Category: 6834-42-0

Synthesis, Crystal Structure, Anti-inflammatory and Anti-hyperglycemic Activities of Novel 3,4-Disubstituted 1,2,4-Triazol-5(4H)-one Derivatives was written by Saleem, Muhammad;Yu, Seon-Mi;Rafiq, Muhammad;Kim, Song-Ja;Seo, Sung-Yum;Lee, Ki Hwan. And the article was included in Medicinal Chemistry (Sharjah, United Arab Emirates) in 2014.Computed Properties of C9H9ClO2 This article mentions the following:

A new series of 3,4-disubstituted 1,2,4-triazol-5(4H)-ones I (n = 0, 1; X = 2-F, 4-F, 2-OMe, etc; Y = 3-Me, 2-OMe, 3,4-(OMe)₂, etc.) was synthesized by the dehydrocyclization of hydrazinecarboxamides by refluxing in a 2N sodium hydroxide solution Hydrazinecarboxamides were synthesized via condensation of the corresponding aralkanoic acid hydrazides, with fluoro-, tolyl- and methoxyphenylisocyanates. The structure of compound I (n = 1; X, Y = 2-F) was determined by single crystal X-ray diffraction anal. The final compounds were screened for their anti-inflammatory and anti-diabetic (α-glucosidase and α-amylase inhibition) activity to identify new drugs that might be useful in preventing damage related to diabetes and inflammation. Compounds I (n = 1; X = 3-OMe, 4-OMe, 3,4-(OMe)₂; Y = 3-F, 2-F) decrease the expression of type II collagen in a dose dependent manner; similarly I (n = 1; X = 4-MeO; Y = 3F) decrease the COX-2 expression of rabbit articular chondrocytes in a dose dependent manner possessing potent anti-inflammatory potential while some of derivatives including I (X = 4-F, 2-OMe; Y = 3,4-(OMe)₂ 2-F, 4-F)cause inflammation. Meanwhile, excellent α-glucosidase and moderate α-amylase inhibitory profiles against carbohydrate modulating enzymes were demonstrated by compounds I (n = 0, 1; X = 2-F, 2-OMe, 4-OMe; Y = 3-Me, 3-F, 2-F,) compared to the reference standard acarbose, while some exhibited moderate to low enzyme inhibition potential. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Computed Properties of C9H9ClO2).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Computed Properties of C9H9ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of macrosporin and related 9,10-anthraquinones by biomimetic polyketide aromatization and cyclization of 6-benzylresorcylates was written by Cordes, Jens;Barrett, Anthony G. M.. And the article was included in European Journal of Organic Chemistry in 2013.Recommanded Product: 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

The synthesis of an array of 1-hydroxy-3-methoxy-9,10-anthraquinones by initial preparation of 6-benzylresorcylates from oxo-dioxinone precursors and their subsequent conversion to anthrones by cyclization and oxidn was described. The resorcylates were obtained by an improved 2-step procedure from 6-(4-allyloxy-2,4-dioxobutyl)-2,2-dimethyl-2,4-dihydro-1,3-dioxin-4-one and benzeneacetyl chlorides. These methods were applied in a 7-step synthesis of the fungal natural product macrosporin. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Recommanded Product: 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Scalable Methodology for the Catalytic, Asymmetric α-Bromination of Acid Chlorides was written by Dogo-Isonagie, Cajetan;Bekele, Tefsit;France, Stefan;Wolfer, Jamison;Weatherwax, Anthony;Taggi, Andrew E.;Lectka, Thomas. And the article was included in Journal of Organic Chemistry in 2006.Reference of 6834-42-0 This article mentions the following:

The optimization of a practical, catalytic, asym. process for the α-bromination of acid chlorides to produce synthetically versatile, optically active α-bromo esters was reported. A range of products was produced in high enantioselectivity and moderate to good chem. yields with retention of both upon scale-up. The reactions were catalyzed by cinchona alkaloid derivatives with the best performance achieved by the use of a proline cinchona alkaloid conjugate designed in a de novo fashion. Thus, PhCH₂COCl in THF containing NaH, 15-crown-5, and the ester of N-Boc-proline with quinine at -78° reacted with 1,1,3,6-tetrabromo-2(1H)-naphthalenone for five hours to give 55% of the tribromonaphthyl bromophenylacetate I with 99% enantiomeric excess. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Reference of 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Reference of 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics