Category: 61881-19-4

Some common heterocyclic compound, 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, molecular formula is C8H5ClF3N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 2,2,2-Trifluoro-N-phenylacetimidoyl chloride

Compound 16 (97 mg, 42.9 mol) was reacted with (N-phenyl)-2,2,2-trifluoroacetoimidoyl chloride (17.8 mg, 85.8 mol) andK2CO3 (29.7 mg, 215 mol) in acetone (1.7 mL) as described for 13. The crude product was purified bysilica gel column chromatography with hexane-EtOAc (83:17) and gel permeation chromatography[S-X1, toluene-EtOAc (75:25)] to give the title product 17 (94.7 mg, 91%). [alpha]D -35.2 (c 1.3, CHCl3);1H-NMR (500 MHz, CDCl3) delta7.38-7.07 (m, 43H, Ar), 6.82 (d, 1H, J2,NH = 9.4 Hz, NH), 6.71-6.69 (m,2H, Ar), 6.26 (br, 1H, H-1GlcN), 6.00 (d, 1H, J2,NH = 4.7 Hz, NH), 5.88-5.81 (m, 1H, H2C=CHCH2),5.30-5.14 (m, 10H, H2C=CHCH2 2, H-1Fuc 2, H-2Fuc 2, H-3Fuc 2, H-4Fuc 2), 5.07 (d, 1H,J1,2 = 8.1 Hz, H-1GlcN), 5.03-5.00 (m, 2H, H-5Fuc, PhCH2), 4.94 (dd, 1H, J4,5 = 12.7 Hz, J5,6 = 6.4 Hz,H-5Fuc), 4.78 (d, 1H, Jgem = 11.6 Hz, PhCH2), 4.71 (d, 1H, Jgem = 11.2 Hz, PhCH2), 4.63 (d, 1H,Jgem = 11.9 Hz, PhCH2), 4.60-4.37 (m, 13H, PhCH2 11, H-1Gal, H-2GlcN), 4.32 (d, 1H, J1,2 = 7.8 Hz,H-1Gal), 4.20 (t, 1H, J2,3 = J3,4 = 9.2 Hz, H-3GlcN), 4.07-4.01 (m, 3H, H2C=CHCH2 2, H-4GlcN),3.93-3.77 (m, 8H, H-4GlcN, H-2GlcN, H-6aGal, H-6aGal, H-4Gal, H-5GlcN, H-4Gal, H-6bGal), 3.76-3.65(m, 3H, H-3Gal, H-3GlcN, H-2Gal), 3.62-3.52 (m, 5H, H-6aGlcN, H-6bGlcN, H-6aGlcN, H-6bGal, H-2Gal),3.49-3.44 (m, 2H, H-5Gal, H-6bGlcN), 3.38 (dd, 1H, J5,6a = 5.5 Hz, J5,6b = 7.5 Hz, H-5Gal), 3.21-3.18 (m,2H, H-3Gal, H-5GlcN), 2.16 (s, 3H, Ac), 2.15 (s, 3H, Ac), 2.14 (s, 3H, Ac), 2.05 (s, 3H, Ac), 2.01 (s, 6H,Ac 2), 0.85 (d, 3H, H-6Fuc), 0.69 (d, 3H, J5,6 = 6.4 Hz, H-6Fuc); 13C-NMR (125 MHz, CDCl3) delta170.4,170.3, 170.2, 170.1, 169.4, 160.9, 160.7, 142.7, 139.0, 138.8, 138.4, 138.3, 138.2, 138.1, 137.8, 137.6, 137.3,134.9, 129.3, 129.0, 129.0, 128.8, 128.5, 128.4, 128.4, 128.3, 128.2, 128.2, 128.2, 128.1, 128.1, 127.9, 127.8,127.7, 127.7, 127.6, 127.5, 127.3, 127.3, 125.2, 124.6, 119.2, 117.0, 116.6, 114.8, 103.4, 103.2, 99.4, 96.0, 95.6,93.3, 92.6, 92.4, 81.8, 80.8, 78.5, 78.1, 77.6, 76.5, 75.1, 74.9, 74.7, 74.6, 74.4, 74.3, 74.1, 73.4, 73.3, 73.2, 72.9,72.8, 72.4, 72.0, 71.6, 71.5, 71.4, 68.8, 68.5, 68.2, 68.1, 68.0, 67.9, 67.1, 66.7, 64.8, 64.5, 58.7, 54.6, 30.9,29.6, 21.4, 20.9, 20.8, 20.8, 20.7, 20.7, 15.7, 15.2, 14.1. HRMS (ESI) m/z: found [M + Na]+ 2450.6466,C119H130Cl6F3N3O35 calcd. for [M + Na]+ 2450.6466.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 61881-19-4, its application will become more common.

Reference:
Article; Kobayashi, Daisuke; Ueki, Akiharu; Yamaji, Tomoya; Nagao, Kazuya; Imamura, Akihiro; Ando, Hiromune; Kiso, Makoto; Ishida, Hideharu; Molecules; vol. 21; 5; (2016);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 61881-19-4, HPLC of Formula: C8H5ClF3N

To a solution of the hemiacetal 28 in acetone (10mL) and water (50muL), Cs2CO3 (189mg, 0.6mmol) and (N-phenyl)trifluoroacetimidoyl chloride (56muL, 0.4mmol) were added at room temperature. The reaction mixture was stirred for 3h at room temperature. After complete reaction (monitored by TLC), the mixture was filtered through Celite by elution with chloroform. The combined filtrates were concentrated and purified by flash chromatography (solvent D) to yield compound 29 (236mg, 87%) as a colorless foam: [alpha]D23 +164.2 (c 0.3, CHCl3); Rf=0.57 (solvent B2); 1H NMR (500.13MHz, CDCl3): delta 8.08 (m, 2H), 7.97 (m, 2H), 7.81 (m, 2H), 7.61-7.56 (m, 4H), 7.49-7.42 (m, 4H), 7.41-7.08 (m, 22H), 7.05 (m, 2H), 6.83 (m, 2H) (4 CH2C6H5, 3 COC6H5, NC6H5); 6.27 (br, 1H, H-1); 5.93 (dd, 1H, 3J2?,3?=10.7Hz, 3J3?,4?=3.5Hz, H-3?); 5.78 (dd, 1H, 3J2,3=3.0Hz, 3J1,2=2.0Hz, H-2); 5.58 (dd, 1H, 3J3?,4?=3.5Hz, 3J4?,5?=1.4Hz, H-4?); 5.46 (d, 1H, 3J1?,2?=3.3Hz, H-1?); 5.07 (dd, 1H, 3J2?,3?=3.3Hz, 3J1?,2?=1.9Hz, H-2?); 5.08, 4.94 (2d, 2H, 2J=10.4Hz, CH2C6H5); 4.89 (d, 1H, 3J1?,2?=1.9Hz, H-1?); 4.74, 4.58 (2d, 2H, 2J=11.4Hz, CH2C6H5); 4.68 (m, 1H, H-5?); 4.55 (dd, 1H, 3J3,4=9.8Hz, 3J2,3=3.0Hz, H-3); 4.50 (dd, 1H, 3J2?,3?=10.7Hz, H-2?); 4.24 (center of qAB, 2H, 2J=12.2Hz), 4.15, 3.43 (2d, 2H, 2J=10.7Hz), (2 CH2C6H5); 4.03 (dq, 1H, 3J4,5=9.2Hz, 3J5,6=6.1Hz, H-5); 3.98 (dq, 1H, 3J4?,5?=9.1Hz, 3J5?,6?=6.3Hz, H-5?); 3.98 (?t?, 1H, 3J3,4=9.8Hz, 3J4,5=9.5Hz, H-4); 3.43 (dd, 1H, 3J5?,6a?=6.3Hz, H-6a?); 3.31 (dd, 1H, 2J6a?,6b?=10.2Hz, 3J5?,6b?=5.7Hz, H-6b?); 3.26 (dd, 1H, 3J3?,4?=8.8Hz, 3J2?,3?=3.3Hz, H-3?); 3.23 (?t?, 1H, 3J4?,5?=9.1Hz, H-4?); 1.63 (s, 3H, COCH3); 1.54 (d, 3H, 3J5,6=6.1Hz, H-6); 1.39 (d, 3H, 3J5?,6?=6.3Hz, H-6?); 13C NMR (125.8MHz, CDCl3): delta 168.8 (COCH3); 165.1, 165.2, 165.5 (3 COC6H5); 143.2 (i-NC6H5); 137.4, 137.8, 138.2, 138.9 (4 i-CH2C6H5); 133.4, 133.3, 133.0 (3 p-COC6H5); 130.6-127.2 (several signals of o-, m-COC6H5, o-, m-, p-CH2C6H5, m-NC6H5); 129.5, 129.3, 128.8 (3 i-COC6H5); 124.4 (p-NC6H5); 119.4 (o-NC6H5); 115.9 (q, 1JC,F=287Hz, CF3); 100.0 (C-1?); 94.4 (C-1?); 93.7 (br, C-1); 79.9 (C-4?); 79.0 (C-4); 77.8 (C-3?); 76.3, 75.0, 72.8, 71.2 (4 CH2C6H5); 71.7 (C-2?); 71.5 (C-3); 71.3 (C-5); 70.8 (C-3?); 69.8 (C-4?); 68.5 (C-5?); 68.4 (C-2?); 67.8 (C-6?); 67.3 (C-5?); 66.7 (C-2); 20.3 (COCH3); 18.4 (C-6); 18.1 (C-6?); CCF3 signal not given; 19F NMR (282.4MHz, CDCl3): delta -75.7 (CF3). HRMS (ESI-TOF): calcd for C77H74F3NO18 (M+Na+): m/z 1380.4750, found: m/z 1380.4751.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Nilsson, Inga; Michalik, Dirk; Silipo, Alba; Molinaro, Antonio; Vogel, Christian; Carbohydrate Research; vol. 404; (2015); p. 98 – 107;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 61881-19-4

General procedure: t-BuOK (40.3mg, 0.36mmol) were added to a solution of fluorinated imidoyl chlorides 1 (0.45mmol) and isocyanides 2 (0.3mmol) in DMF (2.0mL). The mixture was stirred at 60C under air for 1h. After the completion of the reaction (monitored by TLC), the reaction mixture was cooled to ambient temperature, quenched by water and extracted with ethyl acetate (3¡Á15mL). The extract was dried over anhydrous Na2SO4 and the solvent was removed in vacuo to provide a crude product, which was purified by column chromatography on silica gel with petroleum ether/EtOAc as eluent to afford the imidazole products 3.

The synthetic route of 61881-19-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Chen, Zhengkai; Hu, Sipei; Wu, Xiao-Feng; Yang, Hefei; Tetrahedron; (2020);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 61881-19-4,Some common heterocyclic compound, 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, molecular formula is C8H5ClF3N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: In a typical experimental procedure, a dry, two-necked, 50 mL round-bottomed flask equipped with a nitrogen inlet was charged with 5 mL of dry MeCN, 0.117 g (1.0 mmol) of indole and 0.24 g (1.0 mmol) of NaH. The solution was stirred under a nitrogen atmosphere at room temperature for 30 min, then a solution of 2a (1.0 mmol in 2 mL of dry MeCN) was added dropwise via a syringe. The mixture was stirred at room temperature for 20 h under an N2 atmosphere and then filtered. After removing the solvent under reduced pressure, the crude product was purified by preparative thin-layer chromatography on silica gel [eluent: n-hexane/EtOAC, 4:1] to give the product 4a. The products obtained from indole-3-carbaldehyde were purified by recrystallization from EtOH (twice).

The synthetic route of 61881-19-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Darehkordi, Ali; Rahmani, Fariba; Hashemi, Vahide; Tetrahedron Letters; vol. 54; 35; (2013); p. 4689 – 4692;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 61881-19-4, A common heterocyclic compound, 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, molecular formula is C8H5ClF3N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 12 (1.35 g, 1.16 mmol), (N-phenyl)-2,2,2-trifluoroacetoimidoyl chloride (482 mg, 2.32 mmol), andK2CO3 (802 mg, 5.80 mmol) in acetone (23.2 mL) was stirred for 1 h at room temperature. The reaction mixture was filtered through Celite, and concentrated. The crude product was purified by gelpermeation chromatography [S-X3, toluene-EtOAc (75:25)] and silica gel column chromatography with hexane-EtOAc (71:29) to give the title product 13 (1.31 g, 85%). [alpha]D -0.7 (c 1.4, CHCl3);1H-NMR (500 MHz, CDCl3) delta7.38-7.08 (m, 23H, Ar), 6.75-6.71 (m, 3H, Ar, NH), 6.32 (br, 1H, H-1GlcN),5.88-5.80 (m, 1H, H2C=CHCH2), 5.31-5.21 (m, 5H, H2C=CHCH2, H-1Fuc, H-2Fuc, H-3Fuc, H-4Fuc),5.14 (dd, 1H, Jtrans = 10.5 Hz, Jgem = 1.4 Hz, H2C=CHCH2), 4.95 (dd, 1H, J4,5 = 10.5 Hz, J5,6 = 6.4 Hz,H-5Fuc), 4.84 (d, 1H, Jgem = 11.9 Hz, PhCH2), 4.73 (d, 1H, Jgem = 11.4 Hz, PhCH2), 4.64-4.49 (m, 7H,PhCH2 5, H-2GlcN, H-1Gal), 4.44 (d, 1H, Jgem = 11.6 Hz, PhCH2), 4.16 (t, 1H, J2,3 = J3,4 = 9.2 Hz,H-3GlcN), 4.10-4.05 (m, 3H, H2C=CHCH2 2, H-4GlcN), 3.87-3.81 (m, 3H, H-4Gal, H-6aGal, H-5GlcN),3.70 (dd, 1H, J5,6b = 7.5 Hz, Jgem = 9.2 Hz, H-6bGal), 3.62-3.56 (m, 3H, H-2Gal, H-6aGlcN, H-6bGlcN),3.46-3.44 (m, 1H, H-5Gal), 3.24 (dd, 1H, J2,3 = 9.7 Hz, J3,4 = 2.7 Hz, H-3Gal), 2.14 (s, 3H, Ac), 2.02 (s, 3H,Ac), 2.00 (s, 3H, Ac), 0.78 (d, 3 H, H-6Fuc); 13C-NMR (125 MHz,CDCl3) delta 170.4, 120.2, 169.5, 161.2, 142.9, 138.7, 138.4, 138.2, 137.5, 134.9, 129.2, 129.0, 128.8, 128.5, 128.4,128.3, 128.2, 128.1, 128.0, 127.8, 127.8, 127.7, 127.6, 127.3, 124.6, 119.3, 116.6, 103.8, 95.9, 92.4, 81.9, 78.5, 77.6,74.9, 74.8, 74.2, 73.7, 73.7, 73.3, 73.2, 72.2, 71.9, 71.7, 71.6, 68.7, 68.1, 68.0, 66.7, 64.8, 54.7, 20.8, 20.8, 20.7, 15.4.HRMS (ESI) m/z: found [M + Na]+ 1351.3539, C65H70Cl3F3N2O18 calcd. for [M + Na]+ 1351.3539.

The synthetic route of 61881-19-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kobayashi, Daisuke; Ueki, Akiharu; Yamaji, Tomoya; Nagao, Kazuya; Imamura, Akihiro; Ando, Hiromune; Kiso, Makoto; Ishida, Hideharu; Molecules; vol. 21; 5; (2016);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 61881-19-4,Some common heterocyclic compound, 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, molecular formula is C8H5ClF3N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

10249] To a solution of 6-(6?-azidohexyl)-2,3,4-tri-O-ben- zyl-a/3-D-galactopyranose 18 (400 mg, 0.70 mmol) in CH2C12 (7 mE) was added cesium carbonate (340 mg, 1.04 mmol). To the mixture was added 2,2,2-trifluoro-N-pheny- lacetimidoyl chloride 24 (216 mg, 1.04 mmol) and the reaction mixture was stirred at r.t. for 3.5 h after which it was filtered over celite and washed with CH2C12. The solvent was removed in vacuo and the crude product was purified by flash column chromatography on silica gel (gradient hexanes/ EtOAc1 0:1 – 1:1) to yield the imidate 19 (490 mg, 94%) as a colorless oil. [a]Dt+60.8 (c0.4, CHC13); R1O.8O (Hexanes/EtOAc 2:1); IR (film) vm,x 3064, 2934, 2865, 2094, 1717, 1598, 1454, 1321, 1207, 1099, 1027, 910, 734, 696cm?; ?H NMR (400 MHz, CDC13) oe 7.45-6.60 (m, 20H),5.56 (s, 1H), 4.90 (d, J11.5 Hz, 1H), 4.75 (s, J1.5 Hz, 2H),4.68 (s, J12.4 Hz, 2H), 4.58 (d, J11.6 Hz, 1H), 4.00 (t,J8.7 Hz, 1H), 3.84 (d, J2.4 Hz, 1H), 3.58-3.39 (m, 4H),3.34 (dt, J9.3, 6.5 Hz, 1H), 3.23 (dt, J9.3, 6.5 Hz, 1H), 3.14(t, J6.9 Hz, 2H), 1.52-1.38 (m, 4H), 1.32-1.16 (m, 4H); ?3CNMR (101 MHz, CDC13) oe 138.6, 138.3, 138.2, 128.8, 128.6,128.5, 128.4, 128.4, 128.3, 128.0, 127.9, 127.8, 127.7, 124.3,119.4,82.3,78.3,77.4,77.2,76.8,75.7,74.9,74.6,73.4,73.2,71.4, 68.7, 51.5, 29.7, 28.9, 26.7, 25.8; HR ESI Calcd forC41H45F3N406 [M+Na]: 769.3183. found: 769.3239.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, its application will become more common.

Reference:
Patent; Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.; UNIVERSITAeTSSPITAL BASEL; Seeberger, Peter H.; Stallforth, Pierre; De Libero, Gennaro; Cavallari, Marco; US2015/238597; (2015); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 61881-19-4,Some common heterocyclic compound, 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, molecular formula is C8H5ClF3N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Add sodium acetate, trifluoroethylimidyl chloride (II), hydrazone (III), and 1 mL of organic solvent to the 35 mL Schlenk tube according to the raw material ratio in Table 1.Mix and stir well. After the reaction is completed according to the reaction conditions in Table 2, 2-4 hours,Add elemental iodine, continue the reaction for 1-2 hours, filter, and stir the sample in silica gel.After purification by column chromatography, the corresponding 5-trifluoromethyl-substituted 1,2,4-triazole compound (I) is obtained. The reaction process is shown by the following formula:

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, its application will become more common.

Reference:
Patent; Zhejiang Sci-Tech University; Chen Zhengkai; Hu Sipei; Yang Zuguang; (10 pag.)CN110467579; (2019); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 61881-19-4, The chemical industry reduces the impact on the environment during synthesis 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, I believe this compound will play a more active role in future production and life.

2.9. Synthesis of N-Phenyl Trifluoroacetimidate (3,4,6-tri-O-acetyl-2-azido-2-deoxy-alpha-D-glucopyranosyl)-(1? 2)-3,7-di-O-benzoyl-4-O-para-bromobenzyl-6-O-benzyl-L-glycero-D-manno-heptopyranoside 2 To a solution of compound 30 (83 mg, 0.072 mmol) in acetone/H2O (10/1, v/v, 2.2 mL), was added NBS (38 mg, 0.22 mmol). After being stirred at room tempearature for 1 h, the mixture was diluted with EtOAc, washed with saturated aqueous NaHCO3 and brine. The organic layer was dried over Na2SO4, filtered, and concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane/EtOAc: 2/1) to afford the corresponding hemiacetal (54 mg, 76%) as a colorless syrup. To a solution of the above hemiacetal (69 mg, 0.070 mmol) and K2CO3 (27 mg, 0.195 mmol) in acetone (1.5 mL), was added 2,2,2-trifluoro-N-phenylacetimidoyl chloride (100 mg, 0.482 mmol). After being stirred at room temperature for 30 min, the solution was filtered and concentrated in vacuo to a residue, which was purified by silica gel column chromatography (hexane/EtOAc: 3/1) to afford 2 (70 mg, 87%) as a colorless syrup: [alpha]20D = +47.32 (c 0.8, CHCl3); 1H NMR (400 MHz, CDCl3) delta 8.06 – 8.01 (m, 4 H), 7.61 – 7.09 (m, 18 H), 6.86 – 6.81 (m, 4 H), 5.62 (dd, J = 9.2, 10.4 Hz, 1 H), 5.59 (dd, J = 2.8, 9.2 Hz, 1 H), 5.05 (dd, J = 9.6, 10.4 Hz, 1 H), 4.85 (d-like, J = 12.0 Hz, 1 H), 4.77 (dd, J = 5.2, 10.8 Hz, 1 H), 4.60 (d-like, J = 12.4 Hz, 1 H), 4.49 – 4.40 (m, 5 H), 4.27 (dd, J = 4.0, 12.4 Hz, 1 H), 4.15 (t, J = 6.4 Hz, 1 H), 4.08 (d-like, J = 9.6 Hz, 1 H), 3.99 (d-like, J = 12.4 Hz, 1 H), 3.40 (dd, J = 4.0, 10.8 Hz, 1 H), 2.12 (s, 3 H), 2.01 (s, 3 H), 1.95 (s, 3 H); 13C NMR (100 MHz, CDCl3) delta 170.5, 169.8, 169.7, 166.2, 165.9, 143.2, 137.8, 136.7, 133.6, 133.3, 131.4, 129.8, 129.7, 129.6, 129.3, 129.2, 128.9, 128.8, 128.6, 128.5, 128.2, 128.1, 124.6, 121.6, 119.4, 99.3, 77.3, 73.6, 73.5, 72.7, 72.5, 72.2, 70.4, 68.5, 68.2, 62.3, 61.5, 61.1, 20.8, 20.7, 20.6; HRMS (ESI) m/z calcd for C55H52BrF3N4O16Na [M+Na]+ 1185.2400, found 1185.2423.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.; Seeberger, Peter H.; Yang, You; Anish, Chakkumkal, Dr.; Reinhardt, Anika; EP2573100; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 61881-19-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, This compound has unique chemical properties. The synthetic route is as follows.

Cs2C03 (3.0 equiv.), CF3C(NPh)CI (3.0 equiv.) were added to a stirred solution of 22 in DCM (10 mL/1 g) at 0C. After 10 min., the mixture was brought to rt and stirred for 1 h. After complete consumption of 22, reaction mixture was filtered, and the filtrate was concentrated. The obtained crude residue was purified by automated flash column chromatography on silica gel (0-60% EtOAc in cyclohexane) to afford the desired imidate donor 23 (87%) as foam.

The chemical industry reduces the impact on the environment during synthesis 2,2,2-Trifluoro-N-phenylacetimidoyl chloride. I believe this compound will play a more active role in future production and life.

Reference:
Patent; VAXXILON AG; EMMADI, Madhu; LISBOA, Marilda P; KNOPP, Daniel; MONNANDA, Bopanna; VON BONIN, Arne; PEREIRA, Claney Lebev; (309 pag.)WO2020/104697; (2020); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 61881-19-4,Some common heterocyclic compound, 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, molecular formula is C8H5ClF3N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Alcohol 15* (136 mg, 0.19 mmol) was dissolved in CH2CI2(2 mL). Levulinic acid (0.1 mL, 0.96 mmol), 4-dimethylaminopyridine (140 mg, 1 .15 mmol) and di-/sopropylcarbodiimide (0.15 mL, 0.96 mmol) were added. The reaction mixture was stirred at r.t. overnight. The mixture was diluted with CH2CI2, washed with brine and then concentrated in vacuo. The crude product was purified by chromatography column on silica gel (Hexanes/EtOAc = 1 :1 ) to afford the levulinate ester (150 mg, 97%). The levulinate ester (161 mg, 0.199 mmol) was dissolved in acetone and water (6.25 mL, v/v = 4/1 ) at 0 C. TCCA (46 mg, 0.199 mmol) was added. The reaction mixture was allowed to warm to r.t. overnight. The reaction mixture was diluted with ethyl acetate, washed with sat NaHCO3 and brine. The organic layer was dried over MgSO4, filtered and concentrated in vacuo. The residue was purified by column chromatography on silica gel (Hexanes/EtOAc = 1/2) to give the hemiacetal (121 mg, 79%). To a solution of hemiacetal (121 mg, 0.158 mmol) in acetone (3 mL) was added K2CO3(66 mg, 0.48 mmol) and PhN=C(CI)CF3(98 mg, 0.48 mmol). The mixture was stirred overnight at r.t.. The solution was filtered and concentrated in vacuo. The residue was purified by column chromatography on silica gel (Hexanes/EtOAc = 2.2/1 to 1/1 ) to give the imidate 24* (139 mg, 94%). [a]D25= 59.57 (c = 0.25, CHCIs);1H NMR (400 MHz, CDCI3) delta 7.31 -7.25 (m, 16H), 7.19 (m, 1 H), 7.09 (m, 1 H), 6.73 (m, 3 H), 5.42 (brs, 1 H), 5.31 (dd, J = 2.0, 10.8 Hz, 1 H), 4.97 (br, 1 H), 4.86 (d, J = 10.8 Hz, 1 H), 4.74-4.56 (m, 6 H), 4.37 (d, J = 1 1 .2 Hz, 1 H), 4.01 (dd, J = 2.8, 10.4 Hz, 1 H), 3.79 (s, 3 H), 3.77 (m, 1 H), 3.68 (m, 1 H), 3.36 (t, J = 9.6 Hz, 1 H), 2.89-2.69 (m, 3 H), 2.52 (m, 1 H), 2.18 (s, 3 H), 2.1 1 (s, 3 H), 1 .29 (d, J = 6.4 Hz, 3 H);13C NMR (101 MHz, CDCI3) delta 206.31 , 172.54, 170.44, 167.16, 143.40,138.75, 138.08, 137.33, 128.88, 128.64, 128.53, 128.38, 128.23, 128.20, 127.89,127.76, 127.67, 127.61 , 124.44, 1 19.45, 100.57, 79.70, 77.76, 77.31 , 75.19, 73.1 1 , 72.07, 72.01 , 71 .75, 71 .18, 68.94, 68.86, 52.79, 37.97, 29.81 , 27.86, 21 .27, 18.08; HRMS (ESI): calcd for C49H52F3NOi4Na [M + Na]+: 958.3238, found: 958.3303.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, its application will become more common.

Reference:
Patent; MAX-PLANCK-GESELLSCHAFT ZUR FOeRDERUNG DER WISSENSCHAFTEN E.V.; SEEBERGER, Peter; PEREIRA, Claney Lebev; XIAO, Guozhi; KHAN, Naeem; ANISH, Chakkumkal; (120 pag.)WO2016/156338; (2016); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics