Category: 620-20-2

Liu, Qian; Zhao, Xiaoqian; Xu, Feng; Li, Gaoqiang published an article on February 13 ,2020. The article was titled 《Metal-free oxidative coupling of alkyl chlorides with thiols: An efficient access to sulfoxides》, and you may find the article in Tetrahedron Letters.COA of Formula: C7H6Cl2 The information in the text is summarized as follows:

An efficient and step-economical access to sulfoxides from thiols and alkyl halides in the presence of I2O5 and DBU via direct oxidative coupling was described. It is the first case that combined Williamson sulfide synthesis and subsequent sulfide oxidation into one step manipulation for sulfoxides preparation This protocol features wide substrate scope, mild and metal-free conditons, the use of naturally abundant starting materials and avoidance of over-oxidation The experimental process involved the reaction of 3-Chlorobenzylchloride(cas: 620-20-2COA of Formula: C7H6Cl2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.COA of Formula: C7H6Cl2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《A novel series of [1,2,4]triazolo[4,3-a]pyridine sulfonamides as potential antimalarial agents: in silico studies, synthesis and in vitro evaluation》 were Karpina, Veronika R.; Kovalenko, Svitlana S.; Kovalenko, Sergiy M.; Drushlyak, Oleksandr G.; Bunyatyan, Natalya D.; Georgiyants, Victoriya A.; Ivanov, Vladimir V.; Langer, Thierry; Maes, Louis. And the article was published in Molecules in 2020. SDS of cas: 620-20-2 The author mentioned the following in the article:

For the development of new and potent antimalarial drugs, the virtual library with three points of randomization of novel [1,2,4]triazolo[4,3-a]pyridines bearing a sulfonamide fragment, e.g., I has been described. The library of 1561 compounds has been investigated by both virtual screening and mol. docking methods using falcipain-2 as a target enzyme. 25 Chosen hits were synthesized and evaluated for their antimalarial activity in vitro against Plasmodium falciparum. 3-Ethyl-N-(3-fluorobenzyl)-N-(4-methoxyphenyl)-[1,2,4]triazolo[4,3-a]pyridine-6-sulfonamide and 2-(3-chlorobenzyl)-8-(piperidin-1-ylsulfonyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one showed in vitro good antimalarial activity with inhibitory concentration IC50 = 2.24 and 4.98μM, resp. This new series of compounds may serve as a starting point for future antimalarial drug discovery programs. After reading the article, we found that the author used 3-Chlorobenzylchloride(cas: 620-20-2SDS of cas: 620-20-2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.SDS of cas: 620-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Chemical Science included an article by Joung, Seewon; Bergmann, Allison M.; Brown, M. Kevin. Quality Control of 3-Chlorobenzylchloride. The article was titled 《Ni-catalyzed 1,2-benzylboration of 1,2-disubstituted unactivated alkenes》. The information in the text is summarized as follows:

Nickel-catalyzed 1,2-carboboration of alkenes is emerging as a useful method for chem. synthesis. Prior studies have been limited to only the incorporation of aryl groups. In this manuscript, a method for the 1,2-benzylboration of unactivated alkenes is presented. The reaction combines readily available alkenes, diboron reagents and benzylchlorides to generate synthetically versatile products with control of stereochem. The utility of the products as well as the mechanistic details of the process are also presented.3-Chlorobenzylchloride(cas: 620-20-2Quality Control of 3-Chlorobenzylchloride) was used in this study.

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Quality Control of 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yuan, Huihui; Wang, Mingyue; Fan, Lei; Yang, Jia; Wang, Shuai; Zhong, Hong published their research in Tetrahedron Letters on December 21 ,2021. The article was titled 《A solvent-free method for the preparation of phosphinates from P(O)-OH compounds with alkyl chlorides》.Formula: C7H6Cl2 The article contains the following contents:

Herein, a new solvent-free synthetic method using P(O)-OH compound and alkyl chloride for phosphinate compounds is disclosed. This transformation proceeds smoothly under the promotion of a lone base and presents the advantages of an easily available raw material source, a simple post treatment process, good functional group tolerance and high reaction efficiency. Good yield was obtained when the reaction was magnified to gram scale(coating), and the molar ratio of P(O)-OH compounds and alkyl chlorides can be decreased to 1:2. This protocol provides a practical method for the preparation of phosphorus derivatives Furthermore, the reaction mechanism was explored by 31P NMR. The experimental process involved the reaction of 3-Chlorobenzylchloride(cas: 620-20-2Formula: C7H6Cl2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Formula: C7H6Cl2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fu, Dong-Jun; Cui, Xin-Xin; Zhu, Ting; Zhang, Yan-Bing; Hu, Yang-Yang; Zhang, Li-Rong; Wang, Sheng-Hui; Zhang, Sai-Yang published their research in Bioorganic Chemistry on February 28 ,2021. The article was titled 《Discovery of novel indole derivatives that inhibit NEDDylation and MAPK pathways against gastric cancer MGC803 cells》.Name: 3-Chlorobenzylchloride The article contains the following contents:

A series of novel indole derivatives were synthesized and evaluated for their antiproliferative activity against three selected cancer cell lines (MGC803, EC-109 and PC-3). Among these analogs, 2-(5-methoxy-1H-indol-1-yl)-N-(4-methoxybenzyl)-N-(3,4,5-trimethoxyphenyl)acetamide (I) showed the best inhibitory activity against MGC803 cells with an IC50 value of 1.59μM. Cellular mechanisms elucidated that I inhibited colony formation, induced apoptosis and arrested cell cycle at G2/M phase. Importantly, indole analog I inhibited NEDDylation pathway and MAPK pathway against MGC803 cells. In the experiment, the researchers used many compounds, for example, 3-Chlorobenzylchloride(cas: 620-20-2Name: 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Name: 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Yurong; Liu, Yafei; Zhang, Jun; Gu, Ren; Han, Shiqing published their research in Tetrahedron Letters on December 5 ,2019. The article was titled 《An alternatively metal-free synthesis of 1,3,5-triazines or 1,2,4-thiadiazoles from benzyl chlorides and benzylamines mediated by elemental sulfur》.Quality Control of 3-Chlorobenzylchloride The article contains the following contents:

An elemental sulfur mediated reaction of benzyl chlorides with benzylamines was developed, which allows the practical synthesis of valuable 1,3,5-triazines. This protocol that was metal free, ligand free, and uses inexpensive elemental sulfur as oxidant or raw material displays mild reaction conditions, a broad substrate scope and moderate to good yields. Moreover, the modified sulfur-mediated reaction system was used to synthesize 1,2,4-thiadiazoles, by simply switching the stoichiometry of sulfur powder from 0.75 equiv to 5 equivalent The results came from multiple reactions, including the reaction of 3-Chlorobenzylchloride(cas: 620-20-2Quality Control of 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Quality Control of 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Category: chlorides-buliding-blocksOn May 31, 2021, Cao, Chaotun; Cao, Chenzhong; Qu, Junyan published an article in Journal of Luminescence. The article was 《Quantifying and fine adjusting the solid-state fluorescence wavelength of 1-thienyl-2-arylethylene》. The article mentions the following:

Thirty two 1-thienyl-2-arylethylene derivatives (XAEY) were synthesized and their solid-state fluorescence emission wavelengths Em (nm) were determined The effects of substituents X and Y on the fluorescence wavelengths were analyzed in detail. The quant. correlation anal. for the Em was carried out by employing the ground-state polarity parameters and excited-state parameters of the substituents X and Y. A quant. equation was obtained and its reliability was verified by the leave-one-out (LOO) method. The obtained results show: (1) For the compounds XAEY, when the group Y on the aryl group is fixed, the Em order is 2′-methyl-2-thienyl-AEY > 3-thienyl-AEY > 2-thienyl-AEY; when thienyl (X) is fixed, the Em of XAEY with electron-withdrawing group Y is longer than that of XAEY with electron-donating group Y; (2) The Em of XAEY can be finely adjusted by changing groups X and Y. That is, one can obtain a series of compounds with continuous fluorescence emission wavelength in range of 450-600 nm via selecting different groups X or Y. (3) The 2′-Me has an addnl. red shift effect on the Em of 2′- methyl-2-thienyl-AEY. The results of this paper can provide an important reference for studying theor. solid-state fluorescence emission spectra of organic compounds and designing corresponding fluorescent material mols. In the experimental materials used by the author, we found 3-Chlorobenzylchloride(cas: 620-20-2Category: chlorides-buliding-blocks)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Recommanded Product: 620-20-2On November 30, 2019 ,《An improved method for the synthesis of phenylacetic acid derivatives via carbonylation》 appeared in Journal of Chemical Research. The author of the article were Li, He; Zhang, Yijun; Liu, Dinghua; Liu, Xiaoqin. The article conveys some information:

A series of phenylacetic acid derivatives RCH2CO2H [R = 2-ClC6H4, 4-MeC6H4, 2,4-Cl2C6H3, etc.] was synthesized via bistriphenylphosphine palladium dichloride catalyzed carbonylation reaction of benzyl chloride derivatives in presence of tetraethylammonium chloride and sodium hydroxide as reagents and xylene as solvent at 80°C under a CO atm. 2,4-Dichlorophenylacetic acid was obtained in a maximum yield of 95% from 2,4-dichlorobenzyl chloride using the same reaction system. In the experimental materials used by the author, we found 3-Chlorobenzylchloride(cas: 620-20-2Recommanded Product: 620-20-2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Recommanded Product: 620-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Synthesis, antimicrobial activities, and molecular docking studies of dihydrotriazine derivatives bearing a quinoline moiety》 were Bai, Xueqian; Chen, Ying; Liu, Zhe; Zhang, Linhao; Zhang, Tianyi; Feng, Bo. And the article was published in Chemistry & Biodiversity in 2019. Recommanded Product: 3-Chlorobenzylchloride The author mentioned the following in the article:

In this article, three series of dihydrotriazine derivatives bearing a quinoline moiety (5a, 5b, 8a-8c, and 9a-9m) have been designed, synthesized, and evaluated as antibacterial agents. Compounds 8a-8c were found to be the most potent of all of the compounds tested with an MIC value of 1 μg/mL against several Gram-pos. (S. aureus 4220 and MRSA CCARM 3506) and Gram-neg. (E. coli 1924) strains of bacteria. In addition, 3-[4-amino-6-(phenethylamino)-2,5-dihydro-1,3,5-triazin-2-yl)-6-[(3-chlorobenzyl)oxy]quinolin-2-ol (8a) showed potent inhibitory activity (MIC=2 μg/mL) against Pseudomonas aeruginosa 2742, indicating that its antibacterial spectrum is similar to those of the pos. controls gatifloxacin and moxifloxacin. Structure-activity relationships (SAR) analyses and docking studies implicated the dihydrotriazine group in increasing the antimicrobial potency of the quinoline compounds In vitro enzyme study implied that compound 8a also displayed DHFR inhibition. In addition to this study using 3-Chlorobenzylchloride, there are many other studies that have used 3-Chlorobenzylchloride(cas: 620-20-2Recommanded Product: 3-Chlorobenzylchloride) was used in this study.

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Recommanded Product: 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 620-20-2On November 30, 2020 ,《Design and synthesis of C-ring quinoxaline-substituted sinomenine 1,2,3-triazole derivatives via click reactions》 appeared in Journal of Chemical Research. The author of the article were Lu, Tong; Dong, Ling; Pan, Hongmei; Wu, Xuedan; Chen, Xia; Gu, Chengwen; Tao, Naili; Wang, Ao; Zhang, Kehua; Jin, Jie. The article conveys some information:

The synthesis of C-ring quinoxaline-substituted sinomenine 1,2,3-triazole derivatives at the 4-OH via click reactions was accomplished, and a total of 16 novel sinomenine double N-heterocyclic derivatives are obtained in 74%-95% yields. The C-ring is first transformed into a 1,2-diketone structure under the action of hydrochloric acid, and then reacted with o-phenylenediamine to obtain a C-ring quinoxaline-substituted structure. The 4-OH of sinomenine reacted with chloropropyne to give an alkynyl sinomenine, and then reacts with sodium azide and various benzyl chlorides to give the target compounds All the synthesized derivatives were characterized by Fourier-transform IR spectrometry, high resolution mass spectrometry, 1H NMR, and 13C NMR spectroscopy. In the experimental materials used by the author, we found 3-Chlorobenzylchloride(cas: 620-20-2Application of 620-20-2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Application of 620-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics