyl sulfonylamino aryl carboxamide preparation reduction catalyst iron, nitrophenyl sulfonylamino aryl carboxylic acid preparation aminoethanol coupling and other aspects.Formula: C7H6ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On June 3, 2020, Song, Bichao; Xie, Peipei; Li, Yingzi; Hao, Jiping; Wang, Lu; Chen, Xiangyang; Xu, Zhongliang; Quan, Haitian; Lou, Liguang; Xia, Yuanzhi; Houk, K. N.; Yang, Weibo published an article.COA of Formula: C7H6ClNO2 The title of the article was Pd-Catalyzed Decarboxylative Olefination: Stereoselective Synthesis of Polysubstituted Butadienes and Macrocyclic P-glycoprotein Inhibitors. And the article contained the following:

The efficient and stereoselective synthesis of polysubstituted butadienes, especially the multifunctional butadienes, represents a great challenge in organic synthesis. Herein, we wish to report a distinctive Pd(0) carbene-initiated decarboxylative olefination approach that enables the direct coupling of diazo esters with vinylethylene carbonates (VECs), vinyl oxazolidinones, or vinyl benzoxazinones to afford alc.-, amine-, or aniline-containing 1,3-dienes in moderate to high yields and with excellent stereoselectivity. This protocol features operational simplicity, mild reaction conditions, a broad substrate scope, and gram-scalability. Notably, a structurally unique allylic Pd(II) intermediate was isolated and characterized. DFT calculation and control experiments demonstrated that a rare Pd(0) carbene intermediate could be involved in this reaction. Moreover, the polysubstituted butadienes as novel building blocks were unprecedentedly assembled into macrocycles, which efficiently inhibited the P-glycoprotein and dramatically reversed multidrug resistance in cancer cells by 190-fold. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).COA of Formula: C7H6ClNO2

The Article related to vinylethylene carbonate diazo ester palladium decarboxylative olefination catalyst, vinyloxazolidinone diazo ester palladium decarboxylative olefination catalyst, vinylbenzoxazinone diazo ester palladium decarboxylative olefination catalyst, butadiene polysubstituted stereoselective preparation and other aspects.COA of Formula: C7H6ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On January 17, 2020, Chen, Kai-Chi; Barve, Indrajeet J.; Sun, Chung-Ming published an article.Formula: C7H6ClNO2 The title of the article was Catalyst-Controlled Regioselective Synthesis of Benzotriazolodiazepin-7-ones and Benzotriazolodiazocin-8-ones. And the article contained the following:

A catalyst-controlled highly chemoselective and regioselective intramol. cycloamidation of triazol-1-ylbenzamides toward the synthesis of scarcely known heterocycles is reported. In the presence of a palladium catalyst, this cycloisomerization reaction afforded substituted benzotriazolodiazepin-7-ones via intramol. insertion of a palladium into C-C triple bond in a 7-exo-dig way. Alternatively, the use of a silver catalyst in the reaction produced substituted benzotriazolodiazocin-8-ones in a highly regioselective manner through 8-endo-dig intramol. ring closure. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Formula: C7H6ClNO2

The Article related to palladium catalyst triazolylbenzamide diastereoselective chemoselective regioselective intramol cycloamidation, benzotriazolodiazepinone preparation, silver catalyst triazolylbenzamide diastereoselective chemoselective regioselective intramol cycloamidation, benzotriazolodiazocinone preparation and other aspects.Formula: C7H6ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 16, 2020, Wang, Peng-Fei; Jensen, Anders A.; Bunch, Lennart published an article.Related Products of 89-77-0 The title of the article was From Methaqualone and Beyond: Structure-Activity Relationship of 6-, 7-, and 8-Substituted 2,3-Diphenyl-quinazolin-4(3H)-ones and in Silico Prediction of Putative Binding Modes of Quinazolin-4(3H)-ones as Positive Allosteric Modulators of GABAA Receptors. And the article contained the following:

Methaqualone (2-methyl-3-(o-tolyl)-quinazolin-4(3H)-one, MTQ) is a moderately potent pos. allosteric modulator (PAM) of GABAA receptors (GABAARs). In a previous structure-activity relationship (SAR) study probing the importance of 2- and 3-substituents in the quinazolin-4(3H)-one scaffold, several potent GABAAR PAMs were identified, including 2,3-diphenylquinazolin-4(3H)-one (PPQ) and 3-(2-chlorophenyl)-2-phenylquinazolin-4(3H)-one (Cl-PPQ). Here, PPQ was applied as lead in a SAR study of 6-, 7-, and 8-substituents in the quinazolin-4(3H)-one by synthesis and functional characterization of 36 PPQ analogs at various GABAAR subtypes. While none of the new analogs were significantly more potent than PPQ or displayed pronounced subtype selectivity across the GABAARs tested, several interesting SAR observations were extracted from the study. In an in silico study, the putative binding modes of MTQ, PPQ, and Cl-PPQ in the transmembrane β2(+)/α1(-) interface of the α1β2γ2S GABAAR were predicted. Several plausible binding modes were identified for the three PAMs, and rationalization of the mol. basis for their different modulatory potencies was attempted. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Related Products of 89-77-0

The Article related to quinazolinone preparation gaba receptor allosteric modulator, structure quinazolinone binding selectivity gaba receptor, mol docking complex quinazolinone gabaa transmembrane domain, gabaa positive allosteric modulators (pams), gabaa receptors, docking, methaqualone, structure−activity relationship (sar) study, transmembrane domain and other aspects.Related Products of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 1, 2021, Kadaiahgari, Chandra Sekhar; Saha, Moumita; Ravuri, Srinath; Nandigama, Sandeep; Saha, Krishna Das; Banerji, Biswadip published an article.Formula: C7H6ClNO2 The title of the article was Sulphonamide-Containing Oxazoline Hybrids as New Class of Neuroprotective Agents and Lead Molecule as Autophagy Inducer. And the article contained the following:

In the present study, a series of sulfonamide containing oxazoline hybrids I [R1 = 2-NH2, 3-NH2, 4-NH2; R2 = H, Cl, MeO; R3 = H, MeO; R2R3 = HC=CHCH=CH] were synthesized and their neuroprotective efficacy in neuronal cell lines was explored. All the compounds I showed moderate to good neuroprotection against adrenal medulla cell lines (PC 12). Compound I [R1 = 4-NH2; R2R3 = HC=CHCH=CH] had good neuroprotective activity against PC 12 cell lines showing increased expression of autophagy regulatory proteins (ATG7, LC 3B, p62, Beclin-1) and anti-apoptotic proteins (Bcl-2) and also decreased expression of pro-apoptotic proteins (Bax and Bad). This study demonstrated clearly that compound I [R1 = 4-NH2; R2R3 = HC=CHCH=CH] showed neuroprotective effect through the induction of autophagy and opens up new avenues for a new class of compounds as neuroprotective therapeutic agents. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Formula: C7H6ClNO2

The Article related to amino dihydrooxazolyl aryl benzenesulfonamide preparation neuroprotective agent autophagy human, aminophenyl sulfonylamino hydroxyethyl aryl carboxamide preparation mitsunobu reaction, hydroxyethyl nitrophenyl sulfonylamino aryl carboxamide preparation reduction catalyst iron, nitrophenyl sulfonylamino aryl carboxylic acid preparation aminoethanol coupling and other aspects.Formula: C7H6ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics