Category: 87-63-8

Authors Li, X; Xie, WJ; Wang, XT; Huang, ZZ; Bian, XL; Wang, KW; Sun, Q in PERGAMON-ELSEVIER SCIENCE LTD published article about ACETYLCHOLINE-RECEPTOR AGONIST; PHARMACOLOGICAL CHARACTERIZATION; IDENTIFICATION; APOPTOSIS; SUBUNIT; RELEASE in [Li, Xin; Xie, Wenjun; Huang, Zongze; Sun, Qi] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China; [Xie, Wenjun; Wang, Xintong; Bian, Xiling; Wang, KeWei] Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China; [Wang, KeWei] Qingdao Univ, Sch Pharm, Dept Pharmacol, Qingdao 266021, Shandong, Peoples R China in 2019, Cited 38. Application In Synthesis of 2-Chloro-6-methylaniline. The Name is 2-Chloro-6-methylaniline. Through research, I have a further understanding and discovery of 87-63-8

Structural modifications of nicotinamide, a form of vitamin B3, gave rise to a series of compounds (8aa-8ce) that exhibit activities as type I positive allosteric modulators (PAMs) of human alpha 7 nAChR expressed in Xenopus oocytes in two-electrode voltage clamp assay. The compound 8ai was a potent and efficacious PAM with an EC50 = 3.34 +/- 1.13 mu M and the maximum activation effect of alpha 7 current over 1474 +/- 246% in the presence of acetylcholine (100 mu M). It is highly specific to alpha 7 nAChR over other subtypes of nAChR and 5-HT3A receptors. The structure-activity relationship analysis identified a key skeleton of nicotinamide nucleus critical for biological activity. Taken together, the 8ai as a type I PAM of alpha 7 nAChR may be beneficial for improvement of cognitive deficit.

Application In Synthesis of 2-Chloro-6-methylaniline. Welcome to talk about 87-63-8, If you have any questions, you can contact Li, X; Xie, WJ; Wang, XT; Huang, ZZ; Bian, XL; Wang, KW; Sun, Q or send Email.

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Guo, HC; Zheng, RH; Jiang, HJ; Xu, ZY; Xia, AB in [Guo, Haichang; Zheng, Renhua; Jiang, Huajiang] Taizhou Univ, Sch Pharmaceut & Mat Engn, Taizhou 318000, Peoples R China; [Xu, Zhenyuan; Xia, Aibao] Zhejiang Univ Technol, Catalyt Hydrogenat Res Ctr, Zhejiang Key Lab Green Pesticides & Cleaner Prod, Hangzhou 310014, Zhejiang, Peoples R China published Preparation of sub-microspherical Fe3O4@PDA-Pd NPs catalyst and application in catalytic hydroreduction reaction of halogenated aromatic nitro compounds to prepare halogenated aromatic amines in 2019, Cited 32. SDS of cas: 87-63-8. The Name is 2-Chloro-6-methylaniline. Through research, I have a further understanding and discovery of 87-63-8.

Background The side reactions of dehalogenation or C-N coupling tend to occur when halogenated aromatic amines are prepared by catalytic hydrogenation reduction of halogenated aromatic nitro compounds. In this paper, we prepared the sub-microspherical Fe3O4@PDA-Pd NPs catalyst apply it efficiently in the hydrogenation reduction of halogenated aromatic nitro compounds to prepare the halogenated aromatic amines under atmospheric pressure. The catalyst shows a high selectivity of greater than 96% and can effectively inhibit the occurrence of the side reactions of dehalogenation and C-N coupling. Results The optimum condition of the hydroreduction reaction is when tetrahydrofuran is used as solvent and the reaction happens at 50 degrees C for 5 h. The selectivity of the chlorinated aromatic amine and the fluorinated aromatic amine products exceed 99% and the yield exceeds 90%. Only a small amount of dehalogenated products and C-N coupling by-products were produced in the brominated aromatic compound and the iodinated aromatic compound. Conclusion We developed a promising method for preparing the superparamagnetic and strongly magnetic Fe3O4@PDA core-shell sub-microsphere-supported nano-palladium catalyst for catalyzing the hydrogenation reduction of halogenated aromatic nitro compounds. The halogenated aromatic amines were efficiently and highly selectively prepared under atmospheric pressure, with the side reactions of dehalogenation and C-N coupling effectively inhabited simultaneously.

Welcome to talk about 87-63-8, If you have any questions, you can contact Guo, HC; Zheng, RH; Jiang, HJ; Xu, ZY; Xia, AB or send Email.. SDS of cas: 87-63-8

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019 CHEM COMMUN published article about DEEP EUTECTIC SOLVENT; ONE-POT; AZO-DYES; EFFICIENT DIAZOTIZATION; DIAZONIUM SALTS; ARYL AMINES; CATALYST; WATER; HALOGENATION; IODINATION in [Kamble, Sujit Suresh; Shankarling, Ganapati Subray] Inst Chem Technol, Dyestuff Technol Dept, NP Marg, Mumbai 400019, Maharashtra, India in 2019, Cited 33. The Name is 2-Chloro-6-methylaniline. Through research, I have a further understanding and discovery of 87-63-8. Quality Control of 2-Chloro-6-methylaniline

An environmentally benign, one-pot diazotization and coupling reaction using ChCl: tartaric acid DES at room temperature is described. The bulky tartrate ion renders stability to the diazonium salt at room temperature, also evidenced by H-1 NMR. The isolated diazonium salt is stable and active even after 192 h at room temperature.

Welcome to talk about 87-63-8, If you have any questions, you can contact Kamble, SS; Shankarling, GS or send Email.. Quality Control of 2-Chloro-6-methylaniline

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Colomer, I in [Colomer, Ignacio] Univ Autonoma Madrid, Dept Organ Chem, Madrid 28049, Spain; [Colomer, Ignacio] IMDEA Nanociencia, Madrid 28049, Spain published Hydroarylation of Alkenes Using Anilines in Hexafluoroisopropanol in 2020, Cited 65. Formula: C7H8ClN. The Name is 2-Chloro-6-methylaniline. Through research, I have a further understanding and discovery of 87-63-8.

Providing new methods for the selective functionalization of small molecules is highly desirable, because installing molecular diversity in a desired position, for example, allows one to modulate bioactive molecules. This work reports a method for the selective functionalization of anilines using hexafluoroisopropanol (HFIP) as a solvent to promote an acid-catalyzed hydroarylation of olefins. Mechanistic experiments revealed that HFIP both protonates the alkene and selectively enables anilines toward the electrophilic aromatic substitution. This powerful strategy has been applied to the functionalization of the anti-inflammatory mefenamic acid with chemocontrol and regiocontrol.

Formula: C7H8ClN. Bye, fridends, I hope you can learn more about C7H8ClN, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Recommanded Product: 87-63-8. Authors Dinh, AN; Maddox, SM; Vaidya, SD; Saputra, MA; Nalbandian, CJ; Gustafson, JL in AMER CHEMICAL SOC published article about in [Dinh, Andrew N.; Maddox, Sean M.; Vaidya, Sagar D.; Saputra, Mirza A.; Nalbandian, Christopher J.; Gustafson, Jeffrey L.] San Diego State Univ, Dept Chem & Biochem, San Diego, CA 92182 USA in 2020, Cited 54. The Name is 2-Chloro-6-methylaniline. Through research, I have a further understanding and discovery of 87-63-8

We report a highly efficient ortho-selective electrophilic chlorination of phenols utilizing a Lewis basic selenoether catalyst. The selenoether catalyst resulted in comparable selectivities to our previously reported bis-thiourea ortho-selective catalyst, with a catalyst loading as low as 1%. The new catalytic system also allowed us to extend this chemistry to obtain excellent ortho-selectivities for unprotected anilines. The selectivities of this reaction are up to >20:1 ortho/para, while the innate selectivities for phenols and anilines are approximately 1:4 ortho/para. A series of preliminary studies revealed that the substrates require a hydrogen-bonding moiety for selectivity.

Welcome to talk about 87-63-8, If you have any questions, you can contact Dinh, AN; Maddox, SM; Vaidya, SD; Saputra, MA; Nalbandian, CJ; Gustafson, JL or send Email.. Recommanded Product: 87-63-8

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Formula: C7H8ClN. Authors Dinh, AN; Maddox, SM; Vaidya, SD; Saputra, MA; Nalbandian, CJ; Gustafson, JL in AMER CHEMICAL SOC published article about in [Dinh, Andrew N.; Maddox, Sean M.; Vaidya, Sagar D.; Saputra, Mirza A.; Nalbandian, Christopher J.; Gustafson, Jeffrey L.] San Diego State Univ, Dept Chem & Biochem, San Diego, CA 92182 USA in 2020, Cited 54. The Name is 2-Chloro-6-methylaniline. Through research, I have a further understanding and discovery of 87-63-8

We report a highly efficient ortho-selective electrophilic chlorination of phenols utilizing a Lewis basic selenoether catalyst. The selenoether catalyst resulted in comparable selectivities to our previously reported bis-thiourea ortho-selective catalyst, with a catalyst loading as low as 1%. The new catalytic system also allowed us to extend this chemistry to obtain excellent ortho-selectivities for unprotected anilines. The selectivities of this reaction are up to >20:1 ortho/para, while the innate selectivities for phenols and anilines are approximately 1:4 ortho/para. A series of preliminary studies revealed that the substrates require a hydrogen-bonding moiety for selectivity.

Welcome to talk about 87-63-8, If you have any questions, you can contact Dinh, AN; Maddox, SM; Vaidya, SD; Saputra, MA; Nalbandian, CJ; Gustafson, JL or send Email.. Formula: C7H8ClN

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019 BIOORG MED CHEM LETT published article about ACETYLCHOLINE-RECEPTOR AGONIST; PHARMACOLOGICAL CHARACTERIZATION; IDENTIFICATION; APOPTOSIS; SUBUNIT; RELEASE in [Li, Xin; Xie, Wenjun; Huang, Zongze; Sun, Qi] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China; [Xie, Wenjun; Wang, Xintong; Bian, Xiling; Wang, KeWei] Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China; [Wang, KeWei] Qingdao Univ, Sch Pharm, Dept Pharmacol, Qingdao 266021, Shandong, Peoples R China in 2019, Cited 38. The Name is 2-Chloro-6-methylaniline. Through research, I have a further understanding and discovery of 87-63-8. SDS of cas: 87-63-8

Structural modifications of nicotinamide, a form of vitamin B3, gave rise to a series of compounds (8aa-8ce) that exhibit activities as type I positive allosteric modulators (PAMs) of human alpha 7 nAChR expressed in Xenopus oocytes in two-electrode voltage clamp assay. The compound 8ai was a potent and efficacious PAM with an EC50 = 3.34 +/- 1.13 mu M and the maximum activation effect of alpha 7 current over 1474 +/- 246% in the presence of acetylcholine (100 mu M). It is highly specific to alpha 7 nAChR over other subtypes of nAChR and 5-HT3A receptors. The structure-activity relationship analysis identified a key skeleton of nicotinamide nucleus critical for biological activity. Taken together, the 8ai as a type I PAM of alpha 7 nAChR may be beneficial for improvement of cognitive deficit.

Welcome to talk about 87-63-8, If you have any questions, you can contact Li, X; Xie, WJ; Wang, XT; Huang, ZZ; Bian, XL; Wang, KW; Sun, Q or send Email.. SDS of cas: 87-63-8

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Recently I am researching about ACETYLCHOLINE-RECEPTOR AGONIST; PHARMACOLOGICAL CHARACTERIZATION; IDENTIFICATION; APOPTOSIS; SUBUNIT; RELEASE, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [NSFC 21572011, 81573410, 31370741, 21272009]; Ministry of Science and Technology of ChinaMinistry of Science and Technology, China [2013CB531302]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Li, X; Xie, WJ; Wang, XT; Huang, ZZ; Bian, XL; Wang, KW; Sun, Q. The CAS is 87-63-8. Through research, I have a further understanding and discovery of 2-Chloro-6-methylaniline. SDS of cas: 87-63-8

Structural modifications of nicotinamide, a form of vitamin B3, gave rise to a series of compounds (8aa-8ce) that exhibit activities as type I positive allosteric modulators (PAMs) of human alpha 7 nAChR expressed in Xenopus oocytes in two-electrode voltage clamp assay. The compound 8ai was a potent and efficacious PAM with an EC50 = 3.34 +/- 1.13 mu M and the maximum activation effect of alpha 7 current over 1474 +/- 246% in the presence of acetylcholine (100 mu M). It is highly specific to alpha 7 nAChR over other subtypes of nAChR and 5-HT3A receptors. The structure-activity relationship analysis identified a key skeleton of nicotinamide nucleus critical for biological activity. Taken together, the 8ai as a type I PAM of alpha 7 nAChR may be beneficial for improvement of cognitive deficit.

About 2-Chloro-6-methylaniline, If you have any questions, you can contact Li, X; Xie, WJ; Wang, XT; Huang, ZZ; Bian, XL; Wang, KW; Sun, Q or concate me.. SDS of cas: 87-63-8

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An article Biopsy rate and nonalcoholic steatohepatitis (NASH) in patients with nonalcoholic fatty liver disease (NAFLD) WOS:000542449900001 published article about FIBROSIS; MANAGEMENT; ASSOCIATION; VALIDATION; SYSTEM; SCORE; EASD in [Gerhardt, Florian; Blank, Valentin; Boehlig, Albrecht; van Boemmel, Florian; Berg, Thomas; Karlas, Thomas; Wiegand, Johannes] Univ Hosp Leipzig, Clin & Polyclin Oncol Gastroenterol Hepatol Pneum, Liebigstr 20, D-04103 Leipzig, Germany; [Petroff, David] Univ Leipzig, Clin Trial Ctr Leipzig, Leipzig, Germany; [Blank, Valentin] Univ Leipzig, Integrated Res & Treatment Ctr Adipos Dis, Leipzig, Germany; [Wittekind, Christian] Univ Hosp Leipzig, Inst Pathol, Leipzig, Germany in 2020, Cited 30. Quality Control of 2-Chloro-6-methylaniline. The Name is 2-Chloro-6-methylaniline. Through research, I have a further understanding and discovery of 87-63-8

Background:Licensed therapies for nonalcoholic fatty liver disease (NAFLD) do not yet exist, but clinical trials are testing treatment options. Inclusion criteria often require liver biopsy showing fibrosis (F2/3) or cirrhosis (F4) and nonalcoholic steatohepatitis (NASH). However, histological criteria pose a serious obstacle for recruitment. Aims:Characterize the relevance of liver biopsies in the selection of patients with NAFLD. Methods:Patients between 2013 and 2018 with the ICD-10 code K76.0 were analyzed. Fibrosis was defined by the NASH clinical research network (CRN) fibrosis staging system, NASH by a NAFLD activity score (NAS) >= 4. Predictive factors were determined by logistic regression. Results:Liver biopsy was performed in 87/638 (13.6%) patients (49% female, age 52.5 +/- 14.0, BMI 30.4 +/- 5.9 kg/m(2)). Fibrosis stage F0/F1/F2/F3/F4 was observed inN = 7/47/7/17/9, an NAS >= 4 inN = 27. Fibrosis stage F2/F3 and F4 along with NAS >= 4 was found in 1.7% and 0.5% of cases. Liver stiffness measurement, LSM (OR 2.3 per doubling of value; CI 1.3-4.4,p = .005) and FIB-4 (OR 2.3 per doubling of value; CI 1.2-4.4,p = .012) were significant predictors for fibrosis >= F2. Predictive factors for NASH were not identified. Conclusion:The biopsy rate in NAFLD patients is low and fibrosis >= F2 along with NAS >= 4 only present in a few cases. Transient elastography and FIB-4 are useful to select patients at risk for fibrosis for liver biopsy.

Quality Control of 2-Chloro-6-methylaniline. About 2-Chloro-6-methylaniline, If you have any questions, you can contact Gerhardt, F; Petroff, D; Blank, V; Bohlig, A; van Bommel, F; Wittekind, C; Berg, T; Karlas, T; Wiegand, J or concate me.

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An article Biopsy rate and nonalcoholic steatohepatitis (NASH) in patients with nonalcoholic fatty liver disease (NAFLD) WOS:000542449900001 published article about FIBROSIS; MANAGEMENT; ASSOCIATION; VALIDATION; SYSTEM; SCORE; EASD in [Gerhardt, Florian; Blank, Valentin; Boehlig, Albrecht; van Boemmel, Florian; Berg, Thomas; Karlas, Thomas; Wiegand, Johannes] Univ Hosp Leipzig, Clin & Polyclin Oncol Gastroenterol Hepatol Pneum, Liebigstr 20, D-04103 Leipzig, Germany; [Petroff, David] Univ Leipzig, Clin Trial Ctr Leipzig, Leipzig, Germany; [Blank, Valentin] Univ Leipzig, Integrated Res & Treatment Ctr Adipos Dis, Leipzig, Germany; [Wittekind, Christian] Univ Hosp Leipzig, Inst Pathol, Leipzig, Germany in 2020, Cited 30. The Name is 2-Chloro-6-methylaniline. Through research, I have a further understanding and discovery of 87-63-8. HPLC of Formula: C7H8ClN

Background:Licensed therapies for nonalcoholic fatty liver disease (NAFLD) do not yet exist, but clinical trials are testing treatment options. Inclusion criteria often require liver biopsy showing fibrosis (F2/3) or cirrhosis (F4) and nonalcoholic steatohepatitis (NASH). However, histological criteria pose a serious obstacle for recruitment. Aims:Characterize the relevance of liver biopsies in the selection of patients with NAFLD. Methods:Patients between 2013 and 2018 with the ICD-10 code K76.0 were analyzed. Fibrosis was defined by the NASH clinical research network (CRN) fibrosis staging system, NASH by a NAFLD activity score (NAS) >= 4. Predictive factors were determined by logistic regression. Results:Liver biopsy was performed in 87/638 (13.6%) patients (49% female, age 52.5 +/- 14.0, BMI 30.4 +/- 5.9 kg/m(2)). Fibrosis stage F0/F1/F2/F3/F4 was observed inN = 7/47/7/17/9, an NAS >= 4 inN = 27. Fibrosis stage F2/F3 and F4 along with NAS >= 4 was found in 1.7% and 0.5% of cases. Liver stiffness measurement, LSM (OR 2.3 per doubling of value; CI 1.3-4.4,p = .005) and FIB-4 (OR 2.3 per doubling of value; CI 1.2-4.4,p = .012) were significant predictors for fibrosis >= F2. Predictive factors for NASH were not identified. Conclusion:The biopsy rate in NAFLD patients is low and fibrosis >= F2 along with NAS >= 4 only present in a few cases. Transient elastography and FIB-4 are useful to select patients at risk for fibrosis for liver biopsy.

HPLC of Formula: C7H8ClN. About 2-Chloro-6-methylaniline, If you have any questions, you can contact Gerhardt, F; Petroff, D; Blank, V; Bohlig, A; van Bommel, F; Wittekind, C; Berg, T; Karlas, T; Wiegand, J or concate me.

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics