Category: 620-20-2

《Semicarbazone derivatives bearing phenyl moiety: synthesis, anticancer activity, cell cycle, apoptosis-inducing and metabolic stability study》 was written by Ma, Junjie; Ni, Xin; Gao, Yali; Huang, Kun; Wang, Yu; Liu, Jiaan; Gong, Guowei. Related Products of 620-20-2 And the article was included in Chemical & Pharmaceutical Bulletin on April 30 ,2019. The article conveys some information:

A series of semicarbazone derivatives bearing Ph moiety I [R = Me, Et; R1 = H, benzyloxidanyl, 2-(2H-1,3-benzodioxol-5-ylmethyl)-(1,3-thiazol-4-yl)-methyloxy, [(4-chlorophenyl)methyl]oxidanyl, etc.; R2 = t-Bu, H, prop-2-en-1-yl; R3 = H, t-Bu] was synthesized and evaluated for the vitro anticancer activities in four human cancer cell lines (human colon cancer (HT29), human neuroblastoma (SK-N-SH), human breast cancer (MDA-MB-231), and human gastric cancer (MKN45)). Biol. evaluation led to the identification of I [(I) R = Me, R1 H, R2 = R3 = t-Bu; (II) R = Et, R1 H, R2 = R3 = t-Bu], which showed excellent anticancer activities against tested cancer cell lines with IC50 values ranging from 0.32 to 1.57 μM, resp., while exhibiting weak cytotoxicity on the normal cells (human umbilical vein endothelial cell (HUVEC)). Flow cytometric assay for cell cycle and apoptosis revealed that (I) and (II) caused an arrest in the Sub-G1 cell cycle and inhibited proliferation of cancer cells by inducing apoptosis in a dose-dependent manner. Further enzymic assay suggested that (I) and (II) could significantly activated procaspase-3 to caspase-3. Metabolic stability study indicated that (I) and (II) showed moderate stability in vitro in human and rat liver microsomes. In view of promising pharmacol. activities of (I) and (II), which had emerged as the valuable lead for further development in the treatment for cancer. In the part of experimental materials, we found many familiar compounds, such as 3-Chlorobenzylchloride(cas: 620-20-2Related Products of 620-20-2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Related Products of 620-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Synergistic effects of cinnamaldehyde and cinnamic acid in cinnamon essential oil against S. pullorum》 was written by Huang, Zhaoxiang; Pang, Daorui; Liao, Sentai; Zou, Yuxiao; Zhou, Pengfei; Li, Erna; Wang, Weifei. Formula: C7H6Cl2 And the article was included in Industrial Crops and Products on April 30 ,2021. The article conveys some information:

Cinnamon is an important spice crop that is widely cultivated in tropical regions. In this study, the antibacterial activities of four accessions of cinnamon essential oil (CEO) belonging to three different species (CEO1 and CEO4, Cinnamomum cassia Presl. (Lauraceae) bark; CEO2, Cinnamomum zeylanicum Blume (Lauraceae) bark; CEO3, Cinnamomum burmannii Blume (Lauraceae) bark) toward Salmonella enterica subsp. enterica serovar pullorum (S. pullorum) were evaluated by microdilution assay and kinetic anal. The min. inhibitory concentration (MIC) of the CEOs were all 0.31 mg/mL, and kinetic anal. suggested that the lag phase and maximum specific growth rate of bacteria were concentration dependent. Furthermore, to explore the synergistic antibacterial effects between main components and minor components, the volatile constituents of CEOs were determined by gas chromatog.-mass spectrometry (GC-MS). Cinnamaldehyde (CM) (57.73 %-91.79 %) was the principal constituent in CEO1-CEO4 (p < 0.05), with CEO3 having the highest CM contents. A synergistic effect against S. pullorum was observed when CA was combined with CM. To explore the potential synergistic mechanism, the membrane glycerophospholipid (GPL) composition of S. pullorum was characterized by ultra-performance liquid chromatog.-tandem mass spectrometry (UPLC-MS/MS). CM, CA, and their combination regulated the levels of most phosphatidylethanolamines (PEs), phosphatidylglycerols (PGs), phosphatidic acids (PAs), and some cardiolipins (CLs). In the experiment, the researchers used 3-Chlorobenzylchloride(cas: 620-20-2Formula: C7H6Cl2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Formula: C7H6Cl2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Pronounced activity of aromatic selenocyanates against multidrug resistant ESKAPE bacteria》 was published in New Journal of Chemistry in 2019. These research results belong to Nasim, Muhammad Jawad; Witek, Karolina; Kincses, Annamaria; Abdin, Ahmad Yaman; Zeslawska, Ewa; Marc, Malgorzata Anna; Gajdacs, Mario; Spengler, Gabriella; Nitek, Wojciech; Latacz, Gniewomir; Karczewska, Elzbieta; Kiec-Kononowicz, Katarzyna; Handzlik, Jadwiga; Jacob, Claus. Electric Literature of C7H6Cl2 The article mentions the following:

Selenocyanates represent an interesting class of organic selenium compounds Due to their similarity with better known natural (iso-)thiocyanates, they promise high biol. activity and may also be metabolized to other reactive selenium species (RSeS), such as selenols, diselenides, and seleninic acids. Thirteen arylmethyl selenocyanates were synthesized and evaluated for potential antimicrobial, nematicidal, and cytotoxic activity. The compounds exhibit pronounced antimicrobial activity against various strains of Gram-pos. and Gram-neg. bacteria and yeasts, including multidrug resistant strains. The results obtained so far demonstrate that these arylmethyl selenocyanates are also non-mutagenic and have limited cytotoxicity against human cells. Here, benzyl selenocyanate represents the most active anti-ESKAPE agent, with potent activity against multidrug resistant MRSA strains (HEMSA 5) with a competitive MIC value of just 0.76 μg/mL (3.88 μM), whereas it exhibits low(er) cytotoxicity (IC50 = 31 μM) and no mutagenicity against mammalian cells. Due to this selective antimicrobial activity, aromatic selenocyanates may provide an interesting lead in the development of antimicrobial agents, particularly in the context of drug resistance. In addition to this study using 3-Chlorobenzylchloride, there are many other studies that have used 3-Chlorobenzylchloride(cas: 620-20-2Electric Literature of C7H6Cl2) was used in this study.

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Electric Literature of C7H6Cl2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Synthesis of trans-stilbenes via phosphine-catalyzed coupling reactions of benzylic halides》 were Zhang, Sheng; Xie, Zhilong; Ye, Zhanqiang; Zhang, Mingyang; Li, Dongdeng; Yamaguchi, Masahiko; Bao, Ming. And the article was published in Organic & Biomolecular Chemistry in 2022. SDS of cas: 620-20-2 The author mentioned the following in the article:

An efficient and practical phosphine-catalyzed homo-coupling reaction of benzyl chlorides was described. The reactions proceed smoothly in the presence of CsF/B(OMe)3 and NaH as the base, resp., to provide trans-stilbenes in good yields with a broad scope. Unsym. stilbenes was also generated from the reactions of benzyl chlorides with phosphonium salts. Several P-based key intermediates was detected by NMR and HRMS analyses, which shed light on the postulated catalytic cycle. In the presence of different bases, the transformations involve two different pathways, in which phenylcarbene and phosphonium alkoxide was considered as key intermediates, resp. The two pathways were complementary in synthesis but different in mechanisms. The synthetic utility, including gram-scale reactions and straightforward access to π-conjugated mols., was demonstrated as well. In the experiment, the researchers used many compounds, for example, 3-Chlorobenzylchloride(cas: 620-20-2SDS of cas: 620-20-2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.SDS of cas: 620-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Facile one-pot synthesis of diarylacetylenes from arylaldehydes via an addition-double elimination process》 were Chen, Jianyang; Zhang, Xuan; Wu, Jiajun; Wang, Rui; Lei, Chunlin; An, Yanan. And the article was published in Organic & Biomolecular Chemistry in 2021. Application of 620-20-2 The author mentioned the following in the article:

A practical one-pot protocol has been developed to synthesize diarylacetylenes ArCCAr1 (Ar = Ph, naphthalen-1-yl, furan-2-yl, etc.; Ar1 = Ph, 4-chlorophenyl, naphthalen-2-yl, etc.) from arylaldehydes ArCHO by treatment with 1-(arylmethyl)benzotriazoles I and LiN(SiMe3)2. The reaction proceeded through imine formation, Mannich-type addition and double elimination to deliver products in up to 99% yields with broad substrate scope. In addition, gram-scale synthesis of diarylacetylene (Ar = 4-bromophenyl, Ar1 = Ph) has been demonstrated. The experimental process involved the reaction of 3-Chlorobenzylchloride(cas: 620-20-2Application of 620-20-2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Application of 620-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Emami, Leila; Khabnadideh, Soghra; Faghih, Zahra; Solhjoo, Aida; Malek, Saba; Mohammadian, Amir; Divar, Masoumeh; Faghih, Zeinab published an article in Journal of Heterocyclic Chemistry. The title of the article was 《Novel N-substituted isatin-ampyrone Schiff bases as a new class of antiproliferative agents: Design, synthesis, molecular modeling and in vitro cytotoxic activity》.Synthetic Route of C7H6Cl2 The author mentioned the following in the article:

Thirteen novel isatin-ampyrone Schiff bases derivatives such as I [X = H, Cl; R = H, 3-F, 4-OMe, etc.] were synthesized by the reaction of isatins and benzyl halides followed by condensation with ampyrone. In vitro cytotoxic activity of these new Schiff bases against three human tumor cell lines (MCF-7, A549, and SCOV3) as well as normal breast cell line (MCF-10A) were evaluated by MTT assay. Structure-activity relationship of the tested compounds revealed that chlorine group at C-5 position of the isatin ring significantly increased the cytotoxic activity. This study generally led to introduce a highly active mol. I [X = Cl; R = 3-Cl] with IC50 values of 5.12, 25.5, and 12.9μM, on MCF-7, A549, and SCOV3, resp. Furthermore, mol. docking studies of the synthesized compounds were also done to investigate their binding modes to toward VEGFR-2 and JNK3-MAP kinase as the main targets for isatin-containing anticancer agents. Binding free energy values of the compounds showed pos. correlation with their cytotoxic activities. To confirm the docking results, mol. docking simulations of potent compound I [X = Cl; R = 3-Cl] against VEGFR-2 and JNK3 MAP kinase were also performed. According to the cytotoxic results and in silico ADMET predictions together, I [X = Cl; R = 3-Cl] could be considered as a potent candidate for the future anticancer studies. In the experimental materials used by the author, we found 3-Chlorobenzylchloride(cas: 620-20-2Synthetic Route of C7H6Cl2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Synthetic Route of C7H6Cl2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Menghan; Liu, Jianmin; Wang, Yue; Wang, Ping; Morris-Natschke, Susan; Lee, Kuo-Hsiung published an article on January 15 ,2022. The article was titled 《Molecular hybridization used to design and synthesize neo-tanshinlactone derivatives as PD-1/PD-L1 inhibitors》, and you may find the article in Bioorganic & Medicinal Chemistry.Reference of 3-Chlorobenzylchloride The information in the text is summarized as follows:

Four series of mol. hybrids (37 final products) of neo-tanshinlactone, a natural product extracted from Salvia miltiorrhiza Bunge, and known PD-1/PD-L1 interaction inhibitors were prepared as possible chemotherapeutic agents against triple neg. breast cancer. Screening using a homogenous time-resolved fluorescence method resulted in three lead compounds (MZ52 IC50 74 ± 4 nM; MZ58 IC50 134 ± 17 nM; MZ61 IC50 225 ± 19 nM). With less T cell cytotoxicity and effects in activating CD8+ T cells in a T cell proliferation assay and a functionality experiment, MZ58 was selected as the best candidate for animal experiments MZ58 exhibited antitumor effects in a s.c. transplantation tumor model as well as effects in reducing T cell exhaustion. In conclusion, after in vivo and in vitro experiments, we successfully acquired an effective candidate (MZ58) showing antitumor effects with low cytotoxicity toward T cells as well as the ability to activate CD8+ T cells and reduce T cell exhaustion. The experimental process involved the reaction of 3-Chlorobenzylchloride(cas: 620-20-2Reference of 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Reference of 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Triazolopyrimidinium salts: discovery of a new class of agents for cancer therapy》 was published in Future Medicinal Chemistry in 2020. These research results belong to Badolato, Mariateresa; Manetti, Fabrizio; Garofalo, Antonio; Aiello, Francesca. Reference of 3-Chlorobenzylchloride The article mentions the following:

Aim: The [1,2,4]triazolo[1,5-a]pyrimidine core is highly privileged in medicinal chem. due to its versatile pharmacol. activity profile. Recently, the search for novel anticancer agents has focused on [1,2,4]triazolo[1,5-a]pyrimidine derivatives Results: Our hit functionalization has led to the discovery of new [1,2,4]triazolo[1,5-a]pyrimidinium salts with potential anticancer activity. Among a small library of mols., compound 9 significantly inhibits cancer cell growth in a panel of in vitro models. Mol. docking studies and preliminary binding assay have displayed that 9 could directly bind the Src homol. 2 (SH2) domain of STAT3 protein. Conclusion: Compound 9 is a novel promising lead compound that motivates addnl. evaluation of [1,2,4]triazolo[1,5-a]pyrimidinium salts as novel potential chemotherapeutics. After reading the article, we found that the author used 3-Chlorobenzylchloride(cas: 620-20-2Reference of 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Reference of 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Synthesis and antimicrobial activities of new thiosemicarbazones and thiazolidinones in indole series》 was written by Benmohammed, Abdelmadjid; Rekiba, Nawel; Sehanine, Yassine; Louail, Ahmed Amine; Khoumeri, Omar; Kadiri, Mokhtaria; Djafri, Ayada; Terme, Thierry; Vanelle, Patrice. Quality Control of 3-Chlorobenzylchloride And the article was included in Monatshefte fuer Chemie on August 31 ,2021. The article conveys some information:

New thiosemicarbazones I [R1 = H, 3-Cl, 4-F, etc.; R2 = H, OMe] were synthesized via condensation of N-benzylindole-3-carboxaldehydes with N4-substituted thiosemicarbazides in excellent yield. These thiosemicarbazones I were reacted with Et bromoacetate to produce original heterocyclic-substituted indole derivatives possessing a 4-oxo-thiazolidine group II. Anal. IR and NMR spectra and elemental anal. were performed to reveal their structures. The antimicrobial activity of all synthesized compounds was evaluated for antibacterial activity in vitro against Gram-pos. and Gram-neg. bacteria. Antibacterial screening data showed that two compounds I and II demonstrated activity against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. These preliminary results indicated that newly synthesized compounds such as I [R1 = 3-Cl, R2 = OMe] and II [R1 = H, R2 = H] showed a promising antibacterial potency.3-Chlorobenzylchloride(cas: 620-20-2Quality Control of 3-Chlorobenzylchloride) was used in this study.

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Quality Control of 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Safety of 3-ChlorobenzylchlorideOn March 15, 2022, Yang, Xi; Sun, Hang; Maddili, Swetha Kameswari; Li, Shuo; Yang, Ren-Guo; Zhou, Cheng-He published an article in European Journal of Medicinal Chemistry. The article was 《Dihydropyrimidinone imidazoles as unique structural antibacterial agents for drug-resistant gram-negative pathogens》. The article mentions the following:

The health crisis caused by severe multidrug resistance increasingly compels the exploitation of new alternative antibacterial drugs. A library of structurally unique dihydropyrimidinone imidazoles as novel potential antibacterial agents was developed with the aim to confront drug resistance. Some target compounds exhibited strong antibacterial activities, especially, sulfamethoxazole hybridized dihydropyrimidinone imidazole 8b was found to be extremely active against multidrug-resistant K. pneumonia and A. baumanii at a low concentration of 0.5 μg/mL, which outperformed norfloxacin even clinafloxacin. This active compound not only exhibited low cytotoxicity to mammalian cells (human red blood cells, HepG2 and ECs), but also possessed rapid bactericidal property, good biofilm inhibition ability, and a low propensity to induce K. pneumonia and A. baumanii resistance. Further studies revealed that the inhibitory effect of the active compound 8b might be achieved by disrupting membrane integrity, increasing ROS generation, reducing GSH activity and interacting with DNA. These findings provided a bright hope for developing dihydropyrimidinone imidazoles to combat emergent drug resistance. The results came from multiple reactions, including the reaction of 3-Chlorobenzylchloride(cas: 620-20-2Safety of 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Safety of 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics