Category: 6834-42-0

Synthesis and biological evaluation of thieno[3,2-d]pyrimidinones, thieno[3,2-d]pyrimidines and quinazolinones: conformationally restricted 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) inhibitors was written by Perspicace, Enrico;Marchais-Oberwinkler, Sandrine;Hartmann, Rolf W.. And the article was included in Molecules in 2013.Formula: C9H9ClO2 This article mentions the following:

In this study, a series of conformationally restricted thieno[3,2-d]pyrimidinone derivatives, thieno[3,2-d]pyrimidine derivatives and quinazolinone derivatives was designed and synthesized with the goal of improving the biol. activity as 17β-hydroxysteroid dehydrogenase type 2 inhibitors of the corresponding amidothiophene derivatives Two moderately active compounds were discovered and this allowed the identification of the biol. active open conformer as well as the extension of the enzyme binding site characterization. The title compounds thus formed included a thienopyrimidine derivative (I) and related substances, such as quinazoline analogs. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Formula: C9H9ClO2).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Formula: C9H9ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Carbon Dioxide-Catalyzed Stereoselective Cyanation Reaction was written by Roy, Tamal;Kim, Myungjo J.;Yang, Yang;Kim, Suyeon;Kang, Gyumin;Ren, Xinyi;Kadziola, Anders;Lee, Hee-Yoon;Baik, Mu-Hyun;Lee, Ji-Woong. And the article was included in ACS Catalysis in 2019.COA of Formula: C9H9ClO2 This article mentions the following:

We report a Michael-type cyanation reaction of coumarins by using CO₂ as a catalyst. The delivery of the nucleophilic cyanide was realized by catalytic amounts of CO₂, which forms cyanoformate and bicarbonate in the presence of water. Under ambient conditions, CO₂-catalyzed reactions afforded high chemo- and diastereoselectivity of β-nitrile carbonyls, whereas only low reactivities were observed under argon or N₂. Computational and exptl. data suggest the catalytic role of CO₂, which functions as a Lewis acid, and a protecting group to mask the reactivity of the product, suppressing byproducts and polymerization The utility of this convenient method was demonstrated by preparing biol. relevant heterocyclic compounds with ease. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0COA of Formula: C9H9ClO2).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.COA of Formula: C9H9ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On-Demand Control of the Photochromic Properties of Naphthopyrans was written by Kuroiwa, Hayato;Inagaki, Yuki;Mutoh, Katsuya;Abe, Jiro. And the article was included in Advanced Materials (Weinheim, Germany) in 2019.SDS of cas: 6834-42-0 This article mentions the following:

Photofunctional compounds have emerged as critically important materials for both fundamental studies and industrial applications. Control of the thermal decoloration speed to within several seconds while sustaining satisfactory photochromic colorability is an important challenge for the application of such materials to photochromic lenses and smart windows. Photochromic naphthopyran derivatives are utilized for photochromic lenses because of their high durability and easily controllable colorability. However, the residual color imparted by the long-lived transient species upon ceasing light irradiation remains a hindrance to practical applications. In this study, a strategy is demonstrated for on-demand control of the thermal decoloration speed of the transient colored species of naphthopyran derivatives The increase in the ring-size of the alkylenedioxy moiety on the naphthopyrans accelerates the thermal back-reaction independently of the maximum-absorption wavelength of the colored isomer, leading to the realization of yellow-, red-, and blue-photochromic naphthopyrans with similar thermal fading speeds. This novel mol. design provides a strategy for the future development of advanced photoresponsive materials. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0SDS of cas: 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.SDS of cas: 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

8-Substituted 3,4-dihydroquinolinones as a novel scaffold for atypical antipsychotic activity was written by Singer, Jamie M.;Barr, Bridget M.;Coughenour, Linda L.;Gregory, Tracy F.;Walters, Michael A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Synthetic Route of C9H9ClO2 This article mentions the following:

Several new, potent dopamine subtype 2 (DA D₂) active compounds with serotonin subtype 2A (5-HT_2A) pharmacol. are presented. 8-Substituted 3,4-dihydroquinolinones, tetrahydroquinolines, and N-acyl tetrahydroquinolines were evaluated in primary assays. Subtle changes on this novel scaffold translated to large changes in potency and selectivity in vitro. These compounds show promise as novel atypical antipsychotics for the treatment of schizophrenia. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Synthetic Route of C9H9ClO2).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Synthetic Route of C9H9ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of the new morphine partial structure – 15,16-secomorphinan was written by Revesz, Laszlo. And the article was included in Helvetica Chimica Acta in 1984.Safety of 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

1-Methylcyclohexene was cyclized with p-MeOC₆H₄CH₂COCl in CH₂Cl₂ containing AlCl₃ followed by oximation to give the phenanthrenone oxime I, which was reduced to give the phenanthrenamines II and III (R = R¹ = H). II and III (R = R¹ = H) were converted to II and III (R = H, R¹ = F₃CCO, cyclopropylcarbonyl; R = H, Me, R¹ = cyclopropylmethyl). (±)-15,16-Secocyclorphan (III, R = Me, R¹ = cyclopropylmethyl) has the analgesic potency of morphine and exhibites good binding to the opiate receptor. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Safety of 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Safety of 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

N-monoarylacetothioureas as potent urease inhibitors: synthesis, SAR, and biological evaluation was written by Li, Wei-Yi;Ni, Wei-Wei;Ye, Ya-Xi;Fang, Hai-Lian;Pan, Xing-Ming;He, Jie-Ling;Zhou, Tian-Li;Yi, Juan;Liu, Shan-Shan;Zhou, Mi;Xiao, Zhu-Ping;Zhu, Hai-Liang. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2020.Name: 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

A urease inhibitor with good in vivo profile is considered as an alternative agent for treating infections caused by urease-producing bacteria such as Helicobacter pylori. Here, we report a series of N-monosubstituted thioureas, which act as effective urease inhibitors with very low cytotoxicity. One compound () was evaluated in detail and shows promising features for further development as an agent to treat H. pylori caused diseases. Excellent values for the inhibition of against both extracted urease and urease in intact cell were observed, which shows IC₅₀ values of 0.16 ± 0.05 and 3.86 ± 0.10μM, being 170- and 44-fold more potent than the clin. used drug AHA, resp. Docking simulations suggested that the monosubstituted thiourea moiety penetrates urea binding site. In addition, is a rapid and reversible urease inhibitor, and displays nM affinity to urease with very slow dissociation (k_off=1.60 × 10^-3 s^-1) from the catalytic domain. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Name: 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Name: 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and SAR of 5-, 6-, 7- and 8-Aza Analogues of 3-Aryl-4-hydroxyquinolin-2(1H)-one as NMDA/Glycine Site Antagonists was written by Zhou, Z.-L.;Navratil, J. M.;Cai, S. X.;Whittemore, E. R.;Espitia, S. A.;Hawkinson, J. E.;Tran, M.;Woodward, R. M.;Weber, E.;Keana, J. F. W.. And the article was included in Bioorganic & Medicinal Chemistry in 2001.COA of Formula: C9H9ClO2 This article mentions the following:

A series of 5-, 6-, 7- and 8-aza analogs of 3-aryl-4-hydroxyquinolin-2(1H)-one was synthesized and assayed as NMDA/glycine receptor antagonists. The in vitro potency of these antagonists was determined by displacement of the glycine site radioligand [³H]5,7-dichlorokynurenic acid ([³H]DCKA) in rat brain cortical membranes. Selected compounds were also tested for functional antagonism using electrophysiol. assays in Xenopus oocytes expressing cloned NMDA receptor (NR) 1A/2C subunits. Among the 5-, 6-, 7-, and 8-aza-3-aryl-4-hydroxyquinoline-2(1H)-ones investigated, 5-aza-7-chloro-4-hydroxy-3-(3-phenoxyphenyl)quinolin-2-(1H)-one (I) is the most potent antagonist, having an IC₅₀ value of 110 nM in [³H]DCKA binding and a K_b of 11 nM in the electrophysiol. assay. Compound I is also an active anticonvulsant when administered systemically in the mouse maximum electroshock-induced seizure test (ED₅₀=2.3 mg/kg, IP). In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0COA of Formula: C9H9ClO2).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.COA of Formula: C9H9ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Base-Mediated One-pot Synthesis of Oxygen-Based Heterocycles from 2-Hydroxyphenyl-Substituted para-Quinone Methides was written by Singh, Gurdeep;Kumar, Suresh;Chowdhury, Arjun;Vijaya Anand, Ramasamy. And the article was included in Journal of Organic Chemistry in 2019.Reference of 6834-42-0 This article mentions the following:

One-pot synthesis of oxygen-containing heterocycles has been achieved through alkylation/acylation of 2-hydroxyphenyl-substituted para-quinone methides followed by an intramol. 1,6-conjugate addition/cyclization and oxidation sequence. This protocol provides access to a wide range of oxygen-based heterocycles, such as 2,3-disubstituted benzo[b]furans, 2,3-dihydrobenzofurans and diaryl-substituted coumarin derivatives in moderate to good yields. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Reference of 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Reference of 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of μ-opioid selective ligands derived from 1-aminotetralin scaffolds made via metal-catalyzed ring-opening reactions was written by Dockendorff, Chris;Jin, Shujuan;Olsen, Madeline;Lautens, Mark;Coupal, Martin;Hodzic, Lejla;Spear, Nathan;Payza, Kemal;Walpole, Christopher;Tomaszewski, Miroslaw J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.Application of 6834-42-0 This article mentions the following:

A series of 1-aminotetralin scaffolds was synthesized via metal-catalyzed ring-opening reactions of heterobicyclic alkenes. Small libraries of amides and amines were made using the amino group of each scaffold as a handle. Screening of these libraries against human opioid receptors led to the identification of (S)-(S)-I as a high-affinity selective μ ligand (IC₅₀ μ = 5 nM, κ = 707 nM, δ = 3,795 nM) displaying μ-agonist/antagonist properties due to its partial agonism (EC₅₀ = 2.6 μM; E _max = 18%). In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Application of 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application of 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structure activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 2 was written by Takeuchi, Kumiko;Holloway, William G.;Mitch, Charles H.;Quimby, Steven J.;McKinzie, Jamie H.;Suter, Todd M.;Statnick, Michael A.;Surface, Peggy L.;Emmerson, Paul J.;Thomas, Elizabeth M.;Siegel, Miles G.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Recommanded Product: 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

A series of 6-bicycloaryloxynicotinamides were identified as opioid receptor antagonists at mu, kappa, and delta receptors. Compounds in the 6-(2,3,4,5-tetrahydro-1H-benzo[c]azepin-7-yloxy)nicotinamide scaffold exhibited potent in vitro functional antagonism at all three receptors. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Recommanded Product: 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics