Category: 89-77-0

On March 19, 2021, Qi, Lin-Jun; Shi, Chong-Yang; Chen, Peng-Fei; Li, Long; Fang, Gang; Qian, Peng-Cheng; Deng, Chao; Zhou, Jin-Mei; Ye, Long-Wu published an article.Product Details of 89-77-0 The title of the article was Gold-Catalyzed 1,1-Carboalkoxylation of Oxetane-Ynamides via Exocyclic Metal Carbenes: Divergent and Atom-Economical Synthesis of Tricyclic N-Heterocycles. And the article contained the following:

Here, an unprecedented gold-catalyzed 1,1-carboalkoxylation of ynamides I (R1 = H, 4-Br, 5-Cl, 4-OMe, etc.; R2 = Ph, Me, 2-thienyl, etc.; R3 = Ts, Ms, benzenesulfonyl, etc.) for the generation of exocyclic gold carbenes via exo-cyclization under room temp was reported. Subsequent 1,2-N-migration and 1,2-H-migration into the gold carbenes lead to the divergent and atom-economical synthesis of valuable tetrahydrofuran-fused 1,4-dihydroquinolines II (R1 = H, 8-Br, 7-Cl, 8-OMe, etc.) and furoindolines III (R4 = H, 5-Br, 6-F, 5-OMe, etc.; R5 = Me, Et, n-Pr, etc.). Moreover, the asym. synthesis of these tricyclic N-heterocycles e.g., IV can be achieved by a chirality-transfer strategy, and the possibility of enantioselective cyclization via chiral gold-catalyzed kinetic resolution also emerges. In addition, the mechanistic rationale for this 1,1-carboalkoxylation, in particular accounting for the distinct migration into gold carbenes, is also strongly supported by theor. calculations The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Product Details of 89-77-0

The Article related to tricyclic nitrogen heterocycle preparation, ynamide oxetane preparation carboxylation gold catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Product Details of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Yiming; Wang, Yuhong; Yang, Tilong; Lin, Zhenyang; Jiang, Xuefeng published an article in 2021, the title of the article was Selenium-catalyzed intramolecular atom- and redox-economical transformation of o-nitrotoluenes into anthranilic acids.Computed Properties of 89-77-0 And the article contains the following content:

Herein, a straightforward strategy to transform abundant o-nitrotoluenes into biol. and pharmaceutically significant AAs without any extra reductants, oxidants and protecting groups was demonstrated. Various sensitive groups, such as halogens, sulfide, aldehyde, pyridines, quinolines, etc., can be tolerated in this transformation. A hundred-gram-scale operation was realized efficiently with almost quant. selenium recycling. Further mechanistic studies and DFT calculations disclosed the proposed atom-exchange processes and the key roles of the selenium species. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Computed Properties of 89-77-0

The Article related to nitrotoluene selenium catalyst redox reaction mechanism, anthranilic acid preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Computed Properties of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 16, 2021, Fairuz Binte Sheikh Ismail, Siti Nur; Yang, Binmiao; Zhao, Yu published an article.Application In Synthesis of 2-Amino-4-chlorobenzoic acid The title of the article was Access to 5,6-Spirocycles Bearing Three Contiguous Stereocenters via Pd-Catalyzed Stereoselective [4 + 2] Cycloaddition of Azadienes. And the article contained the following:

We present herein a highly diastereo- and enantioselective Pd-catalyzed [4 + 2] cycloaddition of benzofuran-derived azadienes with vinyl benzoxazinanones, which represents a rare highly stereoselective cycloaddition of this class of fused azadienes as a two-atom synthon. The use of a phosphoramidite ligand bearing a chiral secondary amine with a simple biphenyl backbone proved to be the key to construct the novel spirocyclic tetrahydroquinoline scaffold containing three contiguous stereocenters in high enantioselectivity. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Application In Synthesis of 2-Amino-4-chlorobenzoic acid

The Article related to vinyl benzoxazinanone azadiene palladium phosphoramidite ligand diastereoselective enantioselective cycloaddition, spirocyclic tetrahydroquinoline stereoselective preparation and other aspects.Application In Synthesis of 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On July 1, 2021, Mezeiova, Eva; Hrabinova, Martina; Hepnarova, Vendula; Jun, Daniel; Janockova, Jana; Muckova, Lubica; Prchal, Lukas; Kristofikova, Zdena; Kucera, Tomas; Gorecki, Lukas; Chalupova, Katarina; Kunes, Jiri; Hroudova, Jana; Soukup, Ondrej; Korabecny, Jan published an article.Synthetic Route of 89-77-0 The title of the article was Huprine Y – Tryptophan heterodimers with potential implication to Alzheimer’s disease treatment. And the article contained the following:

The search for novel and effective therapeutics for Alzheimers disease (AD) is the main quest that remains to be resolved. The goal is to find a disease-modifying agent able to confront the multifactorial nature of the disease pos. Herewith, a family of huprineY-tryptophan heterodimers was prepared, resulting in inhibition of cholinesterase and neuronal nitric oxide synthase enzymes, with effect against amyloid-beta (Aβ) and potential ability to cross the blood-brain barrier. Their cholinesterase pattern of behavior was inspected using kinetic anal. in tandem with docking studies. These heterodimers exhibited a promising pharmacol. profile with strong implication in AD. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Synthetic Route of 89-77-0

The Article related to hupriney tryptophan heterodimer neuroprotective agent alzheimer disease, acetylcholinesterase, alzheimer’s disease, amyloid-beta, multi-target directed ligands, huprine y, l-tryptophan and other aspects.Synthetic Route of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On May 31, 2022, Ma, Jiajia; Chen, Shuming; Bellotti, Peter; Wagener, Tobias; Daniliuc, Constantin; Houk, Kendall N.; Glorius, Frank published an article.Quality Control of 2-Amino-4-chlorobenzoic acid The title of the article was Facile access to fused 2D/3D rings via intermolecular cascade dearomative [2+2] cycloaddition/rearrangement reactions of quinolines with alkenes. And the article contained the following:

Two types of energy-transfer-mediated cascade dearomative [2+2] cycloaddition/rearrangement reactions of quinoline derivatives with alkenes, which provide a straightforward avenue to 2D/3D pyridine-fused 6-5-4-3- and 6-4-6-membered ring systems are reported. Notably, this energy-transfer-mediated strategy features excellent diastereoselectivity that bypasses the general reactivity and selectivity issues of photochem. [2+2] cycloaddition of various other aromatics Tuning the aza-arene substitutions enabled selective diversion of the iridium photocatalyzed energy transfer manifold towards either cyclopropanation or cyclobutane-rearrangement products. D. functional theory calculations revealed a cascade energy transfer scenario to be operative. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Quality Control of 2-Amino-4-chlorobenzoic acid

The Article related to quinoline alkene iridium photochem diastereoselective intermol dearomative cycloaddition rearrangement, azatetracyclododecatriene preparation, tetrahydro benzocyclobutapyridine preparation and other aspects.Quality Control of 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 15, 2022, Sun, Bin; Ding, Hao; Tian, Hai-Xia; Huang, Pan-Yi; Jin, Can; Wu, Chun-Lei; Shen, Run-Pu published an article.Product Details of 89-77-0 The title of the article was Photo-Triggered Self-Induced Homolytic Dechlorinative Sulfonylation/Cyclization of Unactivated Alkenes: Synthesis of Quinazolinones Containing a Sulfonyl Group. And the article contained the following:

A self-photocatalyzed sulfonylation/cyclization of quinazolinones containing unactivated alkenes with various sulfonyl chlorides was developed. The protocol provided access to sulfonyl radicals via energy transfer from quinazolinone skeleton to sulfonyl chloride. Notably, transformations proceeded without any external photocatalysts, additives, or oxidants, providing an alternative method for fabricating sulfonylated compounds I [R = Et, cyclopropyl, Ph, etc.; R1 = H, 3-F, 2-MeO, etc.; n = 0, 1]. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Product Details of 89-77-0

The Article related to quinazolinone containing sulfonyl group regioselective preparation photochem green chem, sulfonyl chloride quinazolinone tandem sulfonylation heterocyclization energy transfer photocatalyst and other aspects.Product Details of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fernandez, Gabriela A.; Castro, Eliana F.; Rosas, Rocio A.; Fidalgo, Daniela M.; Adler, Natalia S.; Battini, Leandro; Espana de Marco, Maria J.; Fabiani, Matias; Bruno, Ana M.; Bollini, Mariela; Cavallaro, Lucia V. published an article in 2020, the title of the article was Design and optimization of quinazoline derivatives: new non-nucleoside inhibitors of bovine viral diarrhea virus.Application of 89-77-0 And the article contains the following content:

In a previous work, potential mols. that dock into an allosteric binding pocket of BVDV RdRp via a structure-based virtual screening approach was identified. One of them, N-(2-morpholinoethyl)-2-phenylquinazolin-4-amine I [R2 = Ph; R4 = 2-morpholinoethylamino; R7 = H] [50% effective concentration (EC50) = 9.7 ± 0.5μM], was selected to perform different chem. modifications. Among synthesized derivatives I [R2 = H, Ph, 4-MeC6H4, etc.; R4 = 4-methylpiperazin-1-yl, HN(CH2)5CH3, 4-methoxyanilino, etc.; R7 = H, Cl], compound I [R2 = H, Ph, 4-(Me)2NC6H4; R4 = 4-methylpiperazin-1-yl, 3-(dimethylamino)propylamino, 4-(2-hydroxyethyl)piperazin-1-yl, (2-morpholinoethylamino), 2-(1-piperidyl)ethylamino, 2-(1-piperidyl)ethylamino, (2,2,6,6-tetramethyl-4-piperidyl)amino, ; R7 = H, Cl] of them showed considerable antiviral activity. Mol. modeling of the most active compounds I [R2 = H, Ph, 4-MeC6H4, 4-MeOC6H4, 4-O2NC6H4, 4-(Me)2NC6H4; R4 = 4-methylpiperazin-1-yl, 3-(dimethylamino)propylamino, 4-(2-hydroxyethyl)piperazin-1-yl, 2-morpholinoethylamino, 2-(1-piperidyl)ethylamino, (2,2,6,6-tetramethyl-4-piperidyl)amino; R7 = H, Cl] showed that they bind to a pocket located in the fingers and thumb domains in BVDV RdRp, which was different than that identified for other non-nucleoside inhibitors (NNIs) such as thiosemicarbazone (TSC). Compound 2-[4-(2-phenylquinazolin-4-yl)piperazin-1-yl]ethanol I [R2 = Ph; R4 = 4-(2-hydroxyethyl)piperazin-1-yl; R7 = H] ( EC50 = 1.7 ± 0.4μM) was selected for further anal. Compound I [R2 = Ph; R4 = 4-(2-hydroxyethyl)piperazin-1-yl; R7 = H] was found to inhibit the in vitro replication of TSC-resistant BVDV variants, which carry the N264D mutation in the RdRp. In addition, I [R2 = Ph; R4 = 4-(2-hydroxyethyl)piperazin-1-yl; R7 = H] presented adequate solubility in different media and a high-stability profile in murine and bovine plasma. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Application of 89-77-0

The Article related to quinazolinyl amine preparation antiviral docking cytotoxicity pharmacokinetic stability, bvdv inhibitors, rdrp protein, molecular dynamics, pharmacokinetics in vitro properties, quinazoline derivatives and other aspects.Application of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 17, 2021, Li, Xiaoyu; Golden, Jennifer E. published an article.HPLC of Formula: 89-77-0 The title of the article was Construction of N-Boc-2-Alkylaminoquinazolin-4(3H)-Ones via a Three-Component, One-Pot Protocol Mediated by Copper(II) Chloride that Spares Enantiomeric Purity. And the article contained the following:

A multicomponent procedure integrating anthranilic acids, N-Boc-amino acids and amines in the presence of methanesulfonyl chloride, N-methylimidazole, and copper(II) chloride was developed to mildly afford N-Boc-2-alkylaminoquinazolin-4(3H)-ones, e.g., I, with excellent preservation of enantiomeric purity (>99% ee). Copper(II) chloride was essential to retaining enantiopurity and reaction component structural changes were well tolerated, resulting in an efficient, all-in-one procedure that promoted sequential coupling, lactonization, aminolysis and cyclization in good yields. The method was applied to the rapid assembly of four key intermediates used in the synthesis of high profile quinazolinones, including several PI3K inhibitor drugs. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).HPLC of Formula: 89-77-0

The Article related to boc alkylaminoquinazolinone preparation enantioselective, anthranilic acid amino aniline copper chloride mediated multicomponent, pi3 kinase, copper-mediated, enantiopurity, quinazolinone, racemization and other aspects.HPLC of Formula: 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On July 31, 2020, Cieslikiewicz-Bouet, Monika; Naldi, Marina; Bartolini, Manuela; Perez, Belen; Servent, Denis; Jean, Ludovic; Araoz, Romulo; Renard, Pierre-Yves published an article.Application In Synthesis of 2-Amino-4-chlorobenzoic acid The title of the article was Functional characterization of multifunctional ligands targeting acetylcholinesterase and alpha 7 nicotinic acetylcholine receptor. And the article contained the following:

Alzheimer’s disease (AD) is a neurodegenerative disorder associated with cholinergic dysfunction, provoking memory loss and cognitive dysfunction in elderly patients. The cholinergic hypothesis provided over the years with mol. targets for developing palliative treatments for AD, acting on the cholinergic system, namely, acetylcholinesterase and α7 nicotinic acetylcholine receptor (α7 nAChR). In our synthetic work, we used “click-chem.” to synthesize two Multi Target Directed Ligands (MTDLs) MB105 and MB118 carrying tacrine and quinuclidine scaffolds which are known for their anticholinesterase and α7 nAChR agonist activities, resp. Both, MB105 and MB118, inhibit human acetylcholinesterase and human butyrylcholinesterase in the nanomolar range. Electrophysiol. recordings on Xenopus laevis oocytes expressing human α7 nAChR showed that MB105 and MB118 acted as partial agonists of the referred nicotinic receptor, albeit, with different potencies despite their similar structure. The different substitution at C-3 on the 2,3-disubstituted quinuclidine scaffold may account for the significantly lower potency of MB118 compared to MB105. Electrophysiol. recordings also showed that the tacrine precursor MB320 behaved as a competitive antagonist of human α7 nAChR, in the micromolar range, while the quinuclidine synthetic precursor MB099 acted as a partial agonist. Taken all together, MB105 behaved as a partial agonist of α7 nAChR at concentrations where it completely inhibited human acetylcholinesterase activity paving the way for the design of novel MTDLs for palliative treatment of AD. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Application In Synthesis of 2-Amino-4-chlorobenzoic acid

The Article related to preparation tacrine quinuclidine derivative ache nicotinic receptor, acetylcholinesterase, alpha 7 nicotinic acetylcholine receptor, alzheimer’s disease, butyrylcholinesterase, multi-target directed ligand and other aspects.Application In Synthesis of 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 5, 2020, Raza, Abdul Rauf; Nisar, Bushra; Khalid, Muhammad; Gondal, Humaira Yasmeen; Khan, Muhammad Usman; Morais, Sara Figueiredo de Alcantara; Tahir, Muhammad Nawaz; Braga, Ataualpa Albert Carmo published an article.Quality Control of 2-Amino-4-chlorobenzoic acid The title of the article was A facile microwave assisted synthesis and structure elucidation of (3R)-3-alkyl-4,1-benzoxazepine-2,5-diones by crystallographic, spectroscopic and DFT studies. And the article contained the following:

The use of microwave (MW) irradiation in organic synthesis has become increasingly popular within the pharmaceutical and academic arenas because it is a new enabling technol. for drug discovery and development. It is a rapid way of synthesis, which involves faster reaction rates and high selectivity to conventional heating method of syntheses. The MW-assisted 7-exo-tet cyclization of N-acylanthranilic acids afforded (3R)-3-alkyl-4,1-benzoxazepines-2,5-diones in very short duration (20 min) with extraordinary high yields in comparison to conventional heating mode of synthesis. The method development, comparative yields of MW-assisted and thermal method of syntheses, crystallog., spectroscopic and d. functional theory (DFT) studies are reported herein. Four novel compounds I and II [R1 = iBu, R2 = Ph, X = Y = Z = H; R1 = iPr, R2 = H; X = Cl, Y = H, Z = Me; R1 = iPr, R2 = H, X = Z = Br, Y = H] were synthesized, validated by 1HNMR, 13CNMR, FT-IR, UVVis, EIMS spectroscopic techniques and confirmed by using single crystal X-ray diffraction (SC-XRD) study. The DFT and TDDFT calculations at B3LYP/6-311 + G(d,p) level of theory were performed for comparative anal. of spectroscopic data, optimized geometries, frontier MOs (FMOs), natural bond orbital (NBO) anal. and nonlinear optical (NLO) properties of I and II. Overall, exptl. findings were supported nicely by corresponding DFT computed results. The NBO anal. confirmed that the presence of non-covalent interactions, hydrogen bonding and hyper- conjugative interactions are pivotal cause for the existence of I and II in the solid-state. NLO anal. showed that I and II have significant NLO properties as compared to prototype standard compound which disclosed their potential for technol. related applications. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Quality Control of 2-Amino-4-chlorobenzoic acid

The Article related to microwave synthesis crystal structure elucidation alkylbenzoxazepinedione, (3r)-3-alkyl-4,1-benzoxazepine-2,5-diones, chiral pool approach, dft, microwave irradiation, n-acylanthranilic acids, spectroscopic data and other aspects.Quality Control of 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics