Category: 6249-56-5

Cavallaro, G. published the artcileNovel Cationic Copolymers of a Polyasparthylhydrazide: Synthesis and Characterization, HPLC of Formula: 6249-56-5, the publication is Drug Delivery (2005), 12(6), 377-384, database is CAplus and MEDLINE.

α,β-Poly(asparthylhydrazide) (PAHy), a water soluble synthetic polymer, was functionalized by using EDCI chem. with 3-(carboxypropyl)trimethyl-ammonium chloride (CPTACl) obtaining carboxypropyltrimethyl ammonium copolymers (PAHy-CPTA). Three PAHy-CPTA copolymers at increasing derivatization degrees (38%, 48%, 58%) were chosen for subsequent investigations. The capability of these copolymers to bind, neutralize, and protect DNA against degradation by DNase II was evaluated by gel retardation assay and DNA degradation test at pH 5.5. Zeta potential measurements show that all studied polymers are able to neutralize the anionic charge of DNA at polymer/DNA weight ratio in the range of 0.8/1-5/1. Polyplex dimensional distribution analyses in distilled water, saline solution NaCl 0.9%, and HEPES pH 7 show that polyplex size is strongly affected by both presence and type of electrolyte and with time incubation.

Drug Delivery published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, HPLC of Formula: 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sano, Mitsuji published the artcileIdentification of carpronium chloride and its metabolite in human urine by field desorption mass spectrometry using deuterium labeling, Safety of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Biomedical Mass Spectrometry (1979), 6(11), 467-71, database is CAplus and MEDLINE.

After oral administration of carpronium chloride [13254-33-6], it and a major metabolite N-(3-carbohydroxypropyl)trimethylammonium chloride [6249-56-5] were identified in urine by field desorption mass spectrometry using D labeling. Purification from urine included ion pair extraction with an iodine reagent.

Biomedical Mass Spectrometry published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Safety of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sano, Mitsuji published the artcileField desorption mass spectrometry of betaine hydrohalides, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Biomedical Mass Spectrometry (1982), 9(10), 438-42, database is CAplus.

The field desorption mass spectra of betaine hydrohalides (e.g. Me₃N⁺CH₂CO₂H Cl^–) and I were examined Field desorption ions, [betaines +H]⁺, and cluster ions, [nbetaines +H]⁺, were generally observed In compounds where the conformation between the quaternary ammonium N atom and the CO₂H group prohibits betaine formation, the spectra consist only of complex field desorption ions due to thermal decomposition products. Quaternary ammonium cations and cluster ions which arise from ordinary quaternary ammonium compounds are hardly produced. The effect of counter ions and the mechanism of field desorption ion formation are discussed.

Biomedical Mass Spectrometry published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sardo, Carla published the artcileWhen Functionalization of PLA Surfaces Meets Thiol-Yne Photochemistry: Case Study with Antibacterial Polyaspartamide Derivatives, Formula: C7H16ClNO2, the publication is Biomacromolecules (2014), 15(11), 4351-4362, database is CAplus and MEDLINE.

In this work we wish to report on the covalent functionalization of polylactide (PLA) surfaces by photoradical thiol-yne to yield antibacterial surfaces. At first, hydrophilic and hydrophobic thiol fluorescent probes are synthesized and used to study and optimize the conditions of ligation on alkyne-PLA surfaces. In a second part, a new antibacterial polyaspartamide copolymer is covalently grafted. The covalent surface modification and the d. of surface functionalization are evaluated by SEC and XPS analyses. No degradation of PLA chains is observed, whereas covalent grafting is confirmed by the presence of S2p and N1s signals. Antiadherence and antibiofilm activities are assessed against four bacterial strains, including Gram-neg. and Gram-pos. bacteria. A strong activity is observed with adherence reduction factors superior to 99.98% and biofilm formation decreased by 80%. Finally, in vitro cytocompatibility tests of the antibacterial surfaces are performed with L929 murine fibroblasts and show cell viability without promoting proliferation.

Biomacromolecules published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Formula: C7H16ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Henderson, LaVell M. published the artcileMammalian enzymes of trimethyllysine conversion to trimethylaminobutyrate, Application In Synthesis of 6249-56-5, the publication is Federation Proceedings (1982), 41(12), 2843-7, database is CAplus and MEDLINE.

The biosynthesis of carnitine proceeds from trimethyllysine (TML) by β-hydroxylation by liver or kidney mitochondrial TML-α-ketoglutarate dioxygenase (referred to as TML hydroxylase) which requires O₂, α-ketoglutarate, Fe²⁺, and ascorbate. TML hydroxylase is rapidly inactivated by preincubation with Fe²⁺, but not Fe³⁺, suggesting that superoxide is involved in the hydroxylation. β-Hydroxyltrimethyllysine undergoes aldol cleavage to glycine and trimethylaminobutyraldehyde under the influence of serum hydroxymethyltransferase and possibly a specific aldolase. The next step, the aldehyde oxidation, is catalyzed by a specific NAD-dependent aldehyde dehydrogenase from liver cytosol. The product, trimethylaminobutyrate, is then hydroxylated by a cytosolic dioxygenase to carnitine. This enzyme, which has the same cofactor requirements as TML hydroxylase, is found in the liver of all species examined, but is absent from the kidney of some species.

Federation Proceedings published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Application In Synthesis of 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Atthoff, Bjoern published the artcileBiodegradable Ionomers, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Macromolecules (2006), 39(11), 3907-3913, database is CAplus.

Several telechelic anionic or cationic ionomers were synthesized starting from poly(trimethylene carbonate) diols (PTMC) of different mol. weight, ranging from 1000 to 12 000 g/mol. In the synthesis of the anionomer, addition of sulfur trioxide trimethylene complex to the PTMC end-group hydroxyls and subsequent ion exchange afforded a disulfate monoester sodium salt. The cationomer was synthesized in two steps. Acylation of the PTMC diol using 4-chlorobuturyl chloride was followed by displacement of the alkyl chloride with trimethylamine to give a quaternary ammonium salt. These ionomers showed excellent swelling properties, up to around 500% in H₂O, while the unfunctionlized PTMC did not swell at all. The lowest mol. weight ionomers were soluble in both water and chloroform. The phys. properties of the ionomers were analyzed with oscillating rheol. experiments Interestingly, the ionomers displayed “rubbery plateau”. The mech. and swelling properties may be linked to phase separation resulting in ionic aggregates within the bulk, which may function as phys. cross-links. At ambient temperatures, the PTMC starting material behaved like a highly viscous fluid, while the ionomers behaved as elastomers. In a hydrophilic environment, the ionomers displayed a surface rearrangement making the surface of the ionomer hydrophilic by allowing the ionic end groups to appear at the water ionomer interface. In air or vacuum all the ionic groups were found in the bulk of the material as analyzed by XPS or contact angle measurements. Finally, we showed that with the specific ionic groups it was possible to complex specific mols. to the ionomers.

Macromolecules published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Takahashi, Hidehiko published the artcileChemical aspects of plateau formation in the action current of the myelinated nerve fiber, Product Details of C7H16ClNO2, the publication is Japan. J. Physiol. (1960), 280-91, database is CAplus.

Among simple oxidizing agents, only H₂O₂ at concentrations higher than 2% produced a plateau in toad single myelinated nerve fibers in the temporal course of action current. Its effect was mainly due to hypertonicity, but its oxidizing potency was somewhat favorable to plateau formation. p-Quinone depolarized the Ranvier’s node and delayed the repolarization phase at the same time. Although recovery with the addition of cysteine was not so good, its effect was essentially attributable to its oxidizing potency, for hydroquinone at high concentrations caused deterioration. In the plasma membrane of the Ranvier’s node, the repolarization phase of action potential can be delayed most effectively by the –S–M–S– linkage (M represents bivalent transition metals).

Japan. J. Physiol. published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C6H8N2, Product Details of C7H16ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Boyd, G. S. published the artcileThe interrelations and effects of iodothyronines and cholesterol on the myocardium of the rat, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Journal of Atherosclerosis Research (1961), 470-88, database is CAplus and MEDLINE.

3,3′,5-Triiodo-L-thyronine (T₃) was administered to adult male rats at 50 γ/day. Serum cholesterol, O consumption, heart rate, and histology of the heart were studied in these animals. The hyperthyroid state in the rat was accompanied by an increase in O consumption, heart rate, and cardiac hypertrophy. Many of the hearts from hyperthyroid rats exhibited degenerative lesions of the cardiac muscle characterized by focal necrosis and fibrosis. The effect of varying the diet on the metabolic and histol. responses was studied. The inclusion of cholesterol and olive oil in the diet appeared to protect the animal against T₃-induced myocardial lesions. The time-course of these lesions with respect to the cardiac hypertrophy suggests that the effects may be causally related. The lesions can be produced by a wide variety of iodothyronines related to T₃, provided the dosage of the analog is adjusted to produce an approx. equivalent cardiac hypertrophy.

Journal of Atherosclerosis Research published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lourenco, Nuno M. T. published the artcileIonic Acylating Agents for the Enzymatic Resolution of sec-Alcohols in Ionic Liquids, Related Products of chlorides-buliding-blocks, the publication is European Journal of Organic Chemistry (2010), 6938-6943, S6938/1-S6938/52, database is CAplus.

Potential acylating agents containing pendant ionic groups have been screened for the enzymic kinetic resolution of rac-secondary alcs. in ionic liquids with CAL-B as biocatalyst. This study has allowed the identification of the 1-methyl-3-alkylimidazolium cation attached to a carboxylate group through a C₁₀-alkyl chain as an efficient acylating agent for this transformation. This strategy was applied to the resolution of 2-hydroxycyclohexanecarbonitrile in which the 1R,2S enantiomer was isolated in 35 % ee (73 % yield) and the 1S,2R enantiomer in 97 % ee (23 % yield).

European Journal of Organic Chemistry published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Itoh, Hiroaki published the artcileControl of the cytotoxicity of dansylated polytheonamide mimic, an artificial peptide ion channel, by modification of the N-terminal structure, SDS of cas: 6249-56-5, the publication is Tetrahedron Letters (2014), 55(3), 728-731, database is CAplus.

We demonstrate that the cytotoxicity of dansylated polytheonamide mimic is controlled by chem. modification of its N-terminal structure. Dansylated polytheonamide mimic is an ion channel peptide which displays potent cytotoxicity against P388 mouse leukemia cells (IC₅₀ = 12 nM). To modulate its cytotoxicity, three analogs of dansylated polytheonamide mimic, possessing distinct N-terminal structures with different hydrophobicities, were synthesized and their cytotoxicities were evaluated. This focused structure-activity relationship study unveiled that the cytotoxicity of dansylated polytheonamide mimic is enhanced 10-fold by simply changing its N-terminal 5,5-dimethyl-2-oxohexanamide to the more hydrophobic palmitamide. The data obtained here provide new understanding for the functional control of the artificial ion channel peptide.

Tetrahedron Letters published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, SDS of cas: 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics