Category: 620-20-2

Related Products of 620-20-2On March 31, 2022, Xiao, Yulong; Li, Hongsen; Shao, Qun; Liu, Yuan; Xie, Yonghai; Zhao, Linjing; Li, Ya published an article in Chemistry & Biodiversity. The article was 《Design, Synthesis, and Antifungal Activity of Sulfoximine Derivatives Containing Nitroguanidine Moieties》. The article mentions the following:

To discover novel pesticide candidates, a series of sulfoximine derivatives were designed and synthesized via the oxidation coupling reaction of sulfides and N-alkyl nitroguanidines. The compounds were evaluated for their antifungal activity against six phytopathogenic fungi. Most of them exhibited a broad spectrum of fungicidal activity in vitro. Compound 8IV-b displayed good fungicidal activity against Sclerotinia sclerotiorum, Rhizoctonia solani, Botrytis cinerea, Fusarium graminearum, and Phytophthora capsici, with EC50 value of 12.82, 12.50, 17.25, 31.08, and 30.11 mg/L, resp. In addition, compounds 8III-c and 8IV-e had EC50 values of 22.23 and 20.67 mg/L against P. capsic, which were significantly better than that of the com. procymidone (118.15 mg/L). Strikingly, 8IV-d exhibited satisfactory fungicidal activity against B. cinerea, which was comparable to control procymidone in terms of their EC50 values (7.42 vs. 10.83 mg/L), and the bioassays in vivo further confirmed that 8IV-d possessed potent protective effect against B. cinerea at 200 mg/L (72.2 %). These present findings will facilitate the design and development of novel potent fungicides. The results came from multiple reactions, including the reaction of 3-Chlorobenzylchloride(cas: 620-20-2Related Products of 620-20-2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Related Products of 620-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wu, Jie; Ma, Song; Zhang, Tian-Yi; Wei, Zhi-Yu; Wang, Hui-Min; Guo, Fang-Yan; Zheng, Chang-Ji; Piao, Hu-Ri published an article in Medicinal Chemistry Research. The title of the article was 《Synthesis and biological evaluation of ursolic acid derivatives containing an aminoguanidine moiety》.Recommanded Product: 3-Chlorobenzylchloride The author mentioned the following in the article:

Three series of ursolic acid derivatives containing an aminoguanidine moiety were designed, synthesized, and evaluated for anti-bacterial and anti-inflammatory activity. Some compounds displayed potent anti-bacterial activity against Gram-pos. bacterial strains (including multidrug-resistant clin. isolates) and Gram-neg. bacterial strains, with min. inhibitory concentration (MIC) values in the range of 2-64 μg/mL. Compounds 3a, 5a, and 7l showed significant inhibitory activity against the Gram-pos. bacterial strain Staphylococcus aureus RN 4220, the Gram-neg. bacterial strain Escherichia coli 1924, and four multidrug-resistant Gram-pos. bacterial strains, with MIC values of 2 and 4 μg/mL. In anti-inflammatory tests, most of the compounds exhibited potent activity, in particular compound 3a displayed the most potent activity with 81.61% inhibition after i.p. administration, which was more potent than ursolic acid and the reference drugs (ibuprofen and indomethacin). The cytotoxic activity of compound 3a was assessed in HeLa, Hep3B, and A549 cells. In the experimental materials used by the author, we found 3-Chlorobenzylchloride(cas: 620-20-2Recommanded Product: 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Recommanded Product: 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fu, Duo; Dong, Jun; Du, Hongguang; Xu, Jiaxi published an article on February 21 ,2020. The article was titled 《Methanesulfinylation of Benzyl Halides with Dimethyl Sulfoxide》, and you may find the article in Journal of Organic Chemistry.Formula: C7H6Cl2 The information in the text is summarized as follows:

A phenyltrimethylammonium tribromide-mediated nucleophilic substitution/oxygen transformation reaction of benzyl halides with DMSO has been developed. In this transition-metal-free reaction, DMSO acts as not only a solvent but also a “”S(O)Me”” source, thus providing a convenient method for the efficient and direct synthesis of various benzyl Me sulfoxides. The experimental part of the paper was very detailed, including the reaction process of 3-Chlorobenzylchloride(cas: 620-20-2Formula: C7H6Cl2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Formula: C7H6Cl2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Quality Control of 3-ChlorobenzylchlorideOn September 30, 2019 ,《New potent antifungal triazole alcohols containing N-benzylpiperazine carbodithioate moiety: Synthesis, in vitro evaluation and in silico study》 was published in Bioorganic Chemistry. The article was written by Mahmoudi, Yaser; Badali, Hamid; Hashemi, Seyedeh Mahdieh; Ansari, Mahsa; Fakhim, Hamed; Fallah, Marjan; Shokrzadeh, Mohammad; Emami, Saeed. The article contains the following contents:

A number of 1H-1,2,4-triazole alcs. containing N-(halobenzyl)piperazine carbodithioate moiety were designed and synthesized as potent antifungal agents. In vitro bioassays against different Candida species including C. albicans, C. glabrata, C. parapsilosis, C. krusei, and C. tropicalis revealed that the N-(4-chlorobenzyl) derivative(I) with MIC values of 0.063-0.5μg/mL had the best profile of activity, being 4-32-fold more potent than fluconazole. Docking simulation studies confirmed the better fitting of I deriv in the active site of lanosterol 14α-demethylase (CYP51) enzyme, the main target of azole antifungals. Particularly, the potential of I against fluconazole-resistant isolates along with its minimal toxicity against human erythrocytes and HepG2 cells make this prototype compound as a good lead for discovery of potent and safe antifungal agents. The experimental process involved the reaction of 3-Chlorobenzylchloride(cas: 620-20-2Quality Control of 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Quality Control of 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Synthesis, antiviral and antibacterial activities and action mechanism of penta-1,4-dien-3-one oxime ether derivatives containing a quinoxaline moiety》 were Xia, Rongjiao; Guo, Tao; Chen, Mei; Su, Shijun; He, Jun; Tang, Xu; Jiang, Shichun; Xue, Wei. And the article was published in New Journal of Chemistry in 2019. SDS of cas: 620-20-2 The author mentioned the following in the article:

A series of penta-1,4-dien-3-one oxime ether derivatives containing a quinoxaline moiety were synthesized and their antibacterial and antiviral activities were evaluated. Bioassay activity indicated that some of the compounds displayed significant antibacterial and antiviral activities. In particular, some title compounds were found to show remarkable antiviral activities against Tobacco mosaic virus (TMV). Compound 6i showed remarkable curative, protective and inactivation activity against TMV, with a 50% effective concentration (EC50) of 287.1, 157.6 and 133.0μg mL-1, resp. These results were better than or comparable to those of ningnanmycin (356.3, 233.7 and 121.6μg mL-1, resp.). Microscale thermophoresis (MST) also showed that the binding of compound 6i to TMV coat protein (TMV-CP) gave a Kd value of 0.115 ± 0.092μmol L-1, which was better than that of ningnanmycin (0.523 ± 0.254μmol L-1). Meanwhile, the EC50 values of compound 6k against Xanthomonas axonopodis pv. Citri (Xac) and Xanthomonas oryzae pv. oryzae (Xoo) were 16.8 and 33.4μg mL-1 resp., and that of compound 6i against Ralstonia solanacearum (Rs) was 33.9μg mL-1. These results were better than those of bismerthiazol (44.3, 42.5 and 62.4μg mL-1, resp.). The mechanism of antibacterial action of compound 6k against Xac was analyzed through SEM (SEM). This study indicated that the title compounds are valuable in the search for novel agrochems. The results came from multiple reactions, including the reaction of 3-Chlorobenzylchloride(cas: 620-20-2SDS of cas: 620-20-2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.SDS of cas: 620-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Computed Properties of C7H6Cl2On November 1, 2019 ,《Iron-Catalyzed Cross-Coupling of Functionalized Benzylmanganese Halides with Alkenyl Iodides, Bromides, and Triflates》 appeared in Organic Letters. The author of the article were Desaintjean, Alexandre; Belrhomari, Sophia; Rousseau, Lidie; Lefevre, Guillaume; Knochel, Paul. The article conveys some information:

Various substituted benzylic manganese chlorides e.g. I were prepared by insertion of magnesium turnings in the presence of MnCl2.2LiCl in THF at -5° within 2 h. These benzylic manganese reagents underwent smooth cross-couplings with various functionalized alkenyl iodides, bromides, and triflates or iodoacrylates in the presence of 10 mol % FeCl2 at 25° for 1-12 h. Mechanistic studies showed that benzylic manganese halides produced, in the presence of FeCl2, a very reactive iron ate complex. The experimental process involved the reaction of 3-Chlorobenzylchloride(cas: 620-20-2Computed Properties of C7H6Cl2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Computed Properties of C7H6Cl2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2021,New Journal of Chemistry included an article by Sun, Sheng-Xin; Yan, Jing-Hua; Zuo, Jiang-Tao; Wang, Xiao-Bin; Chen, Min; Lu, Ai-Min; Yang, Chun-Long; Li, Guo-Hua. Recommanded Product: 3-Chlorobenzylchloride. The article was titled 《Design, synthesis, antifungal evaluation, and molecular docking of novel 1,2,4-triazole derivatives containing oxime ether and cyclopropyl moieties as potential sterol demethylase inhibitors》. The information in the text is summarized as follows:

In the search for novel sterol demethylase inhibitors (DMIs), a series of 1,2,4-triazole derivatives containing oxime ether and cyclopropyl moieties I (R = Ph, 2,4,6-trichlorophenyl, 2-(1,3-dimethoxy-3-oxoprop-1-en-2-yl)benzen-1-yl, etc.) were designed using the bioactive substructure combination assisted by virtual mol. docking. The antifungal evaluation against Rhizoctonia solani (Rs), Fusarium graminearum (Fg), and Botrytis cinerea (Bc) indicated that most of the target compounds exhibited remarkable inhibitory activities against the above-mentioned tested fungi. Significantly, the compound I (R = 2,6-dichlorophenyl) exhibited outstanding anti-Fg activity with an EC50 value of 1.22μg mL-1 in vitro, and a protective effect of 59.45% in vivo at 200μg mL-1. Further investigation revealed that compound I (R = 2,6-dichlorophenyl) evidently inhibited Fg spore germination and caused some wrinkles and dents on the surface of mycelia. Mol. docking showed that compound I (R = 2,6-dichlorophenyl) bound with the target protein FgCYP51 via coordination, hydrogen bonding and stacking interactions that were similar, but slightly different from the interactions of tebuconazole with FgCYP51. These research results suggested that the target compounds I are valuable for the further structural optimization of novel triazole fungicides. In addition to this study using 3-Chlorobenzylchloride, there are many other studies that have used 3-Chlorobenzylchloride(cas: 620-20-2Recommanded Product: 3-Chlorobenzylchloride) was used in this study.

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Recommanded Product: 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Discovery of novel 2,8-diazaspiro[4.5]decan-1-one derivatives as potent RIPK1 kinase inhibitors》 was written by Niu, Ao; Lin, Lizhi; Zhang, Danyang; Jiang, Kaixuan; Weng, Dan; Zhou, Wenjia; Wang, Jinxin. COA of Formula: C7H6Cl2 And the article was included in Bioorganic & Medicinal Chemistry on April 1 ,2022. The article conveys some information:

Necroptosis, a key form of programmed lytic cell death, has gained recognition as an important driver in various inflammatory diseases. Inhibition of kinase activity of receptor interaction protein kinase 1 (RIPK1), which block the activation of the necroptosis pathway has shown therapeutic potential in many human diseases. In order to find new chemotypes of RIPK1 inhibitors, a virtual screening workflow was performed and led to the discovery of 8-benzoyl-3-benzyl-1,3,8-triazaspiro[4.5]decane-2,4-dione as a hit compound Further structural optimization identified a series of 2,8-diazaspiro[4.5]decan-1-one derivatives as potent RIPK1 inhibitors. Among them, compound 2-(2,5-difluorobenzyl)-8-(1-methyl-1H-indole-6-carbonyl)-2,8- diazaspiro[4.5]decan-1-one exhibited prominent inhibitory activity against RIPK1 with an IC50 value of 92 nM. Meanwhile, compound 2-(2,5-difluorobenzyl)-8-(1-methyl-1H-indole-6-carbonyl)-2,8- diazaspiro[4.5]decan-1-one showed a significant anti-necroptotic effect in a necroptosis model in U937 cells. Therefore, 2-(2,5-difluorobenzyl)-8-(1-methyl-1H-indole-6-carbonyl)-2,8- diazaspiro[4.5]decan-1-one could be employed as a lead compound of RIPK1 inhibitors for further structural optimization. In the part of experimental materials, we found many familiar compounds, such as 3-Chlorobenzylchloride(cas: 620-20-2COA of Formula: C7H6Cl2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.COA of Formula: C7H6Cl2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Asymmetric Transfer Hydrogenation of Unhindered and Non-Electron-Rich 1-Aryl Dihydroisoquinolines with High Enantioselectivity》 was written by Barrios-Rivera, Jonathan; Xu, Yingjian; Wills, Martin. COA of Formula: C7H6Cl2 And the article was included in Organic Letters on August 21 ,2020. The article conveys some information:

The use of arene/Ru/TsDPEN catalysts bearing a heterocyclic group on the TsDPEN in the asym. transfer hydrogenation (ATH) of dihydroisoquinolines (DHIQs) containing meta- or para-substituted aromatic groups at the 1-position results in the formation of products of high enantiomeric excess. Previously, only 1-(ortho-substituted)aryl DHIQs, or with an electron-rich fused ring gave products with high enantioselectivity; therefore, this approach solves a long-standing challenge for imine ATH. In the experiment, the researchers used many compounds, for example, 3-Chlorobenzylchloride(cas: 620-20-2COA of Formula: C7H6Cl2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.COA of Formula: C7H6Cl2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Nickel-catalyzed reductive benzylation of tertiary alkyl halides with benzyl chlorides and chloroformates》 were Wang, Jiabao; Gong, Yuxin; Sun, Deli; Gong, Hegui. And the article was published in Organic Chemistry Frontiers in 2021. Application In Synthesis of 3-Chlorobenzylchloride The author mentioned the following in the article:

Ni-Catalyzed reductive cross-coupling of tertiary alkyl halides with benzyl chlorides and chloroformates has been developed, which provides an efficient method for the construction of benzylated all-carbon quaternary centers in moderate to excellent yields with high functional group tolerance. The results came from multiple reactions, including the reaction of 3-Chlorobenzylchloride(cas: 620-20-2Application In Synthesis of 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Application In Synthesis of 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics