Category: 7447-41-8

Volumetric and Viscosity Coefficient Studies of 1:1 Electrolyte Salts and Alcohols in Aqueous 8 M Urea Solutions at 298.15 K was written by Patil, Prakash D.;Shaikh, Vasim R.;Pawar, Rajesh B.;Patil, Kesharsingh J.. And the article was included in Journal of Chemical & Engineering Data in 2022.HPLC of Formula: 7447-41-8 The following contents are mentioned in the article:

D. and relative viscosity data have been obtained for lithium chloride (LiCl), sodium chloride (NaCl), potassium chloride (KCl), potassium bromide (KBr), cesium bromide (CsBr), tetramethylammonium bromide (Me₄NBr), tetraethylammonium bromide (Et₄NBr), tetrabutylammonium bromide (Bu₄NBr), and promethazine hydrochloride (PM·HCl) salts (1:1 electrolytes) at various concentrations in aqueous 8 M urea solutions at 298.15 K. Similar data also have been obtained for aqueous 8 M urea solutions containing ethanol and tertiary butanol at 298.15 K. The apparent molar volumes of solute at finite concentration (V_ϕ) and apparent molar volumes of solute at infinite dilution (V_ϕ⁰) are calculated at 298.15 K. The viscosity coefficients A and B of the Jones-Dole equation have been obtained for all studied systems at 298.15 K. The V_ϕ⁰, A, and B viscosity coefficient values obtained are compared with the similar data for aqueous solutions of the studied salts and alcs. (i.e., without the addition of urea) at 298.15 K. In protein denaturation studies, the addition of urea is made as a perturbant which is important; however, the exact mechanism of denaturation by urea is not known yet. The differences in binary and ternary aqueous solutions are expected on the basis of the solvent effects (water structural effects). The transfer partial molar volumes (from water to urea solutions) and transfer viscosity coefficients B have been estimated The transfer values for alcs. are pos. The drug promethazine hydrochloride forms micelles in aqueous solutions The results of this system have been explained on the basis of pos. ΔV_ϕ⁰ and viscosity coefficient A (which increases), meaning that in urea solutions, there is an increase in ion-ion and ion-pairing interactions. The results are discussed in terms of decrease in hydrophobic interactions and stacking of drug mols. in the pre-micellar concentration region due to specific drug cation-urea interactions, probably due to the formation of complex aggregates. This study involved multiple reactions and reactants, such as Lithium chloride (cas: 7447-41-8HPLC of Formula: 7447-41-8).

Lithium chloride (cas: 7447-41-8) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.HPLC of Formula: 7447-41-8

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Separation of essential oil from fresh leaves of Phellodendron amurense rupr. By solvent-free microwave-assisted distillation with the addition of lithium salts was written by Peng, Xiaojin;Zhao, Ru;Yang, Xinyu;Feng, Chunte;Gu, Huiyan;Yang, Lei. And the article was included in Journal of Cleaner Production in 2022.HPLC of Formula: 7447-41-8 The following contents are mentioned in the article:

The essential oil was separated from the fresh leaves of Phellodendron amurense Rupr. by solvent-free microwave-assisted distillation in a rotating state with n-hexane extraction and LiCl addition, which ingeniously designed lithium salt addition, rotation unit, and n-hexane extraction effectively improved the yield and separation rate of essential oils. The factors that may affect essential oils yield were screened and optimized by single factor optimization, response surface methodol., and kinetic model to obtain the optimal conditions for the separation of essential oils by this method, which were LiCl content of 8%FW, microwave irradiation power 600 W and microwave irradiation time 40 min. And the yield of essential oils is 2.39 ± 0.12 mg/g in the optimum conditions by this method, which is highly consistent with the predictions from the response surface method (2.39 mg/g) and the first-order kinetic model (2.42 ± 0.04 mg/g). This method effectively ensures the uniform heating of the plant material and the rapid overflow of the essential oil by employing the rotating unit and the addition of LiCl, which effectively avoids the loss of the heat-sensitive components in the essential oil. Moreover, the solvent-free distillation of this method highly improves the heating rate, and the added LiCl can also be effectively recovered and reused, which effectively reduces the economic cost, and environmental stress and will result in a cleaner product. And an accurate quant. anal. method of essential oils was established by n-hexane extraction-UV spectroscopy, which not only effectively avoided the loss of water-soluble components but also provided a new strategy for quant. anal. of essential oils. In addition, the results of the kinetic model indicated that the separation rate constant of essential oils in this method was 1.34 times that of microwave-assisted hydrodistillation and 5.05 times that of conventional hydrodistillation Therefore, this method is an efficient, green, and clean essential oil preparation method, which is very promising to replace existing methods in the future. This study involved multiple reactions and reactants, such as Lithium chloride (cas: 7447-41-8HPLC of Formula: 7447-41-8).

Lithium chloride (cas: 7447-41-8) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.HPLC of Formula: 7447-41-8

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Crystal Engineering and Photomagnetic Studies of CN-Bridged Coordination Polymers Based on Octacyanidometallates(IV) and [Ni(cyclam)]²⁺ was written by Heczko, Michal;Suminska, Ewa;Pinkowicz, Dawid;Nowicka, Beata. And the article was included in Inorganic Chemistry in 2022.Electric Literature of ClLi The following contents are mentioned in the article:

New CN-bridged coordination networks of different dimensionality and topol. were obtained through the modification of reaction conditions between [Ni(cyclam)]²⁺ (cyclam = 1,4,8,11-tetraazacyclotetradecane) and [W(CN)₈]^4-. The factors determining the reaction pathway are temperature and addition of the LiCl electrolyte. The products include three neg. charged frameworks incorporating Li⁺ guests: the 1-dimensional Li₂[Ni(cyclam)][W(CN)₈]·6H₂O (1) straight chain, the 1-dimensional Li₂[Ni(cyclam)][W(CN)₈]·2H₂O (2) zigzag chain, and the 2-dimensional Li₂[Ni(cyclam)]₃[W(CN)₈]₂·24H₂O (3) honeycomb-like network, as well as the 3-dimensional 2-fold interpenetrating [Ni(cyclam)]₅[Ni(CN)₄][W(CN)₈]₂·11H₂O (4) network and the 1-dimensional [Ni(cyclam)][Ni(CN)₄]·2H₂O (5) chain, which result from partial decomposition of the starting complexes. Together with the previously characterized 3-dimensional [Ni(cyclam)]₂[W(CN)₈]·16H₂O (6) network, they constitute the largest family of CN-bridged coordination polymers obtained from the same pair of building blocks. All compounds exhibit paramagnetic behavior because of the separation of paramagnetic Ni(II) centers through the diamagnetic polycyanidometallates. However, the presence of the photomagnetically active octacyanidotungstate(IV) ions allowed observation of the magnetic superexchange after the violet light excitation (405 nm) for 3, which is the 1st example of the photomagnetic effect in a Ni^II-[W^IV(CN)₈] system. The photomagnetic studies for fully hydrated and dehydrated sample of 3, as well as for the isostructural octacyanidomolybdate(IV)-based network are discussed. This study involved multiple reactions and reactants, such as Lithium chloride (cas: 7447-41-8Electric Literature of ClLi).

Lithium chloride (cas: 7447-41-8) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Electric Literature of ClLi

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Near-infrared spectra and molar absorption coefficients of trivalent lanthanides dissolved in molten LiCl-KCl eutectic was written by Moon, Jeremy;Chidambaram, Dev. And the article was included in Progress in Nuclear Energy in 2022.Formula: ClLi The following contents are mentioned in the article:

Determining the concentration of the dissolved lanthanide species in LiCl-KCl eutectic salt is important to the development of pyrochem. reprocessing of used nuclear fuel. In this process, lanthanide fission products are found dissolved in the electrorefiner electrolyte in their trivalent oxidation state. The presence of dissolved trivalent lanthanides increases the liquidus temperature of the electrolyte mixture and can lead to the formation of insoluble oxide or oxychloride phases and must therefore be continuously monitored and controlled during the operation. Absorbance spectroscopy is a promising method for continuous measurement of the concentration of lanthanides and other elements dissolved in the electrolyte. The absorption of light by elements is linearly proportional to the concentration of the element for relatively dilute solutions according to the Beer-Lambert law. Although measurement of the absorption of UV and visible range light by lanthanides in LiCl-KCl eutectic molten salt have been explored previously, near IR (NIR) absorption spectroscopy has received far less attention. It may, however, provide a better anal. signal when insoluble phases are present due to less Raleigh scattering compared to shorter wavelength radiation. Addnl., it may allow for concentration determination for certain elements using NIR absorption features where UV and visible range features are overlapping with features from other species. In this study, we report the UV-Vis-NIR spectra of the trivalent lanthanide chlorides of neodymium, samarium, and dysprosium in LiCl-KCl eutectic. Molar absorption coefficients are reported for anal. useful absorption maxima, with a focus on the molar absorption coefficients for NIR absorption maxima which have not been reported previously. Addnl., we observe a NIR-range absorption band of Nd³⁺ which was previously predicted but never exptl. observed We compare the calculated crystal field levels to the newly observed absorbance band and find them to be in good agreement with previous predictions. This study involved multiple reactions and reactants, such as Lithium chloride (cas: 7447-41-8Formula: ClLi).

Lithium chloride (cas: 7447-41-8) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Formula: ClLi

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Transcriptomic analysis and validation reveal the pathogenesis and a novel biomarker of acute exacerbation of chronic obstructive pulmonary disease was written by Wang, Huijie;Zhong, Yonghong;Li, Na;Yu, Min;Zhu, Lin;Wang, Lina;Chen, Fei;Xu, Yaping;Liu, Jian;Huang, Huaqiong. And the article was included in Respiratory Research in 2022.Product Details of 7447-41-8 The following contents are mentioned in the article:

Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is the main factor that leads to the deterioration of the disease. Currently, the diagnosis of AECOPD mainly relies on clin. manifestations, good predictors or biomarkers are lacking. We aim to reveal specific biomarkers and potential pathogenesis of AECOPD and provide a research basis for the diagnosis and treatment. Four patients with AECOPD, four patients with stable COPD, and five control subjects were enrolled for RNA sequencing and KEGG anal. The mRNA level of target genes was verified by quant. real-time PCR (qPCR) with an expanded sample size (30 patients with AECOPD, 27 patients with stable COPD, and 35 control subjects). ELISA and immunofluorescence were used to identify the target proteins. Furthermore, the expression and function of WNT/β-catenin signaling pathway were assessed in animal models of COPD. RNA sequencing showed that 54 genes were up-regulated and 111 genes were down-regulated in the AECOPD. Differentially expressed genes were mainly enriched in WNT signaling pathway, et al. QPCR revealed that multi-genes of the WNT/β-catenin signaling were significantly down-regulated in AECOPD (P < 0.05), and β-catenin protein was significantly decreased in plasma of AECOPD and stable COPD (P < 0.01), while phosphorylated β-catenin was significantly up-regulated in peripheral blood mononuclear cells of AECOPD (P < 0.05). Similarly, WNT ligands, WNT receptors, and downstream signaling mols. were down-regulated, with an increased phosphorylated β-catenin protein in animal models of COPD. Activation of WNT/β-catenin signaling pathway by lithium chloride reduced the expression of phosphorylated β-catenin and ameliorated the COPD-like airway inflammation in mice. WNT/β-catenin signaling pathway is down-regulated in AECOPD patients and in animal models of COPD. Increased expression of phosphorylated β-catenin in the blood might be a potential biomarker of AECOPD. Activation of WNT/β-catenin pathway may also represent a therapeutic target for AECOPD. This study involved multiple reactions and reactants, such as Lithium chloride (cas: 7447-41-8Product Details of 7447-41-8).

Lithium chloride (cas: 7447-41-8) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Product Details of 7447-41-8

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

FKN/CX3CR1 axis facilitates migraine-Like behaviour by activating thalamic-cortical network microglia in status epilepticus model rats was written by Zhou, Yanjie;Zhang, Lily;Hao, Yuyan;Yang, Liu;Fan, Shanghua;Xiao, Zheman. And the article was included in Journal of Headache and Pain in 2022.Synthetic Route of ClLi The following contents are mentioned in the article:

The incidence of migraines is higher among individuals with epilepsy than in healthy individuals, and these two diseases are thought to shared pathophysiol. mechanisms. Excitation/inhibition imbalance plays an essential role in the comorbidity of epilepsy and migraine. Microglial activation is crucial for abnormal neuronal signal transmission. However, it remains unclear whether and how microglia are activated and their role in comorbidities after being activated. This study aimed to explore the characteristics and mechanism of microglial activation after seizures and their effect on migraine. Model rats of status epilepticus (SE) induced by i.p. injection of lithium chloride (LiCl)-pilocarpine and migraine induced by repeated dural injections of inflammatory soup (IS) were generated, and mol. and histopathol. evidence of the microglial activation targets of fractalkine (FKN) signalling were examined HT22-BV2 transwell coculture assays were used to explore the interaction between neurons and microglia. LPS (a microglial agonist) and FKN stimulation of BV2 microglial cells were used to evaluate changes in BDNF levels after microglial activation. Microglia were specifically hyperplastic and activated in the temporal lobe cortex, thalamus, and spinal trigeminal nucleus caudalis (sp5c), accompanied by the upregulation of FKN and CX3CR1 four days after seizures. Moreover, SE-induced increases in nociceptive behavior and FKN/CX3CR1 axis expression in migraine model rats. AZD8797 (a CX3CR1 inhibitor) prevented the worsening of hyperalgesia and microglial activation in migraine model rats after seizures, while FKN infusion in migraine model rats exacerbated hyperalgesia and microglial activation associated with BDNF-Trkb signalling. Furthermore, in neuron-microglia cocultures, microglial activation and FKN/CX3CR1/BDNF/iba1 expression were increased compared with those in microglial cultures alone. Activating microglia with LPS and FKN increased BDNF synthesis in BV2 microglia. Our results indicated that epilepsy facilitated migraine through FKN/CX3CR1 axis-mediated microglial activation in the cortex/thalamus/sp5c, which was accompanied by BDNF release. Blocking the FKN/CX3CR1 axis and microglial activation are potential therapeutic strategies for preventing and treating migraine in patients with epilepsy. This study involved multiple reactions and reactants, such as Lithium chloride (cas: 7447-41-8Synthetic Route of ClLi).

Lithium chloride (cas: 7447-41-8) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Synthetic Route of ClLi

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Phase equilibria in the ternary systems LiCl-LiBr-H₂O and LiCl-LiBr-CH₃OH at 298 K was written by Zhang, Xue-Ping;Liu, You-Quan;Chang, Qiu-Hao;Zeng, Rong. And the article was included in Journal of Molecular Liquids in 2022.Computed Properties of ClLi The following contents are mentioned in the article:

Oil gas field brine is a dominant liquid mineral resource in Sichuan Basin, and its rational development and utilization is of great significance to the national economy. In order to explore the physicochem. properties of brine and provide theor. guidance for the comprehensive utilization of brine, the isothermal solubilities of the ternary systems LiCl – LiBr – H₂O and LiCl – LiBr – CH₃OH at 298 K were determined by employing the isothermal dissolution equilibrium method. Based on the measured composition of the liquid phase, wet solid phase and equilibrium solid phase, isothermal phase diagrams of the two systems at 298 K were drawn. The results show that according to the phase diagram of the ternary system LiCl – LiBr – H₂O at 298 K, there is no single salt and double salt formation, but the crystalline region precipitated by the solid solution occupies all the crystalline space. The phase region is divided by a solubility boundary line into two parts, namely the liquid phase unsaturated region located below the isotherm and the completely mutually soluble solid solution crystallization region above it. Therefore, the two single salts LiCl and LiBr could not be successfully separated with the guidance of this phase diagram. The ternary system LiCl – LiBr – CH₃OH at 298 K has single salt and solid solution formed, but no double salt determined The phase diagram of the ternary system LiCl – LiBr – CH₃OH consists of an invariant point, two isothermal solubility lines, and two crystallization regions precipitated with Li(Cl, Br) and LiCl, resp. Using the phase diagram as a guiding tool for phase separation, LiCl can be acquired by crystallization and filtration operations, but it cannot be achieved for LiBr. In this work, a combination of wet residue method and XRD is used to identify the equilibrium solid phase. Selecting the particle swarm optimization algorithm, the solubility predictions of the ternary systems LiCl – LiBr – H₂O and LiCl – LiBr – CH₃OH at 298 K were achieved through the well-established Pitzer model. The solubility simulation results satisfactorily matched with the exptl. values, indicating that the parameters selected for the simulation have strong applicability. This study involved multiple reactions and reactants, such as Lithium chloride (cas: 7447-41-8Computed Properties of ClLi).

Lithium chloride (cas: 7447-41-8) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Computed Properties of ClLi

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Modeling the solubility of light hydrocarbon gases and their mixture in brine with machine learning and equations of state was written by Mohammadi, Mohammad-Reza;Hadavimoghaddam, Fahimeh;Atashrouz, Saeid;Abedi, Ali;Hemmati-Sarapardeh, Abdolhossein;Mohaddespour, Ahmad. And the article was included in Scientific Reports in 2022.Product Details of 7447-41-8 The following contents are mentioned in the article:

Knowledge of the solubilities of hydrocarbon components of natural gas in pure water and aqueous electrolyte solutions is important in terms of engineering designs and environmental aspects. In the current work, six machine-learning algorithms, namely Random Forest, Extra Tree, adaptive boosting support vector regression (AdaBoost-SVR), Decision Tree, group method of data handling (GMDH), and genetic programming (GP) were proposed for estimating the solubility of pure and mixture of methane, ethane, propane, and n-butane gases in pure water and aqueous electrolyte systems. To this end, a huge database of hydrocarbon gases solubility (1836 exptl. data points) was prepared over extensive ranges of operating temperature (273-637 K) and pressure (0.051-113.27 MPa). Two different approaches including eight and five inputs were adopted for modeling. Moreover, three famous equations of state (EOSs), namely Peng-Robinson (PR), Valderrama modification of the Patel-Teja (VPT), and Soave-Redlich-Kwong (SRK) were used in comparison with machine-learning models. The AdaBoost-SVR models developed with eight and five inputs outperform the other models proposed in this study, EOSs, and available intelligence models in predicting the solubility of mixtures or/and pure hydrocarbon gases in pure water and aqueous electrolyte systems up to high-pressure and high-temperature conditions having average absolute relative error values of 10.65% and 12.02%, resp., along with determination coefficient of 0.9999. Among the EOSs, VPT, SRK, and PR were ranked in terms of good predictions, resp. Also, the two math. correlations developed with GP and GMDH had satisfactory results and can provide accurate and quick estimates According to sensitivity anal., the temperature and pressure had the greatest effect on hydrocarbon gases’ solubility Addnl., increasing the ionic strength of the solution and the pseudo-critical temperature of the gas mixture decreases the solubilities of hydrocarbon gases in aqueous electrolyte systems. Eventually, the Leverage approach has revealed the validity of the hydrocarbon solubility databank and the high credit of the AdaBoost-SVR models in estimating the solubilities of hydrocarbon gases in aqueous solutions This study involved multiple reactions and reactants, such as Lithium chloride (cas: 7447-41-8Product Details of 7447-41-8).

Lithium chloride (cas: 7447-41-8) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Product Details of 7447-41-8

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Thermal management performance improvement of phase change material for autonomous underwater vehicles’ battery module by optimizing fin design based on quantitative evaluation method was written by Li, Bo;Mao, Zhaoyong;Song, Baowei;Tian, Wenlong;Wang, Yan-Feng;Sunden, Bengt;Lu, Chengyi. And the article was included in International Journal of Energy Research in 2022.COA of Formula: ClLi The following contents are mentioned in the article:

Efficient thermal management of lithium battery modules has become a thorny problem in the development of autonomous underwater vehicles (AUVs), especially under high current discharge. In this article, the fin/phase change material (PCM) composite structure was proposed for AUV’s battery thermal management with consideration of natural convection. The temperature behavior of the battery and the melting behavior of PCM were investigated under different key parameters. In addition, the heat transfer mechanism of the melting process of the PCM was revealed. More importantly, the dimensionless temperature control performance (TCP) factor and the dimensionless heat storage performance (HSP) factor were introduced as new criteria to quant. evaluate the impact of different design parameters on the battery thermal management performance. The results showed that utilizing fins can significantly accelerate the melting of the PCM. Increasing the number of fins can reduce the temperature of the battery and improve the uniformity of the battery temperature distribution. Compared with the pure PCM, the total time required for PCM melting in the fin/PCM battery thermal management unit with different numbers of fins is reduced by at least 11.5%. The decrease of the time of complete PCM melting is not linearly correlated with the length ratio of fins. The fin number of N = 6, length ratio of R = 0.8, and angle between fins of φ = 36° were identified as the optimal parameters of fin/PCM composite structures. The TCP and HSP were enhanced by 38.1% and 4.54%, resp. The conclusions of this work can provide reference for the accurate design of fin/PCM composite structures for the thermal management of AUV batteries. Highlights : The fin/phase change material composite structure was introduced for autonomous underwater vehicles’ battery thermal management. The temperature and melting behavior were investigated with natural convection. The temperature control performance factor and heat storage performance factor were proposed as new evaluation criteria. Temperature deviation index was used to measure the battery temperature uniformity. The performance was enhanced by optimizing the design parameters of fin. This study involved multiple reactions and reactants, such as Lithium chloride (cas: 7447-41-8COA of Formula: ClLi).

Lithium chloride (cas: 7447-41-8) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.COA of Formula: ClLi

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lactobacillus cell envelope-coated nanoparticles for antibiotic delivery against cariogenic biofilm and dental caries was written by Weng, Luting;Wu, Lang;Guo, Rongjuan;Ye, Jiajia;Liang, Wen;Wu, Wei;Chen, Liang;Yang, Deqin. And the article was included in Journal of Nanobiotechnology in 2022.Application of 7447-41-8 The following contents are mentioned in the article:

Due to their prevalence, dental caries ranks first among all diseases endangering human health. Therefore, the prevention of caries is of great significance, as caries have become a serious public health problem worldwide. Currently, using nanoscale drug delivery systems to prevent caries has received increased attention. However, the preventive efficacy of these systems is substantially limited due to the unique physiol. structure of cariogenic biofilms. Thus, novel strategies aimed at combating cariogenic biofilms to improve preventive efficiency against caries are meaningful and very necessary. Herein, inspired by cell membrane coating technol. and Lactobacillus strains, we coated triclosan (TCS)-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (TCS@PLGA-NPs) with an envelope of Lactobacillus (LA/TCS@PLGA-NPs) and investigated their potential as a nanoparticle delivery system against cariogenic biofilms and dental caries. LA/TCS@PLGA-NPs were successfully prepared with favorable properties, including a coated envelope, controllable size, neg. charge, sustained drug-release kinetics and so on. The LA/TCS@PLGA-NPs inherited native properties from the source cell surface, thus the LA/TCS@PLGA-NPs adhered to S. mutans, integrated into the S. mutans biofilm, and interfered with the biofilm formation of S. mutans. The nanoparticles significantly inhibited the activity, biomass and virulence gene expression of S. mutans biofilms in vitro. Addnl., LA/TCS@PLGA-NPs exhibited a long-lasting inhibitory effect on the progression of caries in vivo. The safety performance of the nanoparticles is also favorable. Conclusions: Our findings reveal that the antibiofilm effect of LA/TCS@PLGA-NPs relies not only on the inheritance of native properties from the Lactobacillus cell surface but also on the inhibitory effect on the activity, biomass and virulence of S. mutans biofilms. Thus, these nanoparticles could be considered feasible candidates for a new class of effective drug delivery systems for the prevention of caries. Furthermore, this work provides new insights into cell membrane coating technol. and presents a novel strategy to combat bacterial biofilms and associated infections. This study involved multiple reactions and reactants, such as Lithium chloride (cas: 7447-41-8Application of 7447-41-8).

Lithium chloride (cas: 7447-41-8) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Application of 7447-41-8

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics