Category: 6834-42-0

Kotzamani, Heleni K. et al. published their research in Tetrahedron in 1994 | CAS: 6834-42-0

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Reference of 6834-42-0

An approach to 1-alkyl-3-phenylpiperidine derivatives containing 2,5-functionalized groups: 1-methyl-2-(4-chlorophenylthiomethyl)-3-(3-methoxyphenyl)-5-(methoxycarbonyl)piperidine was written by Kotzamani, Heleni K.;Gourdoupis, Christos G.;Stamos, Ioannis K.. And the article was included in Tetrahedron in 1994.Reference of 6834-42-0 This article mentions the following:

3-MeOC6H4CH2COCH2SC6H4Cl-4 (I) was synthesized by regiospecific addition of 4-chlorothiophenol to diazoketone 3-MeOC6H4CH2COCHN2 in the presence of a rhodium(II) acetate catalyst. Annulation of I with the enamine prepared from MeNH2 and CH2:C(CH2Br)CO2Me gave a tetrahydropyridine derivative Reduction of this compound with sodium cyanoborohydride in the presence of carboxylic acid produced the title compound In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Reference of 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Reference of 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Xie, Shaolei et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2021 | CAS: 6834-42-0

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Synthetic Route of C9H9ClO2

The organocatalytic enantiodivergent fluorination of 尾-ketodiaryl-phosphine oxides for the construction of carbon-fluorine quaternary stereocenters was written by Xie, Shaolei;He, Zhi-Juan;Zhang, Ling-Hui;Huang, Bo-Lun;Chen, Xiao-Wei;Zhan, Zong-Song;Zhang, Fu-Min. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2021.Synthetic Route of C9H9ClO2 This article mentions the following:

Com. available cinchona alkaloids that can catalyze the enantiodivergent fluorination of 尾-ketodiarylphosphine oxides were developed to construct carbon-fluorine quaternary stereocenters. This protocol features a wide scope of substrates and excellent enantioselectivities, and it is scalable. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Synthetic Route of C9H9ClO2).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Synthetic Route of C9H9ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ainscough, Martin A. et al. published their research in Journal of the Chemical Society, Chemical Communications in 1976 | CAS: 6834-42-0

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Name: 2-(3-Methoxyphenyl)acetyl chloride

Novel synthesis of isoquinolin-3-ols was written by Ainscough, Martin A.;Temple, Arthur F.. And the article was included in Journal of the Chemical Society, Chemical Communications in 1976.Name: 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

Cycloaddition reaction of phenacetyl chlorides with alkyl or aryl thiocyanates in the presence of SnCl4 gave 1-substituted isoquinolin-3-ols. E.g., PhCH2COCl with MeSCN in PhNO2 in the presence of SnCl4 gave 65% 1-methylthioisoquinolin-3-ol (I). In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Name: 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Name: 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Woronoff, Gabrielle et al. published their research in Analytical Chemistry (Washington, DC, United States) in 2011 | CAS: 6834-42-0

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Reference of 6834-42-0

New Generation of Amino Coumarin Methyl Sulfonate-Based Fluorogenic Substrates for Amidase Assays in Droplet-Based Microfluidic Applications was written by Woronoff, Gabrielle;El Harrak, Abdeslam;Mayot, Estelle;Schicke, Olivier;Miller, Oliver J.;Soumillion, Patrice;Griffiths, Andrew D.;Ryckelynck, Michael. And the article was included in Analytical Chemistry (Washington, DC, United States) in 2011.Reference of 6834-42-0 This article mentions the following:

Droplet-based microfluidics is a powerful tool for biol. and chem. as it allows the production and the manipulation of picoliter-size droplets acting as individual reactors. In this format, high-sensitivity assays are typically based on fluorescence, so fluorophore exchange between droplets must be avoided. Fluorogenic substrates based on the coumarin leaving group are widely used to measure a variety of enzymic activities, but their application in droplet-based microfluidic systems is severely impaired by the fast transport of the fluorescent product between compartments. Here the authors report the synthesis of new amidase fluorogenic substrates based on 7-aminocoumarin-4-methanesulfonic acid (ACMS), a highly water-soluble dye, and their suitability for droplet-based microfluidics applications. Both substrate and product had the required spectral characteristics and remained confined in droplets from hours to days. As a model experiment, a phenylacetylated ACMS was synthesized and used as a fluorogenic substrate of Escherichia coli penicillin G acylase. Kinetic parameters (kcat and Km) measured in bulk and in droplets on-chip were very similar, demonstrating the suitability of this synthesis strategy to produce a variety of ACMS-based substrates for assaying amidase activities both in microtiter plate and droplet-based microfluidic formats. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Reference of 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Reference of 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Coskun, Necdet et al. published their research in Synthetic Communications in 1997 | CAS: 6834-42-0

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Name: 2-(3-Methoxyphenyl)acetyl chloride

Reactivity of benzylic acylammonium chlorides. A novel method for the synthesis of N-phenacylamides was written by Coskun, Necdet;Tirli, Fatma. And the article was included in Synthetic Communications in 1997.Name: 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

Tertiary amines R1C6H4CH2NR2CH2COC6H4R3-4 [R1 = H, 2,3-(MeO)2, 3,4-(MeO)2, 2-NO2, etc., R2 = Me, PhCH2, 3,4-(MeO)2C6H3CH2, R3 = H, MeO] reacted with acid chlorides R4COCl [R4 = 3-MeOC6H4CH2, 3,4-(MeO)2C6H4CH2, PhCH2, 4-MeOC6H4CH2] to give corresponding benzyl chlorides and N-phenacylamides R4CONR2CH2COC6H4R3-4. The effect of the substituents in the benzyl group on the reactivity of the intermediate acylammonium chlorides was investigated. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Name: 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Name: 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Coskun, Necdet et al. published their research in Synthetic Communications in 1997 | CAS: 6834-42-0

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Name: 2-(3-Methoxyphenyl)acetyl chloride

Reactivity of benzylic acylammonium chlorides. A novel method for the synthesis of N-phenacylamides was written by Coskun, Necdet;Tirli, Fatma. And the article was included in Synthetic Communications in 1997.Name: 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

Tertiary amines R1C6H4CH2NR2CH2COC6H4R3-4 [R1 = H, 2,3-(MeO)2, 3,4-(MeO)2, 2-NO2, etc., R2 = Me, PhCH2, 3,4-(MeO)2C6H3CH2, R3 = H, MeO] reacted with acid chlorides R4COCl [R4 = 3-MeOC6H4CH2, 3,4-(MeO)2C6H4CH2, PhCH2, 4-MeOC6H4CH2] to give corresponding benzyl chlorides and N-phenacylamides R4CONR2CH2COC6H4R3-4. The effect of the substituents in the benzyl group on the reactivity of the intermediate acylammonium chlorides was investigated. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Name: 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Name: 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Serrano, Pedro et al. published their research in Journal of Combinatorial Chemistry in 2007 | CAS: 6834-42-0

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Name: 2-(3-Methoxyphenyl)acetyl chloride

Combinatorial Approach to N-Substituted Amino-Cyclitol Libraries by Solution-Phase Parallel Synthesis and Preliminary Evaluation as Glucocerebrosidase Inhibitors was written by Serrano, Pedro;Casas, Josefina;Zucco, Martine;Emeric, Gilbert;Egido-Gabas, Meritxell;Llebaria, Amadeu;Delgado, Antonio. And the article was included in Journal of Combinatorial Chemistry in 2007.Name: 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

Libraries of N-substituted amino-cyclitol derivatives of the scyllo and racemic chiro series by means of parallel solution-phase methodol. with the help of robotic technol. are described. Chem. diversity has been introduced by reaction of selected scaffolds with a set of aldehydes, acyl chlorides, sulfonyl chlorides, chloroformates, and amines to afford the corresponding amines, amides, sulfonamides, carbamates and ureas, resp. The optimized methodol. has proven excellent, in terms of overall purity of the resulting libraries, for the production of amides. Sulfonamides and carbamates have been obtained in slightly lower purity, while amines afforded modest results. Selected library members have been evaluated as inhibitors of recombinant glucocerebrosidase with Ki values ranging in the low micromolar scale for the most active members. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Name: 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Name: 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhong, Wu et al. published their research in Yaoxue Xuebao in 1999 | CAS: 6834-42-0

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 6834-42-0

Synthesis and antifungal activities of 2-(2,4- difluorophenyl)-3-(N-methyl-N-substituted acylamino)-1-(1H-1,2,4- triazol-1-yl)-2-propanol was written by Zhong, Wu;Zhang, Wannian;Li, Ke;Zhou, Youjun;Zhu, Ju;Lu, Jiaguo. And the article was included in Yaoxue Xuebao in 1999.Recommanded Product: 6834-42-0 This article mentions the following:

Twenty one new triazole compounds were designed and synthesized as potential inhibitors of the fungal cytochrome P 450 14α-demethylase, and their antifungal activities were determined by biol. tests in vitro. All compounds had antifungal activities especially against Candida albicans and Candida parapsilosis. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Recommanded Product: 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bandarage, Upul K. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2018 | CAS: 6834-42-0

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Safety of 2-(3-Methoxyphenyl)acetyl chloride

ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors was written by Bandarage, Upul K.;Cao, Jingrong;Come, Jon H.;Court, John J.;Gao, Huai;Jacobs, Marc D.;Marhefka, Craig;Nanthakumar, Suganthi;Green, Jeremy. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2018.Safety of 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

Rho kinase (ROCK) inhibitors are potential therapeutic agents for the treatment of a variety of disorders including hypertension, glaucoma and erectile dysfunction. Here we disclose a series of potent and selective ROCK inhibitors based on a substituted 7-azaindole scaffold. Substitution of the 3-position of 7-azaindole led to compounds such as 37, which possess excellent ROCK inhibitory potency and high selectivity against the closely related kinase PKA. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Safety of 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Safety of 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kahraman, Mehmet et al. published their research in ACS Medicinal Chemistry Letters in 2019 | CAS: 6834-42-0

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application In Synthesis of 2-(3-Methoxyphenyl)acetyl chloride

Maximizing ER-α Degradation Maximizes Activity in a Tamoxifen-Resistant Breast Cancer Model: Identification of GDC-0927 was written by Kahraman, Mehmet;Govek, Steven P.;Nagasawa, Johnny Y.;Lai, Andiliy;Bonnefous, Celine;Douglas, Karensa;Sensintaffar, John;Liu, Nhin;Lee, KyoungJin;Aparicio, Anna;Kaufman, Josh;Qian, Jing;Shao, Gang;Prudente, Rene;Joseph, James D.;Darimont, Beatrice;Brigham, Daniel;Heyman, Richard;Rix, Peter J.;Hager, Jeffrey H.;Smith, Nicholas D.. And the article was included in ACS Medicinal Chemistry Letters in 2019.Application In Synthesis of 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

The further optimization of ER-α degradation efficacy of a series of ER modulators by refining side-chain substitution led to efficacious selective estrogen receptor degraders (SERDs). A fluoromethyl azetidine group was found to be preferred and resulted in the identification of bis-phenol chromene 17ha. In a tamoxifen-resistant breast cancer xenograft model, 17ha (ER-α degradation efficacy = 97%) demonstrated tumor regression, together with robust reduction of intratumoral ER-α levels. However, despite superior oral exposure, 5a (ER-α degradation efficacy = 91%) had inferior activity. This result suggests that optimizing ER-α degradation efficacy leads to compounds with robust effects in a model of tamoxifen-resistant breast cancer. Compound 17ha (GDC-0927) was evaluated in clin. trials in women with metastatic estrogen receptor-pos. breast cancer. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Application In Synthesis of 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application In Synthesis of 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics