Category: 6249-56-5

Geer, B. W. published the artcileThe growth effects of carnitine, deoxycarnitine, and sulfocholine for Drosophila, Neurospora, and Saccharomyces, Related Products of chlorides-buliding-blocks, the publication is Growth (1965), 29(4), 405-13, database is CAplus.

The physiol. activities of choline (I) were studied in Saccharomyces carlsbergensis, a I-requiring strain of Neurospora crassa, and Drosophila melanogaster. The related compounds deoxycarnitine (II), carnitine (III), and sulfocholine (IV) were then substituted for dietary I. IV was more effective than I in inhibiting the growth response of S. carlsbergensis to inositol, was slightly less effective than I in promoting the growth of I-requiring N. crassa, and was ∼50% as effective as I in stimulating the growth of D. melanogaster larvae. II and III were ineffective in the Neurospora and Saccharomyces systems, but were nearly as effective as I in the Drosophila system. Thus, the Neurospora and Saccharomyces systems are fundamentally similar in their responses to the test compounds The ability to utilize dietary II and III effectively for growth in place of I apparently evolved within the insect order Diptera.

Growth published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Grob, C. A. published the artcileThe nature of the inductive effect, Category: chlorides-buliding-blocks, the publication is Chemistry & Industry (London, United Kingdom) (1955), 1222-3, database is CAplus.

The acidity constants of the α-, β-, and γ-betaine hydrochlorides (ClMe₃N(CH₂)_nCO₂H, where n = 1, 2, and 3, resp.); of the 2-, 3-, and 4-carboxylic acids of N,N-dimethylpiperidinium chloride; and of the 2-, 3-, and 4-carboxylic acids of N-methylquinuclidinium chloride were measured. The magnitude of the acid-strengthening effect decreased proportionally to direct distance rather than to chain length. The so-called general inductive effect appears as a function of the direct distance between electrostatically interacting groups and the dielec. constant of the intervening medium, which can be a chain of atoms, solvent, or empty space, according to the geometry of the system.

Chemistry & Industry (London, United Kingdom) published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mirzaei, Hamid published the artcileEnhancing Electrospray Ionization Efficiency of Peptides by Derivatization, Product Details of C7H16ClNO2, the publication is Analytical Chemistry (2006), 78(12), 4175-4183, database is CAplus and MEDLINE.

With the advent of electrospray ionization mass spectrometry, the world was given a new way to look at complex peptide mixtures Identification of proteins via their signature peptides requires ionization of a representative portion of the peptides derived from proteins by proteolysis. Unfortunately, matrix effects prohibited electrospray ionization of many peptides. This paper describes the development of a new labeling reagent that simultaneously adds a permanent pos. charge to peptides and increases their hydrophobicity to enhance their ionization efficiency. The labeling agent is preactivated with N-hydroxysuccinimide to react with primary amines to form a peptide bond. In the most dramatic case, ionization efficiency of the peptide ADRDQYELLCLDNTRKPVDEYK increased 500-fold after derivatization as opposed to other peptides where ionization efficiency was impacted little. Ionization efficiency of peptides was enhanced roughly 10-fold in general by derivatization. Peptides of less than 500 Da experienced the greatest increase in ionization efficiency by derivatization. Poor ionization efficiency of native peptides was due more to their inherent structural properties than the matrix in which ionization occurs.

Analytical Chemistry published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Product Details of C7H16ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Shuai-Bing published the artcileAntifungal mechanism of 1-nonanol against Aspergillus flavus growth revealed by metabolomic analyses, Product Details of C7H16ClNO2, the publication is Applied Microbiology and Biotechnology (2021), 105(20), 7871-7888, database is CAplus and MEDLINE.

Chem. control of fungal spoilage of postharvest cereal grains is an important strategy for the management of grain storage. Here, the potential antifungal activity of 1-nonanol, a main component of cereal volatiles, against Aspergillus flavus was studied. The growth of A. flavus was completely inhibited by 0.11 and 0.20 μL/mL 1-nonanol at vapor and liquid contact phases, resp. Metabolomic anal. identified 135 metabolites whose expression was significantly different between 1-nonanol-treated and untreated A. flavus. These metabolites were involved in the tricarboxylic acid cycle, amino acid biosynthesis, protein degradation and absorption, aminoacyl-tRNA biosynthesis, mineral absorption, and in interactions with ABC transporters. Biochem. validation confirmed the disruptive effect of 1-nonanol on A. flavus growth, as indicated by the leakage of intracellular electrolytes, decreased succinate dehydrogenase, mitochondrial dehydrogenase, and ATPase activity, and the accumulation of reactive oxygen species. We speculated that 1-nonanol could disrupt cell membrane integrity and mitochondrial function and might induce apoptosis of A. flavus mycelia. Simulated grain storage experiments showed that 1-nonanol vapor, at a concentration of 264 μL/L, completely inhibited A. flavus growth in wheat, corn, and paddy grain with an 18% moisture content. This study provides new insights into the antifungal mechanism of 1-nonanol against A. flavus, indicating that it has a promising potential as a bio-preservative to prevent fungal spoilage of postharvest grains. 1-Nonanol showed higher antifungal activity against A. flavus. · The antifungal mechanisms of 1-nonanol against A. flavus were revealed. · 1-Nonanol could damage cell membrane integrity and mitochondrial function.

Applied Microbiology and Biotechnology published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C2H2N4O2, Product Details of C7H16ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nelson, Peter J. published the artcileEffect of ascorbic acid deficiency on the in vivo synthesis of carnitine, Synthetic Route of 6249-56-5, the publication is Biochimica et Biophysica Acta, General Subjects (1981), 672(1), 123-7, database is CAplus and MEDLINE.

Guinea pig liver and kidney carnitine [541-15-1] levels were not affected by ascorbic acid [50-81-7] deficiency, but scorbutic animals had 50% less carnitine in heart and skeletal muscle than control animals. Labeled carnitine precursors, 6-N-trimethyl-L-lysine [23284-33-5] and 4-N-trimethylaminobutyrate [407-64-7], both of which require ascorbate for their enzymic hydroxylation, were injected into the vena cava of control, pair-fed and scorbutic animals. The uptake of trimethyllysine by the liver was <2% in 1 h, while the kidney took up ∼20% of the ¹⁴C. Control and pair-fed animals converted trimethyllysine to kidney trimethylaminobutyrate 8-10 times as well as did scorbutic animals. Trimethylaminobutyrate hydroxylase [56803-11-3], present in the liver but almost absent from the kidney, converted nearly all of substrate taken up by the liver to carnitine in both the scorbutic and control animals.

Biochimica et Biophysica Acta, General Subjects published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Synthetic Route of 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Dylag, Mariusz published the artcileAntifungal activity of organotin compounds with functionalized carboxylates evaluated by the microdilution bioassay in vitro, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Medical Mycology (2010), 48(2), 373-383, database is CAplus and MEDLINE.

We investigated the susceptibility of 96 well-characterized strains of yeast-like and filamentous fungi towards new organotin compounds: (1) [Sn(C₄H₉)₃(OOCC₆H₄SO₃H-2)], (2) Sn(C₄H₉)₃OOC(CH₂)₃P(C₆H₅)₃Br, and (3) [Sn(C₆H₅)₃OOC(CH₂)₃N(CH₃)₃]Cl. In the case of yeast-like fungi, the in vitro susceptibility tests were carried out according to the Clin. Laboratory Standards Institute (CLSI, formerly NCCLS) reference method M27-A2, while for filamentous fungi the investigations were conducted according to the M38-A and M38-P methods. The organotin complexes 1, 2 and 3 are active antifungal agents. Minimal inhibitory concentrations (MIC) were in the range of 0.25-4.68 μg/mL for all tested fungal strains. Considerably larger differences were found for minimal fungicidal concentrations (MFC). In the case of yeast-like fungi, the fungicidal effect was generally observed at organotin compounds concentrations of 2.34-9.37 μg/mL. The MFC values for filamentous fungi were considerably higher and were in the range of 18.74-50 μg/mL. In conclusion, organotin compounds 1, 2 and 3 showed high fungistatic and fungicidal activities against different species of pathogenic and nonpathogenic fungi. However, they were also highly cytotoxic towards two mammalian cell lines.

Medical Mycology published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gasparini, Giulio published the artcileExploiting neighboring-group interactions for the self-selection of a catalytic unit, Related Products of chlorides-buliding-blocks, the publication is Angewandte Chemie, International Edition (2008), 47(13), 2475-2479, database is CAplus and MEDLINE.

A tethering strategy is used to self-select groups that assist in the cleavage of a neighboring carboxylic ester moiety. A correlation is observed between the amplification at thermodn. equilibrium and the catalytic efficiency.

Angewandte Chemie, International Edition published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wondraczek, Holger published the artcileWater soluble photoactive cellulose derivatives: synthesis and characterization of mixed 2-[(4-methyl-2-oxo-2H-chromen-7-yl)oxy]acetic acid-(3-carboxypropyl)trimethylammonium chloride esters of cellulose, COA of Formula: C7H16ClNO2, the publication is Cellulose (Dordrecht, Netherlands) (2012), 19(4), 1327-1335, database is CAplus.

Photoactive derivatives of cellulose were prepared by a mild esterification of the biopolymer with 2-[(4-methyl-2-oxo-2H-chromen-7-yl)oxy]acetic acid via the activation of the carboxylic acid with N,N’-carbonyldiimidazole. Subsequently, modification with the cationic carboxylic acid (3-carboxypropyl)trimethylammonium chloride was carried out. Thus, water soluble polyelectrolytes decorated with high amounts of photochem. active chromene moieties were obtained. The structures of the novel polysaccharide esters and the polyelectrolytes were evaluated by means of NMR and IR spectroscopy. Moreover, the light triggered photodimerization of the chromene moieties of the photoactive polyelectrolytes was studied by means of UV-Vis spectroscopy in the dissolved state. The photochem. observed may be used to control the properties of the new polysaccharide derivatives and are thus of interest in the design of smart materials.

Cellulose (Dordrecht, Netherlands) published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H8BClO2, COA of Formula: C7H16ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Vega, B. published the artcileStudies on the fibre surfaces modified with xylan polyelectrolytes, HPLC of Formula: 6249-56-5, the publication is Carbohydrate Polymers (2012), 89(3), 768-776, database is CAplus and MEDLINE.

Xylan was isolated from birch wood chips by using pressurized hot water extraction (PHWE). The extracted xylan was chem. modified yielding three different xylan derivatives (XDs): xylan sulfate (XS), carboxymethyl xylan (CMX) and xylan-4-[N,N,N-trimethylammonium]butyrate chloride (XTMAB). The structure and mol. weight of XDs was determined by using NMR spectroscopy and size exclusion chromatog. (SEC). The potential utilization of xylan polyelectrolytes for modifying fiber surfaces was assessed by sorption experiments using bleached pine Kraft pulp as substrate. Polyelectrolyte titration method was chosen for estimating the amount of sorbed XDs onto the fibers. The cationic xylan derivative XTMAB had a strong interaction with fibers while the anionic derivatives did not show any sorption. XPS and time of flight secondary ion mass spectrometry (ToF-SIMS) were selected as advanced surface analyses for studying the amount of surface anionic groups and the surface distribution of the XTMAB. XPS and polyelectrolyte titration results suggested that the XTMAB is sorbed onto the fiber surfaces. ToF-SIMS imaging showed that XTMAB was evenly distributed on fiber surfaces.

Carbohydrate Polymers published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C44H58NO5PPdS, HPLC of Formula: 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Licciardi, Mariano published the artcileCationic Supramolecular Vesicular Aggregates for Pulmonary Tissue Selective Delivery in Anticancer Therapy, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is ChemMedChem (2016), 11(16), 1734-1744, database is CAplus and MEDLINE.

The biopharmaceutical properties of supramol. vesicular aggregates (SVAs) were characterized with regard to their physicochem. features and compared with cationic liposomes (CLs). Neutral and cationic SVAs were synthesized using two different copolymers of poly(aspartyl hydrazide) by thin-layer evaporation and extrusion techniques. Both copolymers were self-assembled in pre-formulated liposomes and formed neutral and cationic SVAs. Gemcitabine hydrochloride (GEM) was used as an anticancer drug and loaded by a pH gradient remote loading procedure, which significantly increased drug loading inside the SVAs. The resulting average size of the SVAs was 100 nm. The anticancer activity of GEM-loaded neutral and cationic SVAs was tested in human alveolar basal epithelial (A549) and colorectal cancer (CaCo-2) cells. GEM-loaded cationic SVAs increased the anticancer activity in A549 and CaCo-2 cells relative to free drug, neutral SVAs, and CLs. In vivo biodistribution in Wistar rats showed that cationic SVAs accumulate at higher concentrations in lung tissue than neutral SVAs and CLs. Cationic SVAs may therefore serve as an innovative future therapy for pulmonary carcinoma.

ChemMedChem published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics