Category: 620-20-2

The author of 《Synthesis and Characterization of Novel Thiazolidinones and Thioxothiazolidinones Derived from Substituted Indole》 were Rekiba, Nawel; Benmohammed, Abdelmadjid; Khanoussi, Sofiane; Djafri, Ayada; Thibonnet, Jerome. And the article was published in Molbank in 2021. Quality Control of 3-Chlorobenzylchloride The author mentioned the following in the article:

Based on recent discoveries concerning the numerous biol. properties of thiazolidinones and thiosemicarbazones, new N-substituted heterocyclic derivatives I [R = F, H, 3-Cl, 3-CF3, 2-C≡N], II and III had been designed by combining the indole ring with thioxothiazolidinone, thiazolidinone or thiosemicarbazone. Thus, a series of new thioxothiazolidinone, thiazolidinone, or thiosemicarbazone derivatives I, II and III bearing indole-based moiety have been designed, synthesized, and developed in good yields. The experimental part of the paper was very detailed, including the reaction process of 3-Chlorobenzylchloride(cas: 620-20-2Quality Control of 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Quality Control of 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Quality Control of 3-ChlorobenzylchlorideOn September 30, 2019 ,《Sodium Selenosulfate from Sodium Sulfite and Selenium Powder: An Odorless Selenylating Reagent for Alkyl Halides to Produce Dialkyl Diselenide Catalysts》 was published in Synlett. The article was written by Liu, Yonghong; Ling, Hai; Chen, Chao; Xu, Qing; Yu, Lei; Jiang, Xuefeng. The article contains the following contents:

Na2SeSO3, which can be generated in situ by the reaction of Na2SO3 with Se power, was found to be an odorless reagent for the selenenylation of alkyl halides RX (R = Bu, cyclohexyl, 3-fluorobenzyl, etc.; X = Cl, Br) to produce dialkyl diselenides RSeSeR. By using aqueous EtOH as the solvent and avoiding the generation of a malodorous selenol intermediate, the selenylation reaction with Na2SeSO3 is much more environmentally friendly than conventional methods. Owing to the cheap and abundant starting materials and selenium reagents, the novel synthetic method reduces the production costs of dialkyl diselenides as organoselenium catalysts, thereby advancing practical applications of organoselenium-catalysis technologies. In the experiment, the researchers used 3-Chlorobenzylchloride(cas: 620-20-2Quality Control of 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Quality Control of 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Synthesis and in vitro antibacterial activity of quaternized 10-methoxycanthin-6-one derivatives》 was published in Molecules in 2019. These research results belong to Li, Na; Liu, Dan; Dai, Jiang-Kun; Wang, Jin-Yi; Wang, Jun-Ru. Reference of 3-Chlorobenzylchloride The article mentions the following:

Background: Based on our previous work, we found that 10-methoxycanthin-6-one displayed potential antibacterial activity and quaternization was an available method for increasing the antibacterial activity. Here, we explored the antibacterial activity of quaternized 10-methoxy canthin-6-one derivatives Methods and Results: Twenty-two new 3-N-benzylated 10-methoxy canthin-6-ones were designed and synthesized through quaternization reaction. The in vitro antibacterial activity against three bacteria was evaluated by the double dilution method. Moreover, the structure-activity relationships (SARs) were carefully summarized in order to guide the development of antibacterial canthin-6-one agents. Two highly active compounds displayed 8-fold superiority (MIC = 3.91 μg/mL) against agricultural pathogenic bacteria R. solanacearum and P. syringae compared to agrochem. streptomycin sulfate, and showed potential activity against B. cereus. Moreover, these two compounds exhibited good “”drug-like”” properties, low cytotoxicity, and no inhibition on seed germination. Conclusions: This work provides two new effective quaternized canthin-6-one derivatives as candidate bactericide, promoting the development of natural-sourced bactericides and preservatives. In the experiment, the researchers used many compounds, for example, 3-Chlorobenzylchloride(cas: 620-20-2Reference of 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Reference of 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Design, synthesis and anticancer activity studies of novel trimethoxyphenyl-quinoline derivatives》 was published in Youji Huaxue in 2020. These research results belong to Wu, Bowen; Cui, Xinxin; Zhu, Ting; Wang, Shenghui; Lu, Chaofan; Wang, Jinjie; Dang, Hexiang; Zhang, Saiyang; Ding, Li-na; Jin, Chengyun. Recommanded Product: 3-Chlorobenzylchloride The article mentions the following:

A series of novel trimethoxyphenyl-quinoline hybrids I [R = 4-MeC6H4, 4-FC6H4, 5-Cl-2-thienyl, etc.] were designed, synthesized and evaluated for antiproliferative activity against three human cancer cell lines. Compound I [R = 3-ClCH2C6H4] showed the most potent antitumor activity against PC-3 cells with IC50 value of 9.23μmol/L. Meanwhile, compound I [R = 3-ClCH2C6H4] inhibited the cell viability and colony formation of PC-3 cells. Further mechanism studies revealed that compound I [R = 3-ClCH2C6H4] could arrest PC-3 cells in G2/M phase and induce cell apoptosis via activating intrinsic and extrinsic apoptosis pathway. In the experimental materials used by the author, we found 3-Chlorobenzylchloride(cas: 620-20-2Recommanded Product: 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Recommanded Product: 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hu, Weitao; Lin, Zhiyang; Wang, Chuan published their research in Organic Letters on August 12 ,2022. The article was titled 《Synthesis of Multisubstituted Allylic Alcohols via a Nickel-Catalyzed Cross-Electrophile Ring-Opening Reaction》.Computed Properties of C7H6Cl2 The article contains the following contents:

Herein, a nickel-catalyzed cross-electrophile ring-opening reaction of vinyl epoxides I (R1 = Ph, 1-naphthyl, benzodioxol-5-yl, etc.; R2 = H, Me, phenyl; R3 = H, Ph, furan-2-yl, thiophen-2-yl) was reported, wherein aryl iodides, alkyl iodides, and benzyl chlorides R4X (R4 = Pr, cyclohexyl, phenyl; X = I, Cl) can all serve as the electrophilic coupling partners, providing a new approach to preparing multisubstituted allylic alcs. R1C(CH(OH)R3)=C(R2)CH2R4. This new method features broad substrate scope multisubstituted allylic alcs., good step-economy, and high L/B- and E/Z selectivity as well as mild reaction conditions.3-Chlorobenzylchloride(cas: 620-20-2Computed Properties of C7H6Cl2) was used in this study.

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Computed Properties of C7H6Cl2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Lijuan; Wang, Xiaobin; Tang, Xu; Xia, Rongjiao; Guo, Tao; Zhang, Cheng; Li, Xiangyang; Xue, Wei published their research in BMC Chemistry on December 31 ,2019. The article was titled 《Design, synthesis, antiviral bioactivities and interaction mechanisms of penta-1,4-diene-3-one oxime ether derivatives containing a quinazolin-4(3H)-one scaffold》.Reference of 3-Chlorobenzylchloride The article contains the following contents:

penta-1,4-diene-3-one oxime ether and quinazolin-4(3H)-one derivatives possess favorable agricultural activities. Aiming to discover novel mols. with highly-efficient agricultural activities, a series of penta-1,4-diene-3-one oxime ether derivatives containing a quinazolin-4(3H)-one scaffold were synthesized and evaluated for their antiviral activities. Antiviral bioassays indicated that some title compounds exhibited significant antiviral activity against tobacco mosaic virus (TMV). In particular, compounds 8c, 8j and 8k possessed appreciable curative activities against TMV in vivo, with half-maximal effective concentration (EC50) values of 138.5, 132.9 and 125.6 μg/mL, resp., which are better than that of ningnanmycin (207.3 μg/mL). Furthermore, the microscale thermophoresis experiments (MST) on the interaction of compound 8k with TMV coat protein (TMV CP) showed 8k bound to TMV CP with a dissociation constant of 0.97 mmol/L. Docking studies provided further insights into the interaction of 8k with the Arg90 of TMV CP. Sixteen penta-1,4-diene-3-one oxime ether derivatives containing a quinazolin-4(3H)-one scaffold were designed, synthesized, and their antiviral activities against TMV were evaluated. Antiviral bioassays indicated that some target compounds exhibited remarkable antiviral activities against TMV. Furthermore, through the MST and docking studies, we can speculate that 8k inhibited the virulence of TMV by binding Arg90 in TMV CP. These results indicated that this kind of penta-1,4-diene-3-one oxime ether derivatives containing a quinazolin-4(3H)-one scaffold could be further studied as potential alternative templates in the search for novel antiviral agents. In addition to this study using 3-Chlorobenzylchloride, there are many other studies that have used 3-Chlorobenzylchloride(cas: 620-20-2Reference of 3-Chlorobenzylchloride) was used in this study.

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Reference of 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of C7H6Cl2On May 31, 2022, Wang, Qi; Yao, Lingyun; Wang, Jian-Shu; Ying, Jun; Wu, Xiao-Feng published an article in Molecular Catalysis. The article was 《Palladium-catalyzed aminocarbonylative cyclization of benzyl chlorides with 2-nitroaryl alkynes to construct indole derivatives》. The article mentions the following:

A palladium-catalyzed aminocarbonylative cyclization of benzyl chlorides RCH2Cl (R = Ph, 3,5-dichlorophenyl, naphthalen-1-yl, etc.) with 2-nitroaryl alkynes 2-NO2-4-R1-5-R2C6H2CCR3 (R1 = H, Me, F; R2 = H, Cl; R3 = Ph, n-Bu, cyclopropyl, etc.) has been developed for the rapid construction of indole skeletons I. The reaction utilized nitroarenes as the nitrogen source, Mo(CO)6 as both the CO surrogate and the reductant to furnish various indole derivatives I in moderate to high yields. In the experiment, the researchers used many compounds, for example, 3-Chlorobenzylchloride(cas: 620-20-2Electric Literature of C7H6Cl2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Electric Literature of C7H6Cl2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Synthesis of 2-Arylbenzoselenazoles from Se-mediated Redox Condensation of 2-Chloronitrobenzene and Arylmethyl Chlorides》 was written by Gan, Haifeng; Cao, Mengru; Wu, Hongli. Formula: C7H6Cl2 And the article was included in ChemistrySelect on April 13 ,2020. The article conveys some information:

A selenium-mediated redox condensation of 2-chloronitrobenzenes 2-Cl-RC6H3NO2 (R = H, 4-Me, 5-F, 5-CF3, etc.) and arylmethyl chlorides R1CH2Cl (R1 = Ph, naphthalen-1-yl, pyridin-3-yl, etc.) to obtain 2-arylbenzoselenazoles I (R2 = H, 6-Me, 5-F, 5-Br, etc.) has been realized under metal-free condition. The reactions proceeded in moderate-to-good yields with good functional compatibility and gram-scale achievement. Primarily mechanistic investigation suggested that key intermediate Bn(Se)nBn II, was first isolated and confirmed by NMR. After reading the article, we found that the author used 3-Chlorobenzylchloride(cas: 620-20-2Formula: C7H6Cl2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Formula: C7H6Cl2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Facile Preparation of Benzoxazoles from S8-Promoted Cyclization of 2-Nitrophenols with Arylmethyl Chloride》 was published in ChemistrySelect in 2019. These research results belong to Gan, Haifeng. Recommanded Product: 3-Chlorobenzylchloride The article mentions the following:

A simple, metal-free methodol. has been obtained for the preparation of 2-arylbenzoxazoles I (R = H, 6-Me, 5-NHC(O)CH3, etc.; R1 = Ph, naphthalen-2-yl, pyridin-4-yl, etc.) from 2-nitrophenols 2-NO2-R2 -C6H3OH (R = H, 5-Me, 4-F, etc.) and arylmethyl chlorides R1CH2Cl via an elemental sulfur-promoted cyclization reaction. The reactions proceeded in moderate to good yields, and gram-scale is applicable. After reading the article, we found that the author used 3-Chlorobenzylchloride(cas: 620-20-2Recommanded Product: 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Recommanded Product: 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Structure-activity relationship study of gatastatin based on the topliss tree approach》 was written by Hayakawa, Ichiro; Shioda, Shuya; Chinen, Takumi; Usui, Takeo; Kigoshi, Hideo. Category: chlorides-buliding-blocks And the article was included in Heterocycles in 2019. The article conveys some information:

Various analogs of gatastatin I [Ar = 3-ClC6H4, 4-MeC6H4, 4-tButC6H4, etc.], a γ-tubulin-specific inhibitor, were designed and synthesized by systematically optimizing the aromatic ring at the O7-benzyl group in accordance with an operational Topliss tree, and their biol. activities were evaluated. Some derivatives showed stronger cytotoxicity against HeLa cells than gatastatin. Especially, the cytotoxicity of the I [Ar = 3-ClC6H4] derivative was about 18-fold stronger than that of gatastatin. However, these derivatives did not exhibit binding ability to the yeast γ-tubulin small complex or inhibitory activity against α,β-tubulin polymerization These results suggested that γ-tubulin strongly recognized the unsubstituted Ph ring of the O7-benzyl group in gatastatin.3-Chlorobenzylchloride(cas: 620-20-2Category: chlorides-buliding-blocks) was used in this study.

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics