6334-18-5 Archives - Page 4 of 10 - Chlorides-buliding-blocks

Ranjbar, Sara team published research in Molecular Diversity in 2022 | 6334-18-5

HPLC of Formula: 6334-18-5, 2,3-Dichlorobenzaldehyde(2,3-DBA)is a useful research compound. Its molecular formula is C7H4Cl2O and its molecular weight is 175.01 g/mol. The purity is usually 95%.
2,3-DBA is an organic compound that is used as a synthetic intermediate in the preparation of other chemicals. It is prepared by reacting 2-chloroacetophenone with hydrochloric acid and sodium carbonate in a reaction vessel. The product can be purified through fractional distillation or crystallization. The optical properties of 2,3-DBA are determined by its dipole moment and the substituents attached to the methylene group. Molecular modeling studies have shown that felodipine can bind to 2,3-DBA through its active methylene group. The reaction products between sulfadiazine and 2,3-DBA are pyridinedicarboxylic acid and 3-chlorobenzaldehyde.
2,3-DBA is part of a group of Benzaldehyde (B119740) derivatives that exhibit activity against Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis in humans. 2,3-DBA is also used as a reagent to synthesize (E)-2-(2-arylhydrazinyl)quinoxalines, compounds that have potent anticancer activity., 6334-18-5.

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 6334-18-5, formula is C7H4Cl2O, Name is 2,3-Dichlorobenzaldehyde. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. HPLC of Formula: 6334-18-5.

Ranjbar, Sara;Khoshneviszadeh, Mehdi;Tavakkoli, Marjan;Miri, Ramin;Edraki, Najmeh;Firuzi, Omidreza research published 《 5-Oxo-hexahydroquinoline and 5-oxo-tetrahydrocyclopentapyridine derivatives as promising antiproliferative agents with potential apoptosis-inducing capacity》, the research content is summarized as follows. In this study, a series of 49 5-oxo-hexahydroquinoline and 5-oxo-tetrahydrocyclopentapyridines I [R¹ = 3-pyridylmethyl, 2-pyridylethyl, 3-pyridylpropyl, etc.; R² = Ph, 2-furanyl, Bu, etc.; X = (CH₂)_n; n = 1, 2], containing different pyridine alkyl carboxylates at C3 and various aliphatic, aromatic, and heteroaromatic substitutions at the C4 position of the central core, were synthesized. The target compounds I were tested for antiproliferative effect against three human cancer cell lines including MOLT-4 (acute lymphoblastic leukemia), K562 (chronic myelogenous leukemia), and MCF-7 (breast adenocarcinoma) by MTT assay, and the effect of the most potent derivatives on cell cycle was evaluated by RNase/propidium iodide (PI) flow cytometric assay. Generally, 5-oxo-hexahydroquinoline derivatives I [R¹ = 3-pyridylpropyl; R² = Ph, 2-furanyl, Bu, etc.; n = 2] possessed superior antiproliferative activities compared to their 5-oxo-tetrahydrocyclopentapyridine counterparts I [R¹ = 3-pyridylpropyl; R² = Ph, 2-furanyl, Bu, etc.; n = 1]. 5-Oxo-hexahydroquinoline compounds bearing 2-pyridyl Pr carboxylates I [R¹ = 2-pyridylpropyl; R² = Ph, 2-furanyl, Bu, etc.; n = 2] and 3-pyridyl Pr carboxylates I [R¹ = 3-pyridylpropyl; R² = Ph, 2-furanyl, Bu, etc.; n = 2] were better antiproliferative agents than those bearing other pyridyl alkyl carboxylates. Five best compounds with IC₅₀ values in the range of 9.5-22.9μM against MOLT-4 cells were selected for cell-cycle anal., which revealed that derivatives I [R¹ = 2-pyridylpropyl; R² = 2,3-dichlorophenyl; n = 2], I [R¹ = 3-pyridylpropyl; R² = 3-nitrophenyl, 2-nitrophenyl; n = 2] with substitutions at C4 position, may induce apoptosis in MOLT-4 cells. Mol. docking anal., which was employed to make some predictions on the interaction of the most active derivatives with the binding site of Bcl-2 and Bcl-xL proteins, suggested that the compounds may be well accommodated within the binding sites of these anti-apoptotic proteins via hydrogen-bonding and hydrophobic interactions. The findings of this study present 5-oxo-hexahydroquinolines I [R¹ = 3-pyridylmethyl, 2-pyridylethyl, 3-pyridylpropyl, etc.; R² = Ph, 2-furanyl,butyl, etc.; n = 2]. as antiproliferative agents with potential apoptosis-inducing ability in cancer cells.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rad, Shiva Asadi team published research in Journal of Molecular Recognition in 2022 | 6334-18-5

6334-18-5, 2,3-Dichlorobenzaldehyde(2,3-DBA)is a useful research compound. Its molecular formula is C7H4Cl2O and its molecular weight is 175.01 g/mol. The purity is usually 95%.
2,3-DBA is an organic compound that is used as a synthetic intermediate in the preparation of other chemicals. It is prepared by reacting 2-chloroacetophenone with hydrochloric acid and sodium carbonate in a reaction vessel. The product can be purified through fractional distillation or crystallization. The optical properties of 2,3-DBA are determined by its dipole moment and the substituents attached to the methylene group. Molecular modeling studies have shown that felodipine can bind to 2,3-DBA through its active methylene group. The reaction products between sulfadiazine and 2,3-DBA are pyridinedicarboxylic acid and 3-chlorobenzaldehyde.
2,3-DBA is part of a group of Benzaldehyde (B119740) derivatives that exhibit activity against Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis in humans. 2,3-DBA is also used as a reagent to synthesize (E)-2-(2-arylhydrazinyl)quinoxalines, compounds that have potent anticancer activity., Name: 2,3-Dichlorobenzaldehyde

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 6334-18-5, formula is C7H4Cl2O, Name is 2,3-Dichlorobenzaldehyde. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Name: 2,3-Dichlorobenzaldehyde.

Rad, Shiva Asadi;Shadjou, Nasrin research published 《 Metformin functionalized dendritic fibrous nanosilica (KCC-1-nPr-Met) as an innovative and green nanocatalyst for the efficient synthesis of tetrahydro-4H -chromene derivatives》, the research content is summarized as follows. An innovative nanocatalyst (KCC-1-nPr-Met) has been prepared from the covalent attachment of metformin on the channels and the pores of Pr amine functionalized dendritic fibrous nanosilica (DFNS) and used towards efficient, green, and high yield synthesis of tetrahydro-4H-chromenes derivatives by one-pot three-component reaction of aromatic aldehydes, malononitrile, and dimedone in H₂O-EtOH at room temperature The designed nanocatalyst has been characterized by energy dispersive X-ray spectroscopy (EDS), Fourier transform IR spectroscopy (FT-IR), and adsorption/desorption anal. (BET) techniques. Also, field emission SEM (FE-SEM) was used to study the morphol. of prepared nanocatalyst. The engineered nanocatalyst with uniform fibrous spheres has dendritic structure, high pore volume (0.35 cm³/g), and great surface area (178 m²/g). Hence, the specific dendritic structure of the prepared nanocatalyst not only improve the diffusion ability of the reactants and products, but also, increase the availability of dynamic sites in the pores and channels of the catalyst. According to the obtained results, a unique strategy was proposed towards the synthesis of important biol. active scaffolds in the presence of nontoxic and environmental friendly nanocatalyst and media. Milder reaction conditions (room temperature), shorter reaction times (5-30 min), excellent yields (92%-98%) of the products with higher purity, very simple workup procedure, and using of EtOH: H₂O as a green solvent are the advantages of the presented work.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

R. Waghmare, Smita team published research in Organic Preparations and Procedures International in 2022 | 6334-18-5

Chlorinated organic compounds are found in nearly every class of biomolecules. 6334-18-5, formula is C7H4Cl2O, Name is 2,3-Dichlorobenzaldehyde. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Safety of 2,3-Dichlorobenzaldehyde.

R. Waghmare, Smita;Deokate, Manisha D.;Lokhande, Pradeep D. research published 《 Ammonium Chloride Promoted Synthesis of β-Aminoketones》, the research content is summarized as follows. Authors have described a simple, novel and efficient three component Mannich reaction using substoichiometric amounts of ammonium chloride to obtain β-aminoketones. Authors used a number of substituted alicyclic and aromatic ketones in reactions with substituted benzaldehydes and anilines to produce the title compounds in very good to excellent yields (82-98%).

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Pedrood, Keyvan team published research in Scientific Reports in 2021 | 6334-18-5

Quality Control of 6334-18-5, 2,3-Dichlorobenzaldehyde(2,3-DBA)is a useful research compound. Its molecular formula is C7H4Cl2O and its molecular weight is 175.01 g/mol. The purity is usually 95%.
2,3-DBA is an organic compound that is used as a synthetic intermediate in the preparation of other chemicals. It is prepared by reacting 2-chloroacetophenone with hydrochloric acid and sodium carbonate in a reaction vessel. The product can be purified through fractional distillation or crystallization. The optical properties of 2,3-DBA are determined by its dipole moment and the substituents attached to the methylene group. Molecular modeling studies have shown that felodipine can bind to 2,3-DBA through its active methylene group. The reaction products between sulfadiazine and 2,3-DBA are pyridinedicarboxylic acid and 3-chlorobenzaldehyde.
2,3-DBA is part of a group of Benzaldehyde (B119740) derivatives that exhibit activity against Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis in humans. 2,3-DBA is also used as a reagent to synthesize (E)-2-(2-arylhydrazinyl)quinoxalines, compounds that have potent anticancer activity., 6334-18-5.

Pedrood, Keyvan;Azizian, Homa;Montazer, Mohammad Nazari;Mohammadi-Khanaposhtani, Maryam;Asgari, Mohammad Sadegh;Asadi, Mehdi;Bahadorikhalili, Saeed;Rastegar, Hossein;Larijani, Bagher;Amanlou, Massoud;Mahdavi, Mohammad research published 《 Arylmethylene hydrazine derivatives containing 1,3-dimethylbarbituric moiety as novel urease inhibitors》, the research content is summarized as follows. A new series of arylmethylene hydrazine derivatives bearing 1,3-dimethylbarbituric moiety I (Ar = Ph, 2,3-dichlorophenyl, naphthalen-1-yl, thiophen-2-yl, etc.) was designed, synthesized, and evaluated for their in vitro urease inhibitory activity. All the title compounds I displayed high anti-urease activity, with IC₅₀ values in the range of 0.61 ± 0.06-4.56 ± 0.18μM as compared to the two standard inhibitors hydroxyurea (IC₅₀ = 100 ± 0.15μM) and thiourea (IC₅₀ = 23 ± 1.7μM). Among the synthesized compounds I, compound I (Ar = 2-nitrophenyl) with 2-nitro benzylidene group was found to be the most potent compound Kinetic study of this above compound revealed that it is a mix-mode inhibitor against urease. Evaluation of the interaction modes of the synthesized compounds in urease active site by mol. modeling revealed that that compounds with higher urease inhibitor activity (I (Ar = 2-nitrophenyl, thiophen-2-yl, 2,4-dihydroxyphenyl, 5-chloro-2-nitrophenyl, 4-nitrophenyl and naphthalen-1-yl), with IC₅₀ of 0.61, 0.86, 1.2, 1.34, 1.33, 1.94μM, resp.) could interact with higher number of residues, specially Arg609, Cys592 (as part of urease active site flap) and showed higher computed free energy, while compounds with lower urease activity (I (Ar = 4-chlorophenyl, 5-chlorothiophen-2-yl, 3-bromophenyl and Ph) with IC₅₀ of 3.56, 4.56, 3.62 and 4.43μM, resp.) and could not provide the proper interaction with Arg609, and Cys592 as the key interacting residues along with lower free binding energy. MD investigation revealed that compound I (Ar = 2-nitrophenyl) interacted with Arg609 and Cys592 which are of the key residues at the root part of mobile flap covering the active site. Interaction with the mentioned residue for a significant amount of time affects the flexibility of the mobile flap covering the active site and causes inhibition of the ureolytic activity. Furthermore, in silico physico-chem. study of compounds I predicted that all these compounds are drug-likeness with considerable orally availability.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Panda, Krishna Chandra team published research in Heterocyclic Letters in 2021 | 6334-18-5

Chloride substituents modify the physical properties of organic compounds in several ways. 6334-18-5, formula is C7H4Cl2O, Name is 2,3-Dichlorobenzaldehyde. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Synthetic Route of 6334-18-5.

Panda, Krishna Chandra;Kumar, B. V. V. Ravi;Sahoo, Biswa Mohan research published 《 Multicomponent one-pot facile synthesis of pyrimidine derivatives under microwave irradiation technique and study of their anti-inflammatory activity》, the research content is summarized as follows. Multicomponent one-pot synthetic protocol is applied for the efficient preparation of a series of pyrimidine derivatives I (R = H, Cl, NO₂; R¹ = H, Cl; R² = H, Me, OMe, NO₂, etc.) under microwave irradiation method. The synthetic process proceeds via Knoevenagel condensation initially with subsequent Michael addition reaction followed by cyclization of equimolar quantities of substituted benzaldehydes 2-R-3-R¹-4-R²-C₆H₂CHO, ethylcyanoacetate and guanidine in the presence of ethanolic sodium hydroxide solution to produce corresponding pyrimidine derivatives I. The reaction mixture was refluxed under microwave radiation for 7-12min at power level-2 which corresponds to 210W. Microwave heating provides cleaner reaction condition with shorter reaction time and improved product yield as compared to conventional heating method. The newly synthesized compounds I were screened for their anti-inflammatory activity in-vitro by using membrane stabilization method (heat induced hemolytic technique). Some of the tested compounds I were found to possess significant anti-inflammatory potential as compared to the standard drug (Diclofenac).

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Osipyan, Angelina team published research in Angewandte Chemie, International Edition in 2020 | 6334-18-5

Organic chlorides are organic molecules with a C-Cl bond, for example chloroform (CH3-Cl) or vinyl chloride(C2H3Cl). 6334-18-5, formula is C7H4Cl2O, Name is 2,3-Dichlorobenzaldehyde. Organic chlorides can be used in production of: PVC, Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. Recommanded Product: 2,3-Dichlorobenzaldehyde.

Osipyan, Angelina;Shaabani, Shabnam;Warmerdam, Robert;Shishkina, Svitlana V.;Boltz, Harry;Doemling, Alexander research published 《 Automated, Accelerated Nanoscale Synthesis of Iminopyrrolidines》, the research content is summarized as follows. Miniaturization and acceleration of synthetic chem. is an emerging area in pharmaceutical, agrochem., and materials research and development. Herein, we describe the synthesis of iminopyrrolidine-2-carboxylic acid derivatives using chiral glutamine, oxo components, and isocyanide building blocks in an unprecedented Ugi-3-component reaction. We used I-DOT, a pos.-pressure-based low-volume and non-contact dispensing technol. to prepare more than 1000 different derivatives in a fully automated fashion. In general, the reaction is stereoselective, proceeds in good yields, and tolerates a wide variety of functional groups. We exemplify a pipeline of fast and efficient nanomole-scale scouting to millimole-scale synthesis for the discovery of a useful novel reaction with great scope.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nivetha, Narayanasamy team published research in Journal of Molecular Structure in 2021 | 6334-18-5

Nivetha, Narayanasamy;Thangamani, Arumugam research published 《 Dispirooxindole-pyrrolothiazoles: Synthesis, anti-cancer activity, molecular docking and green chemistry metrics evaluation》, the research content is summarized as follows. A modest library of a set of dispirooxindole-pyrrolothiazoles I [Ar = C₆H₅, 4-MeC₆H₄, 3-BrC₆H₄, etc.] were synthesized through multicomponent technique employing 1,3-dipolar cycloaddition reaction of azomethine ylide with dipolarophiles, 2,6-dibenzylidene-4-methylcyclohexanones without any catalyst. The reaction provided simple and efficient access to synthetically useful and biol. important dispirooxindole-pyrrolothiazoles I in high yield (86-98%) with high degree of stereo-, regio-, and chemo-selectivities. All the synthesized compounds I were characterized using popular spectral methods like IR, ¹H NMR, ¹³C NMR and 2D NMR techniques. Further, the mol. structure of I [Ar = 3-ClC₆H₄] was confirmed by single crystal XRD. The synthesized compounds were subjected to cytotoxicity evaluation using K562-leukemia cell line. Compound I [Ar = 4-benzyloxyphenyl] was found to be an effective compound of this class in targeting K562-leukemia cell with IC₅₀ value of 13.28 ± 0.11μg/mL. From the mol. docking data, it was realized that these compounds showed a binding energy between -8.1 and -10.8 kcal/mol and thereby inhibited tyrosine Kinases. Smaller E-factor (0.13), high atom-economy (89.74%), percentage yield (98.00%), reaction mass efficiency (88.43%), and carbon efficiency (96.97%) were successful achieved for compound I [Ar = 4-FC₆H₄].

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nope, Eliana team published research in Catalysis Today in 2021 | 6334-18-5

Nope, Eliana;Sathicq, Angel G.;Martinez, Jose J.;Rojas, Hugo;Romanelli, Gustavo research published 《 Hydrotalcites as catalyst in suitable multicomponent synthesis of uracil derivatives》, the research content is summarized as follows. In this work, the multicomponent synthesis of uracil derivatives assisted by layered double hydroxides (LDH) was studied under green chem. conditions. The incorporation of Ni²⁺ or Co²⁺ was successfully performed by co-precipitation method. The yields to uracil derivatives were associated with the presence of weak basic sites and a better interaction of the reagents when the reaction was carried out in solvent-free conditions. The reaction pathway involved the formation of an enone between benzaldehyde and Et cyanoacetate, and subsequent reaction with urea, which was assisted by the presence of a basic catalyst. The scope of this synthesis was illustrated with nine examples.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Panda, Krishna Chandra team published research in Asian Journal of Chemistry in 2022 | 6334-18-5

Application In Synthesis of 6334-18-5, 2,3-Dichlorobenzaldehyde(2,3-DBA)is a useful research compound. Its molecular formula is C7H4Cl2O and its molecular weight is 175.01 g/mol. The purity is usually 95%.
2,3-DBA is an organic compound that is used as a synthetic intermediate in the preparation of other chemicals. It is prepared by reacting 2-chloroacetophenone with hydrochloric acid and sodium carbonate in a reaction vessel. The product can be purified through fractional distillation or crystallization. The optical properties of 2,3-DBA are determined by its dipole moment and the substituents attached to the methylene group. Molecular modeling studies have shown that felodipine can bind to 2,3-DBA through its active methylene group. The reaction products between sulfadiazine and 2,3-DBA are pyridinedicarboxylic acid and 3-chlorobenzaldehyde.
2,3-DBA is part of a group of Benzaldehyde (B119740) derivatives that exhibit activity against Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis in humans. 2,3-DBA is also used as a reagent to synthesize (E)-2-(2-arylhydrazinyl)quinoxalines, compounds that have potent anticancer activity., 6334-18-5.

Panda, Krishna Chandra;Kumar, Bera Venkata Varaha Ravi;Sahoo, Biswa Mohan;Banik, Bimal Krishna;Tiwari, Abhishek research published 《 Microwave irradiated eco-friendly synthesis of pyrimidine derivatives as potential antitubercular agents》, the research content is summarized as follows. Efficient synthesis of pyrimidine derivatives, I [Ar = C₆H₅, 4-CH₃C₆H₄, 2-NO₂C₆H₄, etc.] via Knoevenagel condensation followed by Michael addition reaction and cyclization of equimolar quantities of aromatic aldehydes, Et cyanoacetate and guanidine in the presence of ethanolic NaOH solution under microwave radiation at power level-2 for 7-12 min. The microwave heating technique offered a cleaner reaction with a shorter reaction time and improved product yield as compared to conventional synthesis. All the synthesized pyrimidine derivatives were evaluated in vitro for their antitubercular activity, antimycobacterial activity and the test compounds exhibited promising antitubercular activity against Mycobacterium tuberculosis H37Rv and clin. isolates, S, H, R and E resistant M. tuberculosis.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Min, Xiang-Ting team published research in Journal of the American Chemical Society in 2022 | 6334-18-5

Min, Xiang-Ting;Mei, Yong-Kang;Chen, Bing-Zhi;He, Li-Bowen;Song, Ting-Ting;Ji, Ding-Wei;Hu, Yan-Cheng;Wan, Boshun;Chen, Qing-An research published 《 Rhodium-Catalyzed Deuterated Tsuji-Wilkinson Decarbonylation of Aldehydes with Deuterium Oxide》, the research content is summarized as follows. The recent surge in the applications of deuterated drug candidates has rendered an urgent need for diverse deuterium labeling techniques. Herein, an efficient Rh-catalyzed deuterated Tsuji-Wilkinson decarbonylation of naturally available aldehydes with D₂O is developed. In this reaction, D₂O not only acts as a deuterated reagent and solvent but also promotes Rh-catalyzed decarbonylation. In addition, decarbonylative strategies for the synthesis of terminal monodeuterated alkenes from α,β-unsaturated aldehydes are within reach.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics