Category: 89-77-0

On April 27, 2022, Liu, Jingbo; Shi, Yabing; Tian, Zhicheng; Li, Fengyun; Hao, Zesheng; Wen, Wen; Zhang, Li; Wang, Yuanhong; Li, Yuxin; Fan, Zhijin published an article.Safety of 2-Amino-4-chlorobenzoic acid The title of the article was Bioactivity-Guided Synthesis Accelerates the Discovery of Evodiamine Derivatives as Potent Insecticide Candidates. And the article contained the following:

Pests threaten worldwide food security by decreasing crop yields and damaging their quality. Natural product-based mol. design and structural optimization have been one of the most effective ways to innovate pesticides for integrated insect management. To continue our previous studies on the discovery of insecticidal lead, a series of evodiamine derivatives were designed, synthesized, and evaluated for their insecticidal activities. The bioassay results demonstrated that compounds (I) and (II) exhibited 90 and 80% insecticidal activities against Mythimna separata at 2.5 mg/L, resp., which were superior to evodiamine (10% at 10 mg/L), matrine (45% at 600 mg/L), and rotenone (30% at 200 mg/L). Compounds I, II and (III) showed 90% insecticidal activities against Plutella xylostella at 1.0 mg/L, far more potent than those of evodiamine, matrine, and rotenone. Compound I displayed 60% insecticidal activity against Helicoverpa armigera at 5.0 mg/L, while evodiamine, matrine, and rotenone showed very poor activities. The study on the insecticidal mechanism of action by a calcium imaging experiment indicated that the insect ryanodine receptors (RyRs) could be the potential target of I. Furthermore, the mol. docking indicated that I anchored in the binding site of the RyR of P. xylostella. The above results manifested the potential of evodiamine derivatives as potent insecticide candidates. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Safety of 2-Amino-4-chlorobenzoic acid

The Article related to evodiamine derivative preparation insecticide mythimna plutella helicoverpa ryanodine receptor, evodiamine, insecticidal activity, insecticidal mechanism of action, molecular docking, structure−activity relationship and other aspects.Safety of 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 31, 2021, Faraji, Aram; Motahari, Rasoul; Hasanvand, Zaman; Oghabi Bakhshaiesh, Tayebeh; Toolabi, Mahsa; Moghimi, Setareh; Firoozpour, Loghman; Boshagh, Mohammad Amin; Rahmani, Roya; Ketabforoosh, Shima H. M. E.; Bijanzadeh, Hamid Reza; Esmaeili, Rezvan; Foroumadi, Alireza published an article.Application of 89-77-0 The title of the article was Quinazolin-4(3H)-one based agents bearing thiadiazole-urea: Synthesis and evaluation of anti-proliferative and antiangiogenic activity. And the article contained the following:

A series of quinazolin-4(3H)-one based agents containing thiadiazole-urea I [X = H, Cl; R1 = H, Me, Cl, etc.; R2 = H, Me, F, MeO, Cl] were designed, synthesized and biol. evaluated. The proliferation rate of PC3 cells were moderately reduced by compound I [X = R2 = H, R1 = Me] (IC50 = 17.7μM) which was comparable with sorafenib (IC50 = 17.3μM). There was also a significant reduction in the number of HUVEC cells, when they were exposed to compound I [X = R1 = Cl, R2 = Me] (IC50 = 6.1μM). To test the potential of compounds I in inducing apoptosis, Annexin V-FITC/propidium iodide double staining assay was used. After the treatment of HUVEC cells with compound I [X = R2 = H, R1 = Me], they underwent apoptotic effects. A substantial effort was dedicated to gathering comprehensive data across CAM assay. These data showed that compound I [X = R2 = H, R1 = Me] moderately inhibited the growth of corresponding blood vessels. Finally, the outcomes of Western blotting proposed a mechanism of action, by which the phosphorylation of VEGFR-2 was inhibited by compounds I [X = R2 = H, R1 = Me; X = R1 = Cl, R2 = Me]. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Application of 89-77-0

The Article related to phenylureido thiadiazolylthiomethyl dihydroquinazolinone preparation, antitumor cytotoxicity sar antiangiogenic mol docking apoptosis induction, apoptotic effects, cam assay, pc3 cells, sorafenib, vegfr-2, western blotting and other aspects.Application of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 28, 2022, Rastegari, Arezoo; Safavi, Maliheh; Vafadarnejad, Fahimeh; Najafi, Zahra; Hariri, Roshanak; Bukhari, Syed Nasir Abbas; Iraji, Aida; Edraki, Najmeh; Firuzi, Omidreza; Saeedi, Mina; Mahdavi, Mohammad; Akbarzadeh, Tahmineh published an article.Related Products of 89-77-0 The title of the article was Synthesis and evaluation of novel arylisoxazoles linked to tacrine moiety: in vitro and in vivo biological activities against Alzheimer’s disease. And the article contained the following:

Focusing on the efficient cholinesterase inhibitory activity of tacrine, design and synthesis of arylisoxazole-tacrine analogs, I [R = H, 4-F, 4-O2N, etc.; X = H, Cl] was developed. In-vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition assay confirmed high potency of the title compds I. Among them, compounds I [R = 3-MeO, X = Cl; R = 4-Cl, X = H] demonstrated high activity toward AChE and BChE with IC50 values of 0.050 and 0.039μM, resp. Both compounds I [R = 3-MeO, X = Cl; R = 4-Cl, X = H] showed very good self-induced Aβ aggregation and AChE-induced inhibitory activity (79.4 and 71.4% for compound I [R = 3-MeO, X = Cl] and 61.8 and 58.6% for compound I [R = 4-Cl, X = H], resp.). Also, I [R = 3-MeO, X = Cl] showed good anti-BACE1 activity with IC50 value of 1.65μM. The metal chelation test indicated the ability of compounds I [R = 3-MeO, X = Cl; R = 4-Cl, X = H] to chelate biometals (Zn2+, Cu2+, and Fe2+). However, they showed no significant neuroprotectivity against Aβ-induced damage in PC12 cells. Evaluation of in-vitro hepatotoxicity revealed comparable toxicity of compounds I [R = 3-MeO, X = Cl; R = 4-Cl, X = H] with tacrine. In-vivo studies by Morris water maze (MWM) task demonstrated that compound I [R = 3-MeO, X = Cl] significantly reversed scopolamine-induced memory deficit in rats. Finally, mol. docking studies of compounds I [R = 3-MeO, X = Cl; R = 4-Cl, X = H] confirmed establishment of desired interactions with the AChE, BChE, and BACE1 active sites. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Related Products of 89-77-0

The Article related to phenyl tetrahydroacridinyl aminoethyl isoxazole preparation cholinesterase bace1 inhibition neuroprotection, mol docking sar metal chelation, alzheimer’s disease, bace1, cholinesterase, isoxazole, metal chelating, morris water maze, tacrine and other aspects.Related Products of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wei, Hao-Zhao; Yu, Liu-Zhu; Shi, Min published an article in 2020, the title of the article was Lewis or Bronsted acid-catalysed reaction of propargylic alcohol-tethered alkylidenecyclopropanes with indoles and pyrroles for the preparation of polycyclic compounds tethered with indole or pyrrole motif.Product Details of 89-77-0 And the article contains the following content:

A facile synthetic method to access cyclopenta[b]naphthalene derivatives I (R1 = H, 3-Me, 5-Me, 4-CF3, 5-OMe, 4-MeO, 4-Cl; R2 = Ph, 4-MeOC6H4, 3-thienyl; R3 = H, Me, OMe, Cl, F; R4 = H, Me, OMe, Cl; R5 = N-methylpyrrol-2-yl, indol-3-yl, N-phenylindol-3-yl, etc.) via the Lewis or Bronsted acid catalyzed cascade nucleophilic addition, electronic cyclization, ring-opening rearrangement of propargylic alc.-tethered alkylidenecyclopropanes II (R6 = H, 5-MeO, 5-Cl, 6-Me, etc.) with indole and pyrrole derivatives was developed. The reaction exhibited a broad substrate scope and good functional group tolerance under metal-free conditions, affording the desired products in moderate to good yields. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Product Details of 89-77-0

The Article related to cyclopenta naphthalene indole preparation, propargylic alc alkylidenecyclopropane indole cyclization lewis acid catalyst, naphthalene cyclopenta pyrrole preparation, pyrrole propargylic alc alkylidenecyclopropane cyclization lewis acid catalyst and other aspects.Product Details of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On January 3, 2022, Gui, Qing-Wen; Teng, Fan; Yang, Hao; Xun, Changping; Huang, Wen-Jie; Lu, Zi-Qin; Zhu, Meng-Xue; Ouyang, Wen-Tao; He, Wei-Min published an article.Electric Literature of 89-77-0 The title of the article was Visible-Light Photosynthesis of CHF2/CClF2/CBrF2-Substituted Ring-fused Quinazolinones in Dimethyl Carbonate. And the article contained the following:

With eco-friendly and sustainable CO2-derived di-Me carbonate as the sole solvent, the visible-light-induced cascade radical reactions have been established as a green and efficient tool for constructing various CHF2/CClF2/CBrF2-substituted ring-fused quinazolinones. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Electric Literature of 89-77-0

The Article related to ring fused quinazolinone preparation, alkenyl quinazolinone visible light cascade difluoromethylation cyclization green chem, cascade radical reactions, difluoromethylation, dimethyl carbonate, metal-free, ring-fused quinazolinones and other aspects.Electric Literature of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 3, 2021, Li, Ling; Zhang, Shiqi; Deng, Xiongfei; Li, Guangxun; Tang, Zhuo; Zhao, Gang published an article.Quality Control of 2-Amino-4-chlorobenzoic acid The title of the article was Preparation and Application of α-Imino Ketones through One-Pot Tandem Reactions Based on Heyns Rearrangement. And the article contained the following:

A metal-free and operationally simple strategy was developed to generate α-imino ketones with high regioselectivity. Meanwhile, the method allowed for the preparation of various N,O-ketals with high regioselectivities and diastereoselectivities through cascade reactions in one pot. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Quality Control of 2-Amino-4-chlorobenzoic acid

The Article related to amine hydroxyketone regioselective diastereoselective tandem heyns rearrangement oxidation, imino ketone preparation, hydroxyketone aminoalc regioselective diastereoselective tandem heyns rearrangement oxidation, ketal preparation and other aspects.Quality Control of 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 21, 2022, Nonami, Reina; Morimoto, Yusei; Kanemoto, Kazuya; Yamamoto, Yasunori; Shirai, Tomohiko published an article.Name: 2-Amino-4-chlorobenzoic acid The title of the article was Cationic Iridium-Catalyzed Asymmetric Decarbonylative Aryl Addition of Aromatic Aldehydes to Bicyclic Alkenes. And the article contained the following:

An unprecedented catalytic protocol for the enantioselective decarbonylative transformation of aryl aldehydes. In this process, the decarbonylation of aldehydes catalyzed by chiral iridium complexes enabled the formation of asym. C-C bonds through the formation of an aryl-iridium intermediate. The decarbonylative aryl addition to bicyclic alkenes were fluidly performed without a stoichiometric aryl-metal reagent, such as aryl boronic acid, with a cationic iridium complex generated in-situ from Ir(cod)2(BArF4) and the sulfur-linked bis(phosphoramidite) ligand ((R,R)-S-Me-BIPAM). This reaction has broad functional group compatibility and no waste was generated, except carbon monoxide. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Name: 2-Amino-4-chlorobenzoic acid

The Article related to formylphenyl acetamide norbornene iridium catalyst enantioselective decarbonylation, norbornanyl phenyl acetamide preparation, c−h bond activation, asymmetric catalysis, cationic iridium, decarbonylation, decarbonylative arylation and other aspects.Name: 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 19, 2020, Wang, Ze-Shu; Chen, Yang-Bo; Zhang, Hao-Wen; Sun, Zhou; Zhu, Chunyin; Ye, Long-Wu published an article.Reference of 2-Amino-4-chlorobenzoic acid The title of the article was Ynamide Smiles Rearrangement Triggered by Visible-Light-Mediated Regioselective Ketyl-Ynamide Coupling: Rapid Access to Functionalized Indoles and Isoquinolines. And the article contained the following:

Here, a novel and practical radical Smiles rearrangement triggered by photoredox-catalyzed regioselective ketyl-ynamide coupling is reported, which represents the first radical Smiles rearrangement of ynamides. This method enables facile access to a variety of valuable 2-benzhydrylindoles with broad substrate scope in generally good yields under mild reaction conditions. In addition, this chem. can also be extended to the divergent synthesis of versatile 3-benzhydrylisoquinolines through a similar ketyl-ynamide coupling and radical Smiles rearrangement, followed by dehydrogenative oxidation Moreover, such an ynamide Smiles rearrangement initiated by intermol. photoredox catalysis via addition of external radical sources is also achieved. By control experiments, the reaction was shown to proceed via key ketyl radical and α-imino carbon radical intermediates. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Reference of 2-Amino-4-chlorobenzoic acid

The Article related to cascade regioselective coupling smiles rearrangement iridium photocatalyst, benzoylbenzyl ethynylsulfonamide preparation coupling regioselective smiles rearrangement iridium photocatalyst, indole benzhydryl preparation, isoquinoline benzhydryl preparation and other aspects.Reference of 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Komar, Mario; Kraljevic, Tatjana Gazivoda; Jerkovic, Igor; Molnar, Maja published an article in 2022, the title of the article was Application of Deep Eutectic Solvents in the Synthesis of Substituted 2-Mercaptoquinazolin-4(3H)-Ones: A Comparison of Selected Green Chemistry Methods.Electric Literature of 89-77-0 And the article contains the following content:

In this study, deep eutectic solvents (DESs) were used as green and eco-friendly media for the synthesis of substituted 2-mercaptoquinazolin-4(3H)-ones I [R1 = H, 6-I, 6-Br, 7-Cl, 6,8-dichloro; R2 = Me, Ph, Bn, etc.] from different anthranilic acids and aliphatic or aromatic isothiocyanates. A model reaction on anthranilic acid and Ph isothiocyanate was performed in 20 choline chloride-based DESs at 80 °C to find the best solvent. Based on the product yield, choline chloride:urea (1:2) DES was found to be the most effective, while DESs acted both as solvents and catalysts. Desired compounds were prepared with moderate to good yields using stirring, microwave-assisted, and ultrasound-assisted synthesis. Significantly higher yields were obtained with mixing and ultrasonication (16-76%), while microwave-induced synthesis showed lower effectiveness (13-49%). The structures of the synthesized compounds were confirmed by 1H and 13C NMR spectroscopy. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Electric Literature of 89-77-0

The Article related to mercaptoquinazolinone green preparation, anthranilic acid isothiocyanate microwave ultrasound choline chloride urea catalyst, 2-mercaptoquinazolin-4(3h)-one, deep eutectic solvents, green chemistry, microwave-assisted synthesis, ultrasound-assisted synthesis and other aspects.Electric Literature of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 19, 2020, Wang, Ze-Shu; Chen, Yang-Bo; Zhang, Hao-Wen; Sun, Zhou; Zhu, Chunyin; Ye, Long-Wu published an article.Reference of 2-Amino-4-chlorobenzoic acid The title of the article was Ynamide Smiles Rearrangement Triggered by Visible-Light-Mediated Regioselective Ketyl-Ynamide Coupling: Rapid Access to Functionalized Indoles and Isoquinolines. And the article contained the following:

Here, a novel and practical radical Smiles rearrangement triggered by photoredox-catalyzed regioselective ketyl-ynamide coupling is reported, which represents the first radical Smiles rearrangement of ynamides. This method enables facile access to a variety of valuable 2-benzhydrylindoles with broad substrate scope in generally good yields under mild reaction conditions. In addition, this chem. can also be extended to the divergent synthesis of versatile 3-benzhydrylisoquinolines through a similar ketyl-ynamide coupling and radical Smiles rearrangement, followed by dehydrogenative oxidation Moreover, such an ynamide Smiles rearrangement initiated by intermol. photoredox catalysis via addition of external radical sources is also achieved. By control experiments, the reaction was shown to proceed via key ketyl radical and α-imino carbon radical intermediates. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Reference of 2-Amino-4-chlorobenzoic acid

The Article related to cascade regioselective coupling smiles rearrangement iridium photocatalyst, benzoylbenzyl ethynylsulfonamide preparation coupling regioselective smiles rearrangement iridium photocatalyst, indole benzhydryl preparation, isoquinoline benzhydryl preparation and other aspects.Reference of 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics